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| 1 | CitGVD:a comprehensive database of citrus genomic variations显示文摘Citrus is one of the most important commercial fruit crops worldwide.With the vast genomic data currently available for citrus fruit,genetic relationships,and molecular markers can be assessed for the development of molecular breeding and genomic selection strategies.In this study,to permit the ease of access to these data,a web-based database,the citrus genomic variation database(CitGVD,http://citgvd.cric.cn/home)was developed as the first citrusspecific comprehensive database dedicated to genome-wide variations including single nucleotide polymorphisms(SNPs)and insertions/deletions(INDELs).The current version(V1.0.0)of CitGVD is an open-access resource centered on 1,493,258,964 high-quality genomic variations and 84 phenotypes of 346 organisms curated from in-house projects and public resources.CitGVD integrates closely related information on genomic variation annotations,related gene annotations,and details regarding the organisms,incorporating a variety of built-in tools for data accession and analysis.As an example,CitGWAS can be used for genome-wide association studies(GWASs)with SNPs and phenotypic data,while CitEVOL can be used for genetic structure analysis.These features make CitGVD a comprehensive web portal and bioinformatics platform for citrus-related studies.It also provides a model for analyzing genome-wide variations for a wide range of crop varieties. | Qiang Li Jingjing Qi Xiujuan Qin Wanfu Dou Tiangang Lei Anhua Hu Ruirui Jia Guojin Jiang Xiuping Zou Qin Long Lanzhen Xu Aihong Peng Lixiao Yao Shanchun Chen Yongrui He | 2020 | Horticulture Research2020，7，1： | 4 |
| 2 | True complete left bundle branch block morphology strongly predicts good response to cardiac resynchronization therapy显示文摘 | Yun Tian Ping Zhang Xuebin Li Ying Gao Tiangang Zhu Long Wang Ding Li Jiayu Wang Cuizhen Yuan Jihong Guo | 2013 | Europace2013，，10： | 1 |
| 3 | Presence of notched QRS on paced electrocardiographs as a predictor of poor response to cardiac resynchronization therapy显示文摘 | Wang Jiayu Zhang Ping Li Xuebin Zhu Tiangang Li Hua Wang Long Li Ding Wu Cuncao Gao Ying Tian Yun Guo Jihong | 2014 | Chinese Medical Journal2014，，15： | 1 |
| 4 | Electrochemical and biological performance of hierarchical platinum-iridium electrodes structured by a femtosecond laser显示文摘Neural electrode interfaces are essential to the stimulation safety and recording quality of various bioelectronic therapies.The recently proposed hierarchical platinum-iridium(Pt-Ir)electrodes produced by femtosecond lasers have exhibited superior electrochemical performance in vitro,but their in vivo performance is still unclear.In this study,we explored the electrochemical performance,biological response,and tissue adhesion of hierarchical Pt-Ir electrodes by implantation in adult rat brains for 1,8,and 16 weeks.Regular smooth Pt-Ir electrodes were used as a control.The results showed that the electrochemical performance of both electrodes decreased and leveled off during implantation.However,after 16 weeks,the charge storage capacity of hierarchical electrodes stabilized at~16.8 mC/cm^(2),which was 15 times that of the smooth control electrodes(1.1 mC/cm^(2)).Moreover,the highly structured electrodes had lower impedance amplitude and cutoff frequency values.The similar histological response to smooth electrodes indicated good biocompatibility of the hierarchically structured Pt-Ir electrodes.Given their superior in vivo performance,the femtosecond laser-treated Pt-Ir electrode showed great potential for neuromodulation applications. | Linze Li Changqing Jiang Wanru Duan Zhiyan Wang Feng Zhang Changgeng He Tiangang Long Luming Li | 2022 | Microsystems & Nanoengineering2022，8，5： | 1 |
| 5 | Small molecule inhibitors of RORγt for Th17 regulation in inflammatory and autoimmune diseases显示文摘As a ligand-dependent transcription factor,retinoid-associated orphan receptor gt(RORγt)that controls T helper(Th)17 cell differentiation and interleukin(IL)-17 expression plays a critical role in the progression of several inflammatory and autoimmune conditions.An emerging novel approach to the therapy of these diseases thus involves controlling the transcriptional capacity of RORγt to decrease Th17 cell development and IL-17 production.Several RORγt inhibitors including both antagonists and inverse agonists have been discovered to regulate the transcriptional activity of RORγt by binding to orthosteric-or allosteric-binding sites in the ligand-binding domain.Some of small-molecule inhibitors have entered clinical evaluations.Therefore,in current review,the role of RORγt in Th17 regulation and Th17-related inflammatory and autoimmune diseases was highlighted.Notably,the recently developed RORγt inhibitors were summarized,with an emphasis on their optimization from lead compounds,efficacy,toxicity,mechanisms of action,and clinical trials.The limitations of current development in this area were also discussed to facilitate future research. | Jiuping Zeng Mingxing Li Qianyun Zhao Meijuan Chen Long Zhao Shulin Wei Huan Yang Yueshui Zhao Anqi Wang Jing Shen Fukuan Du Yu Chen Shuai Deng Fang Wang Zhuo Zhang Zhi Li Tiangang Wang Shengpeng Wang Zhangang Xiao Xu Wu | 2023 | Journal of Pharmaceutical Analysis2023，13，6： | 0 |
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