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| 1 | Acute appendicitis following endoscopic mucosal resection of cecal adenoma显示文摘Endoscopic mucosal resection(EMR) allows the removal of flat or sessile lesions, laterally spreading tumors, and carcinoma of the colon or the rectum limited to the mucosa or the superficial submucosa. Acute appendicitis is the most common abdominal emergency requiring emergency surgery, and it is also a rare complication of diagnostic colonoscopy and therapeutic endoscopy, including EMR. In the case presented here, a 53-year-old female underwent colonoscopy due to a positive fecal occult blood test and was diagnosed with cecal adenoma. She was referred to our hospital and admitted for treatment. The patient had no other symptoms. EMR was performed, and 7 h after the surgery, the patient experienced right-lower abdominal pain. Laboratory tests performed the following day revealed a WBC count of 16000/mm3, a neutrophil count of 14144/mm3, and a C-reactive protein level of 2.20 mg/d L, indicating an inflammatory response. Computed tomography also revealed appendiceal wall thickening and swelling, so acute appendicitis following EMR was diagnosed. Antibiotics were initiated leading to total resolution of the symptoms, and the patient was discharged on the sixth post-operative day. Pathological analysis revealed a high-grade cecal tubular adenoma. Such acute appendicitis following EMR is extremely rare, and EMR of the cecum may be a rare cause of acute appendicitis. | Yukako Nemoto Junya Tokuhisa Nagasato Shimada Tatsuya Gomi Iruru Maetani | 2015 | World Journal of Gastroenterology2015，21，27： | 9 |
| 2 | Is endoscopic papillary large balloon dilatation without endoscopic sphincterotomy effective?显示文摘AIM: To evaluate the safety and efficacy of endoscopic papillary large balloon dilatation(EPLBD) without endoscopic sphincterotomy in a prospective study.METHODS: From July 2011 to August 2013, we performed EPLBD on 41 patients with nae papillae prospectively. For sphincteroplasty of EPLBD,endoscopic sphincterotomy(EST) was not performed,and balloon diameter selection was based on the distal common bile duct diameter. The balloon was inflated to the desired pressure. If the balloon waist did not disappear, and the desired pressure was satisfied, we judged the dilatation as complete. We used a retrieval balloon catheter or mechanical lithotripter(ML) to remove stones and assessed the rates of complete stone removal, number of sessions, use of ML and adverse events. Furthermore, we compared the presence or absence of balloon waist disappearance with clinical characteristics and endoscopic outcome.RESULTS: The mean diameters of the distal and maximum common bile duct were 13.5 ± 2.4 mm and16.4 ± 3.1 mm, respectively. The mean maximum transverse-diameter of the stones was 13.4 ± 3.4mm, and the mean number of stones was 3.0 ± 2.4.Complete stone removal was achieved in 97.5%(40/41)of cases, and ML was used in 12.2%(5/41) of cases.The mean number of sessions required was 1.2 ± 0.62.Pancreatitis developed in two patients and perforation in one. The rate of balloon waist disappearance was73.1%(30/41). No significant differences were noted in procedure time, rate of complete stone removal(100% vs 100%), number of sessions(1.1 vs 1.3, P= 0.22), application of ML(13% vs 9%, P = 0.71),or occurrence of pancreatitis(3.3% vs 9.1%, P =0.45) between cases with and without balloon waist disappearance.CONCLUSION: EST before sphincteroplasty may be unnecessary in EPLBD. Further investigations are needed to verify the relationship between the presence or absence of balloon waist disappearance. | Shigefumi Omuta Iruru Maetani Michihiro Saito Hiroaki Shigoka Katsushige Gon Junya Tokuhisa Mieko Naruki | 2015 | World Journal of Gastroenterology2015，21，23： | 5 |
| 3 | Diagnosis of discoid lateral meniscus of the knee on MR imaging 显示文摘 | Samoto N Kozuma M Tokuhisa T | 2002 | Magn Reson Imaging2002，20，1： | 1 |
| 4 | AT1 Receptor antagonist restores cardiac ryanodine receptor function,rendering isoproterenol-induced failing heart less susceptible to Ca2+-leak induced by oxidative stress显示文摘 | Tokuhisa T Yano M Obayashi M | 2006 | Circ J2006，70，6： | 1 |
| 5 | AT1 receptor antagonist restores cardiac ryanodine receptor function,rendering isoproterenol- induced failing heart less susceptible to Ca2+-leak induced by oxidative stress显示文摘 | Tokuhisa T Yano M Obayashi M | 2006 | Circ J2006，70，6： | 1 |
| 6 | IGF and myostatin pathways are respectively induced during the earlier and the later stages of skeletal muscle hypertrophy induced by clenbuterol, a β <sub>2</sub>‐adrenergic agonist显示文摘 | Tokuhisa Abo Ryo‐hei Iida Syuhei Kaneko Takeo Suga Hiroyuki Yamada Yoshiki Hamada Akira Yamane | 2012 | Cell Biochem Funct2012，，8： | 1 |
| 7 | ATl receptor antagonist restores cardiac ryanodine receptor function, rendering isoproterenol-induced failing heart less susceptible to Ca^2 + -leak induced by oxidative stress 显示文摘 | Tokuhisa T Yano M Obayashi M | 2006 | Circ J2006，70，： | 1 |
| 8 | Potato steroidal glycoalkaloids= biosynthesis and genetic manipulation显示文摘 | Ginzberg I Tokuhisa J G Veilleux R E | 2009 | Potato Research2009，52，： | 1 |
| 9 | Activation of STAT3 by the hepatitis C virus core protein leads to cellular transfor- mation显示文摘 | Yoshida T Hanada T Tokuhisa T | 2002 | J Exp Med2002，196，： | 1 |
| 10 | Potato steroid- al glycoalkaloids biosynthesis and genetic manipulation 显示文摘 | Ginzberg I Tokuhisa J G Veilleux R E | 2009 | Potato Research2009，52，： | 1 |
| 11 | Diagnosis of discoid lateral meniscus of the knee on MR imaging 显示文摘 | Samoto N Kozuma M Tokuhisa T | 2002 | Magn Reson Imaging2002，20，： | 1 |
| 12 | IGF and myo- statin pathways are respectively induced during the earlierand the later stages of skeletal muscle hypertrophy induced by clenbuter- ol, a β-adrenergic agonist显示文摘 | Tokuhisa Abo Ryo-hei Iida Syuhei Kaneko | 2012 | Cell Biochem Funct2012，30，： | 1 |
| 13 | The effect of sulfur nutrition on plant glucosinolate content: physiology and molecular mechanisms 显示文摘 | Falk K Tokuhisa J Gershenzon J | 2007 | Plant Biology2007，19，： | 1 |
| 14 | Activation of STAT3 by the hepatitis C virus core protein leads to cellular trans formation显示文摘 | YOSHIDA T HANADA T TOKUHISA T | | 0，，05： | 1 |
| 15 | Activation of STAT3 by the hepatitis C virus core protein leads to cellular transformation显示文摘 | Yoshida T Hanada T Tokuhisa T | 2002 | J Exp Med2002，196，5： | 1 |
| 16 | Preparation and characterization of dendrimer monolayers and dendrimeralkanethiolmixed monolayers adsorbed to gold 显示文摘 | Tokuhisa H Zhao M Baker L A | 1998 | J Am Chem Soc1998，120，： | 1 |
| 17 | Novel low-temperature-sintering type Cu-alloy pastes for silicon solar cells显示文摘 | Manabu Yoshida Hideo Tokuhisa Uichi Itoha | | 0，，： | 1 |
| 18 | Gene expression and glucosinolate accumulation in Arabidopsis thaliana in response to generalist and specialist herbivores of different feeding guilds and the role of defense signaling pathways显示文摘 | Mewis I Tokuhisa J Schultz J | 2006 | Phytochemistry2006，67，22： | 1 |
| 19 | Novel liquid crystalline oxadiazole with high electron mobility显示文摘 | Tokuhisa H Era M Tsutsui T | | 0，，： | 1 |
| 20 | A gene controlling variation in Arabidopsis thaliana glucosinolate composition is part of the methionine chain elongation pathway显示文摘 | Kroyman J Textor S Tokuhisa J G | 2001 | Plant Physiol2001，127，： | 1 |
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