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| 1 | 863 genomes reveal the origin and domestication of chicken显示文摘Despite the substantial role that chickens have played in human societies across the world,both the geographic and temporal origins of their domestication remain controversial.To address this issue,we analyzed 863 genomes from a worldwide sampling of chickens and representatives of all four species of wild jungle fowl and each of the five subspecies of red jungle fowl(RJF).Our study suggests that domestic chickens were initially derived from the RJF subspecies Gallus gallus spadiceus whose present-day distribution is predominantly in southwestern China,northern Thailand and Myanmar.Following their domestication,chickens were translocated across Southeast and South Asia where they interbred locally with both RJF subspecies and other jungle fowl species.In addition,our results show that the White Leghorn chicken breed possesses a mosaic of divergent ancestries inherited from other subspecies of RJF.Despite the strong episodic gene flow from geographically divergent lineages of jungle fowls,our analyses show that domestic chickens undergo genetic adaptations that underlie their unique behavioral,morphological and reproductive traits.Our study provides novel insights into the evolutionary history of domestic chickens and a valuable resource to facilitate ongoing genetic and functional investigations of the world's most numerous domestic animal. | Ming-Shan Wang Mukesh Thakur Min-Sheng Peng Yu Jiang Laurent Alain Francois Frantz Ming Li Jin-Jin Zhang Sheng Wang Joris Peters Newton Otieno Otecko Chatmongkon Suwannapoom Xing Guo Zhu-Qing Zheng Ali Esmailizadeh Nalini Yasoda Hirimuthugoda Hidayat Ashari Sri Suladari Moch Syamsul Arifin Zein Szilvia Kusza Saeed Sohrabi Hamed Kharrati-Koopaee Quan-Kuan Shen Lin Zeng Min-Min Yang Ya-Jiang Wu Xing-Yan Yang Xue-Mei Lu Xin-Zheng Jia Qing-Hua Nie Susan Joy Lamont Emiliano Lasagna Simone Ceccobelli Humpita Gamaralalage Thilini Nisanka Gunwardana Thilina Madusanka Senasige Shao-Hong Feng Jing-Fang Si Hao Zhang Jie-Qiong Jin Ming-Li Li Yan-Hu Liu Hong-Man Chen Cheng Ma Shan-Shan Dai Abul Kashem Fazlul Haque Bhuiyan Muhammad Sajjad Khan Gamamada Liyanage Lalanie Pradeepa Silva Thi-Thuy Le Okeyo Ally Mwai Mohamed Nawaz Mohamed Ibrahim Megan Supple Beth Shapiro Olivier Hanotte Guojie Zhang Greger Larson Jian-Lin Han Dong-Dong Wu Ya-Ping Zhang | 2020 | Cell Research2020，30，8： | 7 |
| 2 | Antiproliferative and apoptosis-inducing potential of 3β-hydroxy-△5-steroidal congeners purified from the soft coral Dendronephthya putteri显示文摘The exploration and identification of antiproliferative phytochemicals have received increased attention in medicinal chemistry. In particular, research focused on the toxicology of marine natural products has increased in recent years. Terpenoids, among many secondary metabolites, have been demonstrated to act as effective anticancer agents. Soft corals, a group of marine invertebrates, produce a variety of terpenoids with biofunctional properties. The current study presents the extraction, purification, and identification of sterol congeners from the soft coral Dendronephthya putteri. The method involves 50% chloroform-methanol extraction, polar column fractionation, and analysis through GC-MSn. Dose-dependent antiproliferative activity was observed within the sterol-rich fraction (DPCMH 2-4), which consisted of 3β-hydroxy-Δ5-steroidal congeners. This fraction inhibited the growth of HL-60 and MCF-7 cells with IC50 values of 25.27±1.43 and 22.81±0.15 μg/mL, respectively. Apoptotic body formation, DNA damage, cell cycle arrest, and apoptotic cell signaling pathway activation were also observed, reinforcing the dose-dependent antiproliferative and apoptosis-inducing activity of 3β-hydroxy-Δ5-steroidal congeners. To our knowledge, this is the first report of anticancer agent identification from the soft coral D. putteri. Based on the observations, these steroidal congeners are promising candidates for the development of anticancer drugs. | Thilina U. JAYAWARDENA Won Woo LEE I. P. Shanura FERNANDO K. K. Asanka SANJEEWA Lei WANG Tee Gee LEE Young Jin PARK Chang-ik KO You-Jin JEON | 2019 | Journal of Oceanology and Limnology2019，37，4： | 1 |
| 3 | Cloud Technologies for Bioinformatics Applications 显示文摘 | Jaliya Ekanayake Thilina Gunarathne Judy Qiu | 2011 | Parallel and Distributed Systems IEEE Transactions on2011，22，6： | 1 |
| 4 | Low viscosity cyanate ester resin for the injection repair of hole-edge delaminations in bismaleimide/carbon fiber composites显示文摘 | Mahendra Thunga Kelsey Larson Wilber Lio Thilina Weerasekera Mufit Akinc Michael R. Kessler | 2013 | Composites Part A2013，，： | 1 |
| 5 | Machine learning techniques for cooperative spectrum sensing in cognitive radio networks显示文摘 | Thilina K M Choi K W Saquib N | 2013 | IEEE Journal on Selected Areas in Communications2013，31，11： | 1 |
| 6 | Machine learn- ing techniques for cooperative spectrum sensing in cognitive ra- dio networks显示文摘 | Thilina K M Kae Won Choi Saquib N | 2013 | IEEE Journal on Selected Areas in Commu nication2013，31，11： | 1 |
| 7 | Emissions of fine particle fluoride from biomass burning 显示文摘 | THILINA J CHELSEA E S ROBERT J | 2014 | EnvironmentalScience & Technology2014，48，12： | 1 |
| 8 | Marine proteins and peptides:Production,biological activities,and potential applications显示文摘Marine protein hydrolysates and peptides have grown in popularity due to their biological activities and robust properties.They are increasingly studied in the functional food,pharmaceutical,and cosmeceutical sectors.This article discusses the current knowledge about preparing protein hydrolysates and peptides from seaweed,seafood,and seafood processing byproducts.Gaps in knowledge and technical expertise required for their industrial integration have been identified.The desire for natural substances to use as functional food has gained prevalence as consumers have become more aware of the adverse side effects of synthetic drugs.Aging-related chronic diseases,including cancer,arteriosclerosis,and diabetes,can be prevented by actively introducing food-based functional ingredients.Marine-derived proteins and peptides still face several hurdles to commercialization,such as scaling up production and maintaining a sustainable supply of raw materials.Further understanding of the physiological functionalities,action mechanisms,and clinical efficacy of these peptides and proteins would facilitate their use in biomedical applications and as functional ingredients in food and cosmetics. | Ilekuttige Priyan Shanura Fernando Thilina UJayawardena Jianping Wu | 2023 | Food Innovation and Advances2023，2，2： | 0 |
| 9 | GETTING TO THE BOTTOM OF FOOTWEAR CUSTOMIZATION显示文摘鞋类主要用商业地可得到的产品被评估了,当一些研究人员使用了特定的鞋时。因此,鞋的各种各样的参数的效果的理解是相当有限的。在最近的年里发明的 footbed 模拟器允许在安静的站要学习的参数的一个范围。在脚跟高度,位子长度,材料,楔角度和脚趾春天评估变化的压力变化的察觉的感觉和中心能被用来。这篇论文打算以研究和鞋的实际生产显示出 footbed 模拟器的价值。研究与二脚跟高度表现了,位子长度和材料和三个楔角度的三联合证明察觉的感觉是仔细与压力的中心有关。结果也证明最佳 footbed 有一种显著地不同的察觉的感觉。因此, footbed 模拟器是产生特定的鞋类图案的一个理想的方法。 | Thilina W.WEERASINGHE Ravindra S.GOONETILLEKE | 2011 | Journal of Systems Science and Systems Engineering2011，20，3： | 0 |
| 10 | Extinction of lizards in Sri Lanka’s geographically isolated locations显示文摘Climate warming is projected to drive the extinction of approximately one-fifth of the world’s lizard species within the next 60 years(by 2080).However,it remains unclear to what extent and how the global lizard population will be affected by this phenomenon on a geographical scale.Furthermore,there is a need to establish a connection between extinction risk and the prioritization of conservation efforts.In this context,we aim to address concerns related to geographically isolated and critically small lizard populations,highlighting why they face an exceptionally high risk of extinction.We also explore the potential for entire populations to vanish without notice.A comprehensive understanding of these factors is essential to inform the prioritization of conservation initiatives aimed at safeguarding lizard populations in tropical countries under future climate change scenarios. | Buddhi Dayananda Thilina Surasinghe Suranjan Karunarathna Buddhika Madurapperuma Lin Zhang | 2023 | Life Research2023，6，4： | 0 |
| 11 | Author Correction:863 genomes reveal the origin and domestication of chicken显示文摘We apologize for a mistake in Fig.2 that was immediately identified by Edward McClure in our article published online on June 25,2020.In the labels of Fig.2a,b,the blue color should represent West Asian chickens while the brown color should depict South Asian chickens.The correct version of Fig.2 is shown below.This correction does not affect the description and conclusion of this article. | Ming-Shan Wang Mukesh Thakur Min-Sheng Pen Yu Jiang Laurent Alain Francois Frantz Ming Li Jin-Jin Zhang Sheng Wang Joris Peters Newton Otieno Otecko Chatmongkon Suwannapoom Xing Guo Zhu-Qing Zheng Ali Esmailizadeh Nalini Yasoda Hirimuthugoda Hidayat Ashari Sri Suladari Moch Syamsul Arifin Zein Szilvia Kusza Saeed Sohrabi Hamed Kharrati-Koopaee Quan-Kuan She Lin Zeng Min-Min Yang Ya-Jiang Wu Xing-Yan Yang Xue-Mei Lu Xin-Zheng Jia Qing-Hua Nie Susan Joy Lamont Emiliano Lasagna Simone Ceccobelli Humpita Gamaralalage Thilini Nisanka Gunwardana Thilina Madusanka Senasige Shao-Hong Feng Jing-Fang Si Hao Zhang Jie-Qiong Jin Ming-Li Li Yan-Hu Liu Hong-Man Chen Cheng Ma Shan-Shan Dai Abul Kashem Fazlul Haque Bhuiyan Muhammad Sajjad Khan Gamamad Liyanage Lalanie Pradeepa Silva Thi-Thuy Le Okeyo Ally Mwai Mohamed Nawaz Mohamed Ibrahim Megan Supple Beth Shapiro Olivier Hanotte Guojie Zhang Greger Larson Jian-Lin Han Dong-Dong Wu Ya-Ping Zhang | 2020 | Cell Research2020，30，9： | 0 |
| 12 | On the potential of documenting decadal-scale avifaunal change from before-and-after comparisons of museum and observational data across North America显示文摘Studies of biodiversity dynamics have been cast on either long(systematics)or short(ecology)time scales,leaving a gap in coverage for moderate time scales of decades to centuries.Large-scale biodiversity information resources now available offer opportunities to fill this gap for many parts of the world via detailed,quantitative comparisons of assemblage composition,particularly for regions without rich time series datasets.We explore the possibility that such changes in avifaunas across the United States and Canada before and after the first three decades of marked global change(i.e.,prior to 1980 versus after 2010)can be reconstructed and characterized from existing primary biodiversity data.As an illustration of the potential of this methodology for sites even in regions not as well sampled as the United States and Canada,we also explored changes at a single site in Mexico(Chichén-Itzá).We analyzed two large-scale datasets:one summarizing bird records in the United States and Canada before 1980,and one for the same region after 2010.We used probabilistic inventory completeness analyses to identify sites that have avifaunas that have likely been inventoried more or less completely.We prepared detailed comparisons between the two time periods to analyze species showing distributional changes over the time period analyzed.We identified 139 sites on a 0.05°grid that were demonstrably well-inventoried before 1980 in the United States and Canada,of which 108 were also well-inventoried after 2010.Comparing presence/absence patterns between the two time periods for 601 bird species,we found significant spatial autocorrelation in overall avifaunal turnover(species gained and lost),but not in numbers of species lost.We noted potential northward retractions of ranges of several species with high-latitude(boreal)distributions,while other species showed dominant patterns of population loss,either rangewide(e.g.,Tympanuchus cupido)or regionally(e.g.,Thryomanes bewickii).We developed linear models to explore a suite of potential drivers of species loss at relatively fine-grained resolutions(<6km),finding significant effects of precipitation increase,particularly on the eastern border of the United States and Canada.Our exploration of biotic change in Chichén-Itzáincluded 265 species and showed intriguing losses from the local avifauna(e.g.,Patagioenas speciosa),as well as vagrant and recent invasive species in the Yucatán Peninsula.The present work documents both the potential for and the problems involved in an approach integrating primary biodiversity data across time periods.This method potentially allows researchers to assess intermediate-time-scale biodiversity dynamics that can reveal patterns of change in biodiversity-rich regions that lack extensive time-series information. | Fernando Machado-Stredel Benedictus Freeman Daniel Jiménez-Garcia Marlon E.Cobos Claudia Nunez-Penichet Laura Jiménez Ed Komp Utku Perktas Ali Khalighifar Kate Ingenloff Walter Tapondjou Thilina de Silva Sumudu Fernando Luis Osorio-Olvera A.Townsend Peterson | 2022 | Avian Research2022，13，1： | 0 |
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