|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | HBsAg quantification for identification of liver disease in chronic hepatitis B virus carriers显示文摘 | Simon B. Larsson Anders Eilard Sebastian Malmstr?m Charles Hannoun Amar P. Dhillon Gunnar Norkrans Magnus Lindh | 2014 | Liver Int2014，，7： | 3 |
| 2 | Effect of process parameters on additive-free electrospinning of regenerated silk fibroin nonwovens显示文摘Silk fibroin is a biomaterial with multiple beneficial properties for use in regenerative medicine and tissue engineering.When dissolving and processing the reconstituted silk fibroin solution by electrospinning,the arrangement and size of fibers can be manifold varied and according fiber diameters reduced to the nanometer range.Such nonwovens show high porosity as well as potential biocompatibility.Usually,electrospinning of most biomaterials demands for the application of additives,which enable stable electrospinning by adjusting viscosity,and are intended to evaporate during processing or to be washed out afterwards.However,the use of such additives increases costs and has to be taken into account in terms of biological risks when used for biomedical applications.In this study,we explored the possibilities of additive-free electrospinning of pure fibroin nonwovens and tried to optimize process parameters to enable stable processing.We used natural silk derived from the mulberry silkworm Bombyx mori.After degumming,the silk fibroin was dissolved and the viscosity of the spinning solution was controlled by partial evaporation of the initial solving agent.This way,we were able to completely avoid the use of additives and manufacture nonwovens,which potentially offer higher biocompatibility and reduced immunogenicity.Temperature and relative humidity during electrospinning were systematically varied(25–35°C,25–30%RH).In a second step,the nonwovens optionally underwent methanol treatment to initiate beta-sheet formation in order to increase structural integrity and strength.Comprehensive surface analysis on the different nonwovens was performed using scanning electron microscopy and supplemented by additional mechanical testing.Cytotoxicity was evaluated using BrdU-assay,XTT-assay,LDH-assay and live-dead staining.Our findings were,that an increase of temperature and relative humidity led to unequal fiber diameters and defective nonwovens.Resistance to penetration decreased accordingly.The most uniform fiber diameters of 998±63 nm were obtained at 30°C and 25%relative humidity,also showing the highest value for resistance to penetration(0.20 N).The according pure fibroin nonwoven also showed no signs of cytotoxicity.However,while the biological response showed statistical evidence,the material characteristics showed no statistically significant correlation to changes of the ambient conditions within the investigated ranges.We suggest that further experiments should explore additional ranges for temperature and humidity and further focus on the repeatability of material properties in dependency of suitable process windows. | Alexander Kopp Ralf Smeets Martin Gosau Nadja Kröger Sandra Fuest Marius Köpf Magnus Kruse Judith Krieger Rico Rutkowski Anders Henningsen Simon Burg | 2020 | Bioactive Materials2020，5，2： | 3 |
| 3 | Multilayers of amorphous carbon prepared by cathodic arc deposition显示文摘 | ANDERS SIMONE CALLAHAN DANIEL L PHARR GEORGE M | 1997 | Surf Coat Technol1997，9495，： | 1 |
| 4 | Neuroflament light and heterogeneity of disease progression in amyotrophic lateral sclerosis:development and validation of a prediction model to improve interventional trials显示文摘Background:Interventional trials in amyotrophic lateral sclerosis(ALS)sufer from the heterogeneity of the disease as it considerably reduces statistical power.We asked if blood neuroflament light chains(NfL)could be used to antici‑pate disease progression and increase trial power.Methods:In 125 patients with ALS from three independent prospective studies-one observational study and two interventional trials-we developed and externally validated a multivariate linear model for predicting disease pro‑gression,measured by the monthly decrease of the ALS Functional Rating Scale Revised(ALSFRS-R)score.We trained the prediction model in the observational study and tested the predictive value of the following parameters assessed at diagnosis:NfL levels,sex,age,site of onset,body mass index,disease duration,ALSFRS-R score,and monthly ALSFRS-R score decrease since disease onset.We then applied the resulting model in the other two study cohorts to assess the actual utility for interventional trials.We analyzed the impact on trial power in mixed-efects models and compared the performance of the NfL model with two currently used predictive approaches,which anticipate disease progression using the ALSFRS-R decrease during a three-month observational period(lead-in)or since disease onset(ΔFRS).Results:Among the parameters provided,the NfL levels(P<0.001)and the interaction with site of onset(P<0.01)contributed signifcantly to the prediction,forming a robust NfL prediction model(R=0.67).Model application in the trial cohorts confrmed its applicability and revealed superiority over lead-in andΔFRS-based approaches.The NfL model improved statistical power by 61%and 22%(95%confdence intervals:54%-66%,7%-29%).Conclusion:The use of the NfL-based prediction model to compensate for clinical heterogeneity in ALS could signif‑cantly increase the trial power.NCT00868166,registered March23,2009;NCT02306590,registered December 2,2014. | Simon Witzel Felix Frauhammer† Petra Steinacker David Devos Pierre‑François Pradat Vincent Meininger Stefen Halbgebauer Patrick Oeckl Joachim Schuster Simon Anders Johannes Dorst Markus Otto Albert C.Ludolph | 2021 | Translational Neurodegeneration2021，10，3： | 1 |
| 5 | Collybial,a new antibiotic sesquiter- penoid from Collybia confluens (Basidiomycetes)显示文摘 | Simon B Anke T Anders U | 1995 | Zur Natur- forsch1995，50，： | 1 |
| 6 | First international reference preparation for individual proteins in urine显示文摘 | Christopher P. Price David J. Newman Sorin Blirup-Jensen Walter G. Guder Anders Grubb Yoshi Itoh Myron Johnson Manfred Lammers Simon Packer Daniel Seymour | 1998 | Clinical Biochemistry1998，，6： | 1 |
| 7 | 查看详情显示文摘 | Joel W Ager Ⅲ Simone Anders | | 0，，1： | 1 |
| 8 | Polymer mediated self- assembly of magnetic nanoparticles 显示文摘 | Shouheng Sun Simone Anders Hendrik F | 2002 | J Am Chem Soc2002，124，： | 1 |
| 9 | Controlled synthesis and assembly of FePt nanoparticles显示文摘 | Shouheng Sun Simone Anders Thomas Thomson | 2003 | J Phys Chem B2003，107，： | 1 |
| 10 | The prognostic relevance of tumour-infiltrating plasma cells and immunoglobulin kappa C indicates an important role of the humoral immune response in non-small cell lung cancer显示文摘 | Miriam Lohr Karolina Edlund Johan Botling Seddik Hammad Birte Hellwig Amnah Othman Anders Berglund Mats Lambe Lars Holmberg Simon Ekman Michael Bergqvist Fredrik Pontén Cristina Cadenas Rosemarie Marchan Jan G. Hengstler J?rg Rahnenführer Patrick Micke | 2013 | Cancer Letters2013，，2： | 1 |
| 11 | Multilayers of amorphous carbon prepared by cathodic arc deposition显示文摘 | Simone Anders Daniel L Callahan George M Pharr | 1997 | Surface and Coatings Technology1997，94，10： | 1 |
| 12 | Development of assay platforms for in vitro screening of Treg modulating potential of pharmacological compounds显示文摘 | Anders Elm Pedersen Kim Holmstr? m Flemming J? rgensen Simon S. Jensen Monika Gad | 2014 | Immunopharmacology and Immunotoxicology2014，，1： | 1 |
| 13 | SorLA Controls Neurotrophic Activity by Sorting of GDNF and Its Receptors GFRα1 and RET显示文摘 | Simon Glerup Maria Lume Ditte Olsen Jens R. Nyengaard Christian B. Vaegter Camilla Gustafsen Erik I. Christensen Mads Kjolby Anders Hay-Schmidt Dirk Bender Peder Madsen Mart Saarma Anders Nykjaer Claus M. Petersen | 2013 | Cell Reports2013，，1： | 1 |
| 14 | Solid fuels in chemical-looping combustion using oxide scale and unprocessed iron ore as oxygen carriers显示文摘 | Henrik Leion Erik Jerndal Britt-Marie Steenari Simon Hermansson Mikael Israelsson Erik Jansson Martin Johnsson Rebecka Thunberg Albin Vadenbo Tobias Mattisson Anders Lyngfelt | 2009 | Fuel2009，，10： | 1 |
| 15 | Lessons from malaria control to help meet the rising challenge of dengue显示文摘 | Katherine L Anders Simon I Hay | 2012 | The Lancet Infectious Diseases2012，，12： | 1 |
| 16 | Effect of Duct Bias on Transport of Vacuum Arc Plas-mas through Curved Magnetic Filters显示文摘 | ANDERS ANDRE ANDERS SIMONE BROWN IAN G | 1994 | J Appl Phys1994，75，： | 1 |
| 17 | S-shaped Magnetic Macroparticle Fil-ter for Cathodic Arc Deposition显示文摘 | ANDERS SIMONE ANDERS ANDRE DICKINSON MICHAEL R | 1997 | IEEE Transactions on Plasma Science1997，25，4： | 1 |
| 18 | 受控的空气污染物暴露与心律失常风险显示文摘[背景]流行病学研究报道了空气污染暴露与心血管疾病发病率和死亡率增加之间的关联。空气污染物暴露可以影响心脏自主神经节律并降低心率变异性,可能增加心律失常的风险,特别是在敏感的患者群体中。[目的]研究在可控制的空气污染物暴露期间和之后,统计分析了健康志愿者和冠状动脉心脏疾病患者的心律失常发生率。[方法]分析数据来自13个随机双盲交叉研究,包括282名参加者(140名健康志愿者和142例稳定性冠状动脉心脏疾病患者)的连续心电图记录。记录研究人群每次暴露时发生心律失常的情况。[结果]在稀释的柴油车尾气、木材烟雾、臭氧、浓缩的环境颗粒物、工程碳纳米颗粒或空气污染高环境水平的暴露期间或者之后,无论在健康志愿者或冠状动脉心脏疾病患者中,任何形式心律失常的发生均没有增加。[结论]急性、可控制的空气污染物暴露不增加受试者发生心律失常的短期风险。研究中所采用的这些技术,对于确定涉及空气污染不利影响的重要病理生理途径依然至关重要,并且在为环境和公共卫生政策决策提供信息中也起着重要的作用。 | Jeremy P.Langrish Simon J.Watts Amanda J.Hunter Anoop S.V.Shah Jenny A.Bosson Jon Unosson Stefan Barath Magnus Lundbck Flemming R.Cassee Ken Donaldson Thomas Sandstrm Anders Blomberg David E.Newby Nicholas L.Mills | 2014 | 环境与职业医学2014，31，10： | 0 |
| 19 | Effects of early postnatal gastric and colonic microbiota transplantation on piglet gut health显示文摘Background Diarrhea is a major cause of reduced growth and mortality in piglets during the suckling and weaning periods and poses a major threat to the global pig industry.Diarrhea and gut dysbiosis may in part be prevented via improved early postnatal microbial colonization of the gut.To secure better postnatal gut colonization,we hypothesized that transplantation of colonic or gastric content from healthy donors to newborn recipients would prevent diarrhea in the recipients in the post-weaning period.Our objective was to examine the impact of transplanting colonic or gastric content on health and growth parameters and paraclinical parameters in recipient single-housed piglets exposed to a weaning transition and challenged with enterotoxigenic Escherichia coli(ETEC).Methods Seventy-two 1-day-old piglets were randomized to four groups:colonic microbiota transplantation(CMT,n=18),colonic content filtrate transplantation(CcFT,n=18),gastric microbiota transplantation(GMT,n=18),or saline(CON,n=18).Inoculations were given on d 2 and 3 of life,and all piglets were milk-fed until weaning(d 20)and shortly after challenged with ETEC(d 24).We assessed growth,diarrhea prevalence,ETEC concentration,organ weight,blood parameters,small intestinal morphology and histology,gut mucosal function,and microbiota composition and diversity.Results Episodes of diarrhea were seen in all groups during both the milk-and the solid-feeding phase,possibly due to stress associated with single housing.However,CcFT showed lower diarrhea prevalence on d 27,28,and 29 compared to CON(all P<0.05).CcFT also showed a lower ETEC prevalence on d 27(P<0.05).CMT showed a higher alpha diversity and a difference in beta diversity compared to CON(P<0.05).Growth and other paraclinical endpoints were similar across groups.Conclusion In conclusion,only CcFT reduced ETEC-related post-weaning diarrhea.However,the protective effect was marginal,suggesting that higher doses,more effective modalities of administration,longer treatment periods,and better donor quality should be explored by future research to optimize the protective effects of transplantation. | Christina Larsen Simone Margaard Offersen Anders Brunse Mattia Pirolo Soumya Kanti Kar Luca Guadabassi Thomas Thymann | 2024 | Journal of Animal Science and Biotechnology2024，15，2： | 0 |
| 20 | 里海海豹(Phoca caspica)幼崽繁殖和哺育分布与人类影响的关系显示文摘为了评估里海海豹这个物种年度幼崽生殖情况及新生幼崽的被自然捕食情况,2005和2006年2月在哈萨克斯坦领海的冬季冰原对里海海豹进行了航空调查。据估计,2005年幼崽生殖数量为21063头,2006年为16905头(每年出生在俄罗斯领土上的里海海豹幼崽估计数包括在内)。大约20 000头雌性里海海豹的繁殖种群数量大大低于所公布的20世纪80年代末以来的估计数。鹰是里海海豹幼崽的头号捕食天敌。尽管2005年,商业破冰船路线没有穿越里海海豹幼崽集中的区域,但是在2006年,商业破冰船路线穿越了这些区域。我们的发现对制定该物种的保护策略有着重要的意义。自然死亡率、捕食者造成的损失,以及更为重要的是,现有的捕猎限额显著超过了里海海豹种群的补充量。人为的致死行为应当得以控制,以避免该物种的进一步减少。 | Tero Harkonen Mart Jüssi Mirgaly Baimukanov Anders Bignert Lilia Dmitrieva Yesbol Kasimbekov Mikhail Verevkin Susan Wilson Simon J.Goodman 黄南艳 林宁 | 2008 | AMBIO-人类环境杂志2008，37，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员