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| 1 | Fatal liver failure due to reactivation of lamivudine-resistant HBV mutant显示文摘We report a case of fatal liver failure due to reactivation of lamivudine-resistant HBV. A 53-year-old man was followed since 1998 for HBV-related chronic hepatitis. Serum HBV-DNA was 150 MEq/mL (branched DNA signal amplification assay) and ALT levels fluctuated between 50-200 IU/L with no clinical signs of liver cirrhosis. Lamivudine (100 mg/d) was started in May 2001 and serum HBV-DNA subsequently decreased below undetectable levels. In May 2002, serum HBV-DNA had increased to 410 MEq/mL, along with ALT flare (226 IU/L). The YMDD motif in the DNA polymerase gene had been replaced by YIDD. Lamivudine was continued and ALT spontaneously decreased to the former levels. On Oct 3 the patient presenting with general fatigue, nausea and jaundice was admitted to our hospital. The laboratory data revealed HBV reactivation and liver failure (ALT: 1828 IU/L, total bilirubin: 10 mg/dL, and prothrombin INR: 3.24). For religious reasons, the patient and his family refused blood transfusion, plasma exchange and liver transplantation. The patient died 10 d after admission. The autopsy revealed remarkable liver atrophy. | Tatehiro Kagawa Norihito Watanabe Hisashi Kanouda Ichiro Takayama Tadahiko Shiba Takashi Kanai Kazuya Kawazoe Shinji Takashimizu Nobue Kumaki Kazuo Shimamura Shohei Matsuzaki Tetsuya Mine | 2004 | World Journal of Gastroenterology2004，10，11： | 10 |
| 2 | Gender differences of low-dose aspirin-associated gastroduodenal ulcer in Japanese patients显示文摘AIM:To clarify the gender differences about the clini-cal features and risk factors of low-dose aspirin (LDA) (81-100 mg daily)-associated peptic ulcer in Japanese patients.METHODS: There were 453 patients under treatment with LDA (298 males, 155 females) who underwent esophagogastroduodenoscopy at the Department of Gastroenterology and Hepatology of Hiratsuka City Hospital between January 2003 and December 2007. They had kept taking the LDA or started treatmentduring the study period and kept taking LDA during the whole period of observation. Of these, 119 patients (87 males, 32 females) were diagnosed as having LDA-associated peptic ulcer. We examined the clinical factors associated with LDA-associated peptic ulcer in both sexes.RESULTS: A history of peptic ulcer was found to be the risk factor for LDA-associated peptic ulcer common to both sexes. In female patients, age greater than 70 years (prevalence ORs 8.441, 95% CI: 1.797-33.649, P = 0.0069) was found to be another significant risk fac-tor, and the time to diagnosis as having LDA-associat-ed peptic ulcer by endoscopy was significantly shorter than that in the male patients (P = 0.0050). CONCLUSION: We demonstrated gender differences about the clinical features and risk factors of LDA-asso-ciated peptic ulcer. Special attention should be paid to aged female patients taking LDA. | Kazuhisa Okada Masahiko Inamori Kento Imajyo Hideyuki Chiba Takashi Nonaka Tadahiko Shiba Takashi Sakaguchi Kazuhiko Atsukawa Hisao Takahashi Etsuo Hoshino Atsushi Nakajima | 2010 | World Journal of Gastroenterology2010，16，15： | 4 |
| 3 | Affinity for α-tocopherol transfer protein as a determinant of the biological activities of vitamin E analogs显示文摘 | Akihiro Hosomi Makoto Arita Yuji Sato Chikako Kiyose Tadahiko Ueda Osamu Igarashi Hiroyuki Arai Keizo Inoue | 1997 | FEBS Letters1997，，1： | 3 |
| 4 | Involvement of micro RNA ‐224 in cell proliferation, migration, invasion, and anti‐apoptosis in hepatocellular carcinoma显示文摘 | Yizhou Zhang Shoichi Takahashi Akiko Tasaka Tadahiko Yoshima Hidenori Ochi Kazuaki Chayama | 2013 | J Gastroenterol Hepatol2013，，3： | 2 |
| 5 | HIF-1α activation under glucose deprivation plays a central role inthe acquisition of anti-apoptosis in human colon cancer cells显示文摘 | Arata Nishimoto Naruji Kugimiya Tohru Hosoyama Tadahiko Enoki Tao-Sheng Li Kimikazu Hamano | 2014 | International Journal of Oncology2014，，6： | 2 |
| 6 | Long-term outcomes of combination of endoscopic submucosal dissection and laparoscopic lymph node dissection without gastrectomy for early gastric cancer patients who have a potential risk of lymph node metastasis显示文摘 | Nobutsugu Abe Hirohisa Takeuchi Atsuko Ohki Osamu Yanagida Tadahiko Masaki Toshiyuki Mori Masanori Sugiyama | 2011 | Gastrointestinal Endoscopy2011，，4： | 2 |
| 7 | A prospective comparison between multidetector-row computed tomography and magnetic resonance imaging in the preoperative evaluation of rectal carcinoma显示文摘 | Hiroyoshi Matsuoka Akihisa Nakamura Tadahiko Masaki Masanori Sugiyama Taro Takahara Junichi Hachiya Yutaka Atomi | 2003 | The American Journal of Surgery2003，，： | 2 |
| 8 | Latest technology of underground rock cavern excavation in Japan显示文摘 | Masanobu Tezuka Tadahiko Seoka | 2003 | Tunnelling and Underground Space Technology incorporating Trenchless Technology Research2003，，2： | 2 |
| 9 | Risk factors predictive of lymph node metastasis in depressed early gastric cancer显示文摘 | Nobutsugu Abe Takashi Watanabe Kazufumi Suzuki Hiromichi Machida Hiroshi Toda Yuzo Nakaya Tadahiko Masaki Toshiyuki Mori Masanori Sugiyama Yutaka Atomi | 2002 | The American Journal of Surgery2002，，2： | 2 |
| 10 | IoT-based Smart and Complex Systems:A Guest Editorial Report显示文摘THE Industrial Revolution starting from about 1760 and ending at around 1840 has been viewed as the first Industrial Revolution.It features with the replacement of human and animal muscle power with steam and mechanical power.Human income per capita had taken 800 years to double by | Naiqi Wu Zhiwu Li Kamel Barkaoui Xiaoou Li Tadahiko Murata MengChu Zhou | 2018 | IEEE/CAA Journal of Automatica Sinica2018，5，1： | 2 |
| 11 | Tin-based amorphous ox-ide:A high capacity lithium-ion atorage material显示文摘 | Yoshio I Tadahiko K Akihiro M | 1997 | Science1997，276，： | 1 |
| 12 | Physiological nitrogen efficiency in rice: Nitrogen utilization photosynthesis and yield potential显示文摘 | Tadahiko Mae | 1997 | Plant Soil1997，196，： | 1 |
| 13 | Modified Glasgow prognostic score in patients with incurable stage IV colorectal cancer显示文摘 | Tomokazu Kishiki Tadahiko Masaki Hiroyoshi Matsuoka Takaaki Kobayashi Yutaka Suzuki Nobutsugu Abe Toshiyuki Mori Masanori Sugiyama | 2013 | The American Journal of Surgery2013，，2： | 1 |
| 14 | Tin-based amorphous oxide:a highcapacity lithium-ion storage material 显示文摘 | Yoshio I Tadahiko K | 1997 | Sci1997，27，6： | 1 |
| 15 | Successive isolation of proteinase hyperproductive mutants of Aspergillus sojae显示文摘 | SEIICHI N TADAHIKO O NOBUYOSHI I | 1971 | Agric Biol Chem1971，35，2： | 1 |
| 16 | Develop- ment of a compact maglev centrifugal blood pump enclosed in a titanium housing 显示文摘 | Chi Nan PAI Tadahiko Shinshi Junichi Asama | 2008 | Journal of Advanced Mechanical Design Systems and Manufacturing2008，2，3： | 1 |
| 17 | 日本水坝的安全管理和地震安全评价显示文摘 | Yoshikazu YAMAGUCHI Toshihide KOBORI Tadahiko SAKAMOTO 陈奇 徐方军 | 2008 | 水利水电技术2008，39，7： | 1 |
| 18 | Distinguishing the 5,5-dimethyl-1-pyrroline N -oxide (DMPO)-OH radical quenching effect from the hydroxyl radical scavenging effect in the ESR spin-trapping method显示文摘 | Linxiang Li Yoshihiro Abe Kiyotada Kanagawa Noriko Usui Kazuhiro Imai Tadahiko Mashino Masataka Mochizuki Naoki Miyata | 2004 | Analytica Chimica Acta2004，，1： | 1 |
| 19 | Develoomental Stazes and Curriculum: A Jaoanese Persoective显示文摘 | TADAHIKO ABIKO | 2002 | Joumal of Curriculum and Suoervision2002，17，2： | 1 |
| 20 | Biosynthesis of fatty acid derived aldehydes is induced upon mechanical wounding and its products show fungicidal activities in cucumber显示文摘 | Kenji Matsui Akari Minami Ellen Hornung Hidetoshi Shibata Kyutaro Kishimoto Volker Ahnert Helmut Kindl Tadahiko Kajiwara Ivo Feussner | 2006 | Phytochemistry2006，，7： | 1 |
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