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| 1 | Optimizing longcirculating liposomes for delivery of simvastatin to C26colon carcinoma cells显示文摘 | Porfire A Tomuta I Muntean D | 2014 | J Liposome Res2014，9，： | 1 |
| 2 | Comparative study of the effects of a 1-year dietary intervention of a low-carbohydrate diet versus a low-fat diet on weight and glycemic control in type 2 diabetes显示文摘 | Nicholia DJ Tomuta N Schechter C | 2009 | Diabetes care2009，32，7： | 1 |
| 3 | Effects of soybean peptide on the damaged muscle: immunological research 显示文摘 | Masuda K Tomuta T Matsuo T | 2001 | Soy Protein Research2001，，4： | 1 |
| 4 | LC/MS quantitative study of glucose by iodine attachment显示文摘 | ROGATSKY E TOMUTA V STEIN D T | 2007 | Analytiea Chimica Acta2007，591，2： | 1 |
| 5 | The magnetic susceptibility, specific heat and dielectric constant of hexagonal YMnO3, LuMnO3 and ScMnO3 显示文摘 | Tomuta D G Ramakrishnan S | 2001 | J Phys: Condens Matter2001，13，： | 1 |
| 6 | High-throughput NIR-chemo- metric methods for determination of drug content and pharmaceuti- cal properties of indapamide tablets 显示文摘 | Tomuta I Rus L Iovanov R | 2013 | J Pharm Biomed Anal2013，84，5： | 1 |
| 7 | Targeting insulin inhibition as a metabolic therapy in advanced cancer: A pilot safety and feasibility dietary trial in 10 patients显示文摘 | Eugene J. Fine C.J. Segal-Isaacson Richard D. Feinman Silvia Herszkopf Maria C. Romano Norica Tomuta Amanda F. Bontempo Abdissa Negassa Joseph A. Sparano | 2012 | Nutrition2012，，10： | 1 |
| 8 | Effects of soybean peptide on the damaged muscle:immunological research显示文摘 | Masuda K Tomuta T Matsuo T | 2001 | Soy Protein Research2001，，4： | 1 |
| 9 | New aro- matic-aliphatic hyperbranched polyesters with vinylie end groups of different length as modifiers of epoxy/anhydride thermosets 显示文摘 | Adrian Tomuta Francesc Ferrando Angels Serra | 2012 | Reac- tive & Functional Polymers2012，72，： | 1 |
| 10 | Optimization of the soniea- tion process for meloxicam nanocrystals preparation显示文摘 | Iurian S Tomuta I Rus L | 2015 | Clujul Med2015，88，3： | 1 |
| 11 | The magnetic susceptibility,specific heat and dielectric constant of hexagonal YMnO3,LuMnO3 and ScMnO3显示文摘 | Tomuta D G Ramakrishman S Nieuwenhugs G J | 2001 | J Phys Condens Matt2001，13，： | 1 |
| 12 | Diabetes-specific quality of life after a low-carbohydrate and low-fat dietary intervention 显示文摘 | Davis NJ Tomuta N Isasi CR | 2012 | Diabetes Edue2012，38，2： | 1 |
| 13 | High-Throughput NIR-Chemomet- ric Method for Meloxicam Assay from Powder Blends for Tableting 显示文摘 | Tomuta I Iovanov R Vonica AL | 2011 | Sci Pharm2011，79，： | 1 |
| 14 | High-throughput NIR-chemometric methods for determination of drug content and pharmaceutical properties of indapamide tablets 显示文摘 | Tomuta Ioan Rus Lucia Iovanov Rares | 2013 | Journal of Pharmaceutical and Biomedical Analysis2013，84，： | 1 |
| 15 | Comparatiye study of the effects of a 1-year dietary intervention of a low-carbohydrate diet versus a low-fat diet on weight and glycemic control in type 2 diabetes显示文摘 | Davis N J Tomuta N Schechter C | 2009 | Diabetes Care2009，32，： | 1 |
| 16 | High - throughput NIR -chemometric methods for determination of drug content and pharmaceutical properties of indapamide tablets 显示文摘 | TOMUTA I RUS L IOVANOV R | 2013 | J Pharm Bi- omed Anal2013，84，： | 1 |
| 17 | Fluidised bed granulation of two APIs:QbD approach and development of a NIR in-line monitoring method显示文摘The study focused on the fluid-bed granulation process of a product with two active pharmaceutical ingredients,intended for coated tablets preparation and further transfer to industrial scale.The work aimed to prove that an accurate control of the critical granulation parameters can level the input material variability and offer a user-friendly process control strategy.Moreover,an in-line Near-Infrared monitoring method was developed,which offered a real time overview of the moisture level along the granulation process,thus a reliable supervision and control process analytical technology(PAT)tool.The experimental design’s results showed that the use of apparently interchangeable active pharmaceutical ingredients(APIs)and filler sorts that comply with pharmacopoeial specifications,lead to different end-product critical attributes.By adapting critical granulation parameters(i.e.binder spray rate and atomising pressure)as a function of material characteristics,led to granules with average sizes comprised in a narrow range of 280–320μm and low nongranulated fraction of under 5%.Therefore,the accurate control of process parameters according to the formulation particularities achieved the maintenance of product within the design space and removed material related variability.To complete the Quality by design(QbD)strategy,despite its limited spectral domain,the microNIR spectrometer was successfully used as a robust PAT monitoring tool that offered a real time overview of the moisture level and allowed the supervision and control of the granulation process. | Alexandru Gavan Sonia Iurian Tibor Casian Alina Porfire Sebastian Porav Ioana Voina Alexandru Oprea Ioan Tomuta | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，4： | 0 |
| 18 | 1年低碳水化合物或低脂饮食干预对2型糖尿病患者体重和血糖的影响显示文摘该研究是一项对105名超重成年2型糖尿病患者的随机临床试验。研究的初级终点为体重和糖化血红蛋白(HbA1c),次级终点为血压和脂质代谢。分别在饮食干预后第3、6、12个月时对干预结果进行测量。结果显示,前3个月患者的体重和HbA1c下降最为明显,低碳水化合物饮食组较低脂饮食组体重减轻更快(P=0.005), | Davis NJ Tomuta N Schechter C | 2009 | 药品评价2009，，10： | 0 |
| 19 | Statins in risk-reduction and treatment of cancer显示文摘Statins,which are competitive inhibitors of 3-hydroxy-3-methyl-glutarylcoenzyme A reductase,reduce cholesterol blood levels and the risk of developing cardiovascular diseases and their related complications.In addition to this main activity,statins show pleiotropic effects such as antioxidant,anti-inflammatory and antiproliferative properties,with applications in many pathologies.Based on their antiproliferative properties,in vitro and in vivo studies have investigated their effects on various types of cancer(i.e.,breast cancer,prostate cancer,colorectal cancer,ovarian cancer,lung cancer)with different genetic and molecular characteristics.Many positive results were obtained,but they were highly dependent on the physiochemical properties of the statins,their dose and treatment period.Combined therapies of statins and cytotoxic drugs have also been tested,and synergistic or additive effects were observed.Moreover,observational studies performed on patients who used statins for different pathologies,revealed that statins reduced the risk of developing various cancers,and improved the outcomes for cancer patients.Currently,there are many ongoing clinical trials aimed at exploring the potential of statins to lower the mortality and the disease-recurrence risk.All these results are the foundation of new treatment directions in cancer therapy. | Cristina I Barbalata Lucia R Tefas Marcela Achim Ioan Tomuta Alina S Porfire | 2020 | World Journal of Clinical Oncology2020，11，8： | 0 |
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