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| 1 | Tumor size as a prognostic factor in patients with advanced gastric cancer in the lower third of the stomach显示文摘AIM: To explore the impact of tumor size on outcomes in patients with advanced gastric cancer in the lower third of the stomach. METHODS: We retrospectively analyzed the clinical records of 430 patients with advanced gastric cancer in the lower third of the stomach who underwent distal subtotal gastrectomy and D2 lymphadenectomy in our hospital from January 1998 to June 2004. Receiver-operating characteristic (ROC) curve analysis was used to determine the appropriate cutoff value for tumor size, which was measured as maximum tumor diameter. Based on this cutoff value, patients were divided into two groups: those with large-sized tumors (LSTs) and those with small-sized tumors (SSTs). The correlations between other clinicopathologic factors and tumor size were investigated, and the 5-year overall survival (OS) rate was compared between the two groups. Potential prognostic factors were evaluated by univariate KaplanMeier survival analysis and multivariate Cox's propor-tional hazard model analysis. The 5-year OS rates in the two groups were compared according to pT stage and pN stage. RESULTS: The 5-year OS rate in the 430 patients with advanced gastric cancer in the lower third of the stomach was 53.7%. The mean ± SD tumor size was 4.9 ± 1.9 cm, and the median tumor size was 5.0 cm. ROC analysis indicated that the sensitivity and specificity results for the appropriate tumor size cutoff value of 4.8 cm were 80.0% and 68.2%, respectively (AUC=0.795, 95%CI: 0.751-0.839, P=0.000). Using this cutoff value, 222 patients (51.6%) had LSTs (tumor size ≥ 4.8 cm) and 208 (48.4%) had SSTs (tumor size<4.8 cm). Tumor size was significantly correlated with histological type (P=0.039), Borrmann type (P=0.000), depth of tumor invasion (P=0.000), lymph node metastasis (P=0.000), tumor-nodes metastasis stage (P=0.000), mean number of metastatic lymph nodes (P=0.000) and metastatic lymph node ratio (P=0.000). Patients with LSTs had a significantly lower 5-year OS rate than those with SSTs (37.1% vs 63.3%, P=0.000). Univariate analysis showed that depth of tumor invasion (c 2=69.581, P=0.000), lymph node metastasis (c 2=138.815, P=0.000), tumor size (c 2=78.184, P=0.000) and metastatic lymph node ratio (c 2=139.034, P=0.000) were significantly associated with 5-year OS rate. Multivariate analysis revealed that depth of tumor invasion (P=0.000), lymph node metastasis (P=0.019) and tumor size (P=0.000) were independent prognostic factors. Gastric cancers were divided into 12 subgroups: pT2N0; pT2N1; pT2N2; pT2N3; pT3N0; pT3N1; pT3N2; pT3N3; pT4aN0; pT4aN1; pT4aN2; and pT4aN3. In patients with pT2-3N3 stage tumors and patients with pT4a stage tumors, 5-year OS rates were significantly lower for LSTs than for SSTs (P<0.05 each), but there were no significant differences in the 5-year OS rates in LST and SST patients with pT23N0-2 stage tumors (P > 0.05). CONCLUSION: Using a tumor size cutoff value of 4.8cm, tumor size is a prognostic factor in patients with pN3 stage or pT4a stage advanced gastric cancer located in the lower third of the stomach. | Hong-Mei Wang, Chang-Ming Huang, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Department of Gastric Surgery, Affiliated Union Hospital of Fujian Medical University, Fuzhou 350001, Fujian Province, China Author contributions: Wang HM and Huang CM conceived of the study, analyzed the data, and drafted the manuscript Zheng CH, Li P and Xie JW helped revise the manuscript critically for important intellectual content Wang JB, Lin JX and Lu J helped collect data and design the study and all authors read and approved the final manuscript. | 2012 | World Journal of Gastroenterology2012，18，38： | 15 |
| 2 | Micronuclei in Nasal Mucosa, Oral Mucosa and Lymphocytes in Students Exposed to Formaldehyde Vapor in Anatomy Class显示文摘The frequency of micronuclei (MN) in cells of the nasal mucosa, oral mucosa and in lym-phocytes was evaluated for 25 students in anatomy classes exposed to formaldehyde (FA) overan 8-week period. Each student served as his or her own control. The time-weighted averageconcentration (TWA) of fOrmaldehyde in anatomical laboratories and in students’ dormitorieswas 0. 508 ± 0. 299 mg/m3 and 0. 012 ± 0. 0025mg/m3, respectively. A higher frequency ofmicronuclei was observed in nasal and oral exfoliative cells after formaldehyde exposure (3. 85± 1. 48 vs 1 .20± 0. 676 and 0. 857 ± 0. 558 vs 0. 568 ± 0. 317, paired-t test: P< 0. 001and P < 0. 01, respectively). No significant increase in the frequency of lymphocyte micronu-clei was found after formaldehyde exposure (P >0. 05 ). The present study shows that nasalmucosa cel1s exposed through respiration are the chief target of FA-induced genotoxic | YING CHEN -JlANG YAN WEN-SHENG ZHAO MEI-YING YE XIAO-LEI XIE HONG YIN SHU-YI ZHU XIAN-SHU(Department of Environmental Health, n Dgurtment of Anatomy,Tongji the ical University, Wuhan, China)(Department of Public Health, Wengzhou theical Chllege, Ch | 1997 | Biomedical and Environmental Sciences1997，10，4： | 7 |
| 3 | Intrahepatic transplantation of hepatic oval cells for fulminant hepatic failure in rats显示文摘AIM:To evaluate the effect of intrahepatic transplantation of hepatic oval cells(HOC)on fulminant hepatic failure(FHF)in rats.METHODS:HOC obtained from rats were labeled with green fluocescent protein(GFP)or 5,6carboxyfluorescein diacetate succinmidyl ester(CFDASE).Cell fluorescence was observed under fluorescent microscope at 6,24,48 and 72 h after labeling.CFDASE labeled HOC(5×10 6 cells each rat)were injected into livers of rats with FHF induced by D-galactosamine.Serum albumin(ALB),alanine aminotransferase(ALT),aspartate aminotransferase(AST)and total bilirubin(TBil)levels were measured at different time points.Liver function of rats was examined on days 3,7,14 and 21 after HOC transplantation.RESULTS:The positive rate of GFP and CFDA-SE labeled HOC was 10%and 90%,respectively,with no significant change in cell viabilities.The survival rate was higher in HOC transplantation group than in control group,especially 48(9/15 vs 6/15)and 72 h(9/15 vs 4/15)after HOC transplantation.The serum ALT,AST and TBil levels were decreased while the serum Alb level was increased after HOC transplantation.Fluorescence became faded and diffused in liver tissues,suggesting that proliferation and differentiation occur in transplanted HOC.CONCLUSION:CFDA-SE is superior to GFP in labeling HOC,although fluorescence intensity is decreased progressively with cell division.HOC transplantation can improve the liver function and increase the survival rate of recipients. | Chen-Xuan Wu,Qi Zou,Zheng-Yan Zhu,Ying-Tang Gao,Yi-Jun Wang,Department of Hepatobiliary,The Third Center of Affiliated Hospital of Tianjin Medical University Key Laboratory of Artificial Cells of Tianjin,Tianjin 300170,China Author contributions:Wang YJ,Wu CH and Zou Q designed the research Zou Q,Zhu ZY,Gao YT performed the research Zou Q analyzed the data Wang YJ and Wu CX wrote the paper.Supported by Tianjin Science Committee,Grant No.05SYSYJC02600 and Tianjin Health Bureau,Grant No.05KYR01 | 2009 | World Journal of Gastroenterology2009，15，12： | 7 |
| 4 | Healing effects of heparin on acetic acid-induced gastric ulcers in rats显示文摘HealingefectsofheparinonaceticacidinducedgastriculcersinratsYangLi,QiBingMeiandChiHinChoDepartmentofPharmacology,FacultyofMe... | Yang Li, Qi Bing Mei and Chi Hin Cho Department of Pharmacology, Faculty of Medicine, The University of Hong Kong, 5 Sassoon Road, Hong Kong (Li Y, Mei QB and Cho CH) | 1998 | Chinese Medical Journal1998，，1： | 2 |
| 5 | PROOF study Group 显示文摘 | Chesnut CH Silveman S Andviano k A vandomized tial of nasal spay salmon calcitonin in postmenopausal women with established osteporosis: the prevnt recurrence of osteoporasis farcture study | 2000 | Am J Med2000，109，6： | 1 |
| 6 | A new method for detection of delirium 显示文摘 | Inouye SK van Dyck CH Alessi CA et aL Clarifying confusion: The Confusion Assessment Method | 1990 | Ann Intern Med1990，113，12： | 1 |
| 7 | Strain BR60显示文摘 | Wyndham RC Cloning and expression of the transposable chlorobenzoate 3 4-dioxygenase genes of Alcaligenes sp | 1993 | Appl Environ Microbio1993，59，： | 1 |
| 8 | - the structures of five new diterpenoid alkaloids显示文摘 | CHEN ZG LAO AN WANG CH et aL Studies on the active principles from Aconitum flavum hand - rnazz | 1987 | Heterocycles1987，26，6： | 1 |
| 9 | Model Formulation and Model Building Procedure显示文摘 | Feng HY Menq CH The Prediction of Cutting Forces in the Ballend Milling Process-I | 1994 | International Journal of Machine Tools and Manufacture1994，34，5： | 1 |
| 10 | technique and results 显示文摘 | Brown CH Jr Steiner ME Carson EW The use of hamstring tendons for anteriorcruciate ligament reconstruction | 1993 | Clin Sporta Med1993，12，4： | 1 |
| 11 | A database study显示文摘 | Hiroki Takahashi Sei Tsuboyama Yoji Umezawa Kazumasa Honda Motohiro Nishio CH/π interactions as demonstrated in the crystal structure of host/guest compounds | 2000 | Tetrahedron2000，56，： | 1 |
| 12 | Is there a nuchar translucency millimeter measurement above which there is no added benefit from first trimester serum screening显示文摘 | Comstock CH Malone FD For the FASTER Research Consortium | | 0，，03： | 1 |
| 13 | ation and IVF outcome in low responders 显示文摘 | Kim CH Howles CM Lee HA The effect of transdermal tes- tosterone gel pretreatment on controlled ovarian sthnu! | 2011 | Fertil Steril2011，95，2： | 1 |
| 14 | aracteristics in metal foams显示文摘 | Boomsma K Poulikakos D The effects of compression and pore Size variations on the liquid flow ch | 2001 | ASME J of Fluids Engineering2001，124，： | 1 |
| 15 | On image analysis by the methods of moments显示文摘 | The CH Chin RT | 1988 | IEEE Transactions on Pattern Analysis and Machine Intelligence1988，10，4： | 1 |
| 16 | Characteristics Developed at the Turning Institute of Textile and Plastics 显示文摘 | MICHELS Ch MAROND R of the Amine Oxide Process TEAGER E | 1996 | Fiber Chemistry1996，28，1： | 1 |
| 17 | stment with H2 - an- tagonist显示文摘 | Pan S Liao CH The histological maturity of generating mucosa of healed duodenal ulcer and ulcer recurrence dter | 1990 | Am J Gast roenteral1990，85，8： | 1 |
| 18 | Investigation on the short-term outcome and prognostic impact of predisposition,and precipitants in inpatients with chronic liver disease from Chinese AcuTe on CHronic LIver FailurE(CATCH-LIFE)cohorts显示文摘Aim:The study aimed to investigate the short-term outcomes of hospitalized patients with chronic liver disease(CLDs)and assess the prognostic impact of predisposition and precipitants,which currently remains unclear.Methods:The study included 3970 hospitalized patients with CLDs from two prospective longitudinal multicenter studies(NCT02457637 and NCT03641872)conducted in highly endemic hepatitis B virus(HBV)areas.Competing risk analysis was used to evaluate the effect of predispositions,including the etiology and severity of CLDs and precipitants;on sequential 28,90,and 365-day liver transplantation(LT)-free mortality.Results:Among all enrolled patients,76.8%of adverse outcomes(including death and LT)within one year occurred within 90 days.Compared with alcoholic etiology,the association of HBV etiology with poorer outcomes was remarkably on the 28th day(hazard ratio[HR],1.81;95%confidence interval[CI],1.07-3.06;p=0.026);however,and dimin-ished or became insignificant at 90 days and 365 days.Cirrhosis increased the adjusted risk for 365-day(HR,1.50;CI,1.13-1.99;p=0.004)LT-free mortality when compared with noncirrhosis.In patients with cirrhosis,prior decompensation(PD)independently increased the adjusted risk of 365-day LT-free mortality by 1.25-fold(p=0.021);however,it did not increase the risk for 90-day mortality.Neither the category nor the number of precipitants influenced the adjusted risk of 28 or 90-day LT-free mortality.Conclusions:The 90-day outcome should be considered a significant endpoint for evaluating the short-term prognosis of hospitalized patients with CLD.Predisposing factors,other than etiology,mainly affected the delayed(365-day)outcome.Timely effective therapy for CLD etiology,especially antiviral treatments for HBV,and post-discharge long-term surveillance monitoring in cirrhotic patients undergoing PD are suggested to enhance disease management and reduce mortality. | Yan Zhang Wenting Tan Xiaobo Wang Xin Zheng Yan Huang Beiling Li Zhongji Meng Yanhang Gao Zhiping Qian Feng Liu Xiaobo Lu Jia Shang Yubao Zheng Weituo Zhang Shan Yin Wenyi Gu Tongyu Wang Jianyi Wei Zixuan Shen Guohong Deng Yi Zhou Yixin Hou Qun Zhang Shue Xiong Jing Liu Liyuan Long Ruochan Chen Jinjun Chen Xiuhua Jiang Sen Luo Yuanyuan Chen Chang Jiang Jinming Zhao Liujuan Ji Xue Mei Jing Li Tao Li Rongjiong Zheng Xinyi Zhou Haotang Ren Yu Shi Hai Li for the CATCH‐LIFE Study Investigators of Chinese(Acute‐on)Chronic Liver Failure(CLIF)Consortium(Ch‐CLIFC) | 2023 | Portal Hypertension & Cirrhosis2023，2，3： | 0 |
| 19 | Probe manipulators for Wendelstein 7-X and their interaction with the magnetic topology显示文摘Probe manipulators are a versatile addition to typical plasma edge diagnostics.Equipped with material samples they allow for detailed investigation of plasma–wall interaction processes,such as material erosion,deposition or impurity transport pathways.When combined with electrical probes,a study of scrape-off layer and plasma edge density,temperature and flow profiles as well as magnetic topologies is possible.A mid-plane manipulator is already in operation on Wendelstein 7-X.A system in the divertor region is currently under development.In the present paper we discuss the critical issue of heat and power loads,power redistribution and experimental access to the complex magnetic topology of Wendelstein 7-X.All the aforementioned aspects are of relevance for the design and operation of a probe manipulator in a device like Wendelstein?7-X.A focus is put on the topological region that is accessible for the different coil current configurations at Wendelstein 7-X and the power load on the manipulator with respect to the resulting different magnetic configurations.Qualitative analysis of power loads on plasma-facing components is performed using a numerical tracer particle diffusion tool provided via the Wendelstein 7-X Webservices. | M RACK D HOSCHEN D REITER B UNTERBERG J W COENEN S BREZINSEK O NEUBAUER S BOZHENKOV G CZYMEK Y LIANG M HUBENY Ch LINSMEIER the Wendelstein 7-X Team | 2018 | Plasma Science and Technology2018，20，5： | 0 |
| 20 | Numerical study on residual current and its impact on mass transport in the Hangzhou Bay and the Changjiang Estuary Ⅱ. Residual current and its impact on mass transport in winter显示文摘Some observational characteristics of residual current and mass transport in the Hangzhou Bay and the Changjiang Estuary in winter are analyzed. The residual current and its impact on mass transport are simulated with a 3 - D joint model for the Hangzhou Bay and the Changjiang Estuary, in which the impacts of river flux, wind, baroclinic pressure gradient (BPG), background current in the East China Sea and tide (including M2, S2, K1 and O1) are taken into account. Based on there studies, further simulations are made to analyze the dynamical mechanisms of the observational characteristics. | Zhu Shouxian, Dang Pingxing, Shi Fengyan, Zhu Jianrong ( State Key Laboratory of Estuarine and Coastal research, East China Normal University, Shanghai 200062, China Meteorology Institute of the PLA Science and Engineering University, Nanjing 211101, Ch | 2001 | Acta Oceanologica Sinica2001，20，2： | 0 |
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