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| 1 | Frost heave control of fine round gravel fillings in deep seasonal frozen regions显示文摘Fine round gravel soil is widely employed in the subgrade of high speed railways in cold regions to prevent frost heaving and thawing. The lower the fines content in fine round gravel soil, the smaller the quantities of frost heaving and thawing, but compaction difficulty increases. This study is to obtain the optimum fines content and limited frost heaving and thawing. The fine round gravel soil filling (FRGSF) used in the Harbin-Qiqihaer Passenger Dedicated Line is taken as the study object. Influence of fines content on optimum water content, maximum dry density and frost heaving properties of FRGSF were studied by means of compaction and frost heaving tests. Results show that the maximum dry density of the FRGSF increases first and then decreases with an increase of fines content, namely there is an optimum fines content for easy compaction. The method of surface-vibratory instrument is fit for coarse-grained soils, and wet state of coarse-grained soil is in favor of compaction. Considering the relationship of fines content with maximum dry density and the frost heaving ratio of FRGSF, the fines content should be limited to within the range of 9%-10%, so that the frost heaving ratio is less than 1%, and the FRGSF is easily compacted. Water supply is proved to be an important factor influencing the amount of frost heaving of FRGSF. We also conclude that in the field, it is imperative to control waterproofing and drainage measures. | ZuRun Yue TianLiang Wang Chao Ma TieCheng Sun | 2013 | Research in Cold and Arid Regions2013，5，4： | 12 |
| 2 | Analysis of temperature field characteristics based on subgrade site measurements of Harbin-Qiqihar High-speed Railway in a deep seasonal frozen soil region显示文摘Recent years have seen a large number of high-speed railways built and will be built in seasonal frozen soil regions of China. Although high-speed railways are characterized by being fast, comfortable and safe, higher standards for deformation of the railways' frozen subgrade are required. Meanwhile, changes in subgrade soil temperatures are the main factors affecting the deformation of frozen subgrade. Therefore, this paper selected typical test subgrade sections of the Harbin–Qiqihar Line, a special line for passenger transport built in the deep seasonal frozen soil regions of China, to monitor field temperatures. Also, the temperature changing laws of railways' subgrade in this region was analyzed by using testing data, the aim of which is to provide a technical support for future design and construction of buildings and structures in a deep seasonal frozen soil region. | ZuRun Yue BoWen Tai TieCheng Sun | 2015 | Research in Cold and Arid Regions2015，7，5： | 7 |
| 3 | Recombinant vaccine containing an RBD-Fc fusion induced protection against SARS-CoV-2 in nonhuman primates and mice显示文摘The novel coronavirus SARS-CoV-2 has infected more than 104 million individuals and resulted in more than 2.2 million deaths worldwide as of February 7,2021(https://covid19.who.int).The COVID-19 pandemic highlights the need for safe and effective vaccines against SARS-CoV-2 infection. | Shihui Sun Lei He Zhongpeng Zhao Hongjing Gu Xin Fang Tiecheng Wang Xiaolan Yang Shaolong Chen Yongqiang Deng Jiangfan Li Jian Zhao Liang Li Xinwang Li Peng He Ge Li Hao Li Yuee Zhao Chunrun Gao Xiaoling Lang Xin Wang Guoqiang Fei Yan Li Shusheng Geng Yuwei Gao Wenjin Wei Zhongyu Hu Gencheng Han Yansong Sun | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 4 | Genetic relationships and diversity among Tibetan wheat, common wheat and European spelt wheat revealed by RAPD markers显示文摘 | Qixin Sun Zhongfu Ni Zhiyong Liu Jianwei Gao Tiecheng Huang | 1998 | Euphytica1998，，3： | 1 |
| 5 | Addition of peroxiredoxin 6 (PRDX6) to IVF fertilization medium maintains motility and longevity of human spermatozoa显示文摘This study aims to investigate the protective effects of peroxiredoxin 6 on the total motility and progressive motility of human spermatozoa.Semen samples with normal parameters were collected from 23 males and supplemented with different concentrations of peroxiredoxin 6.All the semen samples were measured according to the WHO 5th manual,and the motile spermatozoa were extracted using IVF fertilization medium supplemented with different peroxiredoxin 6 concentrations.Total motility and progressive motility were observed at different time-points of culture at room temperature.After peroxiredoxin 6 supplementation,all groups had a significant increase in total motility and progressive motility compared to the control group.The difference in total motility and progressive motility between the 0 and 10−7 mM groups was observed at 24 and 48 h of culture at room temperature.At 24 h,the total motility increased by 30%in the control group(16.03±11.91 vs.11.51±7.84),and progressive motility increased by 21%(10.53±9.4 vs.8.31±6.04).A similar trend was observed in the 48 h group.In addition,we also found that peroxiredoxin 6 had a well protective effect on sperm kinetic parameters at 10−7 mM.The findings of this study suggest that peroxiredoxin 6 can enhance sperm total motility and progressive motility in IVF fertilization medium.Peroxiredoxin 6 may have potential benefits for sperm preparation in assisted reproductive technology. | TIECHENG SUN YANDONG ZHANG JIANHUA LI HONG YU LINGLI SONG XINPING SUN XI CHEN LI TIAN | 2021 | BIOCELL2021，45，3： | 1 |
| 6 | Neutron transmutation doping effect on the optical property of germanium nanocrystals显示文摘 | Youwen Hu Tiecheng Lu Shaobo Dun Qiang Hu Caofeng You Qingyun Chen Ningkang Huang Lev Resnick Issai Shlimak Kai Sun Wen Xu | 2009 | Scripta Materialia2009，，10： | 1 |
| 7 | Influence of fines content on the anti-frost properties of coarse-grained soil显示文摘This paper aims to determine the optimal fines content of coarse-grained soil required to simultaneously achieve weaker frost susceptibility and better bearing capacity. We studied the frost susceptibility and strength properties of coarse-grained soil by means of frost heaving tests and static triaxial tests, and the results are as follows:(1) the freezing temperature of coarse-grained soil decreased gradually and then leveled off with incremental increases in the percent content of fines;(2) the fines content proved to be an important factor influencing the frost heave susceptibility and strength properties of coarse-grained soil. With incremental increases in the percent content of fines, the frost heave ratio increased gradually and the cohesion function of fines effectively enhanced the shear strength of coarse-grained soil before freeze-thaw, but the frost susceptibility of fines weakened the shear strength of coarse-grained soil after freeze-thaw;(3) with increasing numbers of freeze-thaw cycles, the shear strength of coarse-grained soil decreased and then stabilized after the ninth freeze-thaw cycle, and therefore the mechanical indexes of the ninth freeze-thaw cycle are recommended for the engineering design values; and(4) considering frost susceptibility and strength properties as a whole, the optimal fines content of 5% is recommended for railway subgrade coarse-grained soil fillings in frozen regions. | TianLiang Wang ZuRun Yue TieCheng Sun JinChuang Hua | 2015 | Research in Cold and Arid Regions2015，7，4： | 1 |
| 8 | Taurolidine improved protection against highly pathogenetic avian influenza H5N1 virus lethal-infection in mouse model by regulating the NF-κB signaling pathway显示文摘Taurolidine(TRD),a derivative of taurine,has anti-bacterial and anti-tumor effects by chemically reacting with cell-walls,endotoxins and exotoxins to inhibit the adhesion of microorganisms.However,its application in antiviral therapy is seldom reported.Here,we reported that TRD significantly inhibited the replication of influenza virus H5N1 in MDCK cells with the half-maximal inhibitory concentration(EC_(50))of 34.45μg/mL.Furthermore,the drug inhibited the amplification of the cytokine storm effect and improved the survival rate of mice lethal challenged with H5N1(protection rate was 86%).Moreover,TRD attenuated virus-induced lung damage and reduced virus titers in mice lungs.Administration of TRD reduced the number of neutrophils and increased the number of lymphocytes in the blood of H5N1 virus-infected mice.Importantly,the drug regulated the NF-κB signaling pathway by inhibiting the separation of NF-κB and IκBa,thereby reducing the expression of inflammatory factors.In conclusion,our findings suggested that TRD could act as a potential anti-influenza drug candidate in further clinical studies. | Chaoxiang Lv Yuanguo Li Tiecheng Wang Qiqi Zhang Jing Qi Mingwei Sima Entao Li Tian Qin Zhuangzhuang Shi Fangxu Li Xuefeng Wang Weiyang Sun Na Feng Songtao Yang Xianzhu Xia Ningyi Jin Yifa Zhou Yuwei Gao | 2023 | Virologica Sinica2023，38，1： | 0 |
| 9 | CD97 negatively regulates the innate immune response against RNA viruses by promoting RNF125-mediated RIG-I degradation显示文摘The G protein-coupled receptor ADGRE5(CD97)binds to various metabolites that play crucial regulatory roles in metabolism.However,its function in the antiviral innate immune response remains to be determined.In this study,we report that CD97 inhibits virus-induced type-I interferon(IFN-I)release and enhances RNA virus replication in cells and mice.CD97 was identified as a new negative regulator of the innate immune receptor RIG-I,and RIG-1 degradation led to the suppression of the IFN-I signaling pathway.Furthermore,overexpression of CD97 promoted the ubiquitination of RIG-I,resulting in its degradation,but did not impact its mRNA expression.Mechanistically,CD97 upregulates RNF125 expression to induce RNF125-mediated RIG-I degradation via K48-linked ubiquitination at Lys181 after RNA virus infection.Most importantly,CD97-deficient mice are more resistant than wild-type mice to RNA virus infection.We also found that sanguinarine-mediated inhibition of CD97 effectively blocks VSV and SARS-CoV-2 replication.These findings elucidate a previously unknown mechanism through which CD97 negatively regulates RIG-I in the antiviral innate immune response and provide a molecular basis for the development of new therapeutic strategies and the design of targeted antiviral agents. | Huasong Chang Peili Hou Xuefeng Wang Aibiao Xiang Hao Wu Wenjing Qi Rukun Yang Xue Wang Xingyu Li Wenqi He Guimin Zhao Weiyang Sun Tiecheng Wang Daniel Chang He Hongmei Wang Yuwei Gao Hongbin He | 2023 | Cellular & Molecular Immunology2023，20，12： | 0 |
| 10 | Supervision over Court Proceedings to Protect Human Rights显示文摘In any modern society under the role of law, the court, as the organ of trials, invariably has its authority recognized by the constitution and laws, an authority that the general public accepts as a matter of course. Sentences and rulings passed by the court represent recognition of the relevant legal matters in accordance with the law, and their execution is guaranteed by the compulsory power of the state. Nevertheless, judges are human beings and, | JIANG WEI SUN TIECHENG | 2003 | The Journal of Human Rights2003，2，1： | 0 |
| 11 | 2-4 First Isochronous Mass Measurement in Neutron-rich Region at CSRe显示文摘Mass is one of the fundamental properties of atomic nuclei. Isochronous mass spectrometry (IMS), using astorage ring combined with an in-flight separator, has been shown to be a powerful tool for mass measurementof exotic nuclei[1]. Recently, masses of many proton-rich nuclides were accurately determined at the HIRFL-CSRfacility[2]. In this paper, we described the first isochronous mass measurement of neutron-rich nuclides at CSRe.This experiment was performed at the end of 2011. In the experiment, the primary beam of 86Kr28+ ions wasaccumulated and accelerated to an energy of 460.65 MeV/u in the synchrotron CSRm. The 86Kr28+ ions were fastextracted and focused on a 15 mm thick beryllium target which was placed at the entrance of the RIBLL2 (anin-flight fragment separator). | Xu Xing Wang Meng Zhang Yuhu Xu Hushan Tu Xiaolin Yu.A.Litvinov Zhou Xiaohong Sun Baohua Yuan Youjin Xia Jiawen Yang Jiancheng K.Blaum Chen Ruijiu Chen Xiangchen Fu Chaoyi Ge Zhuang Hu Zhengguo Huang Wenjia Liu Dawei Y.H.Lam Ma Xinwen Mao Ruishi T.Uesaka Xiao Guoqing Xing Yuanming T.Yamaguchi Y.Yamaguchi Zeng Qi Yan Xinliang Zhao Hongwei Zhao Tiecheng Zhang Wei Zhan Wenlong | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 12 | 2-7 Charge and Frequency Resolved Isochronous Mass Spectrometry in Storage Rings: First Direct Mass Measurement of the Short-lived Neutron-de cient 51Co Nuclide显示文摘Isochronous mass spectrometry in storage rings is a successful technique for the precision mass measurements ofthe nuclides with half-lives down to tens of microseconds[1]. Since the isochronous condition =t greatly reducesthe influence of the velocity difference on the ion revolution periods, the revolution period difference ΔT =T ??TRof a stored ion with respect to a reference time TR is directly related to its mass-to-charge ratio difference Δ(m=q),written in the first order as: | Shuai Peng Xu Hushan Tu Xiaolin Zhang Yuhu Sun Baohua Yu.A.Litvinov Yan Xinliang K.Blaum Wang Meng Zhou Xiaohong He Jianjun Sun Yang K.Kaneko Yuan Youjin Xia Jiawen Yang Jiancheng G.Audi Chen Xiangcheng Jia Guobin Hu Zhengguo Ma Xinwen Mao Ruishi Mei Bo Sun Zhiyu Wang Shitao Xiao Guoqing Xu Xing T.Yamaguchi Y.Yamaguchi Zang Yongdong Zhao Hongwei Zhao Tiecheng Zhang Wei Zhan Wenlong | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 13 | Melatonin and its protective role against male reproductive toxicity induced by heavy metals,environmental pollutants,and chemotherapy:A review显示文摘Melatonin,as a ubiquitous indoleamine hormone,is synthesized primarily by the pineal gland.It has diverse biological effects through quite complex mechanisms.More recently,studies have focused on the mechanism of melatonin in anti-reproductive toxicity/damage.Since melatonin possesses strong antioxidant and anti-apoptotic properties,researchers have examined its potential role in protecting against male reproductive toxicity/damage,which may be induced by chemotherapy or environmental toxicants and can lead to male infertility.In this article,recent progress regarding the protective effects of melatonin on male reproductive toxicity/damage is reviewed. | TIECHENG SUN LINGLI SONG JING MA HONG YU SHANJIE ZHOU SHUSONG WANG LI TIAN | 2020 | BIOCELL2020，44，4： | 0 |
| 14 | Exotic Behavior of Elastic Scattering Differential Cross Sections of Weakly Bound Nucleus ^(17)F at Small Angels显示文摘The experiment of measuring the differential cross sections dσ/dθat forward angles for the elastically scattered 17F (141 MeV) and 17O (128 MeV) on the 208Pb target has been carried out at the Radioactive Ion Beam Line in Lanzhou (RIBLL). Fig. 1 shows the plots of In(dσ/dθ) versusθ2 for 17F (right panel) and 17O (left panel). The dependence of the ln(dσ/dθ) onθ2 shows quite different behaviors for the two nuclei. For the weakly bound nu- | Han Jianlong, Wang Qi, Xiao Zhigang, Xu Hushan, Sun Zhiyu,Hu Zhengguo, Zhang Xueyin Wang Hongwei, Mao Ruishi, Yuan Xiaohua, Xu Zhiguo, Zhao Tiecheng, Zhang Hongbin Xu Huagen, Qi Huirong, Wang Yue, Jia Fei, Wu Lijie, Ding Xianli, Gao Qi Gao Hui, Li Songlin, Xiao Guoqing and Jin Genming | 2005 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2005，，1： | 0 |
| 15 | A New Multigrid 3D-VAR Optimization Method for Bottom Friction Using HF Radar Current Observation显示文摘This paper proposes a new method for data assimilation of the surface radial current observed by High Frequency ground wave radar and optimization of the bottom friction coefficient.In this method,the shallow water wave equation is introduced into the cost function of the multigrid three-dimensional variation data assimilation method as the weak constraint term,the surface current and the bottom friction coefficient are defined as the analytical variables,and the high spatiotemporal resolution surface radial flow observed by the high-frequency ground wave radar is used to optimize the surface current and bottom friction coefficient.This method can effectively consider the spatiotemporal correlation of radar data and extract multiscale information from surface radial flow data from long waves to short waves.Introducing the shallow water wave equation into the cost function as a weak constraint condition can adjust both the momentum and mass fields simultaneously to obtain more reasonable analysis information.The optimized bottom friction coefficient is introduced into the regional ocean numerical model to carry out numerical experiments.The test results show that the bottom friction coefficient obtained by this method can effectively improve the accuracy of the numerical simulation of sea surface height in the offshore area and reduce the simulation error. | ZHANG Xiaoshuang WU Xinrong LI Wei WANG Bin ZHU Xiande LIU Kexiu SHAO Caixia SUN Chunjian CHAO Guofang ZHANG Tiecheng | 2019 | Journal of Ocean University of China2019，18，6： | 0 |
| 16 | The Application of a Safe Neutralization Assay for Ebola Virus Using Lentivirus-Based Pseudotyped Virus显示文摘Dear Editor,Zaire Ebola virus(EBOV)is a negative-sense singlestranded RNA virus that is capable of causing acute hemorrhagic fever with a frightening fatality rate that can reach up to 90%.Due to its high lethality and frequent recurrence,EBOV is a substantial threat to public health.Research about live EBOV is restricted to BSL-4 laboratories;therefore,conventional serological detection methods do not provide a safe way to evaluate neutralizing activity,resulting in a bottleneck in antibody-based detection of viruses such as EBOV.Here,we aim to develop and apply a neutralization assay for EBOV using a generated lentivirus-based pseudotyped EBOV bearing GP on its surface. | Zengguo Cao Hongli Jin Gary Wong Ying Zhang Cuicui Jiao Na Feng Fangfang Wu Shengnan Xu Hang Chi Yongkun Zhao Tiecheng Wang Weiyang Sun Yuwei Gao Songtao Yang Xianzhu Xia Hualei Wang | 2021 | Virologica Sinica2021，36，6： | 0 |
| 17 | 5 - 21 A Resonant Schottky Measurements of Highly Pickup for Nuclear Physics Charged Ions at CSRe显示文摘 | Zang Yongdong Wu Junxia Zhao Tiecheng Zhang Shenghu Mao Ruishi Xu Hushan Sun Zhiyu Ma Xinwen Fritz Nolden Peter Hulsmann Peter Petri Shahab Sanjari | 2010 | IMP & HIRFL Annual Report2010，，1： | 0 |
| 18 | Performance Test of LASCAR Scintillator Detector Array at RIBLL显示文摘The LASCAR (Large Area Scattering Chamber at PABLL) scintillator detector array is developed to detect neutrons and charged particles from the reaction induced by, the RIBs from RIBLL. It consists of 8 scintillator plus light guide blocks. As shown in Fig.l, each block matches with 49 photomultipliers (PMTs) of 9214SB type from Electron Tubes Limited. Some technical improvements and the latest performance test of the 294 PMTs in 6 blocks of LASCAR are described in this report. | Wang Jinchuan, Xiao Guoqing, Guo Zhongyan, Zhan Wenlong, Qi Huirong, Wu LijieXu Zhiguo, Zhang Li, Ding Xianli, Xu Hushan, Sun Zhiyu, Li Jiaxing, Li ChenWang Meng, Chen Lixin, Hu Zhengguo, Mao Ruishi and Zhao Tiecheng | 2003 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2003，，1： | 0 |
| 19 | Design of Multi-unit Control System of High Voltage Power Supply for LASCAR Scintillator Detector Array显示文摘The power voltages of Photomultipliers (PMTs) at RIBLL LASCAR scintillator detector array are distributed between 900 V and 1 800 V irregularly. 392 CC123 modules are employed to supply high voltage for the PMT array. The CC123 module serves as PMT interface groupware package, and it can transform +12 V DC input voltage to ranges of 0~-2200 V for the PMT power supply corresponding to 0~+5 V output voltage from the control board crate. The relation of PMT power supply with the output voltage of the control crate is shown in Fig.1. | Wu Lijie, Wang Jinchuan, Xiao Guoqing, Guo Zhongyan, Zhan Wenlong, Qi Huirong, Xu ZhiguoZhang Li, Ding Xianli, Xu Hushan, Sun Zhiyu, Li Jiaxing, Li Chen, Wang MengChen Lixin, Hu Zhengguo, Mao Ruishi and Zhao Tiecheng | 2003 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2003，，1： | 0 |
| 20 | Leptin effects on the hypothalamic-pituitary-gonadal axis by activating proopiomelanocortin neurons Correlation between regulatory effects and duration显示文摘BACKGROUND:Leptin preserves reproductive functions by stimulating hypothalamic-pituitary-gonadal axis activities at different levels.Some interneurons play an important role in leptin regulation of the gonadal axis.It remains uncertain whether leptin regulates reproductive functions by activating proopiomelanocortin (POMC) neurons.OBJECTIVE:To investigate leptin effects on secretory function of the neuroendocrine-gonadal axis by activating POMC neurons and to observe and verify the relationship between leptin effects and various time points.DESIGN,TIME AND SETTING:The randomized,controlled,animal study was performed at the Basic Institute of Chengde Medical University and the Research Room of Reproductive Immunology of National Research Institute for Family Planning from June to September 2008.MATERIALS:Leptin (Peprotech,USA),α-melanocyte stimulating hormone and rabbit anti-POMC polyclonal antibody (SC-20148) (Santa Cruz Biotechnology,USA),follicle stimulating hormone,luteinizing hormone,and gonadotropin releasing hormone enzyme-labeled immunosorbent assay (ELISA) kit (ADL,USA) were used in the present study.METHODS:A total of 60 healthy,female,adult,Wistar rats received 17 β-estradiol for 5 consecutive days at 15 days after ovariectomy.The rats were randomly assigned to physiological saline (n=35),leptin (n=35),and α-melanocyte stimulating hormone (n=20) groups.MAIN OUTCOME MEASURES:Changes in gonadotropin releasing hormone,luteinizing hormone,and follicle stimulating hormone were compared following intraventricular injection of physiological saline,leptin,and α-melanocyte stimulating hormone at various time points.Changes in POMC mRNA and protein expression in the hypothalamus were measured following physiological saline and leptin injection via the lateral ventricle.RESULTS:Compared to the physiological saline group,leptin and α-melanocyte stimulating hormone affected secretion in the hypothalamus-pituitary axis.Leptin affected secretion of gonadotropin releasing hormone,luteinizing hormone,and follicle stimulating hormone,whereas α-melanocyte stimulating hormone inhibited secretion of these hormones.Compared to the physiological saline group,POMC mRNA expression was significantly increased in the hypothalamus at 2 and 4 hours after leptin injection (P < 0.05),but expression recovered to physiological saline group levels at 6 hours after injection (P > 0.05).POMC protein expression was significantly increased in the hypothalamus at 4 and 6 hours after leptin injection (P < 0.05).CONCLUSION:Leptin affects secretory function of the neuroendocrine-gonadal axis through combined effects on POMC neurons and other pathways.Results suggested that the regulatory effects of POMC neurons were later compared to other neurons. | Songhe Yang Luyang Cheng Xiuyan Ma Lianzhi Zhao Xiaotong Dong Peiming Feng Xiaoqiang Wang Tiecheng Sun Yuebing Qiao | 2010 | Neural Regeneration Research2010，5，9： | 0 |
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