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| 1 | Frequent and prolonged nocturnal occupation of port areas by Yangtze finless porpoises (Neophocaena asiaeorientalis): Forced choice for feeding?显示文摘During the Yangtze Freshwater Dolphin Expedition 2012,Yangtze finless porpoises(Neophocaena asiaeorientalis)were acoustically monitored in 9 port areas at night.During 6566 min of nocturnal monitoring,porpoise sonar was detected for 488 min(7.43%of the total time).Of all 81 encounters,the longest echolocation span obtained was 102.9 min,suggesting frequent and prolonged porpoise occupation of the port areas.A combined total of 2091 click trains were recorded,with 129(6.2%)containing minimum inter-click intervals(ICIs)below 10 ms(termed a buzz).Buzzes with a decrease in ICIs and search and approach phases that resembled feeding echolocation signals accounted for 44.2%(N=52)of all buzzes.Buzzes with an increase in ICIs,suggesting a mirrored prey capture phase,accounted for 20.2%(N=26)and could reflect attempts to locate escaped prey because they were followed by approach-phase feeding buzzes.Anecdotal evidence of porpoises fleeing the proximity of vessels was observed.The recordings indicating clusters of porpoises feeding near the port areas suggest a forced choice for feeding due to the relatively higher prey availability in the port areas compared to other areas in the Yangtze River that are probably overfished. | Zhitao WANG Tomonari AKAMATSU Zhigang MEI Lijun DONG Tomohito IMAIZUMI Kexiong WANG Ding WANG | 2015 | Integrative Zoology2015，10，1： | 6 |
| 2 | Transcriptomic analysis of epigenetic modification genes in the termite Reticulitermes speratus显示文摘Eusocial insects display a caste system in which different castes are morpho-logically and physiologically specialized for different tasks.Recent studies have revealed that epigenetic modifications,including DNA methylation and histone modification,me-diate caste determination and differentiation,longevity,and polyethism in eusocial insects.Although there has been a growing interest in the relationship between epigenetic mech-anisms and phenotypic plasticity in termites,there is ltte information about differential expression levels among castes and expression sites for these genes in termites.Here we show royaltissuc-specific expression of epigenetic modification genes in the termite Reticulitermes speratus.Using RNA-seq,we identified 74 genes,including three DNA methyltransferases,seven sirtuins,48 Trithorax group proteins,and 16 Polycomb group proteins.Among these genes,15 showed king-specific expression,and 52 showed age-dependent differential expression in kings and queens.Quantitative real-time PCR revealed that DNA methyltransferase 3 is expressed specifically in the king's testis and fat body,whereas some histone modification genes are remarkably expressed in the king's testis and queen's ovary.These findings imply that epigenetic modification plays important roles in the gamete production process in termite kings and queens. | Yuki Mitaka Eisuke Tasaki Tomonari Nozaki Taro Fuchikawa Kazuya Kobayashi Kenji Matsuura | 2020 | Insect Science2020，27，2： | 4 |
| 3 | TTYH2,a human homologue of the Drosophila melanogaster gene tweety,is up-regulated in colon carcinoma and involved in cell proliferation and cell aggregation显示文摘AIM: To investigate the expression patterns of TTYH2 in the human colon cancer and colon cancer cell lines and to evaluate the inhibitory effect of small interfering RNA (siRNA) on the expression of TTYH2 in colon cancer cell lines.METHODS: We investigated the expression patterns of TTYH2 in colon cancer, adjacent non-tumorous colon mucosa, and cancer cell lines (DLD-1, caco-2, and Lovo) by RT-PCR. Furthermore, a siRNA plasmid expression vector against TTYH2 was constructed and transfected into DLD-1 and Caco-2 with LipofectamineTM 2000. The down regulation of TTYH2 expression was detected by RT-PCR and the role of siRNA in inducing cell proliferation and cell aggregation was evaluated by MTT and aggregation assay.RESULTS: TTYH2 gene expression in colon cancer tissue was significantly up-regulated compared with normal colonic mucosa (1.23 ± 0.404 vs 0.655 ± 0.373, P = 0.0103). Colon cancer derived cell lines including DLD-1, Caco-2, and Lovo also expressed high levels of TTYH2. In contrast, transfection with siRNA-TTYH2 signifi cantly inhibited both proliferation and scattering of these cancer cell lines.CONCLUSION: The present work demonstrates, for the fi rst time, that the TTYH2 gene expression is signifi cantly up-regulated in colon cancer. The TTYH2 gene may play an important role in regulating both proliferating andmetastatic potentials of colorectal cancer. | Yuji Toiyama Akira Mizoguchi Kazushi Kimura Junichirou Hiro Yasuhiro Inoue Tomonari Tutumi Chikao Miki Masato Kusunoki | 2007 | World Journal of Gastroenterology2007，13，19： | 4 |
| 4 | Resected tumor seeding in stomach wall due to endoscopic ultrasonography-guided fine needle aspiration of pancreatic adenocarcinoma显示文摘Endoscopic ultrasonography-guided fine needle aspiration(EUS-FNA) is a useful and relatively safe tool for the diagnosis and staging of pancreatic cancer. However, there have recently been several reports of tumor seeding after EUS-FNA of adenocarcinomas. A 78-year-old man was admitted to our hospital due to upper gastric pain. Examinations revealed a 20 mm mass in the pancreatic body, for which EUS-FNA was performed. The cytology of the lesion was adenocarcinoma, and the stage of the cancer was T3N0M0. The patient underwent surgery with curative intent, followed by adjuvant chemotherapy with S-1. An enlarging gastric submucosal tumor was found on gastroscopy at 28 mo after surgery accompanied by a rising level of CA19-9. Biopsy result was adenocarcinoma, consistent with a pancreatic primary tumor. Tumor seeding after EUS-FNA was strongly suspected. The patient underwent surgical resection of the gastric tumor with curative intent. The pathological result of the resected gastric specimen was adenocarcinoma with a perfectly matched mucin special stain result with the previously resected pancreatic cancer. This is the first case report of tumor seeding after EUS-FNA which was surgically resected and inspected pathologically. | Akiko Tomonari Akio Katanuma Tomoaki Matsumori Hajime Yamazaki Itsuki Sano Ryuki Minami Manabu Sen-yo Satoshi Ikarashi Toshifumi Kin Kei Yane Kuniyuki Takahashi Toshiya Shinohara Hiroyuki Maguchi | 2015 | World Journal of Gastroenterology2015，21，27： | 3 |
| 5 | Expression of Human ApoAII in Transgenic Rabbits Leads to Dyslipidemia:a New Model for Combined Hyperlipidemia显示文摘High levels of plasma high-density lipoproteins (HDL) are associated with a low incidence of cardiovascular disease[1]. HDL contains two major apolipoproteins (apo):apoAI and apoAII. It is generally accepted that apoAI plays a central role in reverse cholesterol transport and protects against atherosclerosis[2,3]; however,apoAII functions have not been clearly characterized[4-6]. | Jianglin Fan Tomonari Koike Ying Yu Enqi Liu | 2009 | 中国动脉硬化杂志2009，17，7： | 2 |
| 6 | 1-Methyl-4-phenylpyridinium (MPPγ) induces NADH- dependent superoxide formation and enhances NADH- dependent lipid peroxidation in bovine heart submitochondrial particles显示文摘 | Eiji Hasegawa Koichiro Takasgige Tomonari Oishi | 1990 | Biochem Biophys Res Commun1990，170，3： | 1 |
| 7 | Rice Morphogenesis and Plant Architecture : Measurement, Specification and the Reconstruction of Structural Development by 3D Architectural Modelling 显示文摘 | Tomonari Watanabe Jim S Hanan Peter M Room | 2005 | Annals of Botany2005，，95： | 1 |
| 8 | Controlled precipitation polymerization of phthalimidomethyloxirane in cationic isomerization ring-opening manner显示文摘 | HIGEYOSHI K TOMONARI NISHIMUTRA | 2002 | Macromolecules2002，35，： | 1 |
| 9 | Thermochemical transformation of sulfur compounds in Janapese domestic Allium:Allium victorialis L显示文摘 | Nishimura H Tomonari T Wijaya C H | 2000 | Academic Source Premier2000，13，： | 1 |
| 10 | Vitreous levels of angiopoietin 2 and vascular endothelial growth factor in patients with proliferative diabetic retinopathy显示文摘 | Daisuke Watanabe Kiyoshi Suzuma Izumi Suzuma Hirokazu Ohashi Tomonari Ojima Masafumi Kurimoto Tomoaki Murakami Tetsushi Kimura Hitoshi Takagi | 2005 | American Journal of Ophthalmology2005，，3： | 1 |
| 11 | Ab initio calculations on reactions of CHF3 with its fragments显示文摘 | OKAMOTO Y TOMONARI M | 2000 | Journal of Physical Chemistry A2000，104，12： | 1 |
| 12 | A toxicoproteomic study on eardioprotective effects of pre - administration of docetaxel in a mouse model of adriamycin - induced cardiotoxicity 显示文摘 | Ohyama K Tomonari M Ichibangase T | 2010 | Biochem Pharmacol2010，80，4： | 1 |
| 13 | Generalized distance and existence theorems in complete metric spaces显示文摘 | | 2001 | J Math Anal Appl2001，253，： | 1 |
| 14 | Chronophar-maeology of mizoribine in collagen-induced arthritis rats 显示文摘 | KANASAKI Y TOMONARI M SASAKI H | 2012 | J Pharmacol Sci2012，120，2： | 1 |
| 15 | Acute myelogenous leuke mia M5b developed during clinical remission of Castleman disease 显示文摘 | Tomonari A Shirafuji N Tojo A | 2003 | lnt J Hematol2003，77，3： | 1 |
| 16 | Devel- opment of Nonchromate - treated Tinplate having Excellent Resist- ance to Yellow Staining and Smudging显示文摘 | Ohga Tomonari Hironobu Miyazaki Masahiro Yamamoto | 1997 | Corrosion Engineering1997，46，12： | 1 |
| 17 | Estimating Invasion Probabilities: A Case Study of fire Blight Disease and the Importation of Apple Fruits显示文摘 | Kohji Yamamura Hajime Katsumata Tomonari Watanabe | 2001 | Biological Invasions2001，，4： | 1 |
| 18 | Predictive values of ANP, BNP and cyclic GMP for determining approximate volume state in patients on chronic dialysis显示文摘 | Kurlyama S Tomonari H Hikita M | 1996 | J Jpn Soc Dial Ther1996，29，： | 1 |
| 19 | The Performance of the Dry Roots Pump 'DRYMAC' in LP-CVD Silicon Nitride Process显示文摘 | Yukio Kanke Tomonari Tanaka | 2001 | Applied Surface Science2001，，： | 1 |
| 20 | Rice morphogenesis and plant architecture: measurement, specification and the reconstruction of structural development by 3D architectural modelling 显示文摘 | Tomonari W Jim S H Peter M R | 2005 | Annals of Botany2005，95，： | 1 |
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