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| 1 | Histopathology of nonalcoholic fatty liver disease显示文摘Histological analysis of liver biopsies remains a standard against which other methods of assessment for the presence and amount of hepatic injury due to nonalcoholic fatty liver disease(NAFLD) are measured.Histological evaluation remains the sole method of distinguishing steatosis from advanced forms of NAFLD,i.e.nonalcoholic steatohepatitis(NASH) and fibrosis.Included in the lesions of NAFLD are steatosis,lobular and portal inflammation,hepatocyte injury in the forms of ballooning and apoptosis,and fibrosis.However,patterns of these lesions are as distinguishing as the lesions themselves.Liver injury in adults and children due to NAFLD may have different histological patterns.In this review,the rationale for liver biopsy,as well as the histopathological lesions,the microscopically observable patterns of injury,and the differential diagnoses of NAFLD and NASH are discussed. | Elizabeth M Brunt Dina G Tiniakos | 2010 | World Journal of Gastroenterology2010，16，42： | 16 |
| 2 | E2F transcription factors and digestive system malignancies: How much do we know?显示文摘E2F family of transcription factors regulates various cellular functions related to cell cycle and apoptosis. Its individual members have traditionally been classified into activators and repressors, based on in vitro studies. However their contribution in human cancer is more complicated and difficult to predict. We review current knowledge on the expression of E2Fs in digestive system malignancies and its clinical implications for patient prognosis and treatment. E2F1, the most extensively studied member and the only one with prognostic value, exhibits a tumor-suppressing activity in esophageal, gastric and colorectal adenocarcinoma, and in hepatocellular carcinoma (HCC), whereas in pancreatic ductal adenocarcinoma and esophageal squamous cell carcinoma may function as a tumorpromoter. In the latter malignancies, E2F1 immunohistochemical expression has been correlated with higher tumor grade and worse patient survival, whereas in esophageal, gastric and colorectal adenocarcinomas is a marker of increased patient survival. E2F2 has only been studied in colorectal cancer, where its role is not considered significant. E2F4's role in colorectal, gastric and hepatic carcinogenesis is tumor-promoting. E2F8 is strongly upregulated in human HCC, thus possibly contributing to hepatocarcinogenesis. Adenoviral transfer of E2F as gene therapy to sensitize pancreatic cancer cells for chemotherapeutic agents has been used in experimental studies. Other therapeutic strategies are yet to be developed, but it appears that targeted approaches using E2F-agonists or antagonists should take into account the tissue-dependent function of each E2F member. Further understanding of E2Fs' contribution in cellular functions in vivo would help clarify their role in carcinogenesis. | Athanasios Xanthoulis Dina G Tiniakos | 2013 | World Journal of Gastroenterology2013，19，21： | 10 |
| 3 | Liver histology in ICU patients dying from sepsis:A clinico-pathological study显示文摘AIM:To determine end-stage pathologic changes in the liver of septic patients dying in the intensive care unit. METHODS: Needle liver biopsies obtained immediately after death from 15 consecutive patients with sepsis and no underlying liver disease were subjected to routine histological examination. Liver function tests and clinical monitoring measurements were also recorded. RESULTS: Liver biochemistries were increased in the majority of patients before death. Histology of liver bi- opsy specimens showed portal inflammation in 73.3%, centrilobular necrosis in 80%, lobular inflammation in 66.7%, hepatocellular apoptosis in 66.6% and cholan- gitis/cholangiolitis in 20% of patients. Mixed hepatitic/ cholestatic type of liver injury was observed in 6/15 (40%) patients and hepatitc in 9/15 (60%). Steatosis was ob- served in 11/15 (73.3%) patients affecting 5%-80% of liver parenchyma. Among the histological features, the presence of portal inflammation in liver biopsy was as- sociated with increased hospitalization in the ICU prior death (P = 0.026). CONCLUSION: Features of hepatitis and steatosis arethe main histological findings in the liver in the majority of patients dying from sepsis. | John Koskinas Ilias P Gomatos Dina G Tiniakos Nikolaos Memos Maria Boutsikou Aspasia Garatzioti Athanasios Archimandritis Alexander Betrosian | 2008 | World Journal of Gastroenterology2008，14，9： | 8 |
| 4 | Serum leptin and ghrelin in chronic hepatitis C patients with steatosis显示文摘AIM:To determine the associations between leptin and ghrelin concentrations and sustained virological response(SVR)in chronic hepatitis C patients with ste-atosis.METHODS:We retrospectively assessed 56 patients infected with hepatitis C virus(HCV)genotype-1 and 40 with HCV genotype-3.Patients with decompensated cirrhosis,and those with other causes of chronic liver disease,were excluded.Serum HCV-RNA concentra-tions were measured before the initiation of treatment;at weeks 12(for genotype 1 patients),24 and 48 during treatment;and 24 wk after the end of treatment.Genotype was determined using INNO-LIPA HCV as-says,and serum leptin and ghrelin concentrations were measured using enzyme-linked immunosorbent assay.Biopsy specimens were scored according to the Ishak system and steatosis was graded as mild,moderate,or severe,according to the Brunt classif ication.RESULTS:Overall,SVR was positively related to the presence of genotype-3,to biopsy-determined lower histological stage of liver disease,and lower grade of steatosis.Patients ≥ 40 years old tended to be less responsive to therapy.In genotype-1 infected pa-tients,SVR was associated with a lower grade of liver steatosis,milder fibrosis,and an absence of insulin resistance.Genotype-1 infected patients who did not achieve SVR had significantly higher leptin concen-trations at baseline,with significant increases as the severity of steatosis worsened,whereas those who achieved SVR had higher ghrelin concentrations.In genotype-3 infected patients,SVR was associated only with fibrosis stage and lower homeostasis model as-sessment insulin resistance at baseline,but not with the degree of steatosis or leptin concentrations.Geno-type-3 infected patients who achieved SVR showed signif icant decreases in ghrelin concentration at end of treatment.Baseline ghrelin concentrations were elevat-ed in responders of both genotypes who had moderate and severe steatosis.CONCLUSION:Increased serum leptin before treat-ment may predict non-SVR,especially in HCV geno-type-1 infected patients,whereas increased ghrelin may predict SVR in genotype-1. | Christos Pavlidis Georgios I Panoutsopoulos Dina Tiniakos Sotirios Koutsounas John Vlachogiannakos Irini Zouboulis-Vafiadis | 2011 | World Journal of Gastroenterology2011，17，46： | 6 |
| 5 | Diagnostic value of rapid urease test and urea breath test for Helicobacter pylori detection in patients with Billroth II gastrectomy: A prospective controlled trial显示文摘 | A.B. Adamopoulos G.S. Stergiou G.N. Sakizlis D.G. Tiniakos E.G. Nasothimiou D.K. Sioutis A.D. Achimastos | 2008 | Digestive and Liver Disease2008，，1： | 3 |
| 6 | Liver biopsy in alcoholic and non-alcoholic steatohepatitis patients显示文摘 | D.G. Tiniakos | 2009 | Gastroenterologie Clinique et Biologique2009，，10： | 2 |
| 7 | Nonalcoholic Fatty Liver Disease: Pathology and Pathogenesis显示文摘 | Dina G. Tiniakos Miriam B. Vos Elizabeth M. Brunt | 2010 | Annual Review of Pathology: Mechanisms of Disease2010，，： | 2 |
| 8 | Hepatitis B surface antigen: Relation to hepatitis B replication parameters in HBeAg-negative chronic hepatitis B显示文摘 | Emanuel K. Manesis George V. Papatheodoridis Dina G. Tiniakos Emilia S. Hadziyannis Olga P. Agelopoulou Thalia Syminelaki Christos Papaioannou Theodoros Nastos Peter Karayiannis | 2010 | Journal of Hepatology2010，，1： | 2 |
| 9 | E2F-1 is overexpressed and pro-apoptotic in human hepatocellular carcinoma显示文摘 | Marina Palaiologou John Koskinas Menelaos Karanikolas Evangelia Fatourou Dina Tiniakos | 2012 | Virchows Archiv2012，，5： | 2 |
| 10 | Nonalcoholic Fatty Liver Disease: Pathology and Pathogenesis显示文摘 | Dina G. Tiniakos Miriam B. Vos Elizabeth M. Brunt | 2010 | Annual Review of Pathology: Mechanisms of Disease2010，，： | 2 |
| 11 | Nonalcoholic fatty liver disease: pathology and pathogenesis显示文摘 | Tiniakos DG Vos MB Brunt EM | 2010 | Annual Review of Pathological Mechanical Disease2010，5，： | 1 |
| 12 | Proliferating cell nuclear antigen and Ki -67 labeling in hepatocellular nodules: a comparative study显示文摘 | Brunt EM | 1999 | Liver1999，19，1： | 1 |
| 13 | Hepatitis B surface antigen:relation to hepatitis B replication parameters in HBeAg-negative chronic hepatitis B显示文摘 | Manesis EK Papatheodoridis GV Tiniakos DG | | 0，，1： | 1 |
| 14 | Hypoxemic reperfusion after 120 mins of intestinal ischemia attenuates the histopathologic and inflammatory response 显示文摘 | Douzinas EE Kollias S Tiniakos D | 2004 | Crit Care Med2004，32，11： | 1 |
| 15 | Circulating and liver tissue levels of retinol-binding protein-4 in non-alcoholic fatty liver disease显示文摘 | Schina M Koskinas J Tiniakos D | 2009 | Hepatol Res2009，39，： | 1 |
| 16 | Hepatitis B surface antigen:Relation to hepatitis B replication parame-ters in HBeAg-negative chronic hepatitis B显示文摘 | Manesis EK Papatheodoridis GV Tiniakos DG | | 0，，01： | 1 |
| 17 | Nonalcoholic Fatty Liver Disease: Pathology and Pathogenesis显示文摘 | Dina G. Tiniakos Miriam B. Vos Elizabeth M. Brunt | 2010 | Annual Review of Pathology: Mechanisms of Disease2010，，： | 1 |
| 18 | Inflammation in nonalcoholic steatohepatitis 显示文摘 | Harmon RC Tiniakos DG Argo CK | 2011 | Expert Rev Gastroenterol Hepatol2011，5，2： | 1 |
| 19 | Hepatitis B surface antigen: relation to hepatitis B replication parameters in HBeAg negative chronic hepatitis B 显示文摘 | Manesis EK Papatheodoridis GV Tiniakos DG | 2011 | Hepatology2011，55，1： | 1 |
| 20 | Proliferating cell nuclear antigen and Ki-67 labeling in hepatocellular nodules: a comparative study 显示文摘 | Tiniakos D G Brunt E M | 1999 | Liver1999，19，1： | 1 |
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