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| 1 | Clinical usefulness of biochemical markers of liver fibrosis in patients with nonalcoholic fatty liver disease显示文摘AIM: Nonalcoholic steatohepatitis (NASH) is a severe form of nonalcoholic fatty liver disease (NAFLD), and progresses to the end stage of liver disease. Biochemical markers of liver fibrosis are strongly associated with the degree of histological liver fibrosis in patients with chronic liver disease.However, data are few on the usefulness of markers in NAFLD patients. The aim of this study was to identify better noninvasive predictors of hepatic fibrosis, with special focus on markers of liver fibrosis, type Ⅵ collagen 7S domain and hyaluronic acid.METHODS: One hundred and twelve patients with histologically proven NAFLD were studied.RESULTS: The histological stage of NAFLD correlated with several clinical and biochemical variables, the extent of hepatic fibrosis and the markers of liver fibrosis were relatively strong associated. The best cutoff values to detect NASH were assessed by using receiver operating characteristic analysis: type Ⅵ collagen 7S domain ≥5.0 ng/mL, hyaluronic acid ≥43 ng/mL. Both markers had a high positive predictive value: type Ⅵ collagen 7S domain, 86% and hyaluronic acid,92%. Diagnostic accuracies of these markers were evaluated to detect severe fibrosis. Both markers showed high negative predictive values: type Ⅵ collagen 7S domain (≥5.0 ng/mL),84% and hyaluronic acid (≥50 ng/mL), 78%, and were significantly and independently associated with the presence of NASH or severe fibrosis by logistic regression analysis.CONCLUSION: Both markers of liver fibrosis are useful in discriminating NASH from fatty liver alone or patients with severe fibrosis from patients with non-severe fibrosis. | Hiroshi Sakugawa Tomofumi Nakayoshi Kasen Kobashigawa Tsuyoshi Yamashiro Tatsuji Maeshiro Satoru Miyagi Joji Shiroma Akiyo Toyama Tomokuni Nakayoshi Fukunori Kinjo Atsushi Saito | 2005 | World Journal of Gastroenterology2005，11，2： | 9 |
| 2 | Different natural courses of chronic hepatitis B with genotypes B and C after the fourth decade of life显示文摘AIM: To investigate the different impact of genotypes B and C on the development of liver cirrhosis (LC) among different age groups of patients with chronic hepatitis B (CH-B). METHODS: We examined the outcome of 121 patients with CH-B, divided by age and genotype. Univariate analyses were used to compare different groups. The Cox proportional hazard model was employed to evaluate factors affecting the development of LC. RESULTS: In patients < 30 years old, there were no significant predictors for development of LC. However, in patients ≥ 30 years old, genotype C was the only significant predictor. In the genotype C group, 8 of 12 patients who progressed to LC were 30-49 years old at initial diagnosis of chronic hepatitis (7 patients were positive for HBeAg). In the genotype B group, 4 of 8 patients who developed LC were ≥ 50 years old at initial diagnosis and were HBeAg-negative. CONCLUSION: The rate of development of LC was comparable in patients infected with genotypes B and C when CH-B occurred at < 30 years old. However, CH-B patients infected with genotype C showed poor prognosis if they were 30-49 years old and were positive for HBeAg. Age-specific natural course of CH-B should be considered when patients with CH-B are treated with antiviral drugs. | Tatsuji Maeshiro Shingo Arakaki Takako Watanabe Hajime Aoyama Joji Shiroma Tsuyoshi Yamashiro Tetsuo Hirata Akira Hokama Fukunori Kinjo Tomofumi Nakayoshi Tomokuni Nakayoshi Masashi Mizokami Jiro Fujita Hiroshi Sakugawa | 2007 | World Journal of Gastroenterology2007，13，34： | 7 |
| 3 | Circulating microRNA-21 as a novel biomarker for hepatocellular carcinoma显示文摘 | Yoshito Tomimaru Hidetoshi Eguchi Hiroaki Nagano Hiroshi Wada Shogo Kobayashi Shigeru Marubashi Masahiro Tanemura Akira Tomokuni Ichiro Takemasa Koji Umeshita Tatsuya Kanto Yuichiro Doki Masaki Mori | 2011 | Journal of Hepatology2011，，1： | 3 |
| 4 | Cholinesterase activity in the blood and brain of rats and mice as determined by a rapid colorimetric method 显示文摘 | Tomokuni K Hasegawa T | 1985 | Ind Health1985，23，： | 2 |
| 5 | Over-expression of the decoy receptor 3 ( DcR3 ) gene in peripheral blood mononuclear cells (PBMC) derived from silicosis patients 显示文摘 | Otsuki T Tomokuni A Sakaguchi H | 2000 | Clin Exp Immunol2000，119，2： | 1 |
| 6 | Idiopathic left ventricular tachycardia with block between Purkinje potential and ventricular myocardium显示文摘 | Tomokuni A Igawa O Yamanouchi Y | 1999 | PACE1999，21，： | 1 |
| 7 | Over-expression ol the decoy receptor 3(DcR3)gene in peripheral blood mononuclear cells (PBMC) derived from silicosis patients显示文摘 | Otsuki T Tomokuni A Sakaguchi H | 2000 | Clin Exp Immunol2000，119，2： | 1 |
| 8 | Soluble Fas mRNA is dominantly expressed in cases with silicosis 显示文摘 | Otsuki T Sakaguchi A Tomokuni A | 1998 | Immunology1998，94，： | 1 |
| 9 | IFATS collection: Fibroblast growth factor-2-induced hepatocyte growth factor secretion by adipose-derived stromal ceils inhibits postinjury fibrogenesis through a c-Jun N-terminal kinase-dependent mechanism 显示文摘 | Hirotaka S Hitomi E Tomokuni S | 2009 | Stem Cells Vo12009，27，1： | 1 |
| 10 | Isolationof apoptosis-and differentiation-inducing substances towardhuman promyelocytic leukemia HL-60 cells from leaves ofJuniperus taxifolia 显示文摘 | MUTO N TOMOKUNI T HARAMOTO M | 2008 | Biosci Biotechnol Biochem2008，72，2： | 1 |
| 11 | Over-expression of the decoy receptor 3 ( DcR3 ) gene in peripheral blood mononuclear cells (PBMC) derived from silicosis patients 显示文摘 | Otsuki T Tomokuni A Sakaguchi H | 2000 | Clin Exp Immunol2000，119，2： | 1 |
| 12 | Over-expression of the decoy receptor 3 ( DcR3 ) gene in peripheral blood mononuclear cells(PBMC) derived from silicosis patients显示文摘 | Otsuki T Tomokuni A Sakaguchi H | 2000 | Clin Exp hnmu- no12000，119，2： | 1 |
| 13 | Mechanical properties of aluminum-based dissimilar alloy joints by power beams, arc and FSW processes 显示文摘 | Michinori OKUBO Tomokuni KON | 2007 | Journal of High Temperature Society2007，33，04： | 1 |
| 14 | Soluble Fas mRNA is dominantly expressed in cases with silicosis 显示文摘 | Otsuki Y Sakaguchi A Tomokuni A | 1998 | Immunology1998，94，2： | 1 |
| 15 | Activation-induced celldeath in human peripheral blood lymphocytes after stimulationwithsilicate in vitro显示文摘 | Aikoh T Tomokuni A Matsukii T | 1998 | Int J Oncol1998，12，6： | 1 |
| 16 | Man-made mineral fibers induce apoptosis of human peripheral blood mononuclear cells similarly to chrysotile B显示文摘 | MA Z OTSUKI T TOMOKUNI A | 1999 | Int J Mol Med1999，4，6： | 1 |
| 17 | A case of complete response to S-1 therapy for multiple pulmonary recurrences of hepatocellular carcinoma after hepatic resection显示文摘 | TOMOKUNI A MARUBASHI S NAGANO H | 2009 | Gan To Kagaku Ryoho2009，36，12： | 1 |
| 18 | Over-expression of the decoy receptor 3 (DcR3) gene in peripheral blood mononuclear cells (PBMC) derived from silicosis patients显示文摘 | Otsuki T Tomokuni A Sakaguchi H | 2000 | Clin Exp Immunol2000，119，： | 1 |
| 19 | Elevated soluble Fas/APO-1 (CD95) levels in silicosis patients without clinical symptoms of autoimmune diseases or malignant tumors显示文摘 | Tomokuni A Aikoh T Matsuki T | 1997 | Clin Exp Immunol1997，110，2： | 1 |
| 20 | A case of complete response to S-1 therapy for multiple pulmonary recuorrences of hepatocellular carcinoma after hepatic resection 显示文摘 | TOMOKUNI A MARUBASHI S NAGANO H | 2009 | Gan To Kagaku Ryoho2009，36，12： | 1 |
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