|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Risk of contrast-induced nephropathy in hospitalized patients with cirrhosis显示文摘AIM:To evaluate the incidence of contrast-induced nephropathy(CIN)in cirrhotic patients and to identify risk factors for the development of CIN.METHODS:We performed a retrospective review of 216 consecutive patients with cirrhosis who underwent computed tomography(CT)with intravenous contrast at the University of Rochester between the years 2000-2005.We retrospectively examined factors associated with a high risk for CIN,defined as a decrease in creatinine clearance of 25%or greater within one week after receiving contrast.RESULTS:Twenty-five percent of our patients developed CIN,and 74%of these patients had ascites seen on CT.Of the 75%of patients who did not develop CIN,only 46%had ascites.The presence of ascites was a significant risk factor for the development of CIN(P=0.0009,OR 3.38,95%CI 1.55-7.34)in multivariate analysis.Patient age,serum sodium,Model for End-stage Liver Disease score,diuretic use,and the presence of diabetes were not found to be significant risk factors for the development of CIN.Of the patients who developed CIN,11%developed chronic renal insufficiency,defined as a creatinine clearance less than baseline for 6 wk.CONCLUSION:Our results suggest that in hospitalized cirrhotic patients,especially those with ascites,the risk of CIN is substantial. | Nilesh Lodhia Michael Kader Thalia Mayes Parvez Mantry Benedict Maliakkal | 2009 | World Journal of Gastroenterology2009，15，12： | 9 |
| 2 | Serum levels of undercarboxylated osteocalcin are related to cardiovascular risk factors in patients with type 2 diabetes mellitus and healthy subjects显示文摘AIM To determine a potential relationship between serum undercarboxylated(uc OC) concentration and cardiovascular risk factors in type 2 diabetes(T2D) patients and healthy subjects(HS).METHODS A cross-sectional study was conducted on 140 subjects classified into two groups, 70 with T2D and 70 HS. Medical history and physical examination with anthropometric measurements were obtained from all subjects. Body fat percentage was determined by bioelectrical impendency analysis. Serum uc OC concentration was determined by enzyme immunoassay,while serum levels of insulin and hsC RP were obtained using high sensitivity enzyme-linked immunosorbent assay. Insulin resistance was determined using the homeostasis model assessment-IR. Lipid profile [triglycerides,total cholesterol(TC), high-density lipoproteins(HDL-c),low density lipoproteins(LDL-c), very low-density lipoproteins] was determined by spectrophotometry and standard formulas when applicable. RESULTS The T2D patient group showed significantly higher values of waist circumference, waist-to-hip ratio, systolic blood pressure(SBP), diastolic blood pressure(DBP),current smoking, and alcohol use when compared to the HS group(P < 0.05). We observed a significantly lower serum ucO C concentration in T2D than in HS(1.5 ± 1.4vs 2.3 ± 1.8, P < 0.05). In the whole study population,ucO C concentration was inversely correlated with body mass index(BMI)(r =-0.236, P < 0.05), fasting plasma glucose(r =-0.283, P < 0.01) and HDL-c(r =-0.255,P < 0.05); and positively correlated with LDL-c/HDL-c ratio(r = 0.306, P < 0.05) and TC/HDL-c ratio(r =0.284, P < 0.05). In the T2D group, serum uc OC concentration was inversely correlated with BMI(r =-0.310, P < 0.05) and body-fat percentage(r =-0.311,P < 0.05), and positively correlated with DBP(r = 0.450,P < 0.01). In HS group a positive correlation between serum levels of uc OC and SBP(r = 0.277, P < 0.05)was observed. CONCLUSION Serum uc OC is a potential marker for cardiovascular risk in Mexicans because it is related to adiposity parameters, blood pressure and lipid profile. | Sergio Sanchez-Enriquez Isabel Thalia Ballesteros-Gonzalez JoséRafael Villafán-Bernal Sara Pascoe-Gonzalez Edgar Alfonso Rivera-Leon Blanca Estela Bastidas-Ramirez Jorge David Rivas-Carrillo Juan Luis Alcala-Zermeno Juan Armendariz-Borunda Iris Monserrat Llamas-Covarrubias Abraham Zepeda-Moreno | 2017 | World Journal of Diabetes2017，8，1： | 6 |
| 3 | Hepatitis B surface antigen: Relation to hepatitis B replication parameters in HBeAg-negative chronic hepatitis B显示文摘 | Emanuel K. Manesis George V. Papatheodoridis Dina G. Tiniakos Emilia S. Hadziyannis Olga P. Agelopoulou Thalia Syminelaki Christos Papaioannou Theodoros Nastos Peter Karayiannis | 2010 | Journal of Hepatology2010，，1： | 2 |
| 4 | Additional Value of Upper GI Tract Endoscopy in the Diagnostic Assessment of Childhood IBD显示文摘 | Thalia Z. Hummel Fiebo J.W. ten Kate Johannes B. Reitsma Marc A. Benninga Angelika Kindermann | 2012 | Journal of Pediatric Gastroenterology and Nutrition2012，，6： | 1 |
| 5 | Photodynamic Therapy for Distaland Lateral Subungual Toenail Onychomycosis Caused by Trichnphy-ton rubrum: Preliminary Results of a Single-centre Open Trial 显示文摘 | Eleni S Thalia KE George C | 2009 | AmAcad Dermatol2009，90，： | 1 |
| 6 | The biology and enzymology of protein N-myristoylation 显示文摘 | Thalia FA Gabriel W Jeffrey GI | 2001 | J Biol Chem2001，276，39： | 1 |
| 7 | PCSK9 and carbohydrate metabolism:A double-edged sword显示文摘Proprotein convertase subtilisin/kexin type 9(PCSK9) plays a paramount role in the degradation of lowdensity lipoprotein(LDL) receptors(LDLR) on the hepatic cells surface and subsequently affects LDL particles catabolism and LDL cholesterol(LDL-c) levels. The anti-PCSK9 monoclonal antibodies lead to substantial decrease of LDL-c concentration. PCSK9(which is also expressed in pancreatic delta-cells) can decrease LDLR and subsequently decrease cholesterol accumulation in pancreatic beta-cells, which impairs glucose metabolism and reduces insulin secretion. Thus, a possible adverse effect of PCSK9 inhibitors on carbohydrate metabolism may be expected by this mechanism, which has been supported by the mendelian studies results. On the other hand, clinical data have suggested a detrimental association of PCSK9 with glucose metabolism. So, the inhibition of PCSK9 may be seen as a double-edged sword regarding carbohydrate metabolism. Completed clinical trials have not shown a detrimental effect of PCSK9 inhibitors on diabetes risk, but their short-term duration does not allow definite conclusions. | Theodosios D Filippatos Sebastian Filippas-Ntekouan Eleni Pappa Thalia Panagiotopoulou Vasilios Tsimihodimos Moses S Elisaf | 2017 | World Journal of Diabetes2017，8，7： | 1 |
| 8 | Associations between sleep quality and anxiety and depression symptoms in a sample of young adult twins and siblings显示文摘 | Alice M. Gregory Daniel J. Buysse Thomas A. Willis Fruhling V. Rijsdijk Barbara Maughan Richard Rowe Sally Cartwright Nicola L. Barclay Thalia C. Eley | 2011 | Journal of Psychosomatic Research2011，，4： | 1 |
| 9 | Can the dynamics of the term structure of petroleum futures be forecasted? Evidence from major markets显示文摘 | Thalia Chantziara George Skiadopoulos | 2007 | Energy Economics2007，，3： | 1 |
| 10 | miRNAs in human cancer显示文摘 | Thalia AFarazi Jessica ISpitzer PavelMorozov ThomasTuschl | 2010 | J. Pathol2010，，： | 1 |
| 11 | Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population显示文摘 | Maria A. Loizidou Marios A. Cariolou Susan L. Neuhausen Robert F. Newbold Evy Bashiardes Yiola Marcou Thalia Michael Maria Daniel Eleni Kakouri Panayiotis Papadopoulos Simon Malas Andreas Hadjisavvas Kyriacos Kyriacou | 2010 | Breast Cancer Research and Treatment2010，，1： | 1 |
| 12 | 围产期抑郁症的非药物干预治疗显示文摘围产期抑郁症是一种常见的疾病,并且对母儿均有风险。近年来,随着对孕期和产后妇女心理疾病筛查的增加,新的心理治疗和药物干预模式也在发展。尽管一般人群中的重度抑郁症的个体化治疗相关研究有所增加,但围产期抑郁症的个体化治疗相关指南尚未发布。尤其是在缺乏个体化治疗指南的情况下,将患者与合适的治疗方案相匹配更是一项挑战。本文综述了围产期抑郁症的个体化非药物治疗的证据,包括如何结合患者的个人喜好、新的或正在研究的疗法以及生物标记物在患者与治疗匹配方面的潜在作用。本综述为今后围产期抑郁症的个体化治疗提供了建议。 | Sara L Johansen Thalia K Robakis Katherine Ellie Williams Natalie L Rasgon 马宏伟(译) 刘兴会(审校) | 2021 | 英国医学杂志中文版2021，24，7： | 0 |
| 13 | Laser trimming of the operating wavelength of silicon nitride racetrack resonators显示文摘We demonstrate the possibility of post-fabrication trimming of the response of nitrogen-rich silicon nitride racetrack resonators by using an ultraviolet laser.The results revealed the possibility to efficiently tune the operating wavelength of fabricated racetrack resonators to any point within the full free spectral range.This process is much faster than similar,previously presented methods(in the order of seconds,compared to hours).This technique can also be applied to accurately trim the optical performance of any other silicon photonic device based on nitrogen-rich silicon nitride. | GRETA DE PAOLI SENTA L.JANTZEN THALIA DOMINGUEZ BUCIO ILIAS SKANDALOS CHRISTOPHER HOLMES PETER G.R.SMITH MILAN M.MILOSEVIC FREDERIC Y.GARDES | 2020 | Photonics Research2020，8，5： | 0 |
| 14 | Philosophy and Science Dialogue: Mental Causation显示文摘 | Thalia Wheatley Terence Horgan | 2018 | Frontiers of Philosophy in China2018，13，3： | 0 |
| 15 | A novel GPCR mediates pancreatic cancer associated fibroblast-cancer cell interaction显示文摘OBJECTIVE Pancreatic ductal adenocarcinoma(PDAC),a lethal cancer in need of new,effective therapies,has a unique tumor microenvironment characterized by a dense fibrotic stroma(desmoplasia)that is generated by pancreatic cancer-associated fibroblasts(PCAFs)derived from pancreatic stellate cells(PSCs)and pancreatic fibroblasts(PFs).METHEDS and RESULTS Hypothesizing that G protein-coupled receptors(GPCRs)may regulate PCAFs,we used an unbiased GPCRomic array approach to compare GPCR expression in PCAFs,PFs and PSCs and identified 82 GPCRs commonly expressed by PCAFs derived from primary tumors of five PDAC patients.We discovered that PCAFs have increased expression of numerous GPCRs,in particular a GPCR with much higher expression in PCAFs compared to both PFs and PSCs.Immunohistochemistry revealed increased expression of this GPCR in PDAC tumors.Co-culture of PSCs with PDAC cells or incubation with TNFαinduced its expression.Activation of the GPCR in PCAF sincreased expression of interleukin-6(IL-6)via a cA MP/PKA/CREB signaling pathway.GPCR knockdown with siR NA diminished IL-6 production and secretionby PCAFs and ability of PCAF conditioned media to enhance proliferation of PDAC cells.CONCLUSION We conclude that PDAC cells induce expression by PCAFs of a novel GPCR,resulting in increased IL-6 production by PCAFs and promotion of PDAC cell proliferation.This PCAF-expressed GPCR thus contributes to PDAC cell-PCAF interaction and as such,may be a novel therapeutic target for PDAC tumors. | Shu Z WILEY Krishna SRIRAM Wen-jing LIANG Sarah E CHANG Randall FRENCH Thalia MCCANN Hiroshi NISHIHARA Andrew M LOWY Paul A INSEL | 2017 | 中国药理学与毒理学杂志2017，31，10： | 0 |
| 16 | Modeling neutral-atmospheric electromagnetic delays in a“big data”world显示文摘If left unmodeled,the delay suffered by electromagnetic waves while crossing the neutral atmosphere negatively affects Global Navigation Satellite System positioning.The modeling of the delay has been carried out by means of empirical models formulated based on climatological information or using information extracted from numerical weather prediction(NWP)models.This paper explores the potential use of meteorological information of several types that will become available with the increasing number of sensors(e.g.a cell phone,or the thermometer of a nearby smart home)in cyberspace.How can we make use of these potentially huge datasets,which may help to provide the best possible representation of the neutral atmosphere at any given time,as readily and as accurately as possible?This situation falls in the realm of Big Data.A few potential scenarios,a sequential improvement of Marini mapping function coefficients,a self-feeding NWP,and near real-time empirical model updates,are discussed in this paper.The pros and cons of each approach are discussed in comparison with what is done today.Experiments indicate that they have potential for a positive contribution. | Marcelo C.Santos Thalia Nikolaidou | 2018 | Geo-Spatial Information Science2018，21，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员