6篇
您的检索式：作者名="Toshimitsu Araki"
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| 1 | Persistence of gene expression changes in noninflamed and inflamed colonic mucosa in ulcerative colitis and their presence in colonic carcinoma显示文摘AIM: A few studies have applied genomic-wide gene expression analysis in inflamed colon tissue sample in ulcerative colitis (UC). We reported the first study of non-inflamed mucosal gene expression in UC and explored its clinical implication.METHODS: Non-inflamed mucosa was obtained from 6 UC patients who received total colectomy. The gene expression of UC in noninfliamed mucosa was monitored with a microarray. For a selected gene, RT-PCR was performed to verify array results and to further examine expression pattern in inflamed mucosa of UC, colorectal cancer tissue and normal mucosa using additional matched pairs.RESULTS: Two genes showing 2.5-fold decreased expression with significance set at in UC samples were bomeo box a4 (HOXa4) and mads box transcription enhancer factor 2, polypeptide B (MEF2b). RT-PCR showed that MEF2b expression in non-inflamed mucosa was significantly downregulated, whereas the expression of MEF2b increased in accordance with the severity of mucosal inflammation. HOXa4 expression both in inflamed and non-inflamed mucosa in UC was consistently downregulated, and the downregulation of HOXa4 was also found in colorectal carcinoma.CONCLUSION: It is suggested that the MEF2b expression in UC which increase in accordance with inflammation may be induced by the inflammatory mediator. In contrast the downregulation of HOXa4 may be partly involved in the pathogenesis of disease including UC and UC-related carcinogenesis. | Yuji Toiyama Akira Mizoguchi Kazushi Kimura Toshimitsu Araki Shigeyuki Yoshiyama Kouhei Sakaguchi Chikao Miki Masato Kusunoki | 2005 | World Journal of Gastroenterology2005，11，33： | 2 |
| 2 | Correlation of CCL20 expression in rectal mucosa with the developmentof ulcerative colitis?associated neoplasia显示文摘 | Kiyoshi Hashimoto Susumu Saigusa Toshimitsu Araki Koji Tanaka Yoshiki Okita Hiroyuki Fujikawa Mikio Kawamura Yoshinaga Okugawa Yuji Toiyama Yasuhiro Inoue Keiichi Uchida Yasuhiko Mohri Masato Kusunoki | 2013 | Oncology Letters2013，，5： | 1 |
| 3 | The Increased Expression of CCL20 and CCR6 in Rectal Mucosa Correlated to Severe Inflammation in Pediatric Ulcerative Colitis显示文摘 | Keiichi Uchida Yuhki Koike Kiyoshi Hashimoto Susumu Saigusa Mikihiro Inoue Kohei Otake Koji Tanaka Kohei Matsushita Yoshiki Okita Hiroyuki Fujikawa Toshimitsu Araki Yasuhiko Mohri Masato Kusunoki Paolo Gionchetti | 2015 | Gastroenterology Research and Practice2015，，： | 1 |
| 4 | Huge scrotal, flank, and retroperitoneal lymphangioma successfully treated by OK-432 sclerotherapy显示文摘 | Keiichi Uchida Mikihiro Inoue Toshimitsu Araki Chikao Miki Masato Kusunoki | 2002 | Urology2002，，6： | 1 |
| 5 | Identification of Patients With Developing Ulcerative Colitis–associated Neoplasia by Nitrative DNA Damage Marker 8-Nitroguanin Expression in Rectal Mucosa显示文摘 | Susumu Saigusa Toshimitsu Araki Koji Tanaka Kiyoshi Hashimoto Yoshiki Okita Hiroyuki Fujikawa Yoshinaga Okugawa Yuji Toiyama Yasuhiro Inoue Keiichi Uchida Yasuhiko Mohri Masato Kusunoki | 2013 | Journal of Clinical Gastroenterology2013，，9： | 1 |
| 6 | Secondary pouchitis in a post-operative patient with ulcerative colitis,successfully treated by salvage surgery显示文摘We report a case of secondary pouchitis, defined as a mucosal inflammatory lesion in the ileal reservoir provoked by pouch-related complication following total colectomy and pouch anal anastomosis, which was successfully treated by salvage surgery. A 20-year-old woman with ulcerative colitis developed acute severe bloody diarrhea following proctocolectomy, ileal pouchanal anastomosis and diverting ileostomy. She was diagnosed as having a secondary pouchitis mainly caused by a peripouch abscess and partly concerned with the abnormal pouch formation. The remnantrectum and ileal pouch were excised and ileal pouch-anal anastomosis and diverting ileostomy were constructed.The postoperative course was uneventful with no sign of pouchitis. Salvage surgery may be indicated to treat secondary pouchitis when caused by surgery-related complications. | Yuji Toiyama Toshimitsu Araki Shigeyuki Yoshiyama Chikao Miki Masato Kusunoki | 2005 | World Journal of Gastroenterology2005，11，43： | 0 |
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