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| 1 | MicroRNA-200c modulates epithelial-to-mesenchymal transition (EMT) in human colorectal cancer metastasis显示文摘 | Keun Hur Yuji Toiyama Masanobu Takahashi Francesc Balaguer Takeshi Nagasaka Junichi Koike Hiromichi Hemmi Minoru Koi C Richard Boland Ajay Goel | 2013 | Gut2013，，9： | 6 |
| 2 | TTYH2,a human homologue of the Drosophila melanogaster gene tweety,is up-regulated in colon carcinoma and involved in cell proliferation and cell aggregation显示文摘AIM: To investigate the expression patterns of TTYH2 in the human colon cancer and colon cancer cell lines and to evaluate the inhibitory effect of small interfering RNA (siRNA) on the expression of TTYH2 in colon cancer cell lines.METHODS: We investigated the expression patterns of TTYH2 in colon cancer, adjacent non-tumorous colon mucosa, and cancer cell lines (DLD-1, caco-2, and Lovo) by RT-PCR. Furthermore, a siRNA plasmid expression vector against TTYH2 was constructed and transfected into DLD-1 and Caco-2 with LipofectamineTM 2000. The down regulation of TTYH2 expression was detected by RT-PCR and the role of siRNA in inducing cell proliferation and cell aggregation was evaluated by MTT and aggregation assay.RESULTS: TTYH2 gene expression in colon cancer tissue was significantly up-regulated compared with normal colonic mucosa (1.23 ± 0.404 vs 0.655 ± 0.373, P = 0.0103). Colon cancer derived cell lines including DLD-1, Caco-2, and Lovo also expressed high levels of TTYH2. In contrast, transfection with siRNA-TTYH2 signifi cantly inhibited both proliferation and scattering of these cancer cell lines.CONCLUSION: The present work demonstrates, for the fi rst time, that the TTYH2 gene expression is signifi cantly up-regulated in colon cancer. The TTYH2 gene may play an important role in regulating both proliferating andmetastatic potentials of colorectal cancer. | Yuji Toiyama Akira Mizoguchi Kazushi Kimura Junichirou Hiro Yasuhiro Inoue Tomonari Tutumi Chikao Miki Masato Kusunoki | 2007 | World Journal of Gastroenterology2007，13，19： | 4 |
| 3 | Serum miR-200c Is a Novel Prognostic and Metastasis-Predictive Biomarker in Patients With Colorectal Cancer显示文摘 | Yuji Toiyama Keun Hur Koji Tanaka Yasuhiro Inoue Masato Kusunoki C. Richard Boland Ajay Goel | 2014 | Annals of Surgery2014，，4： | 3 |
| 4 | Correlation of CD133, OCT4, and SOX2 in Rectal Cancer and Their Association with Distant Recurrence After Chemoradiotherapy显示文摘 | Susumu Saigusa Koji Tanaka Yuji Toiyama Takeshi Yokoe Yoshinaga Okugawa Yasuhiro Ioue Chikao Miki Masato Kusunoki | 2009 | Annals of Surgical Oncology2009，，： | 2 |
| 5 | DNA methylation and microRNA biomarkers for noninvasive detection of gastric and colorectal cancer显示文摘 | Yuji Toiyama Yoshinaga Okugawa Ajay Goel | 2014 | Biochemical and Biophysical Research Communications2014，，： | 2 |
| 6 | Persistence of gene expression changes in noninflamed and inflamed colonic mucosa in ulcerative colitis and their presence in colonic carcinoma显示文摘AIM: A few studies have applied genomic-wide gene expression analysis in inflamed colon tissue sample in ulcerative colitis (UC). We reported the first study of non-inflamed mucosal gene expression in UC and explored its clinical implication.METHODS: Non-inflamed mucosa was obtained from 6 UC patients who received total colectomy. The gene expression of UC in noninfliamed mucosa was monitored with a microarray. For a selected gene, RT-PCR was performed to verify array results and to further examine expression pattern in inflamed mucosa of UC, colorectal cancer tissue and normal mucosa using additional matched pairs.RESULTS: Two genes showing 2.5-fold decreased expression with significance set at in UC samples were bomeo box a4 (HOXa4) and mads box transcription enhancer factor 2, polypeptide B (MEF2b). RT-PCR showed that MEF2b expression in non-inflamed mucosa was significantly downregulated, whereas the expression of MEF2b increased in accordance with the severity of mucosal inflammation. HOXa4 expression both in inflamed and non-inflamed mucosa in UC was consistently downregulated, and the downregulation of HOXa4 was also found in colorectal carcinoma.CONCLUSION: It is suggested that the MEF2b expression in UC which increase in accordance with inflammation may be induced by the inflammatory mediator. In contrast the downregulation of HOXa4 may be partly involved in the pathogenesis of disease including UC and UC-related carcinogenesis. | Yuji Toiyama Akira Mizoguchi Kazushi Kimura Toshimitsu Araki Shigeyuki Yoshiyama Kouhei Sakaguchi Chikao Miki Masato Kusunoki | 2005 | World Journal of Gastroenterology2005，11，33： | 2 |
| 7 | Correlation of CD133, OCT4, and SOX2 in Rectal Cancer and Their Association with Distant Recurrence After Chemoradiotherapy显示文摘 | Susumu Saigusa MD Koji Tanaka MD Yuji Toiyama MD Takeshi Yokoe MD Yoshinaga Okugawa MD Yasuhiro Ioue MD PhD Chikao Miki MD PhD Masato Kusunoki MD PhD | 2009 | Annals of Surgical Oncology2009，，12： | 2 |
| 8 | Evaluation of CXCL10 as a novel serum marker for predicting liver metastasis and prognosis in colorectal cancer 显示文摘 | Toiyama Y Fujikawa H Kawamura M | 2012 | Int J Oncol2012，40，2： | 1 |
| 9 | Correlation of CD133, OCT4, and SOX2 in Rectal Cancer and Their Association with Distant Recurrence After Chemoradiotherapy显示文摘 | Susumu Saigusa MD Koji Tanaka MD Yuji Toiyama MD Takeshi Yokoe MD Yoshinaga Okugawa MD Yasuhiro Ioue MD PhD Chikao Miki MD PhD Masato Kusunoki MD PhD | 2009 | Annals of Surgical Oncology2009，，12： | 1 |
| 10 | A large, solitary, semipedunculated gastric polyp in pediatric juvenile polyposis syndrome显示文摘 | Kohei Otake Keiichi Uchida Mikihiro Inoue Kohei Matsushita Kiyoshi Hashimoto Yuji Toiyama Koji Tanaka Kaname Nakatani Kazuo Kawai Masato Kusunoki | 2010 | Gastrointestinal Endoscopy2010，，6： | 1 |
| 11 | Correlation of CCL20 expression in rectal mucosa with the developmentof ulcerative colitis?associated neoplasia显示文摘 | Kiyoshi Hashimoto Susumu Saigusa Toshimitsu Araki Koji Tanaka Yoshiki Okita Hiroyuki Fujikawa Mikio Kawamura Yoshinaga Okugawa Yuji Toiyama Yasuhiro Inoue Keiichi Uchida Yasuhiko Mohri Masato Kusunoki | 2013 | Oncology Letters2013，，5： | 1 |
| 12 | KAP1 is associated with peritoneal carcinomatosis in gastric cancer显示文摘 | Yokoe T Toiyama Y Okugawa Y | 2010 | Ann Surg Oncol2010，17，3： | 1 |
| 13 | Serum miR-200c is a nov_ el prognostic and metastasis-predictive biomarker in patients with colorectal cancer显示文摘 | Toiyama Y Hur K Tanaka K | 2014 | Ann Surg2014，259，4： | 1 |
| 14 | Evaluation of CXCL10 as a novel serum marker for predicting liver metastasis and prognosis in colorectal cancer显示文摘 | Toiyama Y Fujikawa H Kawamura M | 2012 | Int J Oncol2012，40，2： | 1 |
| 15 | Serum hepatocytegrowth factor as a prognostic marker for stage II orH colorectal cancer patients 显示文摘 | Toiyama Y Miki C Inoue Y | 2009 | Int J Cancer2009，125，7： | 1 |
| 16 | Serum miR -21 as a diagnos- tic and prognostic biomarker in coloreetal cancer 显示文摘 | Toiyama Y Takahashi M Hur K et 81 | 2013 | J Nail Cancer Inst2013，105，12： | 1 |
| 17 | Mechanism of resistance tochemoradiation in p53 mutant human colon cancer显示文摘 | Hiro J Inoue Y? Toiyama Y | 2008 | Int J On-col2008，32，6： | 1 |
| 18 | The Range of Optimal Concentration and Mechanisms of Paclitaxel in Radio-Enhancement in Gastrointestinal Cancer Cell Lines显示文摘 | TOIYAMA Y INOUE Y HIRO J OJIMA E WATANABE H NARITA Y HOSONO A MIKI C KUSUNOKI M | 2007 | Cancer Chemother Pharmaco2007，59，6： | 1 |
| 19 | Possibility of paclitaxel as an alternative radiosensitizer to 5-fluorouracil for colon cancer显示文摘 | Hiro J Inoue Y Toiyama Y | 2010 | Oncology Report2010，24，4： | 1 |
| 20 | Increased expression of Slug and Vimentin as nove| predictive biomarkers for lymph node metas- tasis and poor prognosis in coloreclal cancer 显示文摘 | Toiyama Y Yasuda H Saigusa S | 2013 | Carcinogenesis2013，34，11： | 1 |
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