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| 1 | Molecularly targeted therapy for advanced hepatocellular carcinoma-a drug development crisis?显示文摘Hepatocellular carcinoma is the fastest growing cause of cancer related death globally. Sorafenib,a multitargeted kinase inhibitor,is the only drug proven to improve outcomes in patients with advanced disease offering modest survival benefit. Although comprehensive genomic mapping has improved understanding of the genetic aberrations in hepatocellular cancer(HCC),this knowledge has not yet impacted clinical care. The last few years have seen the failure of several first and second line phase Ⅲ clinical trials of novel molecularly targeted therapies,warranting a change in the way new therapies are investigated in HCC. Potential reasons for these failures include clinical and molecular heterogeneity,trial design and a lack of biomarkers. This review discusses the current crisis in HCC drug development and how we should learn from recent trial failures to develop a more effective personalised treatment paradigm for patients with HCC. | Kiruthikah Thillai Paul Ross Debashis Sarker | 2016 | World Journal of Gastrointestinal Oncology2016，8，2： | 9 |
| 2 | Seasonal variations of phytoplankton diversity in the Coleroon coastal waters,southeast coast of India显示文摘The results of an investigation carried out during June 2005 to May 2007 on physico-chemical parameters,species composition and community structure of phytoplankton including Chlorophyll a(Chl-a) at the Coleroon coastal waters(Southeast coast of India) are reported.Air and surface water temperatures(°C) varied from 25.1 to 30.1 and from 24.5 to 28.5 respectively.Salinity values varied from 6 to 28.5 and the pH ranged between 7.0 and 8.3.Variation in dissolved oxygen content was from 3.1 to 7.5 mg/dm-3 while the light extinction coefficient values(LEC) ranged between 3.1 and 10.1 cm.The ranges of inorganic nutrients(μmol/dm-3) viz.,nitrate,nitrite,phosphate and silicate were 10.1-23.4,1.2-8.9,0.2-3.1 and 55-125,respectively.The ranges of Chlorophyll a(μg/dm-3) values was 2.0-7.5.Presently,124 phytoplankton species representing different classes viz:Bacillariophyceae(77),Dinophyceae(19),Cyanophyceae(15),Chlorophyceae(10) and Chrysophyceae(3) were recorded.The phytoplankton cell abundance varied from 0.290 to 111.662 cells/cm-3,with peak diversity(3.38 bits/ind.) during summer season.The maximum abundance was found during summer season coinciding with the stable hydrographical conditions.The seasonal distribution and abundance of phytoplankton are discussed in relation to hydrographical parameters.Canonical Correspondence Analysis(CCA) was applied in this paper for discriminating environmental factors having effect on phytoplankton community at species level.Coleroon coastal water is subjected to long term fluctuations in physico-chemical parameters depending upon the seasonal tidal amplitude and freshwater influx resulting in a continuous exchange of organic,inorganic,plant and animal matters. | Thillai Rajasekar K Rajkumar M SUN Jun Ashok Prabu V Perumal P | 2010 | Acta Oceanologica Sinica2010，29，5： | 3 |
| 3 | Interferon-gamma release as- says for tuberculosis : current and future applications 显示文摘 | Thillai M Pollock K Pareek M | 2014 | Expert Rev Respir Med2014，8，1： | 1 |
| 4 | FOL-FIRINOX-a new paradigm in the treatment ofpancreatic cancer显示文摘 | PAPADATOS-PASTOS D THILLAI K RABBIE R | 2014 | Expert Rev Anticancer Ther2014，14，10： | 1 |
| 5 | Neoadjuvant and adjuvant treatment of renal cell carcinoma显示文摘 | Thillai K Allan S Powles T | | 0，，6： | 1 |
| 6 | Analysis of flow-field in a dual mode ramjet combustor with boundary layer bleed in isolator显示文摘A two-dimensional Reynolds averaged Navier Stokes(RANS)simulation of a dual mode ramjet(DMRJ)combustor is performed,modeling the University of Michigan dual-mode combustor experimental setup operating in reacting mode with different equivalence ratios(4).The simulations are carried out using a k-u SST turbulence model and a steady diffusion flamelet model for non-premixed combustion.Air enters the isolator at Mach 2.2,stagnation pressure and temperature of 549.2 kPa and 1400 K respectively.Hydrogen is injected transverse to the flow direction and upstream of the cavity flame holder to simulate ramjet(4 Z 0.29)and scramjet(4 Z 0.19)modes of operation.Wall static pressure plots are used to validate numerical results against experimental data.Analysis of flow separation in ramjet mode due to the presence of a shock train in the isolator is carried out by means of numerical Schlieren images overlapped with contours of negative axial velocity,showing the effects of shock wave boundary layer interaction(SWBLI).Active control through wall normal boundary layer bleed in the separated flow region is implemented,which weakens the shock train and moves it downstream closer to the cavity.Bleed results in an improved stagnation pressure recovery in ramjet mode,with a marginal increase in combustion efficiency. | Nishanth Thillai Amit Thakur Srikrishnateja K. Dharani J. | 2021 | Propulsion and Power Research2021，10，1： | 1 |
| 7 | Bloom Forming Species of Phytoplankton in Two Coastal Waters in the Southeast Coast of India显示文摘The results of an investigation carried out during June 2005 to May 2007 on bloom-forming phytoplankton species composition and abundance in the Parangipettai and Coleroon coastal waters(Southeast coast of India) are reported.Air and surface water temperatures(℃) varied from 25.1 to 30.1 and 24.5 to 28.5,respectively,in the former waters and from 25.5 to 31.2 and 25.0 to 29.3 in the latter waters.The respective salinities varied from 6.0 to 28.5 and 5.0 to 33.1 and the respective pH ranged between 7.0 and 8.3 and 7.2 and 8.3.Correspondingly,the dissolved oxygen content varied from 3.1 to 7.5 and 3.1 to 7.9 mgL-1 while the light extinction coefficient(LEC) values ranged between 3.1 and 10.1 and 1.8 and 11.0.The content ranges of inorganic nutrients,i.e.,nitrate,nitrite,phosphate and silicate(μmolL-1),in the Parangipettai and Coleroon coastal waters were:6.5-27.0;1.0-8.9;0.1-3.0 and 15.0-140 and 10.1-23.4;1.2-8.9;0.2-3.1 and 55-125 respectively.The chlorophyll a contents in both waters ranged from 2.0-7.5 μgL-1.Presently,124 phytoplankton species representing different classes were recorded in the Coleroon coast,viz,Bacillariophyceae(77);Dinophyceae(19);Cyanophyceae(15);Chlorophyceae(10) and Chrysophyceae(3),whereas 117 phytoplankton species were recorded in the Parangipettai coast,viz,Bacillariophyceae(66);Dinophyceae(22);Cyanophyceae(19);Chlorophyceae(7) and Chrysophyceae(3).The phytoplankton cell abundance in the Parangipettai and Coleroon coastal waters varied from 290 to 111662 and 140 to 132 757 cells L-1,respectively,with peak diversity(3.38 and 3.52 bits ind-1.) recorded in summer.The maximum abundance occurred in summer coinciding with the stable hydrographical conditions.The seasonal distribution and abundance of phytoplankton are discussed in relation to hydrographical parameters.Totally 31 and 24 species of phytoplankton were found to be bloom-forming in the Parangipettai and Coleroon coastal waters,respectively.Presently Trichodesmium bloom was also observed,which appeared at the 10 fathom level of the coastal water and quickly spread to the marine zone of the Vellar estuary and near the mouth region of the mangrove waters.The Parangipettai and Coleroon coastal waters are subject to long term fluctuations in physico-chemical conditions depending upon the seasonal tidal range and freshwater influx,resulting in a continuous exchange of organic,inorganic,plant and animal matters. | K. Thillai Rajasekar M. Rajkumar SUN Jun V. Ashok Prabu E Perumal | 2010 | Journal of Ocean University of China2010，9，3： | 1 |
| 8 | Obstructive lungfunction in sarcoidosis may be missed, especially in older whitepatients显示文摘 | Thillai M Potiphar L Eberhardt C | 2012 | Eur Respir J2012，39，3： | 1 |
| 9 | Venture capital and efficiency of portfolio companies显示文摘 | A Thillai Rajan | | 0，，22： | 1 |
| 10 | Venture Capital and Efficiency of Portfolio Companies显示文摘 | Thillai A | 2010 | IIMB Management Review2010，22，4： | 1 |
| 11 | Pancreatic cancer and depression显示文摘Pancreatic cancer is a highly devastating disease with high mortality rates.Even patients who undergo potential curative surgery have a high risk for recurrence.The incidence of depression and anxiety are higher in patients with cancer than the general population.However,patients with pancreatic cancer are at most of risk of both depression and anxiety and there seems to be a biological link.In some patients,depression seems to be a precursor to pancreatic cancer.In this article we discuss the biological link between depression anxiety and hepatobiliary malignancies and discuss treatment strategies. | Kalliopi Michoglou Amsajini Ravinthiranathan Saw San Ti Saoirse Dolly Kiruthikah Thillai | 2023 | World Journal of Clinical Cases2023，11，12： | 0 |
| 12 | Combustion enhancement in rearward step based scramjet combustor by air injection at step base显示文摘Numerical simulations were performed to model the non-reacting and reacting flow behind a rearward step flameholder in Mach 1.6 supersonic flow with fuel injection at the step base.The combustor geometry was based on the University of Florida scramjet experimental facility.Turbulence was modeled using k-u shear stress transport(SST),laminar flamelet was used for combustion modeling.Wall static pressure showed good agreement with experimental data for non-reacting and reacting flow.For non-reacting flow,dummy fuel helium mole fraction distribution in the recirculation region behind the step was validated with planar laser induced fluorescence(PLIF)images in experiments.To improve the combustion characteristics,air was injected in tandem with hydrogen at step base using various configurations.With all fuel injection as baseline,the case with 2 air jets around each fuel jet and air injected at 2 times the stagnation pressure of fuel showed the most improvement compared to other cases.It was most effective in reducing the local fuel richness,shortening the flame length and increasing combustion efficiency. | Amit Thakur Nishanth Thillai Amritesh Sinha | 2021 | Propulsion and Power Research2021，10，3： | 0 |
| 13 | Progress in pancreatic cancer therapeutics: The potential to exploit molecular targets显示文摘Pancreatic ductal adenocarcinoma is an aggressive and devastating disease associated with poor survival outcomes. Even though significant advances have been made towards understanding the intricate pathology of this cancer, several important aspects remain unknown. Recently, key genetic mutations within the tumour have been identified, but the exact role they play in tumourigenesis has yet to be determined.For many years, the micro-tumour environment and stroma was thought to aid proliferation but there is now emerging research that suggests the contrary. Several novel targeted agents in pre-clinical and early clinical studies have been promising but it remains to be seen whether they will have a significant impact on patient outcomes. In this review we discuss the unique nature of pancreatic cancer biology, current treatment options and summarise the latest results from pre-clinical and clinical research. We also discuss the future strategies that are needed to improve outcomes for this disease. | Kiruthikah Thillai Debashis Sarker Paul Ross | 2015 | World Journal of Pharmacology2015，4，2： | 0 |
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