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| 1 | Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress显示文摘在细胞的 ubiquitin (Ub ) 的改变动态平衡,作为 Ub 知道强调,展示并且影响处于多重条件的细胞的回答,然而,内在的机制不完全地被理解。这里,我们报导 autophagy 受体 p62/sequestosome-1 与结合酶, UBE2D2 和 UBE2D3 的 E2 Ub 交往。内长的 p62 在 Ub 动态平衡的 upregulation 期间经历 E2 依赖的 ubiquitylation,一个条件作为 Ub + 应力称为,那对由 bortezomib 的 Ub overexpression,热吃惊或延长 proteasomal 抑制内在,化学疗法的药。p62 的 Ubiquitylation 破坏 p62 的 UBA 领域的 dimerization,解放它的能力认出为选择 autophagy 的 polyubiquitylated 货物。我们进一步证明这机制可能为在 Ub + 压力条件之上的 autophagy 激活是批评的。机制的描述和在察觉到 Ub 应力并且控制选择 autophagy 的 p62 的规章的角色能帮助理解并且调制细胞的回答到许多内长、环境的挑战,潜在地对 autophagy 相关的病为治疗学的策略的发展打开一条新大街。 | Hong Peng Jiao Yang Guangyi Li Qing You Wen Han Tianrang Li Darning Gao Xiaoduo Xie Byung-Hoon Lee Juan Du Jian Hou Tao Zhang Hai Rao Ying Huang Qinrun Li Rong Zeng Lijian Hui Hongyan Wang Qin Xia Xuemin Zhang Yongning He Masaaki Komatsu Ivan Dikic Daniel Finley Ronggui Hu | 2017 | Cell Research2017，27，5： | 9 |
| 2 | Applications of structural efficiency assessment method on structural-mechanical characteristics integrated design in aero-engines显示文摘In the design process of advanced aero-engines,it is necessary to carry out an effective analysis method between structural features and mechanical characteristics for a better structural optimization.Based on the structural composition and functions of aero-engines,the concept and contents of structural efficiency can reflect the relation between structural features and mechanical characteristics.In order to achieve the integrated design of structural and mechanical characteristics,one quantitative analysis method called Structural Efficiency Assessment Method(SEAM)was put forward.The structural efficiency coefficient was obtained by synthesizing the parameters to quantitatively evaluate the aero-engine structure design level.Parameterization method to evaluate structural design quality was realized.After analyzing the structural features of an actual dual-rotor system in typical high bypass ratio turbofan engines,the mechanical characteristics and structural efficiency coefficient were calculated.Structural efficiency coefficient of high-pressure rotor(0.43)is higher than that of low-pressure rotor(0.29),which directly shows the performance of the former is better,there is room for improvement in structural design of the low-pressure rotor.Thus the direction of structural optimization was pointed out.The applications of SEAM shows that the method is operational and effective in the evaluation and improvement of structural design. | Jie HONG Tianrang LI Huaqiang ZHENG Yanhong MA | 2020 | Chinese Journal of Aeronautics2020，33，4： | 1 |
| 3 | Geological Controls on High Production of Tight Sandstone Gas in Linxing Block, Eastern Ordos Basin, China显示文摘Tight sandstone gas in the Linxing Block, eastern Ordos Basin, has been successfully exploited. The high performance is mainly a result of the special geological conditions. The key geological controls for high production have been discussed on the basis of seismic data, field observation, sample features, mercury porosimetry, mechanical properties, and basin modeling. Firstly, the coal measures have good gas generation potential, not only because of the existence of coalbeds and organic-rich shales, but also because coal laminae and microbial mats in the shales significantly increase their total organic carbon(TOC) contents. Secondly, except for the uplifted zone of the Zijinshan complex and the eastern fault zone, rare large faults develop in the Carboniferous–Permian sequence, ensuing the sealing capacity of cap rock. Small fractures generally concentrated in the sandstones rather than the mudstones. Thirdly, gas accumulation in the Linxing Block was controlled by the tectonic, burial and thermal histories. Gas accumulation in the Linxing Block started in the Late Triassic, followed by three short pauses of thermal maturation caused by relatively small uplifts;the maximum hydrocarbon generation period is the Early Cetaceous as a combined result of regional and magmatic thermal metamorphisms. Field profiles show abundant fractures in sandstone beds but rare fractures in mudstone beds. Mechanical properties, determined by lithostratigraphy, confine the fractures in the sandstones, increasing the permeability of sandstone reservoirs and retaining the sealing capacity of the mudstone cap rocks. The modern ground stress conditions favor the opening of predominant natural fractures in the NNW-SSE and N-S directions. These conclusions are useful for exploring the potential tight sandstone gas field. | QI Yu JU Yiwen MENG Shangzhi YU Kun LI Wuyang JIA Tianrang WU Jianguang CHEN Wangang LUO long | 2020 | Acta Geologica Sinica(English Edition)2020，94，2： | 0 |
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