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| 1 | Phytochromes Regulate SA and JA Signaling Pathways in Rice and Are Required for Developmentally Controlled Resistance to Magnaporthe grisea显示文摘野类型的米饭植物的旧叶子(Oryza sativa L。cv。Nipponbare ) 比新叶子对强风真菌(Magnaporthe grisea ) 更抵抗。相反,米饭 phytochrome 三元组异种(phyAphyBphyC ) 的旧、新的叶子产生强风真菌。我们表明那个致病相关的班 1 (PR1 ) 蛋白质很快并且强烈在 M 期间被导致。grisea 感染和后面的外长的 jasmonate (JA ) 或水杨酸酸(SA ) 在旧叶子,然而并非在新叶子的暴露野类型。相反, PR1 蛋白质的累积显著地在 phyAphyBphyC 异种的旧、新的叶子被稀释。这些结果建议 phytochromes 在米饭为 PR1 蛋白质的正式就职被要求。PR1a 和 PR1b 的基础抄写层次是实质地更高的在象与 phyAphyBphyC 异种相比野类型,也建议那 phytochromes 为 PR1 基因的基础表示被要求。而且,知道在 SA 依赖或 JA 依赖的防卫小径工作的基因的抄本层次到叶年龄和功能的 phytochromes 被调整。一起拿,我们的调查结果证明 phytochromes 为年龄相关的抵抗在米饭被要求到 M。grisea 并且可以间接地由调整 SA 依赖、 JA 依赖的防卫小径增加 PR1 基因表示。 | Xian-Zhi Xie Yan-Jiu Xue Jin-Jun Zhou Bin Zhang Hong Chang Makoto Takano | 2011 | Molecular Plant2011，4，4： | 28 |
| 2 | 水稻抗稻瘟病防御系统中草酸氧化酶的鉴定显示文摘以水稻(Oryzasativa)OSK3蛋白激酶为诱饵,利用酵母双杂交系统中从水稻cDNA文库中筛选与其互作的蛋白,与植物抗病性相关的草酸氧化酶编码基因是所获得的阳性克隆之一,经检测报告基因lacZ的表达验证了互作的真实性。认为属于H2O2产生酶类的草酸氧化酶在水稻OSK3蛋白激酶介导的抗病途径中,可能是位于抗病信号传导链下游的蛋白。 | 冯洁 Takano Makoto | 2004 | 农业生物技术学报2004，12，3： | 12 |
| 3 | 光敏色素影响赤霉素调控的水稻幼苗光形态建成特征显示文摘赤霉素(gibberellin,GA)是一种重要的植物激素,它与光敏色素协同调节拟南芥植株的光形态建成特征.但是GA对水稻幼苗光形态建成和暗形态建成的影响,特别是在此过程中光敏色素与GA之间的相互作用仍不清楚.本研究利用野生型和光敏色素突变体(phyA和phyB)水稻作为研究材料,分析了GA生物合成抑制剂多效唑(PAC)对黑暗和光照下生长的水稻幼苗胚芽鞘、地上部分和主根延伸以及光调控基因LHCB表达的影响.据此推测,在暗生长条件下,PAC处理能够抑制野生型水稻幼苗胚芽鞘的生长,诱导LHCB基因的表达;phyA突变体对PAC处理的反应不如野生型敏感;phyB突变体和野生型反应基本相同.在光照条件下,PAC处理能够抑制水稻幼苗地上部分的生长,phyB突变体对PAC处理的反应不如野生型和phyA突变体敏感.此外,phyB介导的光信号负调控PAC诱导的主根延伸反应.据此推测,GA是维持水稻幼苗暗形态建成、抑制光形态建成所必需的;另一方面,phyA和phyB或正或负调控PAC所诱导的光形态建成反应.本研究结果揭示了光敏色素和GA在水稻幼苗生长发育中的相互作用,为进一步研究光和GA协同调控水稻发育的分子机制奠定了基础. | 刘婧 柳艳梅 TAKANO Makoto 王宝山 谢先芝 | 2010 | 科学通报2010，55，24： | 9 |
| 4 | Biliary drainage strategy of unresectable malignant hilar strictures by computed tomography volumetry显示文摘AIM:To identify criteria for predicting successful drainage of unresectable malignant hilar biliary strictures(UMHBS) because no ideal strategy currently exists.METHODS:We examined 78 patients with UMHBS who underwent biliary drainage.Drainage was considered effective when the serum bilirubin level decreased by ≥ 50% from the value before stent placement within 2 wk after drainage, without additional intervention.Complications that occurred within 7 d after stent placement were considered as early complications.Before drainage, the liver volume of each section(lateral and medial sections of the left liver and anterior and posterior sections of the right liver) was measured using computed tomography(CT) volumetry.Drained liver volume was calculated based on the volume of each liver section and the type of bile duct stricture(according to the Bismuth classification).Tumor volume, which was calculated by using CT volumetry, was excluded from the volume of each section.Receiver operating characteristic(ROC) analysis was performed to identify the optimal cutoff values for drained liver volume.In addition, factors associated with the effectiveness of drainage and early complications were evaluated.RESULTS:Multivariate analysis showed that drained liver volume [odds ratio(OR) = 2.92, 95%CI:1.648-5.197; P < 0.001] and impaired liver function(with decompensated liver cirrhosis)(OR = 0.06, 95%CI:0.009-0.426; P = 0.005) were independent factors contributing to the effectiveness of drainage.ROC analysis for effective drainage showed cutoff values of 33% of liver volume for patients with preserved liver function(with normal liver or compensated livercirrhosis)and 50%for patients with impaired liver function(with decompensated liver cirrhosis).The sensitivity and specificity of these cutoff values were82%and 80%for preserved liver function,and 100%and 67%for impaired liver function,respectively.Among patients who met these criteria,the rate of effective drainage among those with preserved liver function and impaired liver function was 90%and 80%,respectively.The rates of effective drainage in both groups were significantly higher than in those who did not fulfill these criteria(P<0.001 and P=0.02,respectively).Drainage-associated cholangitis occurred in 9 patients(12%).A smaller drained liver volume was associated with drainage-associated cholangitis(P<0.01).CONCLUSION:Liver volume drainage≥33%in patients with preserved liver function and≥50%in patients with impaired liver function correlates with effective biliary drainage in UMHBS. | Ei Takahashi Mitsuharu Fukasawa Tadashi Sato Shinichi Takano Makoto Kadokura Hiroko Shindo Yudai Yokota Nobuyuki Enomoto | 2015 | World Journal of Gastroenterology2015，21，16： | 6 |
| 5 | Risk factors for perforation during endoscopic retrograde cholangiopancreatography in post-reconstruction intestinal tract显示文摘BACKGROUND Endoscopic retrograde cholangiopancreatography(ERCP) in patients with surgically altered anatomy has been a major challenge to gastrointestinal endoscopists with low success rates for reaching the target site as well as high complication rates. The knowledge of ERCP-related risk factors is important for reducing unexpected complications.AIM To identify ERCP-related risk factors for perforation in patients with surgically altered anatomy.METHODS The medical records of 187 patients with surgically altered anatomy who underwent ERCP at our institution between April 2009 and December 2017 were retrospectively reviewed. An analysis of patient data, including age, sex, type of reconstruction, cause of surgery, aim of ERCP, success rate of reaching target site,success rate of procedure, adverse events, type of scope, time to reach the target site, and duration of procedure, was performed. In patients with Billroth-Ⅱ reconstruction, additional potential risk factors were the shape of the inserted scope and whether the anastomosis was antecolic or retrocolic.RESULTS All patients(n = 187) had surgical anatomy, such as Billroth-Ⅰ(n = 22), Billroth-Ⅱ(n = 33), Roux-en-Y(n = 54), Child, or Whipple reconstruction(n = 75). ERCP was performed for biliary drainage in 43 cases(23%), stone removal in 29 cases(16%),and stricture dilation of anastomosis in 59 cases(32%). The scope was unable to reach the target site in 17 cases(9%), and an aimed procedure could not be accomplished in 54 cases(29%). Adverse events were pancreatitis(3%),hyperamylasemia(10%), cholangitis(6%), cholestasis(4%), excessive sedation(1%), perforation(2%), and others(3%). Perforation occurred in three cases, all of which were in patients with Billroth-Ⅱ reconstruction; in these patients, further analysis revealed loop-shaped insertion of the scope to be a significant risk for perforation(P = 0.01).CONCLUSION Risk factors for perforation during ERCP in patients with surgically altered anatomy were Billroth-Ⅱ reconstruction and looping of the scope during BillrothⅡ procedure. | Shinichi Takano Mitsuharu Fukasawa Hiroko Shindo Ei Takahashi Sumio Hirose Yoshimitsu Fukasawa Satoshi Kawakami Hiroshi Hayakawa Hiroshi Yokomichi Makoto Kadokura Tadashi Sato Nobuyuki Enomoto | 2019 | World Journal of Clinical Cases2019，7，1： | 6 |
| 6 | Hemorrhagic shock due to submucosal esophageal hematoma along with mallory-weiss syndrome:A case report显示文摘BACKGROUND Esophageal submucosal hematoma is a rare condition.Although the exact etiology remains uncertain,vessel fragility with external factors is believed to have led to submucosal bleeding and hematoma formation;the vessel was ruptured by a sudden increase in pressure due to nausea,and the hematoma was enlarged by antiplatelet or anticoagulant therapy.Serious conditions are rare,with a better prognosis.We present the first known case of submucosal esophageal hematoma-subsequent hemorrhagic shock due to Mallory-Weiss syndrome.CASE SUMMARY A 73-year-old female underwent endovascular treatment for an unruptured cerebral aneurysm.The patient received aspirin and clopidogrel before surgery and heparin during surgery,and was well during the surgery.Several hours after returning to the ICU,she complained of chest discomfort,vomited 500 m L of fresh blood,and entered hemorrhagic shock.Esophageal submucosal hematoma with Mallory-Weiss syndrome was diagnosed through an endoscopic examination and computed tomography.In addition to a massive fluid and erythrocyte transfusion,we performed a temporary compression for hemostasis with a Sengstaken-Blakemore(S-B)tube.Afterwards,she became hemodynamically stable.On postoperative day 1,we performed an upper gastrointestinal endoscopy and confirmed no expansion of the hematoma nor any recurring bleeding;therefore,we removed the S-B tube and clipped the gastric mucosal laceration at the esophagogastric junction.We started oral intake on postoperative day 10.The patient made steady progress,and was discharged on postoperative day 33.CONCLUSION We present the first known case of submucosal esophageal hematoma subsequent hemorrhagic shock due to Mallory-Weiss syndrome. | Jiro Oba Daisuke Usuda Shiho Tsuge Riki Sakurai Kenji Kawai Shun Matsubara Risa Tanaka Makoto Suzuki Hayabusa Takano Shintaro Shimozawa Yuta Hotchi Kenki Usami Shungo Tokunaga Ippei Osugi Risa Katou Sakurako Ito Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Tomohisa Nomura Manabu Sugita | 2022 | World Journal of Clinical Cases2022，10，27： | 3 |
| 7 | Clinicopathology of pancreaticobiliary maljunction: relationship between alterations in background biliary epithelium and neoplastic development显示文摘 | Makoto Seki Akio Yanagisawa Eiji Ninomiya Yasuro Ninomiya Hirotoshi Ohta Akio Saiura Junji Yamamoto Toshiharu Yamaguchi Akiko Aruga Keiko Yamada Koichi Takano Rikiya Fujita Masayuki Ikeda Keiko Sasaki Yo Kato | 2005 | Journal of Hepato - Biliary - Pancreatic Surgery2005，，3： | 2 |
| 8 | High Risk for Bradyarrhythmic Complications in Patients With Brugada Syndrome Caused by SCN5A Gene Mutations显示文摘 | Takeru Makiyama Masaharu Akao Keiko Tsuji Takahiro Doi Seiko Ohno Kotoe Takenaka Atsushi Kobori Tomonori Ninomiya Hidetada Yoshida Makoto Takano Naomasa Makita Fumiko Yanagisawa Yukei Higashi Youichi Takeyama Toru Kita Minoru Horie | 2005 | Journal of the American College of Cardiology2005，，11： | 1 |
| 9 | Cystathionine β‐synthase as a carbon monoxide–sensitive regulator of bile excretion显示文摘 | Tsunehiro Shintani Takuya Iwabuchi Tomoyoshi Soga Yuichiro Kato Takehiro Yamamoto Naoharu Takano Takako Hishiki Yuki Ueno Satsuki Ikeda Tadayuki Sakuragawa Kazuo Ishikawa Nobuhito Goda Yuko Kitagawa Mayumi Kajimura Kenji Matsumoto Makoto Suematsu | 2008 | Hepatology2008，，1： | 1 |
| 10 | Effects of arc duration and atmosphere on the strength of joints by stud welding of an AZ31B magnesium alloy显示文摘 | HIRAISHI MAKOTO WATANABE TAKEHIKO TAKANO ITARU | 2002 | Journal of Japan Institute of Light Metals2002，52，8： | 1 |
| 11 | Cell Wall Invertase in Developing Rice Caryopsis: Molecular Cloning of OsCIN1 and A- nalysis of its Expression in Relation to its Role in Grain Filling 显示文摘 | Tatsuro Hirose Makoto Takano Tomio Terao | 2002 | Plant and Cell Physiology2002，43，4： | 1 |
| 12 | Bcl-2 expression and its association with cell kinetics in human gastric carcinomas and intestinal metaplasia显示文摘 | Makoto Saegusa Yasuo Takano Isao Okayasu | 1995 | Journal of Cancer Research and Clinical Oncology1995，，6： | 1 |
| 13 | Tissue response of a small saccular aneurysm after incomplete occlusion with a guglielmi detachable coil显示文摘 | Satoru Shimizu Akira Kurata Makoto Takano | 1999 | AJNR1999，20，： | 1 |
| 14 | Tissue Response of a Small Saeeular Aneurysm after Incomplete Occulsion with a Guglielmi Detachable Coil显示文摘 | Satoru Shimizu Akira Kurata Makoto Takano | 1999 | AJNR1999，20，： | 1 |
| 15 | Restoration of cadmium-contaminated paddy soils by washing with ferric chloride: Cd extraction mechanism and bench-scale verification显示文摘 | Tomoyuki Makino Hiroyuki Takano Takashi Kamiya Tadashi Itou Naoki Sekiya Makoto Inahara Yasuhiro Sakurai | 2007 | Chemosphere2007，，6： | 1 |
| 16 | The role of the Epstein-Barr virus in the oncogenesis of EBV(+) gastric carcinomas显示文摘 | Y. Takano Y. Kato Makoto Saegusa Shigeo Mori Mami Shiota Mitsunobu Masuda Tetsuo Mikami Isao Okayasu | 1999 | Virchows Archiv1999，，1： | 1 |
| 17 | Apoptosis, proliferative activity and Bcl-2 expression in Epstein-Barr-virus-positive non-Hodgkin’s lymphomas显示文摘 | Yasuo Takano Makoto Saegusa Mitsunobu Masuda Tetsuo Mikami Isao Okayasu | | 0，，： | 1 |
| 18 | Cholesterol-fed rabbit as a unique model of nonalcoholic, nonobese, non-insulin-resistant fatty liver disease with characteristic fibrosis显示文摘 | Mosaburo Kainuma Makoto Fujimoto Nobuyasu Sekiya Koichi Tsuneyama Chunmei Cheng Yasuo Takano Katsutoshi Terasawa Yutaka Shimada | 2006 | Journal of Gastroenterology2006，，10： | 1 |
| 19 | Absence of human papillomavirus genomic sequences detected by the polymerase chain reaction in oesophageal and gastric carcinomas in Japan显示文摘 | Saegusa Makoto Hashimura Miki Takano | 1997 | British Medical Journal1997，50，2： | 1 |
| 20 | 281 Quantitative Perfusion Analysis of Contrast-Enhanced Harmonic Endoscopic Ultrasonography in Solid Lesions of the Pancreas显示文摘 | Mitsuharu Fukasawa Shinichi Takano Makoto Kadokura Ei Takahashi Tadashi Sato Nobuyuki Enomoto | 2012 | Gastrointestinal Endoscopy2012，，4： | 1 |
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