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| 1 | Gastric adenocarcinoma of fundic gland type with signet-ring cell carcinoma component: A case report and review of the literature显示文摘A depressed lesion was found at a gastric angle of 76-yearold Japanese woman by esophagogastroduodenoscopy. Four years prior, she was diagnosed with a Helicobacter pylori infection but no eradication was performed. The pathological diagnosis of biopsy specimens was signet-ring cell carcinoma. Endoscopic submucosal dissection(ESD) was performed. Histopathological examination of the ESD specimen revealed proliferation of well-differentiated tubular adenocarcinoma mimicking fundic gland cells at the deep layer of the lamina propria mucosae. These tumor cells expressed focally pepsinogen-Ⅰ, diffusely MUC6, and scattered H^+/K^+ ATPase according to immunohistochemistry. Therefore, we diagnosed this tumor as gastric adenocarcinoma of fundic gland type(GA-FG). Adjacent to the GA-FG, proliferation of signet-ring cell carcinoma which diffusely expressed MUC 2 and MUC 5AC was observed. Intestinal metaplasia was focally observed in the surrounding mucosa of the signet-ring cell carcinoma. To the best of our knowledge, this is the first case report of GA-FG with a signet-ring cell carcinoma component. The origin of signet-ring cell carcinoma, i.e., whether it accidentally arose from a non-neoplastic mucosa and coexisted with the GA-FG or dedifferentiated from the GA-FG is unclear at present. We expect the accumulation of similar cases and further analysis to clarify this issue. | Keita Kai Masaaki Satake Osamu Tokunaga | 2018 | World Journal of Gastroenterology2018，24，26： | 19 |
| 2 | 云南汉族HLA-DRB1多态性分析及与9个汉族群体的比较显示文摘应用聚合酶链反应—微孔板杂交 (PolymeraseChainReactionandMicrotitrePlateHybridization ,PCR MPH)的方法对云南 12 9个无亲缘关系的汉族样品进行了HLA DRB1的遗传多态性分析 ,对MPH初分出的DRB1 15组的样品进行了单链构象多态 (Single StrandConformationPolymorphism ,SSCP)检测。共发现 36种等位基因 ,其中等位基因频率大于 0 0 5的有DRB1 15 0 1(0 12 4 0 ) ,DRB1 0 90 12 (0 0 96 9) ,DRB1 0 80 32 (0 0 930 ) ,DRB1 12 0 2(0 0 891) ,DRB1 12 0 1(0 0 814 ) ,DRB1 14 0 1(0 0 775 ) ,DRB1 0 70 1(0 0 6 2 0 )。云南汉族HLA DRB1等位基因频率与中国其他 9个汉族群体进行 χ2 检验 ,结果显示与云南汉族比较 χ2 >10的有西安汉族 (DR8,χ2 =13 9712 )、上海汉族 (DR4 ,χ2 =10 16 32 )、广东汉族 (DR9,χ2 =12 6 12 1)和南京汉族 (DR4 ,χ2 =10 5 796 )。从遗传距离分析发现 ,在 9个国内汉族群体中云南汉族与辽宁汉族有最近的距离 (0 0 5 4 1) ,而与广东汉族最远 (0 185 1)。云南汉族在构成上可能与辽宁汉族更为接近 ,尽管地处南方 ,但已不属典型的南方汉族。这也可能因云南汉族与当地的少数民族存在基因交流 。 | 许绍斌 陶玉芬 黄小琴 初正韬 班贵宏 钱亚屏 OHASHI Jun TOKUNAGA Katsushi 褚嘉祐 | 2004 | 遗传2004，26，6： | 9 |
| 3 | Coatings on Mg alloys and their mechanical properties: A review显示文摘Poor corrosion resistance is a serious drawback of Mg alloys, restricting their practical applications.Coating is one of the effective techniques for improvement in the poor corrosion resistance. In this paper,the coating processes for Mg alloys so far developed are reviewed. Among several processes, the coating processes based on mechanical energy, including metal forming, are attractive because the corrosion resistance and formability of Mg alloys are simultaneously improved. | Toko Tokunaga Munekazu Ohno Kiyotaka Matsuura | 2018 | Journal of Materials Science & Technology2018，34，7： | 9 |
| 4 | HER2 heterogeneity is a poor prognosticator for HER2-positive gastric cancer显示文摘BACKGROUND The clinical significance of intratumoral human epidermal growth factor receptor 2(HER2)heterogeneity is unclear for HER2-positive gastric cancer,although it has been reported to be a significant prognosticator for HER2-positive breast cancer,which has received trastuzumab-based chemotherapy.AIM To clarify the clinical significance of intratumoral HER2 heterogeneity for HER2-positive gastric cancer,which has received trastuzumab-based chemotherapy.METHODS Patients with HER2-positive unresectable or metastatic gastric cancer who received trastuzumab-based chemotherapy as a first line treatment were included.The patients were classified into two groups according to their intratumoral HER2 heterogeneity status examined by immunohistochemistry(IHC)on endoscopic biopsy specimens before treatment,and their clinical response to chemotherapy and survival were compared.RESULTS A total of 88 patients were included in this study,and HER2 heterogeneity was observed in 23(26%)patients(Hetero group).The overall response rate was significantly better in patients without HER2 heterogeneity(Homo group)(Homo vs Hetero:79.5%vs 35.7%,P=0.002).Progression-free survival of trastuzumab-based chemotherapy was significantly better in the Homo group(median,7.9 vs 2.5 mo,HR:1.905,95%CI:1.109-3.268).Overall survival was also significantly better in the Homo group(median survival time,25.7 vs 12.5 mo,HR:2.430,95%CI:1.389-4.273).Multivariate analysis revealed IHC HER2 heterogeneity as one of the independent poor prognostic factors(HR:3.115,95%CI:1.610-6.024).CONCLUSION IHC of HER2 heterogeneity is the pivotal predictor for trastuzumab-based chemotherapy.Thus,HER2 heterogeneity should be considered during the assessment of HER2 expression. | Akio Kaito Takeshi Kuwata Masanori Tokunaga Kohei Shitara Reo Sato Tetsuo Akimoto Takahiro Kinoshita | 2019 | World Journal of Clinical Cases2019，7，15： | 5 |
| 5 | HLA polymorphism of the Zhuang population reflects the common HLA characteristics among Zhuang-Dong language-speaking populations显示文摘A study of the human leukocyte antigen (HLA) genetic characteristics in the Zhuang,the largest ethnic population in China,would provide insight into Zhuang history and give a useful tool for disease associations,transplantation,and anthropology.In the present study,we report the comprehensive HLA-A,HLA-B,HLA-C,and HLA-DRB1 alleles and haplotypes in the Zhuang population of southern China for the first time.A total of 13 HLA-A,24 HLA-B,22 HLA-C,and 18 HLA-DRB1 were identified in 104 Zhuang individuals.The frequencies of HLA-A11:01,A02:07,A24:02,A02:03,and A33:03 on A loci,B15:02,B58:01,B46:01,and B13:01 on B loci,C03:04,C08:01,C01:02,C03:02,and C07:02 on C loci,and DRB115:01,DRB116:02,DRB114:01,DRB115:02,and DRB103:01 on the DRB1 loci were >10%.The A33:03-C03:02-B58:01-DRB103:01 and A02:07-C01:02B46:01-DRB114:01 haplotypes were predominant in the Zhuang.The phylogenetic tree,as well as the analysis of haplotypes,suggested that the Zhuang are genetically similar to southern Chinese populations,especially the Zhuang-Dong language-speaking populations,such as the Bouyei,Dai,and Maonan.Even though the Zhuang and southern Chinese populations shared common alleles and haplotypes,the Zhuang has maintained its unique genetic characteristics. | Li SHI Xiao-qin HUANG Lei SHI Yu-fen TAO Yu-feng YAO Liang YU Ke-qin LIN Wen YI Hao SUN Katsushi TOKUNAGA Jia-you CHU | 2011 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2011，12，6： | 4 |
| 6 | A case of mucosa-associated lymphoid tissue lymphoma of the gastrointestinal tract showing extensive plasma cell differentiation with prominent Russell bodies显示文摘A 73-year-old Japanese woman was hospitalized for detailed examination of nausea, diarrhea and loss of appetite. Atypical erosion in the ileum was found on endoscopy. Biopsy of this erosion showed proliferation of cells containing numerous Russell bodies. Differential diagnoses considered were Russell body enteritis, crystal-storing histiocytosis, Mott cell tumor, immunoproliferative small intestinal disease(IPSID) and mucosaassociated lymphoid tissue(MALT) lymphoma. The cells containing prominent Russell bodies showed diffuse positivity for CD79 a and CD138, but negative results for CD20, CD3, UCHL-1, CD38 and CD68. Russell bodies were diffusely positive for lambda light chain, but negative for kappa light chain, and immunoglobulin(Ig)G, Ig A and Ig M. Based on these findings, Russell body enteritis, crystal-storing histiocytosis and IPSID were ruled out. As the tumor formed no mass lesions and was restricted to the gastrointestinal tract, MALT lymphoma with extensive plasma cell differentiation was finally diagnosed. The patient showed an unexpectedly aggressive clinical course. The number of atypical lymphocytes in peripheral blood gradually increased and T-prolymphocytic leukemia(T-PLL) emerged. The patient died of T-PLL 7 mo after admission. Autopsy was not permitted. | Keita Kai Masaharu Miyahara Yasunori Tokuda Shinich Kido Masanori Masuda Yukari Takase Osamu Tokunaga | 2013 | World Journal of Clinical Cases2013，1，5： | 4 |
| 7 | Hemorrhagic shock due to submucosal esophageal hematoma along with mallory-weiss syndrome:A case report显示文摘BACKGROUND Esophageal submucosal hematoma is a rare condition.Although the exact etiology remains uncertain,vessel fragility with external factors is believed to have led to submucosal bleeding and hematoma formation;the vessel was ruptured by a sudden increase in pressure due to nausea,and the hematoma was enlarged by antiplatelet or anticoagulant therapy.Serious conditions are rare,with a better prognosis.We present the first known case of submucosal esophageal hematoma-subsequent hemorrhagic shock due to Mallory-Weiss syndrome.CASE SUMMARY A 73-year-old female underwent endovascular treatment for an unruptured cerebral aneurysm.The patient received aspirin and clopidogrel before surgery and heparin during surgery,and was well during the surgery.Several hours after returning to the ICU,she complained of chest discomfort,vomited 500 m L of fresh blood,and entered hemorrhagic shock.Esophageal submucosal hematoma with Mallory-Weiss syndrome was diagnosed through an endoscopic examination and computed tomography.In addition to a massive fluid and erythrocyte transfusion,we performed a temporary compression for hemostasis with a Sengstaken-Blakemore(S-B)tube.Afterwards,she became hemodynamically stable.On postoperative day 1,we performed an upper gastrointestinal endoscopy and confirmed no expansion of the hematoma nor any recurring bleeding;therefore,we removed the S-B tube and clipped the gastric mucosal laceration at the esophagogastric junction.We started oral intake on postoperative day 10.The patient made steady progress,and was discharged on postoperative day 33.CONCLUSION We present the first known case of submucosal esophageal hematoma subsequent hemorrhagic shock due to Mallory-Weiss syndrome. | Jiro Oba Daisuke Usuda Shiho Tsuge Riki Sakurai Kenji Kawai Shun Matsubara Risa Tanaka Makoto Suzuki Hayabusa Takano Shintaro Shimozawa Yuta Hotchi Kenki Usami Shungo Tokunaga Ippei Osugi Risa Katou Sakurako Ito Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Tomohisa Nomura Manabu Sugita | 2022 | World Journal of Clinical Cases2022，10，27： | 3 |
| 8 | Laparoscopic and endoscopic cooperative surgery for gastrointestinal stromal tumor dissection显示文摘 | N. Hiki Y. Yamamoto T. Fukunaga T. Yamaguchi S. Nunobe M. Tokunaga A. Miki S. Ohyama Y. Seto | 2008 | Surgical Endoscopy2008，，7： | 3 |
| 9 | Fabrication of Al-Coated Mg-Li Alloy Sheet and Investigation of Its Properties显示文摘An Al-coated Mg-8 mass% Li alloy rectangular bar was fabricated by hot extrusion, and then, it was hot-rolled into a thin sheet. The Al coating was uniform in thickness and had good bonding with the substrate during all the processing. This Alcoated Mg–Li alloy exhibited a good corrosion resistance in a 0.5 mass% HCl aqueous solution. No intermetallic compound was observed at the Al/Mg–Li interface after the extrusion and the rolling. The Al-coated Mg–Li alloy sheet exhibited an elongation to fracture of 35% at room temperature at a strain rate of 0.001 s(-1)without any debonding between the coating and the substrate. When tensile tested at 573 K at 0.001 s(-1)in the air, the Al coating remained undamaged even until an elongation of about 150%. Further elongation generated cracks on the coating and the specimen fractured at an elongation of about 200%. In an Ar atmosphere, the specimen exhibited a fracture elongation of over 400% under the same conditions at 573 K at 0.001 s(-1), although a large number of cracks generated on the Al coating. | Tian-Long Zhang Toko Tokunaga Munekazu Ohno Mi-Lin Zhang Kiyotaka Matsuura | 2019 | Acta Metallurgica Sinica(English Letters)2019，32，2： | 3 |
| 10 | Laparoscopic and endoscopic cooperative surgery for gastrointestinal stromal tumor dissection显示文摘 | N. Hiki Y. Yamamoto T. Fukunaga T. Yamaguchi S. Nunobe M. Tokunaga A. Miki S. Ohyama Y. Seto | 2008 | Surgical Endoscopy2008，，7： | 3 |
| 11 | Activation of Trifluoromethylthio Moiety by Appending Iodonium Ylide under Copper Catalysis for Electrophilic Trifluoromethylation Reaction显示文摘A 小说 iodonium-ylide 化合物 2 那添加 atrifluoromethylthio (SCF 3) 组是被揭示一新,架马厩 electrophilic trifluoromethylation 试剂。不同于已知的架马厩 electrophilic trifluoromethylation 试剂, 2 让稳定的 SCF 3 组织哪个被经由 sulfonium ylide 在铜催化作用下面添加 iodonium ylide 产生 cationic trifluoromethyl 激活(CF 3) 种类。试剂 2 被发现是为大量 silyl enol 醚的有效 electrophilic trifluoromethylation 试剂 3 在铜下面催化作用。周期、非循环的 α-trifluoromethyl 酉同类 4 被在的试剂 2 获得对好收益中等。在另一方面, 5 没影响的 difluoromethylthio 类似物分子间的转移 difluoromethylation 到底层。相反, intramolecular 1,4 迁居继续了类似于 Stevens 重新整理到在 21% 产量提供 6,独立于 nucleophiles 的存在 3。 | Ibrayim Saidalimu Shugo Suzuki Etsuko Tokunaga Norio Shibata | 2016 | Chinese Journal of Chemistry2016，34，5： | 3 |
| 12 | Passive-bending,short-type single-balloon enteroscope for endoscopic retrograde cholangiopancreatography in Roux-en-Y anastomosis patients显示文摘AIM:To evaluate short-type-single-balloon enteroscope(SBE) with passive-bending,high-force transmission functions for endoscopic retrograde cholangiopancreatography(ERCP) in patients with Roux-en-Y anastomosis.METHODS:Short-type SBE with this technology(SIF-Y0004-V01; working length,1520 mm; channel diameter,3.2 mm) was used to perform 50 ERCP procedures in 37 patients with Roux-en-Y anastomosis.The rate of reaching the blind end,time required to reach the blind end,diagnostic and therapeutic success rates,and procedure time and complications were studied retrospectively and compared with the results of 34 sessions of ERCP performed using a short-type SBE without this technology(SIF-Y0004; working length,1520 mm; channel diameter,3.2 mm) in 25 patients.RESULTS:The rate of reaching the blind end was 90% with SIF-Y0004-V01 and 91% with SIF-Y0004(P = 0.59).The median time required to reach the papilla was significantly shorter with SIF-Y0004-V01 than with SIF-Y0004(16 min vs 24 min,P = 0.04).The diagnostic success rate was 93% with SIFY0004-V01 and 84% with SIF-Y0004(P = 0.17).The therapeutic success rate was 95% with SIF-Y0004-V01 and 96% with SIF-Y0004(P = 0.68).The median procedure time was 40 min with SIF-Y0004-V01 and 36 min with SIF-Y0004(P = 0.50).The incidence of hyperamylasemia was 6.0% in the SIF-Y0004-V01 group and 14.7% in the SIF-Y0004 group(P = 0.723).The incidence of pancreatitis was 0% in the SIFY0004-V01 group and 5.9% in the SIF-Y0004 group(P > 0.999).The incidence of gastrointestinal perforation was 2.0%(1/50) in the SIF-Y0004-V01 group and 2.9%(1/34) in the SIF-Y0004 group(P > 0.999).CONCLUSION:SIF-Y0004-V01 is useful for ERCP inpatients with Roux-en-Y anastomosis and may reduce the time required to reach the blind end. | Hiroshi Yamauchi Mitsuhiro Kida Kosuke Okuwaki Shiro Miyazawa Tomohisa Iwai Shuko Tokunaga Miyoko Takezawa Hiroshi Imaizumi Wasaburo Koizumi | 2015 | World Journal of Gastroenterology2015，21，5： | 3 |
| 13 | Intraductal Papillary Mucinous Neoplasms of the Pancreas With Distinct Pancreatic Ductal Adenocarcinomas Are Frequently of Gastric Subtype显示文摘 | Noboru Ideno Takao Ohtsuka Hiroshi Kono Kenji Fujiwara Yasunori Oda Shinichi Aishima Tetsuhide Ito Kousei Ishigami Shoji Tokunaga Kenoki Ohuchida Shunichi Takahata Masafumi Nakamura Kazuhiro Mizumoto Masao Tanaka | 2013 | Annals of Surgery2013，，1： | 2 |
| 14 | IDH 1 and IDH 2 mutations confer an adverse effect in patients with acute myeloid leukemia lacking the NPM 1 mutation显示文摘 | Shunichiro Yamaguchi Eisaku Iwanaga Kenji Tokunaga Tomoko Nanri Taizo Shimomura Hitoshi Suzushima Hiroaki Mitsuya Norio Asou | 2014 | Eur J Haematol2014，，6： | 2 |
| 15 | Investigation of the Lymphatic Stream of the Stomach in Gastric Cancer with Solitary Lymph Node Metastasis显示文摘 | Masanori Tokunaga Shigekazu Ohyama Naoki Hiki Tetsu Fukunaga Kazuhiko Yamada Takeshi Sano Toshiharu Yamaguchi | 2009 | World Journal of Surgery2009，，6： | 2 |
| 16 | Extraction of heavy metals from MSW incinerator fly ashes by chelating agents显示文摘 | Kyung-Jin Hong Shuzo Tokunaga | 2000 | Journal of Hazardous Materials2000，75，： | 2 |
| 17 | Helicobacter pylori eradication therapy for the remnant stomach after gastrectomy显示文摘 | Norio Matsukura Takashi Tajiri Shunji Kato Akiyoshi Togashi Gotaro Masuda Itsuo Fujita Akira Tokunaga Nobutaka Yamada | 2003 | Gastric Cancer2003，，2： | 2 |
| 18 | Checkpoint with forkhead-associated and ring finger promoter hypermethylation correlates with microsatellite instability in gastric cancer显示文摘AIM:To examine the methylation status of the promoter region of the checkpoint with forkhead-associated and ring fi nger(CHFR) and microsatellite mutator status in 59 primary gastric cancers.METHODS:We investigated the promoter methylation of CHFR in 59 cases of gastric cancer using methylation-specifi c PCR.Five microsatellite loci were analyzed using high-intensity microsatellite analysis reported previously, and p53 gene mutations were investigated by direct sequencing.RESULTS:Twenty cases(33.9%) showed promoter methylation and no relation was observed with the clinicopathological factors.We found that the promoter methylation of CHFR was frequently accompanied with microsatellite instability(MIN).Seven of 20(35.0%) cases showed MIN in hypermethylation of the CHFR tumor, while three of 39(7.7%) cases showed MIN in the non-methylated CHFR tumor(P < 0.01).However, we failed to fi nd any relationship between CHFR methylation and p53 mutation status.CONCLUSION:The coordinated loss of both the mitotic check point function and mismatch repair system suggests the potential to overcome the cell cycle check point, which may lead to an accumulation of mutations.However, the p53 mutation was not related to hypermethylation of the CHFR promoter and MIN, which indicates that an abnormality in p53 occurs as an independent process from the mismatch repair deficiency in carcinogenesis. | Eiji Oki Yan Zhao Rintaro Yoshida Takanobu Masuda Koji Ando Masahiiko Sugiyama Eriko Tokunaga Masaru Morita Yoshihiro Kakeji Yoshihiko Maehara | 2009 | World Journal of Gastroenterology2009，15，20： | 2 |
| 19 | Clinical role of a modified seton technique for the treatment of trans-sphincteric and supra-sphincteric anal fistulas显示文摘 | Yukihiko Tokunaga Hirokazu Sasaki Tohru Saito | 2013 | Surgery Today2013，，3： | 2 |
| 20 | Angiotensin receptor blocker neprilysin inhibitors显示文摘Heart failure(HF)is a clinical syndrome that results from a structural or functional cardiac disorder that reduces the ability of the ventricle of the heart to fill with,or eject,blood.It is a multifaceted clinical condition that affects up to 2%of the population in the developed world,and is linked to significant morbidity and mortality;it is therefore considered a major concern for public health.Regarding the mechanism of HF,three neurohumoral factors-the reninangiotensin-aldosterone system,the sympathetic nervous system,and natriuretic peptides—are related to the pathology of chronic HF(CHF),and the targets of treatment.Angiotensin receptor blocker and neprilysin inhibitor(angiotensinreceptor neprilysin inhibitor),namely sacubitril/valsartan(SAC/VAL),has been introduced as a treatment for CHF.SAC/VAL is an efficacious,safe,and costeffective therapy that improves quality of life and longevity in patients with HF with reduced ejection fraction(HFrEF),and reduces hospital admissions.An inhospital initiation strategy offers a potential new avenue to improve the clinical uptake of SAC/VAL.In the last five years,SAC/VAL has been established as a cornerstone component of comprehensive disease-modifying medical therapy in the management of chronic HFrEF.On the other hand,further work,with carefully designed and controlled preclinical studies,is necessary for understanding the molecular mechanisms,effects,and confirmation of issues such as long-term safety in both human and animal models. | Daisuke Usuda Toshihiro Higashikawa Yuta Hotchi Kenki Usami Shintaro Shimozawa Shungo Tokunaga Ippei Osugi Risa Katou Sakurako Ito Toshihiko Yoshizawa Suguru Asako Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Jiro Oba Tomohisa Nomura Manabu Sugita | 2021 | World Journal of Cardiology2021，13，8： | 2 |
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