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| 1 | Mortality associated with gastrointestinal bleeding in children: A retrospective cohort study显示文摘AIM To determine the clinical characteristics of children with gastrointestinal bleeding (GIB) who died during the course of their admission.METHODS We interrogated the Pediatric Hospital Information System database, including International Classification of Diseases, Current Procedural Terminology and Clinical Transaction Classification coding from 47 pediatric tertiary centers extracting the population of patients (1-21 years of age) admitted (inpatient or observation) with acute, upper or indeterminate GIB(1/2007-9/2015). Descriptive statistics, unadjusted univariate and adjusted multivariate analysis of the associations between patient characteristics and treatment course with mortality was performed with mortality as primary and endoscopy a secondary outcome of interest. All analyses were performed using the R statistical package, v.3.2.3. RESULTS The population with GIB was 19528; 54.6% were male, overall mortality was 2.07%;(0.37% in patients with the principal diagnosis of GIB). When consideringonly the mortalities in which GIB was the principal diagnosis, 48% (12 of 25 principal diagnosis GIB mortalities) died within the first 3 d of admission, whereas 19.8% of secondary diagnosis GIB patients died with 3 d of admission. Patients who died were more likely to have received octreotide (19.8% c.f. 4.04%) but tended to have not received proton pump inhibitor therapy in the first 48 h, and far less likely to have undergone endoscopy during their admission(OR = 0.489, P < 0.0001). Chronic liver disease associated with a greater likelihood of endoscopy. Mortalities were significantly more likely to have multiple complex chronic conditions. CONCLUSION GIB associated mortality in children is highest within 7 d of admission. Multiple comorbidities are a risk factor whereas early endoscopy during the admission is protective. | Thomas M Attard Mikaela Miller Chaitanya Pant Ashwath Kumar Mike Thomson | 2017 | World Journal of Gastroenterology2017，23，9： | 6 |
| 2 | Feasibility of confocal endomicroscopy in the diagnosis of pediatric gastrointestinal disorders显示文摘AIM:To evaluate the feasibility and utility of confocal laser endomicroscopy(CLE) in the description of normal gastrointestinal(GI) mucosa and in the diagnosis of GI disorders in children,in comparison to histology.METHODS:Forty-four patients(19 female) median age 10.9 years(range 0.7-16.6 years) with suspected or known GI pathology underwent esophago-gastro-duodenoscopy(OGD)(n = 36) and/or ileocolonoscopy(IC)(n = 31) with CLE using sodium fluorescein and acriflavine as contrast agents.Histological sections were compared with same site confocal images by two experienced pediatric and GI histopathologists and endoscopists,respectively.RESULTS:Duodenum and ileum were intubated in all but one patient undergoing OGD and IC.The median procedure time was 16.4 min(range 7-25 min) for OGD and 27.9 min(range 15-45 min) for IC.A total of 4798 confocal images were compared with 153 biopsies from the upper GI tract from 36 procedures,and 4661 confocal images were compared with 188 biopsies from the ileocolon from 31 procedures.Confocal images were comparable to conventional histology both in normal and in pathological conditions such as esophagitis,Helicobacter pylori gastritis,celiac disease,inflammatory bowel disease,colonic heterotopia,and graft versus host disease.CONCLUSION:CLE offers the prospect of targeting biopsies to abnormal mucosa,thereby increasing diagnostic yield,reducing the number of biopsies,decreasing the burden on the histopathological services,and reducing costs. | Krishnappa Venkatesh Marta Cohen Clair Evans Peter Delaney Steven Thomas Christopher Taylor Ashraf Abou-Taleb Ralf Kiesslich Mike Thomson | 2009 | World Journal of Gastroenterology2009，15，18： | 2 |
| 3 | Oral calcium inhibits rectal epithetlial prolixferation in familial adenomatous polyposis显示文摘 | Thomas MG Thomson JP Williamson RC | 1993 | Br J Surg1993，80，4： | 1 |
| 4 | Endometrial integrin expression in women undergoing IVF and ICSI:a comparison of the two groups and fertile controls显示文摘 | Thomas K Thomson A J Wood S J | 2003 | Human Reproduction2003，18，2： | 1 |
| 5 | BONE MARROW-DERIVED DENDRITIC CELL PROGENITORS (NLDC 145+, MHC CLASS II+, B7-1dim, B7-2?) INDUCE ALLOANTIGEN-SPECIFIC HYPORESPONSIVENESS IN MURINE T LYMPHOCYTES1,2显示文摘 | Lina Lu Delbert McCaslin Thomas E. Starzl Angus W. Thomson | 1995 | Transplantation1995，，12： | 1 |
| 6 | Endometrial integrin expression in women under IVF and ICSI:a comparison of the two groups and fertile 显示文摘 | Thomas K Thomson A J Wood SJ | 2003 | Hum Reprod2003，18，： | 1 |
| 7 | Endometrial integrin expression in women undergoing IVF and ICSI:a comparison of the two groups and fertile显示文摘 | Thomas K Thomson AJ Wood SJ | 2003 | Fertil Steril2003，79，4： | 1 |
| 8 | Virulence determinants in thebacterial phytopathogen,Erwoinia显示文摘 | Thomson N R Thomas J D Salmond G P C | 1999 | Methods in Microbiology1999，29，： | 1 |
| 9 | Endometrial integrin expression in women undergoing in vitro fertilization and the association with subsequent treatment outcome显示文摘 | Thomas K Thomson A Wood S | 2003 | Fertil Steril2003，80，3： | 1 |
| 10 | Endometrial integrin expression in women undergoing IVF and ICSI: a comparison of the two groups and fertile显示文摘 | Thomas K Thomson AJ Wood SJ | 2003 | Hun Reprod2003，18，3： | 1 |
| 11 | Hepatic stellate cells on poly(DL-lactic acid) surfaces control the formation of 3D hepatocyte co-culture aggregates in vitro显示文摘 | Thomas RJ Bennett A Thomson B | 2006 | Eur Cell Mater2006，11，： | 1 |
| 12 | Housing improve ments for health and associated soeio economic outcomes显示文摘 | Thomson H Thomas S Sellstrom E | 2013 | Co- chrane Database of Systematic Reviews2013，28，2： | 1 |
| 13 | Endometrial integrin expression in women undergoing IVF and ICSI:a comparison of the two groups and fertile显示文摘 | Thomas K Thomson AJ Wood SJ | 2003 | Hum Reprod2003，18，2： | 1 |
| 14 | Endometrial inte grin expression in women undergoing IVF and ICSI: a comparison of the two groups and fertile controls显示文摘 | Thomas K Thomson A J Wood SJ | 2003 | Hum Reprod2003，18，2： | 1 |
| 15 | Controlled synthesis and assembly of FePt nanoparticles显示文摘 | Shouheng Sun Simone Anders Thomas Thomson | 2003 | J Phys Chem B2003，107，： | 1 |
| 16 | Whole-body MR1 with diffusion-weighted sequences compared with 18 FDG PET-CT, CT and superficial lymph node ultrasonography in the staging of advanced cutaneous melanoma: a prospective study 显示文摘 | Jouvet JC Thomas L Thomson V | 2013 | J Eur Acad Dermatol Venereol2013，，： | 1 |
| 17 | The Effect of Gonadotrophic Stimulation on Integrin Expression in the Endometrium显示文摘 | Thomas K Thomson A J Sephton V | 2002 | Hum Reprod2002，17，： | 1 |
| 18 | Hepatitis C virus-like particles synthesized in insect cells as a potential vaccine candidate显示文摘 | Thomas F. Baumert John Vergalla Jujin Satoi Michael Thomson Martin Lechmann David Herion Harry B. Greenberg Susumu Ito T.Jake Liang | 1999 | Gastroenterology1999，，6： | 1 |
| 19 | Endometrial integrin expression in women undergoing IVF and ICSI:a comparison of the two groups and fertile显示文摘 | THOMSON AJ WOOD SJ | 2003 | Hum Reprod2003，18，3： | 1 |
| 20 | Detection of pineapple bacilliform virus using the polymmase chain reaction 显示文摘 | THOMSON K G DIETZIGEN R G THOMAS J E | 1996 | Annals of Applied Biology1996，129，： | 1 |
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