|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Recurrence and rejection in liver transplantation for primary sclerosing cholangitis显示文摘Primary sclerosing cholangitis (PSC) is a chronic progressive inflammatory disease affecting the bile ducts, leading to f ibrosis and eventually cirrhosis in most patients. Its etiology is unknown and so far no effective medical therapy is available. Liver transplantation (LTX) is the only curative treatment and at present PSC is the main indication for LTX in the Scandinavian countries. Close to half of the PSC patients experience one or more episodes of acute cellular rejection (ACR) following transplantation and approximately 1/5 of the transplanted patients develop recurrent disease in the graft. In addition, some reports indicate that ACR early after LTX for PSC can infl uence the risk for recurrent disease. For these important post-transplantation entities affecting PSC patients, we have reviewed the current literature on epidemiology, pathogenesis, treatment and the possible infl uence of rejection on the risk of recurrent disease in the allograft. | Bjarte Fosby Tom H Karlsen Espen Melum | 2012 | World Journal of Gastroenterology2012，18，1： | 8 |
| 2 | Cardiotrophin 1 stimulates beneficial myogenic and vascular remodeling of the heart显示文摘出生后的心通过 hypertrophic 生长适应应力和超载,可能病理学或有益的一个过程(生理的肥大) 。生理的肥大改进心脏的性能在健康并且 diseased 个人,然而,宣传这有利改编的机制仍然保持糟糕定义。我们识别 cytokine cardiotrophin (CT1 ) 1 作为能够包括导致的导出 cardiomyocyte 的 angiogenic 信号的心肌层,和刺激的短暂、可逆的肥大概括心的生理的生长的特色的一个因素增加了由脉管形成。CT1 的能力从 caspase 激活的调停 CK2 的制止发源导致生理的肥大,阻止到无限制的病理学的生长的转变。外长的 CT1 蛋白质交货稀释了病理并且在正确的心失败的一个严格的模型恢复了可收缩的功能,建议为这难处理的心脏病的一种新奇处理选择。 | Mohammad Abdul-Ghani Colin Suen Baohua Jiang Yupu Deng Jonathan J Weldrick Charis Putinski Steve Brunette Pasan Femando Tom T Lee Peter Flynn Frans H H Leenen Patrick G Burgon Duncan J Stewar Lynn A Megeney | 2017 | Cell Research2017，27，10： | 8 |
| 3 | Genetic epidemiology of primary sclerosing cholangitis显示文摘The aetiology of primary sclerosing cholangitis (PSC) is not known. A more than 80-fold increased risk of PSC among first-degree relatives emphasizes the importance of genetic factors. Genetic associations within the human leukocyte antigen (HLA) complex on chromosome 6p21 were detected in PSC 25 years ago. Subsequent studies have substantiated beyond doubt that one or more genetic variants located within this genetic region are important. The true identities of these variants,however,remain to be identified. Several candidate genes at other chromosomal loci have also been investigated. However,according to strict criteria for what may be denominated a susceptibility gene in complex diseases,no such gene exists for PSC today. This review summarises present knowledge on the genetic susceptibility to PSC,as well as genetic associations with disease progression and clinical subsets of particular interest (inflammatory bowel disease and cholangiocarcinoma). | Tom H Karlsen Erik Schrumpf Kirsten Muri Boberg | 2007 | World Journal of Gastroenterology2007，13，41： | 7 |
| 4 | Autoantibodies in primary sclerosing cholangitis显示文摘The aetiology of primary sclerosing cholangitis (PSC) is not known and controversy exists as to whether PSC should be denominated an autoimmune disease. A large number of autoantibodies have been detected in PSC patients,but the specifi city of these antibodies is generally low,and the frequencies vary largely between different studies. The presence of autoantibodies in PSC may be the result of a nonspecifi c dysregulation of the immune system,but the literature in PSC points to the possible presence of specifi c antibody targets in the biliary epithelium and in neutrophil granulocytes. The present review aims to give an overview of the studies of autoantibodies in PSC,with a particular emphasis on the prevalence,clinical relevance and possible pathogenetic importance of each individual marker. | Johannes Roksund Hov Kirsten Muri Boberg Tom H Karlsen | 2008 | World Journal of Gastroenterology2008，14，24： | 7 |
| 5 | Cytoreductive surgery and intraperitoneal chemotherapy for colorectal peritoneal metastases显示文摘AIM:To systematically review the available evidence regarding cytoreductive surgery(CRS) and intraperitoneal chemotherapy(IPC) for colorectal peritoneal metastases(CPM).METHODS:An electronic literature search was carried out to identify publications reporting oncological outcome data(overall survival and/or disease free survival and/or recurrence rates)following CRS and IPC for treatment of CPM.Studies reporting outcomes following CRS and IPC for cancer subtypes other than colorectal were only included if data were reported independently for colorectal cancer-associated cases;in addition studies reporting outcomes for peritoneal carcinomatosis of appendiceal origin were excluded.RESULTS:Twenty seven studies,published between1999 and 2013 with a combined population of 2838patients met the predefined inclusion criteria.Included studies comprised 21 case series,5 case-control studies and 1 randomised controlled trial.Four studies provided comparative oncological outcome data for patients undergoing CRS in combination with IPC vs systemic chemotherapy alone.The primary indication for treatment was CPM in 96%of cases(2714/2838)and recurrent CPM(rCPM)in the remaining 4%(124/2838).In the majority of included studies(20/27)CRS was combined with hyperthermic intraperitoneal chemotherapy(HIPEC).In 3 studies HIPEC was used in combination with early post-operative intraperitoneal chemotherapy(EPIC),and 2 studies used EPIC only,following CRS.Two studies evaluated comparative outcomes with CRS+HIPEC vs CRS+EPIC for treatment of CPM.The delivery of IPC was performed using an'open'or'closed'abdomen approach in the included studies.CONCLUSION:The available evidence presented in this review indicates that enhanced survival times can be achieved for CPM after combined treatment with CRS and IPC. | Reza Mirnezami Brendan J Moran Kate Harvey Tom Cecil Kandiah Chandrakumaran Norman Carr Faheez Mohamed Alexander H Mirnezami | 2014 | World Journal of Gastroenterology2014，20，38： | 6 |
| 6 | How to treat intestinal obstruction due to malignant recurrence after Whipple's resection for pancreatic head cancer: description of 2 new endoscopic techniques显示文摘The prognosis of pancreatic cancer remains poor,even after initial surgical therapy. Local recurrence after Whipple's pancreatico-duodenectomy may lead to intestinal obstruction at the level of the afferent limb or the alimentary limb. Endoscopic insertion of a selfexpandable metal stent(SEMS) into the intestinal malignant stricture is the preferred method of choice for palliation. We describe two new endoscopic techniques to treat a malignant intestinal obstruction with the insertion of a SEMS into the afferent limb and the alimentary limb. A case of malignant gastric outlet obstruction after a Whipple's resection was treated by the creation of an endoscopic gastrojejunostomy by the insertion of a lumen apposing Hot Axios stent in between the stomach and the alimentary limb under fluoroscopic and endoscopic ultrasound control. Biliary obstruction and jaundice caused by a malignant stricture of the afferent limb after a Roux-en-Y Whipple's resection was treated by the insertion of a SEMS by means of the single-balloon overtube-assisted technique under fluoroscopic control. Feasibility and advantages of both techniques are discussed. | Christina Mouradides Alaa Taha Ivan Borbath Pierre H Deprez Tom G Moreels | 2017 | World Journal of Gastroenterology2017，23，33： | 3 |
| 7 | Spatial explorations of land use change and grain production in China显示文摘 | Peter H Verburg Youqi Chen Tom (A.) Veldkamp | 2000 | Agriculture Ecosystems and Environment2000，，1： | 2 |
| 8 | Hydroxyethyl Starch Reduces Coagulation Competence and Increases Blood Loss During Major Surgery: Results From a Randomized Controlled Trial显示文摘 | Kirsten C. Rasmussen P?r I. Johansson Michael H?jskov Irina Kridina Thomas Kistorp Peter Thind Henning B. Nielsen Birgitte Ruhnau Tom Pedersen Niels H. Secher | 2014 | Annals of Surgery2014，，2： | 2 |
| 9 | Anticipatory Activation in the Amygdala and Anterior Cingulate in Generalized Anxiety Disorder and Prediction of Treatment Response显示文摘 | Nitschke Jack B Sarinopoulos Issidoros Oathes Desmond J Johnstone Tom Whalen Paul J Davidson Richard J Kalin Ned H | 2009 | The American Journal of Psychiatry2009，，3： | 2 |
| 10 | Mesh optimization显示文摘 | HUGUES H TONY D TOM D | 1994 | Computer Aided Geometric Design1994，11，2： | 1 |
| 11 | 查看详情显示文摘 | James I L Tom D M Salah E Andrew F Karl H S Russell P N | | 0，，： | 1 |
| 12 | Observations on Physical Activity in Physical Locations:Age,Gender,Ethnicity,and Month Effects显示文摘 | Baranowski Tom Thompson W O Durant R H | 1993 | Research Quarterly for Exercise and Sport1993，64，2： | 1 |
| 13 | Predicting Systemic Disease in Patients With Esophageal Cancer After Esophagectomy: A Multinational Study on the Significance of the Number of Involved Lymph Nodes显示文摘 | Christian G. Peyre Jeffrey A. Hagen Steven R. DeMeester Jan J. B. Van Lanschot Arnulf H?lscher Simon Law Alberto Ruol Ermanno Ancona S Michael Griffin Nasser K. Altorki Thomas W. Rice John Wong Toni Lerut Tom R. DeMeester | 2008 | Annals of Surgery2008，，6： | 1 |
| 14 | Tree-age control on reconstructed debris-flow fre- quencies:Examples from a regional dendrogeomorphic reconstruction in the Crimean Mountains 显示文摘 | Silhn Karel Pnek Toms H radeck Jan 9 Stoffel Markus | 2015 | Earth Surface Processes and Landforms2015，40，2： | 1 |
| 15 | Kaposi's Sarcoma in Homosexual Men-A Seroepidemiologic Case-Control Study显示文摘 | Michael Marmor Jean H Tom B | 1984 | Annals of Internal Medicine1984，100，6： | 1 |
| 16 | Targeted cytoplasmic irradiation with alpha particles induces mutations in mammalian cells显示文摘 | Wu L J Zhou H N Tom K H | 1999 | Proc Natl Acad Sci USA1999，96，： | 1 |
| 17 | Quality assurance of a helical tomotherapy machine显示文摘 | J D Fenwick W A Tom'e H A Jaradat | 2004 | Phys Med Biol2004，，49： | 1 |
| 18 | Land use change under conditions of high population pressure : the case of Java显示文摘 | Verburg H Peter Veldkamp A Tom | 1999 | Global Environ mental Change1999，9，4： | 1 |
| 19 | The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP显示文摘 | YUN C H MENGWASSER K E TOMS A V | 2008 | Proc Nat/ Acad Sci U S A2008，105，6： | 1 |
| 20 | Measurement of specific Ig A in faecal extracts and intestinal lavage fluid for monitoring of mucosal immune responses显示文摘 | Harleen M S Tom H K Helene V | 2000 | J Immun Meth2000，239，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员