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| 1 | 噬菌体疗法预防细菌性感染的研究进展及发展方向显示文摘由于抗生素的不合理使用,引起了细菌多重耐药性、药物残留、食品安全、环境菌群不平衡等问题,严重威胁人类及动物的健康。因此,寻找新型抗菌药物及治疗方案已成为当前的研究重点。噬菌体是感染细菌、真菌等微生物的病毒,自发现伊始便用于治疗细菌感染。与传统抗生素相比,噬菌体具有分布广、易筛选、高度的宿主专一性、增殖能力强、安全性高、研发成本低等优势。随着多重耐药菌的广泛流行,噬菌体治疗细菌感染重新引起了人们的重视。本文简述了噬菌体的生物学特性、噬菌体疗法在预防细菌感染的应用及噬菌体研究发展方向,以期为噬菌体疗法预防细菌性感染提供参考。 | 陶程琳 王少辉 张耀东 易正飞 信素华 王瑶 李妍 AFAYIBO Dossêh Jean Apotre 朱红 李涛 祁晶晶 田明星 丁铲 高崧 于圣青 | 2020 | 中国兽医科学2020，50，9： | 17 |
| 2 | Redefining Budd-Chiari syndrome:A systematic review显示文摘AIM:To re-examine whether hepatic vein thrombosis(HVT)(classical Budd-Chiari syndrome)and hepatic vena cava-Budd Chiari syndrome(HVC-BCS)are the same disorder.METHODS:A systematic review of observational studies conducted in adult subjects with primary BCS,hepatic vein outflow tract obstruction,membranous obstruction of the inferior vena cava(IVC),obliterative hepatocavopathy,or HVT during the period of January2000 until February 2015 was conducted using the following databases:Cochrane Library,CINAHL,MEDLINE,Pub Med and Scopus.RESULTS:Of 1299 articles identified,26 were included in this study.Classical BCS is more common in women with a pure hepatic vein obstruction(49%-74%).HVCBCS is more common in men with the obstruction often located in both the inferior vena cava and hepatic veins(14%-84%).Classical BCS presents with acute abdominal pain,ascites,and hepatomegaly.HVC-BCS presents with chronic abdominal pain and abdominalwall varices.Myeloproliferative neoplasms(MPN)are the most common etiology of classical BCS(16%-62%)with the JAK2V617-F mutation found in 26%-52%.In HVCBCS,MPN are found in 4%-5%,and the JAK2V617-F mutation in 2%-5%.Classical BCS responds well to medical management alone and 1st line management of HVC-BCS involves percutaneous recanalization,with few managed with medical management alone.CONCLUSION:Systematic review of recent data suggests that classical BCS and HVC-BCS may be two clinically different disorders that involve the disruption of hepatic venous outflow. | Naomi Shin Young H Kim Hao Xu Hai-Bin Shi Qing-Qiao Zhang Jean Paul Colon Pons Ducksoo Kim Yi Xu Fei-Yun Wu Samuel Han Byung-Boong Lee Lin-Sun Li | 2016 | World Journal of Hepatology2016，8，16： | 6 |
| 3 | Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study显示文摘 | Laurent Beaugerie Nicole Brousse Anne Marie Bouvier Jean Frédéric Colombel Marc Lémann Jacques Cosnes Xavier Hébuterne Antoine Cortot Yoram Bouhnik Jean Pierre Gendre Tabassome Simon Marc Maynadié Olivier Hermine Jean Faivre Fabrice Carrat | 2009 | The Lancet . 2009 (9701)2009，，： | 4 |
| 4 | Maintenance of Remission Among Patients With Crohn’s Disease on Antimetabolite Therapy After Infliximab Therapy Is Stopped显示文摘 | Edouard Louis Jean–Yves Mary Gwenola Vernier–Massouille Jean–Charles Grimaud Yoram Bouhnik David Laharie Jean–Louis Dupas Hélène Pillant Laurence Picon Michel Veyrac Mathurin Flamant Guillaume Savoye Raymond Jian Martine DeVos Rapha?l Porcher Gilles Paint | 2012 | Gastroenterology2012，，1： | 4 |
| 5 | 鉴别大肠杆菌O_(8)/O_(9)血清型双重PCR方法的建立显示文摘为了建立一种能鉴定大肠杆菌O8、O9血清型的高效、快速的双重PCR方法,参考Gen Bank中大肠杆菌O8、O9血清型的O抗原合成基因簇序列筛选特异性靶标基因并设计合成2对PCR引物,通过优化反应条件,分析双重PCR方法的特异性、敏感性,通过检测大肠杆菌临床分离株验证双重PCR的实用性。结果显示,所建立的双重PCR方法可有效鉴定O8、O9血清型大肠杆菌,对其他血清型大肠杆菌及菌株则无交叉反应,表明PCR方法的特异性好;O8和O9血清型的菌体最低检出限分别为1×10^(3)CFU/m L和1×10^(4)CFU/m L,其DNA最低检出限分别为10 pg/μL和500 pg/μL。临床分离菌株检测显示,双重PCR检测结果与传统血清凝集结果一致。结果表明,本研究建立的双重PCR方法可有效、特异、灵敏、快速鉴定大肠杆菌O8、O9血清型,为大肠杆菌O8、O9血清型检测及其流行病学调查提供了新的技术手段。 | 朱红 李妍 魏娟文 张耀东 王瑶 陶程琳 AFAYIBO Dossêh Jean Apotre 李涛 祁晶晶 田明星 丁铲 于圣青 王少辉 | 2021 | 中国兽医科学2021，51，5： | 3 |
| 6 | Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial显示文摘 | Surya SAY Biere Mark I van Berge Henegouwen Kirsten W Maas Luigi Bonavina Camiel Rosman Josep Roig Garcia Suzanne S Gisbertz Jean HG Klinkenbijl Markus W Hollmann Elly SM de Lange H Jaap Bonjer Donald L van der Peet Miguel A Cuesta | 2012 | The Lancet . 2012 (9829)2012，，： | 3 |
| 7 | Split-dose menthol-enhanced PEG vs PEG-ascorbic acid for colonoscopy preparation显示文摘AIM:To compare the efficacy and palatability of 4L polyethylene glycol electrolyte(PEG)plus sugar-free menthol candy(PEG+M)vs reduced-volume 2 L ascorbic acid-supplemented PEG(Asc PEG).METHODS:In a randomized controlled trial setting,ambulatory patients scheduled for elective colonoscopy were prospectively enrolled.Patients were randomized to receive either PEG+M or Asc PEG,both splitdosed with minimal dietary restriction.Palatability was assessed on a linear scale of 1 to 5(1=disgusting;5=tasty).Quality of preparation was scored by assignment-blinded endoscopists using the modified Aronchick and Ottawa scales.The main outcomes were the palatability and efficacy of the preparation.Secondary outcomes included patient willingness to retake the same preparation again in the future and completion of the prescribed preparation.RESULTS:Overall,200 patients were enrolled(100patients per arm).PEG+M was more palatable than Asc PEG(76%vs 62%,P=0.03).Completing the preparation was not different between study groups(91%PEG+M vs 86%Asc PEG,P=0.38)but more patients were willing to retake PEG+M(54%vs 40%respectively,P=0.047).There was no significant difference between PEG+M vs Asc PEG in adequate cleansing on both the modified Aronchick(82%vs77%,P=0.31)and the Ottawa scale(85%vs 74%,P=0.054).However,PEG+M was superior in the left colon on the Ottawa subsegmental score(score0-2:94%for PEG+M vs 81%for Asc PEG,P=0.005)and received significantly more excellent ratings than Asc PEG on the modified Aronchick scale(61%vs 43%,P=0.009).Both preparations performed less well in afternoon vs morning examinations(inadequate:29%vs 15.2%,P=0.02).CONCLUSION:4 L PEG plus menthol has better palatability and acceptability than 2 L ascorbic acidPEG and is associated with a higher rate of excellentpreparations;Clinicaltrial.gov identifier:NCT01788709. | Ala I Sharara Ali H Harb Fayez S Sarkis Jean M Chalhoub Rami Badreddine Fadi H Mourad Mahmoud Othman Omar Masri | 2015 | World Journal of Gastroenterology2015，21，6： | 2 |
| 8 | 双组分系统CpxR影响禽致病性大肠杆菌的耐药性、抗血清杀菌能力及毒力显示文摘CpxR是细菌中Cpx双组分系统(two component system, TCS)的反应调控蛋白,通过调控靶基因的转录表达,在细菌细胞膜稳定及毒力方面发挥作用。本研究旨在探究TCS CpxR对禽致病性大肠杆菌(avian pathogenic Escherichia coli, APEC)基本生物学特性、抗血清杀菌能力及致病性的影响。利用Red同源重组系统及互补质粒构建cpxR基因缺失株、互补株,然后比较分析野生株、基因缺失株与互补株的生长曲线、运动性、生物被膜形成能力、药物敏感性、抗血清杀菌能力、动物致病性的差异。结果显示:cpxR基因缺失株与野生株、互补株的生长速度和运动性能无明显差异,且缺失cpxR基因不影响APEC的生物被膜形成能力。然而,缺失CpxR导致APEC对阿米卡星和卡那霉素耐药性降低。血清杀菌试验结果显示,CpxR有助于APEC的抗血清杀菌能力。动物感染试验结果显示,野生株、cpxR基因缺失株和互补株对雏鸭的半数致死量(LD_(50))分别为7.50×10^(5)、7.50×10^(6)、1.33×10^(6) CFU,表明CpxR缺失显著降低APEC的毒力。综上表明,TCS CpxR在APEC耐药性、抗血清杀菌能力及毒力方面发挥作用,为阐明APEC的环境适应性、生存能力及致病机制提供参考。 | 易正飞 张耀东 王瑶 朱红 陶程琳 AFAYIBO Dossêh Jean Ap tre 李涛 祁晶晶 田明星 丁铲 于圣青 王少辉 | 2021 | 畜牧兽医学报2021，52，4： | 2 |
| 9 | Genetic variation in the PNPLA3 gene and hepatocellular carcinoma in USA: Risk and prognosis prediction显示文摘 | Manal M. Hassan Ahmed Kaseb Carol J. Etzel Hashem El‐Serag Margaret R. Spitz Ping Chang Katherine S. Hale Mei Liu Asif Rashid Mohamed Shama James L. Abbruzzese Evelyne M. Loyer Harmeet Kaur Hesham M. Hassabo Jean‐Nicolas Vauthey Curtis J. Wray Basmah S. H | 2013 | Mol Carcinog2013，，1： | 2 |
| 10 | Chemotherapy in locally advanced nasopharyngeal carcinoma: An individual patient data meta-analysis of eight randomized trials and 1753 patients显示文摘 | Bertrand Baujat Hélène Audry Jean Bourhis Anthony T.C. Chan Haluk Onat Daniel T.T. Chua Dora L.W. Kwong Muhyi al-Sarraf Kwan-Hwa Chi Masato Hareyama Sing F. Leung Kullathorn Thephamongkhol Jean-Pierre Pignon | 2006 | International Journal of Radiation Oncology, Biology, Physics2006，，1： | 2 |
| 11 | Prevention of gut leakiness by a probiotic treatment leads to attenuated HPA response to an acute psychological stress in rats显示文摘 | Afifa Ait-Belgnaoui Henri Durand Christel Cartier Gilles Chaumaz Hélène Eutamene Laurent Ferrier Eric Houdeau Jean Fioramonti Lionel Bueno Vassilia Theodorou | 2012 | Psychoneuroendocrinology2012，，11： | 2 |
| 12 | In vivo growth inhibitory effect of iterative wild-type p53 gene transfer in human head and neck carcinoma xenografts using glucosylated polyethylenimine nonviral vector显示文摘 | GILLES D JEAN L M MRIEL B H | 2002 | Cancer Gene Ther2002，，9： | 1 |
| 13 | Toll receptors in innate immunity显示文摘 | Jean L I Jules H A | 2001 | Trends in Cell Biology2001，11，7： | 1 |
| 14 | 显示文摘 | CHENG K L JEAN Y C LUO X H | 1989 | Critical Review in Analytical Chemistry1989，21，3： | 1 |
| 15 | CT Find- ings of Chemotherapy-induced Toxicity : What Radiologists Need to Know about the Clinical and Radiologic Manifestations of Chemo- therapy Toxicity显示文摘 | Jean M Torrisi MD Lawrence H Schwartz MD | 2011 | Radiology2011，258，： | 1 |
| 16 | Effectiveness of short- term, enhanced, infection control support in improving com- pliance with infection control guidelines and practice in nurs- ing homes: a cluster randomized trial显示文摘 | Gopal Rao G Jeanes A Russell H | 2009 | Epidemiology and Infection2009，137，10： | 1 |
| 17 | Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide显示文摘 | Jean PL Jean H Yasushi T | 2003 | Clin Invest2003，111，2： | 1 |
| 18 | Fas (Apo-1/CD95) and Fas ligand interaction between gastric cancer cells and immune cells 显示文摘 | Lee TB Min YD Lira SC Kim K J Jean H J Choi SM | 2002 | J Gastroenterol Hepatol2002，17，1： | 1 |
| 19 | Raman spectroscopic investigation of maghemite ferrofluids modified by the adsorption of zinc tetrasulfonated phthalocyanine显示文摘 | Jean C O Silva Marcelo H Sousa Francisco A Tourinho | 2002 | Langmuir2002，18，14： | 1 |
| 20 | Kaposi's Sarcoma in Homosexual Men-A Seroepidemiologic Case-Control Study显示文摘 | Michael Marmor Jean H Tom B | 1984 | Annals of Internal Medicine1984，100，6： | 1 |
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