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| 1 | Pediatric primary urolithiasis: Symptoms, medical management and prevention strategies显示文摘In the past few decades pediatric urolithiasis has become more frequent. The reason for this increase is not completely clear but has been attributed to changes in climate, nutritional habits and possibly other environmental factors. Although less frequent than adult stone disease, urolithiasis in the pediatric age group is also related to significant morbidity, particularly since stones tend to recur, and, thus, should not be underestimated. Most children with idiopathic stone disease have an underlying metabolic abnormality substantiating the importance of metabolic evaluation already following initial diagnosis of urolithiasis. Identification of the metabolic abnormality allows for more specific prescription of non pharmacological and pharmacological interventions aimed at preventing recurrent stone formation. A better understanding of the causes of kidney stone disease will provide better strategies for stone prevention in children. | Maria Goretti Moreira Guimar?es Penido Marcelo de Sousa Tavares | 2015 | World Journal of Nephrology2015，4，4： | 4 |
| 2 | New forms of local governance: A theoretical and empirical analysis of municipal corporations in Portugal显示文摘 | Tavares A F Cam?es P J | 2010 | Public management review2010，12，5： | 1 |
| 3 | Bone disease in pediatric idiopathic hypercalciuria显示文摘Idiopathic hypercalciuria(IH) is the leading metabolic risk factor for urolithiasis and affects all age groups without gender or race predominance. IH has a high morbidity with or without lithiasis and reduced bone mineral density(BMD), as described previously in pediatric patients as well as in adults. The pathogenesis of IH is complex and not completely understood, given that urinary excretion of calcium is the end result of an interplay between three organs(gut, bone and kidney), which is further orchestrated by hormones, such as 1,25 dihydroxyvitamin D, parathyroid hormone, calcitonin and fosfatonins(i.e., fibroblast growth-factor-23). Usually, a primary defect in one organ induces compensatory mechanisms in the remaining two organs, such as increased absorption of calcium in the gut secondary to a primary renal loss. Thus, IH is a systemic abnormality of calcium homeostasis with changes in cellular transport of this ion in intestines, kidneys and bones. Reduced BMD has been demonstrated in pediatric patients diagnosed with IH. However, the precise mechanisms of bone loss or failure of adequate bone mass gain are still unknown. The largest accumulation of bone mass occurs during childhood and adolescence, peaking atthe end of the second decade of life. This accumulation should occur without interference to achieve the peak of optimal bone mass. Any interference may be a risk factor for the reduction of bone mass with increased risk of fractures in adulthood. This review will address the pathogenesis of IH and its consequence in bone mass. | Maria Goretti Moreira Guimares Penido Marcelo de Sousa Tavares | 2012 | World Journal of Nephrology2012，1，2： | 1 |
| 4 | Relationship among end-stage renal disease, hypertension, and sleep apnea in nondiabetic dialysis patients显示文摘 | Cassio José de Oliveira Rodrigues Odair Marson Sérgio Tufic Osvaldo Kohlmann Sonia Maria Guimar?es Pereira Togeiro Artur Beltrame Ribeiro Agostinho Tavares | 2005 | American Journal of Hypertension2005，，2： | 1 |
| 5 | Single mitochondrial gene barcodes reliably identify sister-species in diverse clades of birds显示文摘 | Tavares ES Baker AJ | 2008 | BMC Evol Biol2008，8，： | 1 |
| 6 | Hydrolysis of oligosaccharides in soybean products by Debaryomyces hansenii UFV-1 α-galactosidases显示文摘 | Pollyanna Amaral Viana Sebasti?o Tavares de Rezende Daniel Luciano Falkoski Thiago de Almeida Leite Inês Chamel José Maurílio Alves Moreira Valéria Monteze Guimar?es | 2006 | Food Chemistry2006，，2： | 1 |
| 7 | Single mitochondrial gene barcodes reliably identify sister-species in diverse clades of birds显示文摘 | Tavares ES Baker A J | | 0，，01： | 1 |
| 8 | Inter- and intraobserver agreement in computed tomography enterography in inflammatory bowel disease显示文摘AIM To evaluate intra- and interobserver agreement in imaging features in inflammatory bowel disease and comparison with fecal calprotectin(FC) levels.METHODS Our institutional computed tomography enterography(CTE) database was retrospectively queried to identify patients who underwent CTE from January 2014 to June 2015. Patient inclusion criteria were confirmed inflammatory bowel disease(IBD) and FC collected < 4 mo after CTE without any change in clinical treatment or surgical treatment during this interval. The exclusion criterion was poor image quality. Two blinded abdominal radiologists, with 12 and 3 years of experience analyzed the CTE regarding localization(small bowel, colonic, both, or no disease detected);type of IBD(inflammatory, stenosing, fistulizing, > 1 pattern, or normal); and signs of active disease(present or absent). In 42 of 44 patients evaluated, routine CTE reports were made by one of the readers who reevaluated the CTEs ≥ 6 mo later, to determine the intraobserver agreement. FC was considered a sign of disease activity when it was higher than 250 μg/g.RESULTS Forty-four patients with IBD(38 with Crohn's disease and 6 with ulcerative colitis) were included. There was a moderate interobserver agreement regarding localization of IBD(k = 0.540), type of disease(k = 0.410) and the presence of active signs in CTE(k = 0.419). There was almost perfect intraobserver agreement regarding localization, type and signs of active disease in IBD. The k values were 0.902, 0.937 and 0.830, respectively. After a consensus between both radiologists regarding inflammatory activity in CTE, we found that 24(85.7%) of 28 patients who were classified with active disease had elevated FC, and six(37.5%) of 16 patients without inflammatory activity in CTE had elevated FC(P = 0.003). The correlation between elevated FC and the presence of active disease in CTE was significant(k = 0.495, P = 0.001).CONCLUSION We found almost perfect intraobserver and moderate interobserver agreement in the signs of active disease in CTE with concurrence of high FC levels. | Natally Horvat Camila Carlos Tavares Adriana Ribas Andrade Julia Campos Sim?es Cabral Hilton Muniz Le?o Filho Angela Hissae Motoyama Caiado Serli Kiyomi Nakao Ueda André Zonetti de Arruda Leite Aytan Miranda Sipahi Manoel de Souza Rocha | 2016 | World Journal of Gastroenterology2016，22，45： | 1 |
| 9 | Endotoxin-induced acute lung injury is dependent upon oxidative response显示文摘 | Eduardo Tavares Lima Trajano Cinthya Sternberg Maurí cio Caetano Marco Auré lio Santos Silva Luí s Cristó v? o Porto Juliana Carvalho Santos Marcelo Lima Ribeiro Clarissa Bichara Magalh? es Walter Araú jo Zin Clá udia Farias Benjamim Samuel Santos Valen? | 2011 | Inhalation Toxicology2011，，： | 1 |
| 10 | Orthodontic treatment for a patient with advanced periodontal disease: 11-year fol- low-up 显示文摘 | Tavares CA Allgayer S Calvete ES | 2013 | Am J Orthod Dentofacial Orthop2013，144，3： | 1 |
| 11 | Delamination analysis of carbon fibre reinforced laminates: Evaluation of a special step drill显示文摘 | António T. Marques Luís M. Dur?o António G. Magalh?es Jo?o Francisco Silva Jo?o Manuel R.S. Tavares | 2009 | Composites Science and Technology2009，，14： | 1 |
| 12 | Preemptive endoluminal vacuum therapy after pancreaticoduodenectomy: A case report显示文摘BACKGROUND Pancreaticoduodenectomy is a technically demanding operation,with reported morbidity rates of approximately 40%-50%.A novel idea is to use endoscopic vacuum therapy(EVT)in a preemptive setting to prevent anastomotic leakage and pancreatic fistulas.In a recent case series,EVT was proven to be effective in preventing leaks in patients with anastomotic ischemia.There have been no previous reports on preemptive EVT after pancreaticoduodenectomy.CASE SUMMARY We describe the case of a 71-year-old woman with hypertension and diabetes who was admitted to the emergency room with jaundice,choluria,fecal acholia,abdominal pain,and fever.Admission examinations revealed leukocytosis and hyperbilirubinemia(total:13 mg/dL;conjugated:12.1 mg/dL).Abdominal ultrasound showed cholelithiasis and dilation of the common bile duct.Magnetic resonance imaging demonstrated a stenotic area,and a biopsy confirmed cholangiocarcinoma. Considering the high risk of leaks after pancreaticoduodenectomy,preemptive endoluminal vacuum therapy was performed.The system comprised a nasogastric tube,gauze,and an antimicrobial incise drape.The negative pressure was 125 mmHg,and no adverse events occurred.The patient was discharged on postoperative day 5 without any symptoms.CONCLUSION Preemptive endoluminal vacuum therapy may be a safe and feasible technique to reduce leaks after pancreaticoduodenectomy. | Flaubert Sena de Medeiros Epifanio Silvino do Monte Junior Romero de Lima França Heli Clóvis de Medeiros Neto Juliany Medeiros Santos Eligio Alves Almeida Júnior Samuel Oliveira da Silva Júnior Mario Herman Santos Moura Pedreira Tavares Eduardo Guimarães Hourneaux de Moura | 2020 | World Journal of Gastrointestinal Endoscopy2020，12，11： | 0 |
| 13 | 巴西圣保罗州莫日—瓜苏河流流域中的汞:根据^(210)Pb测年剖面估计的沿海泻湖与河流贡献之间的联系显示文摘本文估计了莫日-瓜苏河水和悬浮泥沙样中和位于主河道采样点下游的其三个沿海泻湖(卡廷圭卢、巴里尼亚以及里奥佩德拉斯)的水体和河底泥沙中的总汞含量。结果发现,悬浮泥沙和河底泥沙中的汞浓度均较低。铝被用来作为校正里奥佩德拉斯泻湖沉积岩心中汞浓度的地球化学示踪物(r=0.92)。据估计,莫日-瓜苏河每年输送19kg汞,其中65%处于溶解状态,35%吸附在颗粒性物质上。在1970~1980年期间观察到的急性中毒时期之后,河流流域主要通过自然恢复和进入生态系的汞输入量普通降低,已恢复到其原来的状态。 | Glauco Arnold Tavares JoséRobertoFerreira CarlosEmanueldeCarvallhoMagalhāes Nivaldo Carlos de Silva Maria Helena Tirollo Taddel 林宝法 | 2003 | AMBIO-人类环境杂志2003，32，1： | 0 |
| 14 | Should pediatric idiopathic hypercalciuria be treated with hypocalciuric agents?显示文摘BACKGROUND Hypercalciuria is the most common metabolic risk factor for calcium urolithiasis and is associated with bone loss in adult patients.Reduced bone mineral density(BMD)was already described in idiopathic hypercalciuria(IH)children,but the precise mechanisms of bone loss or inadequate bone mass gain remain unknown.Life-long hypercalciuria might be considered a risk to change bone structure and determine low bone mass throughout life.The peak of bone mass should occur without interferences.A beneficial effect of citrate formulations and thiazides on bone mass in adult and pediatric patients with IH have been shown.AIM To evaluate whether pharmacological therapy has a beneficial effect on bone mass in children and adolescents with IH.METHODS This retrospective cohort study evaluated 40 hypercalciuric children nonresponsive to lifestyle and diet changes.After a 2-mo run-in period of citrate formulation(Kcitrate)usage,the first bone densitometry(DXA)was ordered.In patients with sustained hypercalciuria,a thiazide diuretic was prescribed.The second DXA was performed after 12 mo.Bone densitometry was performed by DXA at lumbar spine(L2-L4).A 24-h urine(calcium,citrate,creatinine)and blood samples(urea,creatinine,uric acid,calcium,phosphorus,magnesium,chloride,hemoglobin)were obtained.Clinical data included age,gender,weight,height and body mass index.RESULTS Forty IH children;median age 10.5 year and median time follow-up 6.0 year were evaluated.Nine patients were treated with Kcitrate(G1)and 31 with Kcitrate+thiazide(G2).There were no differences in age,gender,body mass index z-score and biochemical parameters between G1 and G2.There were no increases in total cholesterol,kalemia and magnesemia.Calciuria decreased in both groups after treatment.Lumbar spine BMD z-score increased after thiazide treatment in G2.There was no improvement in G1.CONCLUSION Results point to a beneficial effect of thiazide on lumbar spine BMD z-score in children with IH.Further studies are necessary to confirm the results of the present study. | Maria Goretti Moreira Guimarães Penido Marcelo de Sousa Tavares | 2021 | World Journal of Nephrology2021，10，4： | 0 |
| 15 | Beyond kidney stones:Why pediatricians should worry about hypercalciuria显示文摘The incidence of urolithiasis(UL)is increasing,and it has become more common in children and adolescents over the past few decades.Hypercalciuria is the leading metabolic risk factor of pediatric UL,and it has high morbidity,with or without lithiasis as hematuria and impairment of bone mass.The reduction in bone mineral density has already been described in pediatric idiopathic hypercalciuria(IH),and the precise mechanisms of bone loss or failure to achieve adequate bone mass gain remain unknown.A current understanding is that hypercalciuria throughout life can be considered a risk of change in bone structure and low bone mass throughout life.However,it is still not entirely known whether hypercalciuria throughout life can compromise the quality of the mass.The peak bone mass is achieved by late adolescence,peaking at the end of the second decade of life.This accumulation should occur without interference in order to achieve the peak of optimal bone mass.The bone mass acquired during childhood and adolescence is a major determinant of adult bone health,and its accumulation should occur without interference.This raises the critical question of whether adult osteoporosis and the risk of fractures are initiated during childhood.Pediatricians should be aware of this pediatric problem and investigate their patients.They should have the knowledge and ability to diagnose and initially manage patients with IH,with or without UL. | Maria Goretti Moreira Guimarães Penido Marcelo de Sousa Tavares | 2021 | World Journal of Clinical Pediatrics2021，10，6： | 0 |
| 16 | Metabolic and nutritional triggers associated with increased risk of liver complications in SARS-CoV-2显示文摘Obesity,diabetes,cardiovascular and respiratory diseases,cancer and smoking are risk factors for negative outcomes in severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which can quickly induce severe respiratory failure in 5%of cases.Coronavirus disease-associated liver injury may occur during progression of SARS-CoV-2 in patients with or without pre-existing liver disease,and damage to the liver parenchyma can be caused by infection of hepatocytes.Cirrhosis patients may be particularly vulnerable to SARS-CoV-2 if suffering with cirrhosis-associated immune dysfunction.Furthermore,pharmacotherapies including macrolide or quinolone antibiotics and steroids can also induce liver damage.In this review we addressed nutritional status and nutritional interventions in severe SARS-CoV-2 liver patients.As guidelines for SARS-CoV-2 in intensive care(IC)specifically are not yet available,strategies for management of sepsis and SARS are suggested in SARS-CoV-2.Early enteral nutrition(EN)should be started soon after IC admission,preferably employing iso-osmolar polymeric formula with initial protein content at 0.8 g/kg per day progressively increasing up to 1.3 g/kg per day and enriched with fish oil at 0.1 g/kg per day to 0.2 g/kg per day.Monitoring is necessary to identify signs of intolerance,hemodynamic instability and metabolic disorders,and transition to parenteral nutrition should not be delayed when energy and protein targets cannot be met via EN.Nutrients including vitamins A,C,D,E,B6,B12,folic acid,zinc,selenium andω-3 fatty acids have in isolation or in combination shown beneficial effects upon immune function and inflammation modulation.Cautious and monitored supplementation up to upper limits may be beneficial in management strategies for SARS-CoV-2 liver patients. | Rosangela Passos de Jesus Jozélio Freire de Carvalho Lucivalda Pereira Magalhães de Oliveira Carla de Magalhães Cunha Thaisy Cristina Honorato Santos Alves Sandra Tavares Brito Vieira Virginia Maria Figueiredo Allain Amador Bueno | 2022 | World Journal of Hepatology2022，14，1： | 0 |
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