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| 1 | Treatment strategy for gastric non-invasive intraepithelial neoplasia diagnosed by endoscopic biopsy显示文摘Treatment strategies,whether as follow-up or'total incisional biopsy'for gastric noninvasive intraepithelial neoplasia diagnosed by examination of an endoscopic forceps biopsy specimen,are controversial due to problems associated with the diagnostic accuracy of endoscopic forceps biopsy and questions about the safety and efficacy of endoscopic treatment.Based on the histological findings of the biopsy specimen,it is difficult to differentiate between reactive or regenerative changes,inflammation and neoplastic changes,intraepithelial and invasive tumors.Therefore,gastric neoplasia diagnosed as noninvasive intraepithelial often develop into invasive carcinoma during follow-up.Recent advances in endoscopic modalities and treatment devices,such as image-enhanced endoscopy and highfrequency generators,may make endoscopic treatment,such as endoscopic submucosal dissection(ESD),a therapeutic option for gastric intraepithelial neoplasia,including low-grade neoplasms.Future studies are required to evaluate whether ESD is a valid strategy for gastric intraepithelial neoplasm with regard to safety and cost effectiveness. | Tsutomu Nishida Shusaku Tsutsui Motohiko Kato Takuya Inoue Shunsuke Yamamoto Yoshito Hayashi Tomofumi Akasaka Takuya Yamada Shinichiro Shinzaki Hideki Iijima Masahiko Tsujii Tetsuo Takehara | 2011 | World Journal of Gastrointestinal Pathophysiology2011,2,6: | 18 |
| 2 | Comparative study of esomeprazole and lansoprazole in triple therapy for eradication of Helicobacter pylori in Japan显示文摘AIM:To evaluate the efficacy and safety of esomeprazole-based triple therapy compared with lansoprazole therapy as first-line eradication therapy for patients with Helicobacter pylori(H.pylori)in usual post-marketing use in Japan,where the clarithromycin(CAM)resistance rate is 30%.METHODS:For this multicenter,randomized,openlabel,non-inferiority trial,we recruited patients(≥20years of age)with H.pylori infection from 20 hospitals in Japan.We randomly allocated patients to esomeprazole therapy(esomeprazole 20 mg,CAM 400 mg,amoxicillin(AC)750 mg for the first 7 d,with all drugs given twice daily)or lansoprazole therapy(lansoprazole30 mg,CAM 400 mg,AC 750 mg for the first 7 d,with all drugs given twice daily)using a minimization method with age,sex,and institution as adjustment factors.Our primary outcome was the eradication rate by intention-to-treat(ITT)and per-protocol(PP)analyses.H.pylori eradication was confirmed by a urea breath test from 4 to 8 wk after cessation of therapy.RESULTS:ITT analysis revealed the eradication rates of 69.4%(95%CI:61.2%-76.6%)for esomeprazole therapy and 73.9%(95%CI:65.9%-80.6%)for lansoprazole therapy(P=0.4982).PP analysis showed eradication rate of 76.9%(95%CI:68.6%-83.5%)for esomeprazole therapy and 79.8%(95%CI:71.9%-86.0%)for lansoprazole therapy(P=0.6423).There were no differences in adverse effects between the two therapies.CONCLUSION:Esomeprazole showed non-inferiority and safety in a 7 day-triple therapy for eradication of H.pylori compared with lansoprazole. | Tsutomu Nishida Masahiko Tsujii Hirohisa Tanimura Shusaku Tsutsui Shingo Tsuji Akira Takeda Atsuo Inoue Hiroyuki Fukui Toshiyuki Yoshio Osamu Kishida Hiroyuki Ogawa Masahide Oshita Ichizo Kobayashi Shinichiro Zushi Makoto Ichiba Naoto Uenoyama Yuichi Yasunaga Ryu Ishihara Mamoru Yura Masato Komori Satoshi Egawa Hideki Iijima Tetsuo Takehara | 2014 | World Journal of Gastroenterology2014,20,15: | 13 |
| 3 | Inflammatory pseudotumor of the liver and spleen diagnosed by percutaneous needle biopsy显示文摘An inflammatory pseudotumor (IPT) is a relatively rare lesion characterized by chronic inf iltration of inflammatory cells and areas of f ibrosis. IPTs are diff icult to diagnose because of the absence of specif ic symptoms or of characteristic hematological or radiological f indings. In this study, a case of a woman aged over 70 years was reported, who presented with a general malaise lasting more than two months. A computed tomography scan demonstrated a diffusely spread lesion of the liver with a portal vein occlusion and a splenic lesion surrounded by a soft density layer. Since the percutaneous liver biopsy showed f indings that suggested an IPT, although the radiological f indings did not exclude the possibility of a malignancy, we performed a percutaneous spleen biopsy to enable a more defi nitive diagnosis. The microscopic f indings from the spleen specimen lead us to a diagnosis of IPT involving the liver and spleen. Sub-sequent steroid pulse therapy was effective, and rapid resolution of the disease was observed. | Tsukasa Kawaguchi Kiyoshi Mochizuki Takashi Kizu Masanori Miyazaki Takayuki Yakushijin Shusaku Tsutsui Eiichi Morii Tetsuo Takehara | 2012 | World Journal of Gastroenterology2012,18,1: | 11 |
| 4 | Network DEA: A slacks-based measure approach显示文摘 | Kaoru Tone Miki Tsutsui | 2008 | European Journal of Operational Research2008,,1: | 4 |
| 5 | Hepatocyte growth factor gene therapy of liver cirrhosis in rats显示文摘 | Ueki T Kaneda Y Tsutsui H | | 0,,: | 3 |
| 6 | Partial gastrectomy using natural orifice translumenal endoscopic surgery (NOTES) for gastric submucosal tumors: early experience in humans显示文摘 | Kiyokazu Nakajima Toshirou Nishida Tsuyoshi Takahashi Yoshihito Souma Johji Hara Takuya Yamada Toshiyuki Yoshio Tateki Tsutsui Takeshi Yokoi Masaki Mori Yuichiro Doki | 2009 | Surgical Endoscopy2009,,12: | 2 |
| 7 | INTERLEUKIN-18 REGULATES BOTH TH1 AND TH2 RESPONSES显示文摘 | Kenji Nakanishi Tomohiro Yoshimoto Hiroko Tsutsui Haruki Okamura | 2001 | Annual Review of Immunology2001,,: | 2 |
| 8 | 三菱新型2.8L4缸柴油机显示文摘在轻型载重汽车市场,以柴油机为动力的越野四轮驱动客货两用汽车为主和由此派生的厢式货车,由于燃油经济性好,赢得了用户的青睐。特别是在日本市场,这类汽车的销量迅速增长,比过去5年的总销售量增加约2倍,其中柴油机稳占90%左右。在这样的情况下,用户对柴油汽车的要求变得越来越高,主要是要求高功率、低噪声、低振动和排烟少,与对汽油机的要求类似。另一方面,柴油机的废气排放法规也逐渐变得严格起来,且在不久的将来会变得很严格。三菱汽车公司已在生产一种排量为2.5L的4缸柴油机(4D56系列),用于轻型载重汽车。但考虑到上述要求,又研制了4M40系列。这种全新设计的2.8L的4缸柴油机于1993年7月发表,装在'NEW PAJERO'汽车上。本文介绍4 M40系列柴油机的设计特点。 | Osaki N Tsutsui Y Kakoi Y 陈其萃 | 1996 | 国外内燃机1996,28,1: | 2 |
| 9 | Dynamic DEA: A slacks-based measure approach显示文摘 | Kaoru Tone Miki Tsutsui | 2009 | Omega2009,,3: | 2 |
| 10 | Dynamic DEA with network structure: A slacks-based measure approach显示文摘 | Kaoru Tone Miki Tsutsui | 2014 | Omega2014,,1: | 2 |
| 11 | Coronary blood flow reserve response to left anterior descending coronary artery stenting and its value in predicting coronary restenosis显示文摘 | Tsutsui J M Mathias W Jr Frimm C C | 2003 | J Am Soc Echocardiogr2003,16,5: | 2 |
| 12 | An epsilon-based measure of efficiency in DEA – A third pole of technical efficiency显示文摘 | Kaoru Tone Miki Tsutsui | 2010 | European Journal of Operational Research2010,,3: | 2 |
| 13 | Network DEA: A slacks-based measure approach显示文摘 | Kaoru Tone Miki Tsutsui | 2008 | European Journal of Operational Research2008,,1: | 2 |
| 14 | Clinical Effect of Addition of Beraprost Sodium to Pioglitazone Treatment on the Blood Glucose Levels in Patients with Type 2 Diabetes Mellitus显示文摘 | T. Chen M. Kusunoki D. Sato H. Tsutsui T. Nakamura T. Miyata Y. Oshida | 2013 | Exp Clin Endocrinol Diabetes2013,,: | 2 |
| 15 | Progno stic value of CerbB-2 expression in breast cancer显示文摘 | Tsutsui S Ohno S Murakami S | 2002 | Surg Oncol2002,79,4: | 1 |
| 16 | Inhibition of TGF-beta signaling exacerbates early cardiac dysfunction but prevents late remodeling after infarction 显示文摘 | IKEUCHI M TSUTSUI H SHIOMI T | 2004 | Cardiovasc Res2004,64,3: | 1 |
| 17 | Asymmetric dimethylarginine produces vascular lesions in endothelial nitric oxide synthase-deficient mice: involvement of reninangiotensin system and oxidative stress 显示文摘 | Suda O Tsutsui M Morishita T | 2004 | Arterioscler Thromb Vasc Biol2004,24,9: | 1 |
| 18 | New anterolateral thigh perforator flap with a short pedicle for reconstruction of defects in the upper extremities显示文摘 | Koshima I Nanba Y Tsutsui T | 2003 | Ann Plast Surg2003,51,1: | 1 |
| 19 | Contribution of Toll-like receptor/myeloid differentiation显示文摘 | Seki E Tsutsui H Limuro Y | 2005 | Hepatology2005,41,3: | 1 |
| 20 | Crucial role of nitric oxide synthases system in endothelium-dependent hyperpolarization in mice显示文摘 | Takaki A Morikawa K Tsutsui M | 2008 | J Exp Med2008,205,9: | 1 |