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| 1 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 2 | Empirical analysis of audit uncertainty qualifications 显示文摘 | T B Bell and R H Tabor | 1991 | Journal of Accounting Research1991，1991，： | 1 |
| 3 | Value of speckle-tracking echocardiography for prediction of left ventricular remodeling in patients with ST-elevation myocardial infarction treated by primary percutaneous intervention显示文摘 | Bochenek T Wita K Tabor Z | 2011 | J Am Soc Echocardiogr2011，24，12： | 1 |
| 4 | Bulked seregant analysis identifies markers linked to Melampsora medusae resistance in Populus deltoides显示文摘 | TABOR G M KUBISIAK T L KLOPFENSTEIN N B | 2000 | Phytopathology2000，90，： | 1 |
| 5 | Does compression-only cardiopulmonary resuscitation generate adequate passive ventilation during cardiac arrest ?显示文摘 | DEAKINCD O'NEILL J F TABOR T | 2007 | Resuscitation2007，75，1： | 1 |
| 6 | Does compression-only cardiopulmonary resuscitation generate adequate passive ventilation during cardiac arrest显示文摘 | Deakin CD O'Neill JF Tabor T | 2007 | Resuscitation2007，75，1： | 1 |
| 7 | Respiratory dead space measurement in the investigation of pulmonary embolism in outpatients with pleuritic chest pain显示文摘 | Hogg K Dawson D Tabor T | | 0，，： | 1 |
| 8 | Ecophysiology of salt marsh plants and predicted responses to climate change in South Africa显示文摘 | Tabor P T Adams J B | 2013 | Ocean and Coastal Management2013，80，： | 1 |
| 9 | Targeting PI3K/Akt represses Hypoxia inducible factor-1 alpha activation and sensitizes Rhabdomyosarcoma and Ewing's sarcoma cells for apoptosis显示文摘 | Kilic-Eren M Boylu T Tabor V | 2013 | Cancer Cell Int2013，13，1： | 1 |
| 10 | Quantitative paleoenvironmental and paleoclimatic econstruction using aleosols显示文摘 | SHELDON N D TABOR N T | 2009 | Earth-Science Reviews2009，95，： | 1 |
| 11 | Targeting P13K/Akt represses hypoxia inducible factor-1alpha activation and sensitizes Rhabdomyosarcoma and Ewing's sarcoma cells for apoptosis显示文摘 | Kilic-Eren M Boylu T Tabor V | | 0，，1： | 1 |
| 12 | Value of speckle-tracking echocardiography for prediction of left ventricular remodeling in patients with ST-elevation myocardial infarction treated by primary percutaneous intervention显示文摘 | Bochenek T Wita K Tabor Z | 2011 | J Am Soc Echocardiogr2011，24，： | 1 |
| 13 | Value of speckle-tracking echocardiography for prediction' of left ventricular remodeling in patients with ST-elevation myocardial infarction treated by primary percutaneous intervention 显示文摘 | Bochenek T Wita K Tabor Z | 2011 | Am Soc Echocardiogr2011，24，12： | 1 |
| 14 | Targeting PI3K/Akt represses Hypoxia inducible factor-1α activation and sensitizes Rhabdomyosarcoma and Ewing ' s sarcoma cells for apoptosis显示文摘 | Kilic-Eren M Boylu T Tabor V | 2013 | Cancer Cell Int2013，13，： | 1 |
| 15 | Empirical analysis of audit uncertainty qualifications 显示文摘 | Bell T Tabor R | 1991 | Journal of Accounting Research1991，29，： | 1 |
| 16 | Primate animal models and tiered inocula for the study of human hepatitis A,hepatitis B,and non-A,non-B hepatitis显示文摘 | Tabor E Purcell RH Charlse T | 1983 | J Med Primatology1983，12，4： | 1 |
| 17 | Value of speckle-tracking echocargrap-h for prediction Of left ventricular rdmodeling in patients with ST-elevation myocardial infarction treated by primary percutaneous interven-tion 显示文摘 | Bochenek T Wita K Tabor Z | 2011 | J Am Soc Echocardigro2011，24，9： | 1 |
| 18 | Polyamines显示文摘 | Tabor C T Tabor H | 1984 | Annual Review of Biochemistry1984，53，： | 1 |
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