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| 1 | Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress显示文摘在细胞的 ubiquitin (Ub ) 的改变动态平衡,作为 Ub 知道强调,展示并且影响处于多重条件的细胞的回答,然而,内在的机制不完全地被理解。这里,我们报导 autophagy 受体 p62/sequestosome-1 与结合酶, UBE2D2 和 UBE2D3 的 E2 Ub 交往。内长的 p62 在 Ub 动态平衡的 upregulation 期间经历 E2 依赖的 ubiquitylation,一个条件作为 Ub + 应力称为,那对由 bortezomib 的 Ub overexpression,热吃惊或延长 proteasomal 抑制内在,化学疗法的药。p62 的 Ubiquitylation 破坏 p62 的 UBA 领域的 dimerization,解放它的能力认出为选择 autophagy 的 polyubiquitylated 货物。我们进一步证明这机制可能为在 Ub + 压力条件之上的 autophagy 激活是批评的。机制的描述和在察觉到 Ub 应力并且控制选择 autophagy 的 p62 的规章的角色能帮助理解并且调制细胞的回答到许多内长、环境的挑战,潜在地对 autophagy 相关的病为治疗学的策略的发展打开一条新大街。 | Hong Peng Jiao Yang Guangyi Li Qing You Wen Han Tianrang Li Darning Gao Xiaoduo Xie Byung-Hoon Lee Juan Du Jian Hou Tao Zhang Hai Rao Ying Huang Qinrun Li Rong Zeng Lijian Hui Hongyan Wang Qin Xia Xuemin Zhang Yongning He Masaaki Komatsu Ivan Dikic Daniel Finley Ronggui Hu | 2017 | Cell Research2017，27，5： | 9 |
| 2 | Atg5 regulates late endosome and lysosome biogenesis显示文摘Autophagy is an evolutionarily conserved lysosome-based degradation process.Atg5 plays a very important role in autophagosome formation.Here we show that Atg5 is required for biogenesis of late endosomes and lysosomes in an autophagy-independent manner.In Atg5 cells,but not in other essential autophagy genes defecting cells,recycling and retrieval of late endosomal components from hybrid organelles are impaired,causing persistent hybrid organelles and defective formation of late endosomes and lysosomes.Defective retrieval of late endosomal components from hybrid organelles resulting from impaired recruitment of a component of V1-ATPase to acidic organelles blocks the pH-dependent retrieval of late endosomal components from hybrid organelles.Lowering the intracellular pH restores late endosome/lysosome biogenesis in Atg5 cells.Our data demonstrate an unexpected role of Atg5 and shed new light on late endosome and lysosome biogenesis. | PENG JunYa ZHANG Ran CUI YiTong LIU HaoDong ZHAO XiaoXin HUANG Lei HU MingXu YUAN XiaoXi MA BenYu MA XiaoWei TAKASHI Ueno MASAAKI Komatsu LIANG XingJie YU Li | 2014 | Science China(Life Sciences)2014，57，1： | 6 |
| 3 | Functions of autophagy in normal and diseased liver显示文摘 | Mark J. Czaja Wen-Xing Ding Terrence M. Donohue Scott L. Friedman Jae-Sung Kim Masaaki Komatsu John J. Lemasters Antoinette Lemoine Jiandie D. Lin Jing-hsiung James Ou David H. Perlmutter Glenn Randall Ratna B. Ray Allan Tsung Xiao-Ming Yin | 2013 | Autophagy2013，，8： | 2 |
| 4 | Comprehensive proteomics analysis of autophagy-deficient mouse liver显示文摘 | Naomi Matsumoto Junji Ezaki Masaaki Komatsu Katsuyuki Takahashi Reiko Mineki Hikari Taka Mika Kikkawa Tsutomu Fujimura Mitsue Takeda-Ezaki Takashi Ueno Keiji Tanaka Eiki Kominami | 2008 | Biochemical and Biophysical Research Communications2008，，3： | 1 |
| 5 | Raman scattering spectra ofCdS microcrystallites in silicate glasses显示文摘 | Takayuki Komatsu Hiroharu Mohri Masaaki Ohno | 1992 | J Mater Sci Lett1992，11，： | 1 |
| 6 | Detection of common bile duct stones: comparison between endoscopic ultrasonography, magnetic resonance cholangiography, and helical-computed-tomographic cholangiography显示文摘 | Shintaro Kondo Hiroyuki Isayama Masaaki Akahane Nobuo Toda Naoki Sasahira Yosuke Nakai Natsuyo Yamamoto Kenji Hirano Yutaka Komatsu Minoru Tada Haruhiko Yoshida Takao Kawabe Kuni Ohtomo Masao Omata | 2004 | European Journal of Radiology2004，，2： | 1 |
| 7 | Ubiquitylation of Autophagy Receptor Optineurin by HACE1 Activates Selective Autophagy for Tumor Suppression显示文摘 | Zhengzhao Liu Peng Chen Hong Gao Yu Gu Jiao Yang Hong Peng Xingxing Xu Haifeng Wang Meiqiang Yang Xiaoying Liu Libin Fan Shiyao Chen Jian Zhou Yihong Sun Kangchen Ruan Shuqun Cheng Masaaki Komatsu Eileen White Lin Li Hongbin Ji Daniel Finley Ronggui Hu | 2014 | Cancer Cell2014，，： | 1 |
| 8 | Loss of autophagy promotes murine acetaminophen hepatotoxicity显示文摘 | Yuki Igusa Shunhei Yamashina Kousuke Izumi Yoshihiro Inami Hiroo Fukada Masaaki Komatsu Keiji Tanaka Kenichi Ikejima Sumio Watanabe | 2012 | Journal of Gastroenterology2012，，4： | 1 |
| 9 | Loss of Autophagy Diminishes Pancreatic β Cell Mass and Function with Resultant Hyperglycemia显示文摘 | Hye Seung Jung Kun Wook Chung Jeong Won Kim Jin Kim Masaaki Komatsu Keiji Tanaka Yen Hoang Nguyen Tong Mook Kang Kun-Ho Yoon Ji-Won Kim Yeon Taek Jeong Myoung Sook Han Moon-Kyu Lee Kwang-Won Kim Jaekyoon Shin Myung-Shik Lee | 2008 | Cell Metabolism2008，，4： | 1 |
| 10 | Smoking history before surgery and prognosis in patients with stage IA non-small-cell lung cancer—a multicenter study显示文摘 | Haruyuki Kawai Atsuhiko Tada Masaaki Kawahara Kaoru Nakai Hazime Maeda Ryuusei Saitou Fumiyuki Iwami Kiyoshi Ishikawa Shimao Fukai Hikotaro Komatsu | 2005 | Lung Cancer2005，，1： | 1 |
| 11 | Autophagy: Renovation of Cells and Tissues显示文摘 | Noboru Mizushima Masaaki Komatsu | 2011 | Cell2011，，4： | 1 |
| 12 | Trilemma and macroeconomic policies under different financial structures in Indonesia显示文摘 | Yuniarto Hadiwibowo Masaaki Komatsu | 2011 | Journal of Asian Economics2011，，4： | 1 |
| 13 | Aggrephagy: Selective Disposal of Protein Aggregates by Macroautophagy显示文摘 | Trond Lamark Terje Johansen Masaaki Komatsu | 2012 | International Journal of Cell Biology2012，，： | 1 |
| 14 | Physiological significance of selective degradation of p62 by autophagy显示文摘 | Masaaki Komatsu Yoshinobu Ichimura | 2010 | FEBS Letters2010，，7： | 1 |
| 15 | Quantitative Insulin Sensitivity Check Index and the Reciprocal Index of Homeostasis Model Assessment Are Useful Indexes of Insulin Resistance in Type 2 Diabetic Patients with Wide Range of Fasting Plasma Glucose显示文摘 | Hisayo Yokoyama Masanori Emoto Shigehiko Fujiwara Koka Motoyama Tomoaki Morioka Miyoko Komatsu Hideki Tahara Hidenori Koyama Tetsuo Shoji Masaaki Inaba Yoshiki Nishizawa | 2004 | The Journal of Clinical Endocrinology & Metabolism2004，，3： | 1 |
| 16 | Autophagy:Renovation of Cells and Tissues显示文摘 | Noboru Mizushima Masaaki Komatsu | 2011 | Cell2011，147，： | 1 |
| 17 | Autophagy: Renovation of Cells and Tissues显示文摘 | Noboru Mizushima Masaaki Komatsu | 2011 | Cell2011，，4： | 1 |
| 18 | Selective degradation of p62 by autophagy显示文摘 | Yoshinobu Ichimura Masaaki Komatsu | 2010 | Seminars in Immunopathology2010，，4： | 1 |
| 19 | Autophagy Is Important in Islet Homeostasis and Compensatory Increase of Beta Cell Mass in Response to High-Fat Diet显示文摘 | Chie Ebato Toyoyoshi Uchida Masayuki Arakawa Masaaki Komatsu Takashi Ueno Koji Komiya Kosuke Azuma Takahisa Hirose Keiji Tanaka Eiki Kominami Ryuzo Kawamori Yoshio Fujitani Hirotaka Watada | 2008 | Cell Metabolism2008，，4： | 1 |
| 20 | Loss of Autophagy Diminishes Pancreatic β Cell Mass and Function with Resultant Hyperglycemia显示文摘 | Hye Seung Jung Kun Wook Chung Jeong Won Kim Jin Kim Masaaki Komatsu Keiji Tanaka Yen Hoang Nguyen Tong Mook Kang Kun-Ho Yoon Ji-Won Kim Yeon Taek Jeong Myoung Sook Han Moon-Kyu Lee Kwang-Won Kim Jaekyoon Shin Myung-Shik Lee | 2008 | Cell Metabolism2008，，4： | 1 |
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