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| 1 | Deep-learning-based phase control method for tiled aperture coherent beam combining systems显示文摘We incorporate deep learning(DL)into tiled aperture coherent beam combining(CBC)systems for the first time,to the best of our knowledge.By using a well-trained convolutional neural network DL model,which has been constructed at a non-focal-plane to avoid the data collision problem,the relative phase of each beamlet could be accurately estimated,and then the phase error in the CBC system could be compensated directly by a servo phase control system.The feasibility and extensibility of the phase control method have been demonstrated by simulating the coherent combining of different hexagonal arrays.This DL-based phase control method offers a new way of eliminating dynamic phase noise in tiled aperture CBC systems,and it could provide a valuable reference on alleviating the long-standing problem that the phase control bandwidth decreases as the number of array elements increases. | Tianyue Hou Yi An Qi Chang Pengfei Ma Jun Li Dong Zhi Liangjin Huang Rongtao Su Jian Wu Yanxing Ma Pu Zhou | 2019 | High Power Laser Science and Engineering2019，7，4： | 10 |
| 2 | Deep-learning-assisted, two-stage phase control method for high-power mode-programmable orbital angular momentum beam generation显示文摘High-power mode-programmable orbital angular momentum(OAM)beams have received substantial attention in recent years.They are widely used in optical communication,nonlinear frequency conversion,and laser processing.To overcome the power limitation of a single beam,coherent beam combining(CBC)of laser arrays is used.However,in specific CBC systems used to generate structured light with a complex wavefront,eliminating phase noise and realizing flexible phase modulation proved to be difficult challenges.In this paper,we propose and demonstrate a two-stage phase control method that can generate OAM beams with different topological charges from a CBC system.During the phase control process,the phase errors are preliminarily compensated by a deep-learning(DL)network,and further eliminated by an optimization algorithm.Moreover,by modulating the expected relative phase vector and cost function,all-electronic flexible programmable switching of the OAM mode is realized.Results indicate that the proposed method combines the characteristics of DL for undesired convergent phase avoidance and the advantages of the optimization algorithm for accuracy improvement,thereby ensuring the high mode purity of the generated OAM beams.This work could provide a valuable reference for future implementation of high-power,fast switchable structured light generation and manipulation. | TIANYUE HOU YI AN QI CHANG PENGFEI MA JUN LI LIANGJIN HUANG DONG ZHI JIAN WU RONGTAO SU YANXING MA PU ZHOU | 2020 | Photonics Research2020，8，5： | 8 |
| 3 | Biomolecule-assisted Solvothermal Synthesis and Enhanced Visible Light Photocatalytic Performance of Bi2S3/BiOCl Composites显示文摘Novel Bi_2S_3/BiOCl photocatalysts were successfully synthesized via a facile biomoleculeassisted solvothermal method and biomolecule L-cysteine was used as the sulfur source.The structures,morphology,and optical properties of the synthesized samples were characterized by X-ray diffraction(XRD),X-ray photoelectron spectroscopy(XPS),Raman spectroscopy,transmission electron microscopy(TEM),and UV-vis diffuse reflectance spectroscopy(DRS).The presence of Bi_2S_3 in the Bi_2S_3/BiOCl composites could not only improve the optical properties but also enhance the photocatalytic activities for the degradation of Rhodamine B(Rh B) under visible-light irradiation(λ>420 nm) as compared with single Bi_2S_3 and BiOCl.Especially,the sample displayed the best performance of the photodegradation when the feed molar ratio of BiCl_3 and L-cysteine was 2.4:1,which was about 10 times greater than that of pure Bi OCl.The enhanced photocatalytic activities could be ascribed to the effective separation of photoinduced electrons and holes and the photosensitization of dye.Moreover,the possible photodegradation mechanism was also proposed,and the results revealed that the active holes(h+) and superoxide radicals(·O_2^-) were the main reactive species during photocatalytic degradation. | 贾志民 chen wei liu tianyu huang ting 刘孝恒 | 2016 | Journal of Wuhan University of Technology(Materials Science)2016，31，4： | 5 |
| 4 | LIN28 coordinately promotes nucleolar/ribosomal functions and represses the 2C-like transcriptional program in pluripotent stem cells显示文摘LIN28 is an RNA binding protein with important roles in early embryo development,stem cell differentiation/re-programming,tumorigenesis and metabolism.Previous studies have focused mainly on its role in the cytosol where it interacts with Let-7 microRNA precursors or mRNAs,and few have addressed LIN28's role within the nucleus.Here,we show that LIN28 displays dynamic temporal and spatial expression during murine embryo development.Maternal LIN28 expression drops upon exit from the 2-cell stage,and zygotic LIN28 protein is induced at the forming nucleolus during 4-cell to blas-tocyst stage development,to become dominantly expressed in the cytosol after implantation.In cultured pluripotent stem cells(PSCs),loss of LIN28 led to nucleolar stress and activation of a 2-cell/4-cell-like transcriptional program characterized by the expression of endogenous retrovirus genes.Mechanistically,LIN28 binds to small nucleolar RNAs and rRNA to maintain nucleolar integrity,and its loss leads to nucleolar phase separation defects,ribosomal stress and activation of P53 which in turn binds to and activates 2C transcription factor Dux.LIN28 also resides in a complex containing the nucleolar factor Nucleolin(NCL)and the transcrip-tional repressor TRIM28,and LIN28 loss leads to reduced occupancy of the NCL/TRIM28 complex on the Dux and rDNA loci,and thus de-repressed Dux and reduced rRNA expression.Lin28 knockout cells with nucleolar stress are more likely to assume a slowly cycling,translationally inert and anabolically inactive state,which is a part of previously unappreciated 2C-like transcriptional program.These findings elucidate novel roles for nucleolar LIN28 in PSCs,and a new mechanism linking 2C program and nucleolar functions in PSCs and early embryo development. | Zhen Sun Hua Yu Jing Zhao Tianyu Tan Hongru Pan Yuqing Zhu Lang Chen Cheng Zhang Li Zhang Anhua Lei Yuyan Xu Xianju Bi Xin Huang Bo Gao Longfei Wang Cristina Correia Ming Chen Qiming Sun Yu Feng Li Shen Hao Wu Jianlong Wang Xiaohua Shen George Q.Daley Hu Li Jin Zhang | 2022 | Protein & Cell2022，13，7： | 4 |
| 5 | Deep-blue organic light-emitting diodes based on a doublet d-f transition cerium(Ⅲ) complex with 100% exciton utilization efficiency显示文摘Compared to red and green organic light-emitting diodes(OLEDs),blue OLEDs are still the bottleneck due to the lack of efficient emitters with simultaneous high exciton utilization efficiency(EUE)and short excited-state lifetime.Different from the fluorescence,phosphorescence,thermally activated delayed fluorescence(TADF),and organic radical materials traditionally used in OLEDs,we demonstrate herein a new type of emitter,cerium(Ⅲ)complex Ce-1 with spin-allowed and parity-allowed d-f transition of the centre Ce^(3+) ion.The compound exhibits a high EUE up to 100% in OLEDs and a short excited-state lifetime of 42 ns,which is considerably faster than that achieved in efficient phosphorescence and TADF emitters.The optimized OLEDs show an average maximum external quantum efficiency(EQE)of 12.4% and Commission Internationale de L’Eclairage(CIE)coordinates of(0.146,0.078). | Liding Wang Zifeng Zhao Ge Zhan Huayi Fang Hannan Yang Tianyu Huang Yuewei Zhang Nan Jiang Lian Duan Zhiwei Liu Zuqiang Bian Zhenghong Lu Chunhui Huang | 2020 | Light(Science & Applications)2020，9，1： | 3 |
| 6 | Advantages of targeting the tumor immune microenvironment over blocking immune checkpoint in cancer immunotherapy显示文摘Despite great success in cancer immunotherapy,immune checkpoint-targeting drugs are not the most popular weapon in the armory of cancer therapy.Accumulating evidence suggests that the tumor immune microenvironment plays a critical role in anticancer immunity,which may result in immune checkpoint blockade therapy being ineffective,in addition to other novel immunotherapies in cancer patients.In the present review,we discuss the deficiencies of current cancer immunotherapies.More importantly,we highlight the critical role of tumor immune microenvironment regulators in tumor immune surveillance,immunological evasion,and the potential for their further translation into clinical practice.Based on their general targetability in clinical therapy,we believe that tumor immune microenvironment regulators are promising cancer immunotherapeutic targets.Targeting the tumor immune microenvironment,alone or in combination with immune checkpoint-targeting drugs,might benefit cancer patients in the future. | Tianyu Tang Xing Huang Gang Zhang Zhengtao Hong Xueli Bai Tingbo Liang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 3 |
| 7 | Noncontrast-enhanced MRI-based Noninvasive Score for Portal Hypertension(CHESS1802):An International Multicenter Study显示文摘Background and Aims:This study aimed to determine the performance of the non-invasive score using noncontrastenhanced MRI(CHESS-DIS score)for detecting portal hy-pertension in cirrhosis.Methods:In this international multicenter,diagnostic study(ClinicalTrials.gov,NCT03766880),patients with cirrhosis who had hepatic venous pressure gradient(HVPG)measurement and noncontrast-enhanced MRI were prospectively recruited from four university hospitals in China(n=4)and Turkey(n=1)between December 2018 and April 2019.A cohort of patients was retrospectively recruited from a university hospital in Italy between March 2015 and November 2017.After segmentation of the liver on fat-suppressed T1-weighted MRI maps,CHESS-DIS score was calculated automatically by an in-house developed code based on the quantification of liver surface nodularity.Results:A total of 149 patients were included,of which 124 were from four Chinese hospitals(training cohort)and 25 were from two international hospitals(validation cohort).A positive correlation between CHESS-DIS score and HVPG was found with the correlation coefficients of 0.36(p<0.0001)and 0.55(p<0.01)for the training and validation cohorts,respectively.The area under the receiver operating characteristic curve of CHESS-DIS score in detection of clinically significant portal hypertension(CSPH)was 0.81 and 0.9 in the training and validation cohorts,respectively.The intra-class correlation coefficients for assessing the inter-and intra-observer agreement were 0.846 and 0.841,respectively.Conclusions:A non-invasive score using noncontrast-enhanced MRI was developed and proved to be significantly correlated with invasive HVPG.Besides,this score could be used to detect CSPH in patients with cirrhosis. | Yanna Liu Tianyu Tang NecatiÖrmeci Yifei Huang Jitao Wang Xiaoguo Li Zhiwei Li Weimin An Dengxiang Liu Chunqing Zhang Changchun Liu Jinqiang Liu Chuan Liu Guangchuan Wang Cristina Mosconi Alberta Cappelli Antonio Bruno Seray Akçalar EmrecanÇelebioğlu EvrenÜstüner Sadık Bilgiç Zeynep Ellik ÖzgünÖmer Asiller Lei Li Haijun Zhang Ning Kang Dan Xu Ruiling He Yan Wang Yang Bu Ye Gu Shenghong Ju Rita Golfieri Xiaolong Qi | 2021 | Journal of Clinical and Translational Hepatology2021，9，6： | 3 |
| 8 | Efficient red phosphorescent OLEDs based on the energy transfer from interface exciplex: the critical role of constituting molecules显示文摘A novel acceptor material,9-(4′-(4,6-diphenyl-1,3,5-triazin-2-yl)-[1,1′-biphenyl]-3-yl)-9H-carbazole(o-DTPPC)was developed to form interface exciplex with commonly used donors,to maximize the performances of red phosphorescent organic light emitting diodes(PHOLEDs).It is found that the exciplex involving 4,4′-(cyclohexane-1,1-diyl)bis(N,N-di-p-tolylaniline)(TAPC)exhibits the most significant thermally activated delayed fluorescence(TADF)property,derived from the high triplet energy level as well as strong hole-transporting ability of TAPC.Intriguingly,it is the same donor-acceptor combination which achieved the highest device efficiency when adopted as the host for red PHOLEDs.Maximum efficiencies as high as31.36 cd A^(-1),17.95 lm W^(-1),and 21.01%for the current efficiency,power efficiency and external quantum efficiency,respectively with low efficiency roll-off were realized.The improved performance can be attributed to the efficient TADF properties of the interface exciplex-forming host constituting TAPC,benefiting the F?rster energy transfer.The article first underlines the importance of the constituting molecules in the interface exciplex-forming hosts,shedding new insight about the choice of interface exciplex as the host for PHOLEDs,which may lead to even higher performances,paving their ways towards practical applications. | Xiaozeng Song Dongdong Zhang Tianyu Huang Minghan Cai Lian Duan | 2018 | Science China Chemistry2018，61，7： | 3 |
| 9 | Anti-aging effects of chlorpropamide depend on mitochondrial complex-Ⅱ and the production of mitochondrial reactive oxygen species显示文摘Sulfonylureas are widely used oral anti-diabetic drugs.However,its long-term usage effects on patients’lifespan remain controversial,with no reports of influence on animal longevity.Hence,the anti-aging effects of chlorpropamide along with glimepiride,glibenclamide,and tolbutamide were studied with special emphasis on the interaction of chlorpropamide with mitochondrial ATP-sensitive K+(mito K-ATP)channels and mitochondrial complex II.Chlorpropamide delayed aging in Caenorhabditis elegans,human lung fibroblast MRC-5 cells and reduced doxorubicin-induced senescence in both MRC-5 cells and mice.In addition,the mitochondrial membrane potential and ATP levels were significantly increased in chlorpropamide-treated worms,which is consistent with the function of its reported targets,mito K-ATP channels.Increased levels of mitochondrial reactive oxygen species(mt ROS)were observed in chlorpropamide-treated worms.Moreover,the lifespan extension by chlorpropamide required complex II and increased mt ROS levels,indicating that chlorpropamide acts on complex II directly or indirectly via mito K-ATP to increase the production of mt ROS as a pro-longevity signal.This study provides mechanistic insight into the anti-aging effects of sulfonylureas in C.elegans. | Zhifan Mao Wenwen Liu Yunyuan Huang Tianyue Sun Keting Bao Jiali Feng Alexey Moskalev Zelan Hu Jian Li | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 2 |
| 10 | Generation of isogenic single and multiplex gene knockout mice by base editing-induced STOP显示文摘Although CRISPR/Cas9 has been widely used to generate knockout mice, two major limitations remain:the founders usually carry a mixture of genotypes, and mosaicism harboring multiple genotypes.Therefore, it takes a long time to get homozygous mutants. Recently developed base editing(BE) system,which introduces C-to-T conversion without double strand DNA cleavage, has been used to introduce artificial stop codons(i-STOP) to prematurely terminate translation, providing a cleaner strategy for genome engineering. Using this strategy, we generated CD160 KO and VISTA/CD160 double KO mice by microinjection of a single sg RNA targeting CD160 and a mixture of sg RNAs targeting VISTA and CD160,respectively. The BE system induced STOP efficiently in mouse embryos and consequently in founder mice without detectable off-target. Most interestingly, the majority of the mutants harbor same genetic modifications, indicating we generated isogenic single and multiplex gene mutant mice by BE-induced STOP. We also obtained homozygous mutant mouse in F1 mice, demonstrating the accelerated strategy in generating animal models. | Guang Yang Tianyu Zhu Zongyang Lu Guanglei Li Hao Zhang Songjie Feng Yajing Liu Jianan Li Yu Zhang Jia Chen Xuejiang Guo Xingxu Huang | 2018 | Science Bulletin2018，63，17： | 2 |
| 11 | Hippo-YAP/TAZ signaling in osteogenesis and macrophage polarization:Therapeutic implications in bone defect repair显示文摘Bone defects caused by diseases or surgery are a common clinical problem.Researchers are devoted to finding biological mechanisms that accelerate bone defect repair,which is a complex and continuous process controlled by many factors.As members of transcriptional costimulatory molecules,Yes-associated protein(YAP)and transcriptional co-activator with PDZ-binding motif(TAZ)play an important regulatory role in osteogenesis,and they affect cell function by regulating the expression of osteogenic genes in osteogenesis-related cells.Macrophages are an important group of cells whose function is regulated by YAP/TAZ.Currently,the relationship between YAP/TAZ and macrophage polarization has attracted increasing attention.In bone tissue,YAP/TAZ can realize diverse osteogenic regulation by mediating macrophage polarization.Macrophages polarize into M1 and M2 phenotypes under different stimuli.M1 macrophages dominate the inflammatory response by releasing a number of inflammatory mediators in the early phase of bone defect repair,while massive aggregation of M2 macrophages is beneficial for inflammation resolution and tissue repair,as they secrete many anti-inflammatory and osteogenesis-related cytokines.The mechanism of YAP/TAZ-mediated macrophage polarization during osteogenesis warrants further study and it is likely to be a promising strategy for bone defect repair.In this article,we review the effect of Hippo-YAP/TAZ signaling and macrophage polarization on bone defect repair,and highlight the regulation of macrophage polarization by YAP/TAZ. | Haochen Wang Hui Yu Tianyu Huang Bin Wang Lin Xiang | 2023 | Genes & Diseases2023，10，6： | 2 |
| 12 | Chromobox homolog 4 overexpression inhibits TNF-α-induced matrix catabolism and senescence by suppressing activation of NF-κB signaling pathway in nucleus pulposus cells显示文摘Intervertebral disc degeneration(IDD)is featured as enhanced catabolism of extracellular matrix(ECM)in the nucleus pulposus(NP),in which tumor necrosis factor-alpha(TNF-α)-related cell senescence is involved.Chromobox homolog protein 4(CBX4)exhibits anti-inflammatory effects and shows promising therapeutic potential.Thus,in the present study,we explore the role of CBX4 in IDD.Immunohistochemistry staining reveals that CBX4 expression is decreased in severe degenerative NP tissues compared to mild degenerative tissues,and real-time PCR and western blot analysis results show that CBX4 expression is downregulated under TNF-αstimulation in NP cells.siRNA and adenoviruses are used to knockdown or overexpress CBX4,respectively.The results demonstrate that CBX4 knockdown augments the catabolism of ECM in human NP cells,while CBX4 overexpression in rat NP cells restores the ECM degradation induced by TNF-α,as illustrated by immunofluorescence and western blot analysis.In addition,transcriptome sequencing results reveal the regulatory effect of CBX4 on the cell cycle,and further western blot analysis and senescence-associatedβ-galactosidase staining assay indicate that CBX4 overexpression alleviates cell senescence in the presence of TNF-α.Moreover,the phosphorylation of p65,which indicates the activation of NF-κB signaling,is measured by western blot analysis and immunofluorescence assay,and the results reveal that CBX4 overexpression reduces the TNF-α-induced increase in the p-p65/p65 ratio.In addition,the effect of CBX4 overexpression in NP cells is suppressed by NF-κB agonist.In summary,our results indicate that CBX4 overexpression can suppress TNF-α-induced matrix catabolism and cell senescence in the NP by inhibiting NF-κB activation.This study may provide new approaches for preventing and treating IDD. | Yangyang Zhang Shuangxing Li Junmin Hong Jiansen Yan Zhengqi Huang Jiajun Wu Zhihuai Deng Tianyu Qin Kang Xu Wei Ye | 2022 | Acta Biochimica et Biophysica Sinica2022，54，7： | 2 |
| 13 | Intelligent microneedle patch with prolonged local release of hydrogen and magnesium ions for diabetic wound healing显示文摘Diabetes mellitus,an epidemic with a rapidly increasing number of patients,always leads to delayed wound healing associated with consistent pro-inflammatory M1 polarization,decreased angiogenesis and increased reactive oxygen species(ROS)in the microenvironment.Herein,a poly(lactic-co-glycolic acid)(PLGA)-based microneedle patch loaded with magnesium hydride(MgH_(2))(MN-MgH_(2))is manufactured for defeating diabetic wounds.The application of microneedle patch contributes to the transdermal delivery and the prolonged release of MgH_(2) that can generate hydrogen(H_(2))and magnesium ions(Mg^(2+))after reaction with body fluids.The released H_(2) reduces the production of ROS,transforming the pathological microenvironment induced by diabetes mellitus.Meanwhile,the released Mg^(2+)promotes the polarization of pro-healing M2 macrophages.Consequently,cell proliferation and migration are improved,and angiogenesis and tissue regeneration are enhanced.Such intelligent microneedle patch provides a novel way for accelerating wound healing through steadily preserving and releasing of H_(2) and Mg^(2+)locally and sustainably. | Pei Wang Jiayingzi Wu Haiyan Yang Hengke Liu Tianyu Yao Chang Liu Yan Gong Mingsong Wang Guangyu Ji Peng Huang Xiansong Wang | 2023 | Bioactive Materials2023，，6： | 2 |
| 14 | Elevated atmospheric CO_(2) reduces CH_(4)and N_(2)O emissions under two contrasting rice cultivars from a subtropical paddy field in China显示文摘Elevated CO_(2)(eCO_(2))and rice cultivars can strongly alter CH_(4)and N_(2)O emissions from paddy fields.However,detailed information on how their interaction affects greenhouse gas fluxes in the field is still lacking.In this study,we investigated CH_(4)and N_(2)O emissions and rice growth under two contrasting rice cultivars(the strongly and weakly responsive cultivars)in response to eCO_(2),200μmol mol^(-1)higher than the ambient CO_(2)(aCO_(2)),in Chinese subtropical rice systems relying on a multi-year in-situ free-air CO_(2)enrichment platform from 2016 to 2018.The results showed that compared to aCO_(2),eCO_(2)increased rice yield by 7%-31%,while it decreased seasonal cumulative CH_(4)and N_(2)O emissions by 10%-59%and 33%-70%,respectively,regardless of rice cultivar.The decrease in CH_(4) emissions under eCO_(2)was possibly ascribed to the lower CH_(4)production potential(MPP)and the higher CH_(4)oxidation potential(MOP)correlated with the higher soil redox potential(Eh)and O_(2)concentration([O_(2)])in the surface soil.The mitigating effect of eCO_(2)on N_(2)O emissions was likely associated with the reduction of soil soluble N content.The strongly responsive cultivars had lower CH_(4)and N_(2)O emissions than the weakly re sponsive cultivars,and the main reason might be that the former induced higher soil Eh and[O_(2)]in the surface soil and had larger plant biomass and greater N uptake.The findings indicated that breeding strongly responsive cultivars with the potential for greater rice production and lower greenhouse gas emissions is an effective agricultural practice to ensure food security and environmental sustainability under future climate change scenarios. | Haiyang YU Guangbin ZHANG Jing MA Tianyu WANG Kaifu SONG Qiong HUANG Chunwu ZHU Qian JIANG Jianguo ZHU Hua XU | 2022 | Pedosphere2022，32，5： | 2 |
| 15 | Sur-face analysis of plasma grafted carbon fiber 显示文摘 | ZHANG Xuezhong HUANG Yudong WANG Tianyu | 2006 | Appl SurfSci2006，253，5： | 1 |
| 16 | 3D hierarchical architecture collaborating with 2D/2D interface interaction in Ni Al-LDH/Ti_(3)C_(2) nanocomposite for efficient and selective photoconversion of CO_(2)显示文摘Photocatalytic conversion of CO_(2)into a special chemical fuel with high yield and selectivity is still a major challenge.Herein,a 3 D hierarchical Ni Al-LDH/Ti_(3)C_(2)MXene(LDH/TC)nanocomposite is constructed through in situ loading of Ti_(3)C_(2)nanosheets on the Ni Al-LDH scaffold during the hydrothermal process.The formation of a uniform and well-defined 2 D/2 D heterogeneous interface can be realized by optimizing the ratio of Ti_(3)C_(2)and the precursors for Ni Al-LDH.The 3 D hierarchical scaffold with high specific surface area contributes to the favourable photon adsorption and utilization.The intimate contact between Ti_(3)C_(2)and Ni Al-LDH with numerous interfaces effectively promotes the separation of the photoinduced electron-hole pairs in Ni Al-LDH.Together with the highly exposed oxidation-reduction active sites and the enhanced CO_(2)capture and activation.The maximum photocatalytic CO production rate on Ni AlLDH/Ti_(3)C_(2)reaches 11.82 lmol g^(-1)h^(-1)with 92%selectivity and superior stability.This work provides an effective approach for the development of an ideal photocatalyst by collaborative utilization of materials with different dimensionalities. | Qunrong Shi Xiaoyue Zhang Yong Yang Junjie Huang Xiaolong Fu Tianyu Wang Xiaodong Liu Aiwu Sun Jianhua Ge Jinyou Shen Yong Zhou Zuliang Liu | 2021 | Journal of Energy Chemistry2021，30，8： | 1 |
| 17 | Soil pH value, organic matter and macronutrients contents prediction using optical diffuse reflectance spectroscopy显示文摘 | Wang Yubing Huang Tianyu Liu ling | 2015 | Computers and Electronics in Agriculture2015，111，111： | 1 |
| 18 | mRNA vaccines in disease prevention and treatment显示文摘mRNA vaccines have emerged as highly effective strategies in the prophylaxis and treatment of diseases,thanks largely although not totally to their extraordinary performance in recent years against the worldwide plague COVID-19. | Gang Zhang Tianyu Tang Yinfeng Chen Xing Huang Tingbo Liang | 2023 | Signal Transduction and Targeted Therapy2023，8，10： | 1 |
| 19 | FOXP3 Is an X-Linked Breast Cancer Suppressor Gene and an Important Repressor of the HER-2/ErbB2 Oncogene显示文摘 | Tao Zuo Lizhong Wang Carl Morrison Xing Chang Huiming Zhang Weiquan Li Yan Liu Yin Wang Xingluo Liu Michael W.Y. Chan Jin-Qing Liu Richard Love Chang-gong Liu Virginia Godfrey Rulong Shen Tim H.-M. Huang Tianyu Yang Bae Keun Park Cun-Yu Wang Pan Zheng Yan | 2007 | Cell2007，，7： | 1 |
| 20 | FOXP3 Is an X-Linked Breast Cancer Suppressor Gene and an Important Repressor of the HER-2/ErbB2 Oncogene显示文摘 | Tao Zuo Lizhong Wang Carl Morrison Xing Chang Huiming Zhang Weiquan Li Yan Liu Yin Wang Xingluo Liu Michael W.Y. Chan Jin-Qing Liu Richard Love Chang-gong Liu Virginia Godfrey Rulong Shen Tim H.-M. Huang Tianyu Yang Bae Keun Park Cun-Yu Wang Pan Zheng Yan | 2007 | Cell2007，，7： | 1 |
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