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| 1 | Role of Helicobacter pylori infection in gastric carcinogenesis:Current knowledge and future directions显示文摘Helicobacter pylori(H. pylori) plays a role in the patho-genesis of gastric cancer. The outcome of the infection depends on environmental factors and bacterial and host characteristics. Gastric carcinogenesis is a multistep process that is reversible in the early phase of mucosal damage, but the exact point of no return has not been identified. Therefore, two main therapeutic strategies could reduce gastric cancer incidence:(1) eradication of the already present infection; and(2) immunization(prior to or during the course of the infection). The success of a gastric cancer prevention strategy depends on timing because the prevention strategy must be introduced before the point of no return in gastric carcinogenesis. Although the exact point of no return has not been identified, infection should be eradicated before severe atrophy of the gastric mucosa develops. Eradication therapy rates remain suboptimal due to increasing H. pylori resistance to antibiotics and patient noncompliance. Vaccination against H. pylori would reduce the cost of eradication therapies and lower gastric cancer incidence. A vaccine against H. pylori is still a research challenge. An effective vaccine should have an adequate route of delivery, appropriate bacterial antigens and effective and safe adjuvants. Future research should focus on the development of rescue eradication therapy protocols until an efficacious vaccine against the bacterium becomes available. | Aleksandra Sokic-Milutinovic Tamara Alempijevic Tomica Milosavljevic | 2015 | World Journal of Gastroenterology2015，21，41： | 30 |
| 2 | Drug-induced liver injury: Do we know everything?显示文摘Interest in drug-induced liver injury(DILI) has dramatically increased over the past decade, and it has become a hot topic for clinicians, academics, pharmaceutical companies and regulatory bodies. By investigating the current state of the art, the latest scientific findings, controversies, and guidelines, this review will attempt to answer the question: Do we know everything? Since the first descriptions of hepatotoxicity over 70 years ago, more than 1000 drugs have been identified to date, however, much of our knowledge of diagnostic and pathophysiologic principles remains unchanged. Clinically ranging from asymptomatic transaminitis and acute or chronic hepatitis, to acute liver failure, DILI remains a leading causes of emergent liver transplant. The consumption of unregulated herbal and dietary supplements has introduced new challenges in epidemiological assessment and clinician management. As such, numerous registries have been created, including the United States Drug-Induced Liver Injury Network, to further our understanding of all aspects of DILI. The launch of Liver Tox and other online hepatotoxicity resources has increased our awareness of DILI. In 2013, the first guidelines for the diagnosis and management of DILI, were offered by the Practice Parameters Committee of the American College of Gastroenterology, and along with the identification of risk factors and predictors of injury, novel mechanisms of injury, refined causality assessment tools, and targeted treatment options have come to define the current state of the art, however, gaps in our knowledge still undoubtedly remain. | Tamara Alempijevic Simon Zec Tomica Milosavljevic | 2017 | World Journal of Hepatology2017，9，10： | 13 |
| 3 | Expression of cytokeratins in Helicobacter pylori-associated chronic gastritis of adult patients infected with cagA+strains:An immunohistochemical study显示文摘瞄准:为了与长期的胃炎在成年病人的胃的上皮调查不同 cytokeratins (CK ) 的表示,与 Helicobacter pylori (H pylori ) 感染了 cagA+ 紧张。方法:CK 7 的表示, 8, 18, 19 和 20 在 84 个病人的窦的胃的活体检视组织化学地是学习免疫。所有 CK 是在 cagA+H pylori 胃炎(57 个案例) 染色的免疫, non-H pylori 胃炎(17 个案例) 和正常胃粘膜(10 个案例) 。结果:在 cagA+ H pylori 胃炎, CK8 从表面上皮可比较地被表示到正常的窦粘膜到深腺。CK18 和 CK 19 的分发是未改变的,即表示的 transmucosal,而是紧张在与正常相比的小凹的区域是不同的胃粘膜。Cytokeratin 18 免疫反应在与 H pylori 否定的胃炎和控制相比的 H pylori 积极的胃炎的小凹的上皮是显著地更高的。相反,在 CK19 免疫反应的减少发生在 H pylori 积极的胃炎的小凹的上皮。在没有 H pylori 感染的正常、煽动的窦粘膜, CK20 在表面上皮和上面的小凹的区域强烈 / 中等并且同类地被表示,但是在 H, pylori 导致了胃炎在小凹的区域的表示的重要减少被注意。通常,在正常窦的粘膜和 H pylori 否定的胃炎,, CK7 的表示没被观察在关于半 cagA+ , H 感染 pylori 的病人,节制颈的焦点的 CK7 免疫反应,卷的腺区域被登记,特别在区域与更严重煽动性渗入。结论:在 CK 7 的表示的改变, 18, 19 和 20 在感染 cagA+ 紧张的成年病人和 CK8 的正常表示发生在 H 联系 pylori 的长期的胃炎的窦粘膜。在不同 cytokeratins 表示力量的改变贡献在 H 感染 pylori 的胃粘膜观察的上皮的紧密的连接变弱。 | Vera Todorovic Neda Drndarevic Olivera Mitrovic Institutefor MedicalResearch Aleksandra Sokic-Milutinovic Tomica Milosavljevic Marjan Micev Ivan Nikolic Thomas Wex Peter Malfertheiner | 2006 | World Journal of Gastroenterology2006，12，12： | 2 |
| 4 | Endoscopic manometry of the sphincter of Oddi and pancreatic duct in patients with chronic pancreatitis显示文摘 | Milenko Uglje?i? Mirko Bulaji? Tomica Milosavljevi? Bojan ?timec | 1996 | International Journal of Pancreatology1996，，3： | 1 |
| 5 | An incidental finding of unicomuate uterus with unilateral ovarian agenesis during laparoscopy in patient who gave birth to eleven children:a case report显示文摘 | Alvir I Puljiz M Tomica D | | 0，，01： | 1 |
| 6 | Gastrin and antral G cells in course of Helicobacter pylori eradication: Six months follow up study显示文摘AIM: To assess long-term effects of Helicobacter pylori (H pylori) eradication on antral G cell morphology and function in patients with and without duodenal ulcer (DU).METHODS: Consecutive dyspeptic patients referred to the endoscopy entered the study. Out of 39 H pylori positive patients, 8 had DU (H pylori+DU) and 31 gastritis (H pylori +G). Control groups consisted of 11 uninfected dyspeptic patients (CG1) and 7 healthy volunteers (CG2). Basal plasma gastrin (PGL), antral tissue gastrin concentrations (ATGC), immunohistochemical and electron microscopic characteristics of G cells were determined, prior to and 6 mo after therapy.RESULTS: We demonstrated elevated PGL in infected patients compared to uninfected controls prior to therapy.Elevated PGL were registered in all H pylori+patients (H pylori +DU: 106.78±22.72 pg/mL, H pylori+G: 74.95±15.63,CG1: 68.59±17.97, CG2:39.24±5.59 pg/mL, P<0.01).Successful eradication (e) therapy in H pylori+patients lead to significant decrease in PGL (H pylori+DU: 59.93±9.40and H pylori+Ge: 42.36±10.28 pg/mL, P<0.001). ATGC at the beginning of the study were similar in infected and uninfected patients and eradication therapy lead to significant decrease in ATGC in H pylori+gastritis, but not in DU patients. In the H pylori+DU patients, the mean number of antral G cells was significantly lower in comparison with all other groups (P<0.01), but after successful eradication was close to normal values found in controls. By contrast, G cell number and volume density were significantly decreased (P<0.01) in H pylori+Ge group after successful eradication therapy (294±32 and 0.31±0.02,respectively), in comparison to values before eradication (416±40 and 0.48±0.09). No significant change of the G cell/total endocrine cell ratio was observed during the 6 mo of follow up in any of the groups. A reversible increase in G cell secretory function was seen in all infected individuals, demonstrated by a more prominent secretory apparatus. However, differences between DU and gastritis group were identified.CONCLUSION: H pylori infection induces antral G cell hyperfunction resulting in increased gastrin synthesis and secretion. After eradication therapy complete morphological and functional recovery is observed in patients with gastritis. In the DU patients some other factors unrelated to the H pylori infection influence antral G cell morphology and function. | Aleksandra Sokic-Milutinovic Vera Todorovic Tomica Milosavljevic Marjan Micev Neda Drndarevic Olivera Mitrovic | 2005 | World Journal of Gastroenterology2005，11，27： | 1 |
| 7 | An incidental finding of unicornuate uterus with unilateral ovarian agenesis during laparoscopy in patient who gave birth to eleven children: a case report 显示文摘 | Alvir I Puljiz M Tomica D | 2013 | Coll Antropol2013，37，1： | 1 |
| 8 | A correlation between theexpression of the estrogen receptors and progesterone receptors incancer cells and in the myometrium and prognostic factors inendometrial cancer显示文摘 | Tomica D Ramie S Danolic D | 2014 | Coll Antropol2014，38，1： | 1 |
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