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| 1 | 在有煽动性、非煽动性的腹的疼痛显型的孩子的 interleukin-6 和桅杆房间的反的关系显示文摘 AIM: To investigate interleukin-6 (IL-6), mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P in the gastrointestinal mucosa of children with abdominal pain. METHODS: Formalin-fixed paraffin-embedded gas-trointestinal biopsy blocks from patients (n = 48) with non-inflammatory bowel disease (irritable bowel syndrome and functional abdominal pain) and inflammatory bowel disease were sectioned and stained for IL-6, mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P. All children had chronic abdominal pain as part of their presenting symptoms. Biopsy phenotype was confirmed by a pathologist, blinded to patient information. Descriptive statistics, chi-square, and independent sample t tests were used to compare differences between the inflammatory and non-inflammatory groups. RESULTS: The cohort (n = 48), mean age 11.9 years (SD = 2.9), 54.2% females, 90% Caucasian, was comprised of a non-inflammatory (n = 26) and an inflammatory (n = 22) phenotype. There was a significant negative correlation between substance P expression and mast cell count (P = 0.05, r = -0.373). Substance P was found to be expressed more often in female patient biopsies and more intensely in the upper gastrointestinal mucosa as compared to the lower mucosa. There were significantly increased gastrointestinal mucosal immunoreactivity to IL-6 (P = 0.004) in the inflammatory phenotype compared to non-inflammatory. Additionally, we found significantly increased mast cells (P = 0.049) in the mucosa of the non-inflammatory phenotype compared to the inflammatory group. This difference was particularly noted in the lower colon biopsies. CONCLUSION: The findings of this study yield preliminary evidence in identifying biomarkers of undiagnosed abdominal pain in children and may suggest candidate genes for future evaluation. | Wendy A Henderson Ravi Shankar Tara J Taylor Arseima Y Del Valle-Pinero David E Kleiner Kevin H Kim Nader N Youssef | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，6： | 2 |
| 2 | 细胞分离培养在实验室诊断眼部单纯疱疹病毒感染疾病的误诊和漏诊情况(英文)显示文摘目的:对比聚合酶链反应(PCR)和细胞分离培养在实验室诊断眼部单纯疱疹病毒(HSV)感染疾病的作用。方法:我们对连续患者的实验室结果(PCR实验,细胞分离培养及临床诊断)及病历进行回顾性研究在诊断眼部HSV感染疾病过程中,PCR检测结果、细胞分离培养及首诊结果进行了统计比较。结果:患者581例经过检查后,520例PCR检查阴性,细胞培养阴性(89.6%);0例PCR检查阴性,细胞培养阳性(0%);27例PCR检查阳性,细胞培养阴性(4.6%);34例PCR检查阳性,细胞培养阳性(5.8%)。PCR检测阳性率高于细胞分离培养(McNemars,P=0.0001)。47例PCR检查为HSV初诊感染阳性患者中,19例患者中有14例为细胞培养阴性结果(74%),5例HSV患者因缺PCR检测结果将被误诊;28例患者中有25例患者细胞培养阳性(占89%),3例HSV患者因缺PCR检测结果将被漏诊。结论:PCR诊断眼部HSV感染优于细胞分离培养。细胞分离培养对于眼部HSV感染的非典型表现不易诊断。 | Regis P Kowalski Paul P Thompson Tara H Cronin | 2010 | 国际眼科杂志2010，10，11： | 2 |
| 3 | 2-Methoxyestradiol-a unique blend of activities generating a new class of anti-tumour/ anti-inflammatory agents 显示文摘 | TARA E S ROBIN L A RICHARD A H | 2007 | J Biol Chem2007，12，1314： | 1 |
| 4 | Silk-based biomaterials显示文摘 | Gregory H Altman Frank Diaz Caroline Jakuba Tara Calabro Rebecca L Horan Jingsong Chen Helen Lu John Richmond David L Kaplan | 2002 | Biomaterials2002，，3： | 1 |
| 5 | Prooxidant-antioxidant balance in pregnancy:a randomized double-blind placebo-controlled trial of selenium supplementation显示文摘 | Tara F Rayman M P Boskabadi H | 2010 | Perinat Med2010，38，5： | 1 |
| 6 | Effeets of furoquinoline alkaloids on the growth and feeding of two polyphagous lepidopterans显示文摘 | Tara E Saekett G H Neil Towers Murray B Isman | 2007 | Chemoecology2007，17，： | 1 |
| 7 | Moyamoya disease: Diagnostic imaging显示文摘 | Taras 6w E Ku?akowska h Lukasiewicz A | 2011 | Pol J Radio12011，76，1： | 1 |
| 8 | Dedifferentiation of committed epithelial cells into stem ceils in vivo 显示文摘 | Tara PR Mou H Pardo-Saganta A | 2013 | Nature2013，503，7475： | 1 |
| 9 | Edible packaging显示文摘 | TARA H HUGH M C | 2001 | Academic Research Library2001，8，11： | 1 |
| 10 | Cell culture isolation can miss the laboratory diagnosis of HSV ocular infection显示文摘AIM:We compared polymerase chain reaction(PCR)to cell culture isolation for the laboratory diagnosis of ocular herpes simplex virus(HSV)disease. ? METHODS:Laboratory and medical records of consecutive patients were reviewed for results of 1)HSV PCR testing,2) HSV cell culture isolation,and 3)clinical diagnosis.PCR results were statistically compared to cell culture isolation and patients initially diagnosed for ocular HSV infection. RESULTS:Of 581 cases submitted for laboratory testing, 520 were PCR negative,cell culture negative(89.6%);0 were PCR negative,cell culture positive(0%);27 were PCR positive,cell culture negative(4.6%);and 34 were PCR positive,cell culture positive(5.8%).PCR tested more positive than cell culture isolation(McNemar’s,P=0.0001).Of 47 HSV PCR positive cases with complete medical records,19 were cell culture negative for HSV and 28 were cell culture positive for HSV.Fourteen of 19 cell culture negative cases (74%)(Without PCR,5 cases of HSV would be missed)and 25 of the 28 cell culture positive cases(89%)(Laboratory testing was necessary for diagnosing 3 cases)were clinically diagnosed with HSV at the initial examination. CONCLUSION:PCR was a more definitive test for diagnosing HSV ocular infection than cell culture isolation.Cell culture isolation alone can miss an atypical presentation of HSV ocular infection. | Regis P Kowalski Paul P Thompson Tara H Cronin | 2010 | International Journal of Ophthalmology(English edition)2010，3，2： | 1 |
| 11 | Drying and quality characteristics of fresh and sugar-infused blueberries dried with infrared radiation heating显示文摘 | Shi Junling Pan Zhongli Tara H | 2008 | LWT-Food Science and Technology2008，41，10： | 1 |
| 12 | The AustralianCancer Anaemia Survey:a snapshot of anaemia in adult patientswith cancer显示文摘 | Tara Seshadri H Miles Prince David R Bel | 2005 | MJA2005，182，9： | 1 |
| 13 | Dynamic Hepatitis C Virus Genotypic and Phenotypic Changes in Patients Treated With the Protease Inhibitor Telaprevir显示文摘 | Christoph Sarrazin Tara L. Kieffer Doug Bartels Brian Hanzelka Ute Müh Martin Welker Dennis Wincheringer Yi Zhou Hui–May Chu Chao Lin Christine Weegink Henk Reesink Stefan Zeuzem Ann D. Kwong | 2007 | Gastroenterology2007，，5： | 1 |
| 14 | Numb mediates the interaction between Wnt and Notch to modulate primitive erythropoietic speci- fication from the hemangioblast 显示文摘 | Xin C Tara H Vincent C | 2008 | Development2008，135，20： | 1 |
| 15 | Silk-based biomaterials显示文摘 | Gregory H Altman Frank Diaz Caroline Jakuba Tara Calabro Rebecca L Horan Jingsong Chen Helen Lu John Richmond David L Kaplan | 2002 | Biomaterials2002，，3： | 1 |
| 16 | Numb mediates the interac- tion between Wnt and Notch to modulate primitive erythropoietic specification from the hemangioblast 显示文摘 | Xin Cheng Tara H Vincent C | 2008 | Development2008，135，： | 1 |
| 17 | Agrohocterium tumefaciens- mediated transformation as a tool for random mutagenesis of Colletotriehum trifolii显示文摘 | Tak~tara H Tsuji G Kubo Y et-al | 2004 | J gen Plant Pathol2004，70，： | 1 |
| 18 | Nutrition and student performance at school显示文摘 | TARAS H | 2005 | J SchHealth2005，75，6： | 1 |
| 19 | Physical activity and student performance at school显示文摘 | TARAS H | 2005 | JSch Health2005，75，6： | 1 |
| 20 | Genetic variants of theprotein kinase C-/3{ gene and development of end-stage renaldisease in patients with type 2 diabetes 显示文摘 | Ma R C Tara C H Wang Y | 2010 | JAMA2010，304，8： | 1 |
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