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| 1 | 光照对肉鸡生长发育影响的研究进展与应用显示文摘光照在肉鸡生产中起关键作用,本文就光照对肉鸡的基本作用及光源、光照颜色、光照强度和光照周期等对肉鸡影响因素的研究与应用进行综述,总结不同饲养条件下的最适光照方案,为肉鸡生产中光照的选择提供帮助。 | 武玉珺 王梦梦 张明 Tausif Raza 燕磊 杨鹰 | 2018 | 中国畜牧杂志2018，54，7： | 5 |
| 2 | Liquid chromatography tandem mass spectrometry method for the estimation of lamotrigine in human plasma:Application to a pharmacokinetic study显示文摘A reliable,selective and sensitive liquid chromatography tandem mass spectrometry method was developed and validated for the quantification of lamotrigine in human plasma using lamotrigine13C3,d3 as an internal standard.Analyte and internal standard were extracted from human plasma by solid-phase extraction and detected in positive ion mode by tandem mass spectrometry with electrospray ionization(ESI) interface.Chromatographic separation was performed on a Chromolith s SpeedROD;RP-18e column(50-4.6 mm i.d.) using acetonitrile:570.1 mM ammonium formate solution(90:10,v/v) as the mobile phase at a flow rate of 0.500 mL/min.The calibration curves were linear over the range of 5.02-1226.47 ng/mL with the lower limit of quantitation validated at 5.02 ng/mL.The analytes were found stable in human plasma through three freeze(-20℃)-thaw(ice-cold water bath) cycles and under storage on bench-top in ice-cold water bath for at least 6.8 h,and also in the mobile phase at 10℃ for at least 57h.The method has shown good reproducibility,as the intra-and inter-day precisions were within 3.0%,while the accuracies were within 76.0% of nominal values.The validated LC-MS/MS method was applied for the evaluation of pharmacokinetic and bioequivalence parameters of lamotrigine after an oral administration of 50mg lamotrigine tablet to thirty-two healthy adult male volunteers. | Santosh Ghatol Vatsal Vithlani Sanjay Gurule Arshad Khuroo Tausif Monif Pankaj Partani | 2013 | Journal of Pharmaceutical Analysis2013，3，2： | 4 |
| 3 | Gene-gene,gene-environment,gene-nutrient interactions and single nucleotide polymorphisms of inflammatory cytokines显示文摘Inflammation plays a significant role in the etiology of type 2 diabetes mellitus(T2DM).The rise in the pro-inflammatory cytokines is the essential step in glucotoxicity and lipotoxicity induced mitochondrial injury,oxidative stress and beta cell apoptosis in T2 DM.Among the recognized markers are interleukin(IL)-6,IL-1,IL-10,IL-18,tissue necrosis factor-alpha(TNF-α),C-reactive protein,resistin,adiponectin,tissue plasminogen activator,fibrinogen and heptoglobins.Diabetes mellitus has firm genetic and very strong environmental influence; exhibiting a polygenic mode of inheritance.Many single nucleotide polymorphisms(SNPs) in various genes including those of pro and antiinflammatory cytokines have been reported as a risk for T2 DM.Not all the SNPs have been confirmed by unifying results in different studies and wide variations have been reported in various ethnic groups.The inter-ethnic variations can be explained by the fact that gene expression may be regulated by gene-gene,gene-environment and gene-nutrient interactions.This review highlights the impact of these interactions on determining the role of single nucleotide polymorphism of IL-6,TNF-α,resistin and adiponectin in pathogenesis of T2 DM. | Amina Nadeem Sadaf Mumtaz Abdul Khaliq Naveed Muhammad Aslam Arif Siddiqui Ghulam Mustafa Lodhi Tausif Ahmad | 2015 | World Journal of Diabetes2015，6，4： | 4 |
| 4 | Simultaneous quantitation of atorvastatin and its two active metabolites in human plasma by liquid chromatography/(–) electrospray tandem mass spectrometry显示文摘A sensitive, accurate and selective liquid chromatography–tandem mass spectrometry method(LC–MS/MS) was developed and validated for the simultaneous quantitation of atorvastatin(AT) and its equipotent hydroxyl metabolites, 2-hydroxy atorvastatin(2-AT) and 4-hydroxy atorvastatin(4-AT), in human plasma. Electrospray ionization(ESI) interface in negative ion mode was selected to improve the selectivity and the sensitivity required for this application. Additionally, a solid phase extraction(SPE)step was performed to reduce any ion-suppression and/or enhancement effects. The separation of all compounds was achieved in less than 6 min using a C18reverse-phase fused-corescolumn and a mobile phase, composed of a mixture of 0.005% formic acid in water:acetonitrile:methanol(35:25:40, v/v/v), in isocratic mode at a flow rate of 0.6 mL/min. The method has lower limit of quantitation(LLOQ) of0.050 ng/mL for all analytes. The method has shown tremendous reproducibility, with intra- and inter-day precision less than 6.6%, and intra- and inter-day accuracy within 74.3% of nominal values, for all analytes, and has proved to be highly reliable for the analysis of clinical samples. | Pankaj Partani S.Manaswita Verma Sanjay Gurule Arshad Khuroo Tausif Monif | 2014 | Journal of Pharmaceutical Analysis2014，4，1： | 3 |
| 5 | 对急性憩室出血患者进行早期结肠镜诊治可提高医疗资源利用率显示文摘背景:在发达国家,憩室出血是严重的急性下消化道出血最常见的原因。早期结肠镜(≤24小时)的作用仍然存在争议,目前尚无早期肠镜应用于急性憩室出血的数据。本研究旨在通过美国全国住院患者样本库,评估结肠镜诊治的时机对急性憩室出血患者预后的影响。方法:采用第9版国际疾病分类(ICD 9),对全国住院患者样本库中2012-2014年间的病例进行选择并提取资料。纳入出院诊断(包括主要诊断或第二诊断)为憩室病合并出血和憩室炎合并出血的病例,排除年龄不满18周岁以及住院期间未行结肠镜检查的病例。首要结局指标为住院时间和住院总费用。结果:共计88,600例患者纳入研究,其中45,020例(50.8%)在入院24小时内接受了结肠镜检查(早期肠镜组),而另外43,580例(49.2%)则是在入院24小时后行结肠镜检查(晚期肠镜组)。早期肠镜组较晚期肠镜组患者住院时间显著缩短(3.7天vs 5.6天,P<0.001),住院总花费显著降低($9317 vs$11,767,P<0.001)。两组患者病死率的差异无统计学意义(0.7%vs 0.8%)。对潜在致混淆因素进行校正后,两组间住院时间和住院总费用的差异仍然具有统计学意义。结论:对于急性憩室出血,早期结肠镜诊治可显著缩短住院时间,降低住院费用,而且并不会增加病死率。选择适宜的急性憩室出血病例进行早期结肠镜诊治,具有节省医疗资源的潜在意义。进一步研究需明确哪些憩室出血患者能从早期结肠镜诊治中获益。 | Hamzeh Saraireh Obada Tayyem Mohamed Tausif Siddiqui Bashar Hmoud Mohammad Bilal | 2019 | Gastroenterology Report2019，7，2： | 1 |
| 6 | Medications in type-2 diabetics and their association with liver fibrosis显示文摘BACKGROUND The prevalence of nonalcoholic fatty liver disease(NAFLD) is significantly rising worldwide. Type-2 diabetes(T2D) is a major risk factor for NAFLD progression.AIM To assess the association of commonly used medications to advanced fibrosis(AF) in patients with biopsy-proven NAFLD and T2D.METHODS We used the International Classification of Disease 9 th Revision Clinical Modification coding system to identify patients with T2D and included patients who underwent liver biopsy for suspected NAFLD between January 1, 2000 to December 31, 2015. We compared demographics, clinical characteristics, and differences in pattern of medication use in patients who had biopsy-proven AF to those without it. A univariate and multivariate analysis was performed to assess the association of different classes of medication with the presence of AF.RESULTS A total of 1183 patients were included in the final analysis, out of which 32%(n =381) had AF on liver biopsy. Mean age of entire cohort was 52 years and majority were females(65%) and Caucasians(85%). Among patients with AF, 51% were on oral hypoglycemics, 30% were on insulin, 66% were on antihypertensives and 27% were on lipid lowering agents for the median duration of 19 mo, 10 mo, 26 mo, and 24 mo respectively. Medications associated with decreased risk of AF included metformin, liraglutide, lisinopril, hydrochlorothiazide, atorvastatin and simvastatin while the use of furosemide and spironolactone were associated with higher prevalence of AF.CONCLUSION In our cohort of T2D with biopsy proven NAFLD, the patients who were receiving metformin, liraglutide, lisinopril, hydrochlorothiazide, atorvastatin and simvastatin were less likely to have AF on biopsy, while patients who were receiving furosemide and spironolactone had a higher likelihood of having AF when they underwent liver biopsy. Future studies are needed to confirm these findings and to establish measures for prevention of NAFLD progression in patients with T2D. | Mohamed Tausif Siddiqui Hina Amin Rajat Garg Pravallika Chadalavada Wael Al-Yaman Rocio Lopez Amandeep Singh | 2020 | World Journal of Gastroenterology2020，26，23： | 1 |
| 7 | Comparative Bioavailability Study with Two Pantoprazole Delayed-released Tablet Formulations Administered with and without Food in Healthy Subjects显示文摘 | Mendes Fabiana Patni Anil Reyer Simrit Monif Tausif Moreira Leonard Ilha Jaime Mendes Gustavo Nucci Gilberto | 2008 | Arzneimittelforschung2008，，03： | 1 |
| 8 | Survey of the current state of emergency care in Chennai, India显示文摘 | Jay Khadpe Tausif Thangalvadi Parivalavan Rajavclu Richard Sinert | 2011 | World Journal of Emergency Medicine2011，2，3： | 1 |
| 9 | Glucose-regulated insulin production in hepatocytes显示文摘 | Tausif A Hans WS | 2002 | Transplanation2002，74，： | 1 |
| 10 | Quantitative estimation of irbesartan in two different matrices and its application to human and dog bioavailability studies using LCeMS/MS显示文摘A simple,rapid and robust high-throughput assay for the quantitative analysis of irbesartan in plasma from two species using liquid chromatography tandem mass spectrometric method was developed and validated.Solid phase extraction was used and quantification was achieved using a positive electrospray ionization interface under multiple reactions monitoring condition.Complete validation(as per recent regulatory requirements)was done using human plasma.The same method was validated using dog plasma and the validation parameters met respective acceptance criteria.The method has shorter run time of 3 min.This will help in high throughput.The low aliquot volume in the method helped us to take enough sampling time points for better pharmacokinetic profiles.The calibration curve was shown to be linear from 12.1 to 6018.7 ng/ml in human plasma and 12.1 to 5987.2 ng/ml in dog plasma.This method was successfully applied to samples collected during bioavailability studies of irbesartan in humans and dogs. | Hari Krishan Tiwari Tausif Monif Priya Ranjan Prasad Verma Simrit Reyar Arshad Hussain Khuroo Sanjeev Mishra | 2013 | Asian Journal of Pharmaceutical Sciences2013，8，6： | 0 |
| 11 | Liquid chromatography-tandem mass spectrometry method for the estimation of adefovir in human plasma:Application to a pharmacokinetic study显示文摘An analytical method based on solid phase extraction was developed and validated for analysis of adefovir in human plasma.Adefovir-d_4 was used as an internal standard and Synergi MAX RP80A(150 mm × 4.6 mm,4 μm) column provided the desired chromatographic separation of compounds followed by detection with mass spectrometry.The method used simple isocratic chromatographic condition and mass spectrometric detection in the positive ionization mode.The calibration curves were linear over the range of 0.50-42.47 ng/mL with the lower limit of quantitation validated at 0.50 ng/mL.Matrix effect was assessed by post-column infusion experiment to monitor phospholipids and postextraction addition experiment was performed.The degree of matrix effect for adefovir was deteimined as 7.5% and ion-enhancement in live different lots of human plasma was 7.1% and had no impact on study samples analysis with 4.5 min run time.The intra- and inter-day precision values were within 7.7% and 7.8%,respectively,for adefovir at the lower limit of quantification level.Validated bioanalytical method was successfully applied to clinical sample analysis. | Dipanjan Goswami Sanjay Gurule Arabinda Saha Poonam Vats Arshad Khuroo Tausif Monif | 2015 | Journal of Pharmaceutical Analysis2015，5，3： | 0 |
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