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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | MATRIEX imaging:multiarea two-photon real-time in vivo explorer显示文摘Two-photon laser scanning microscopy has been extensively applied to study in vivo neuronal activity at cellular and subcellular resolutions in mammalian brains.However,the extent of such studies is typically confined to a single functional region of the brain.Here,we demonstrate a novel technique,termed the multiarea two-photon real-time in vivo explorer(MATRIEX),that allows the user to target multiple functional brain regions distributed within a zone of up to 12mm in diameter,each with a field of view(FOV)of ~200μm in diameter,thus performing two-photon Ca2+imaging with single-cell resolution in all of the regions simultaneously.For example,we demonstrate real-time functional imaging of single-neuron activities in the primary visual cortex,primary motor cortex and hippocampal CA1 region of mice in both anesthetized and awake states.A unique advantage of the MATRIEX technique is the configuration of multiple microscopic FOVs that are distributed in three-dimensional space over macroscopic distances(>1 mm)both laterally and axially but that are imaged by a single conventional laser scanning device.In particular,the MATRIEX technique can be effectively implemented as an add-on optical module for an existing conventional single-beam-scanning two-photon microscope without requiring any modification to the microscope itself.Thus,the MATRIEX technique can be readily applied to substantially facilitate the exploration of multiarea neuronal activity in vivo for studies of brain-wide neural circuit function with single-cell resolution. | Mengke Yang Zhenqiao Zhou Jianxiong Zhang Shanshan Jia Tong Li Jiangheng Guan Xiang Liao Bing Leng Jing Lyu Kuan Zhang Min Li Yan Gong Zhiming Zhu Junan Yan Yi Zhou Jian K Liu Zsuzsanna Varga Arthur Konnerth Yuguo Tang Jinsong Gao Xiaowei Chen Hongbo Jia | 2019 | Light(Science & Applications)2019，8，1： | 4 |
| 3 | A Study on the Reaction Mechanism of Bromocresol Green with Bovine Serum Albumin显示文摘AStudyontheReactionMechanismofBromocresolGreenwithBovineSerumAlbuminKenZhu;KeAnLI;ShenYangTONG(ChemistryDepartment,PekingUniv... | Zhu, K Li, KA Tong, SY | 1996 | Chinese Chemical Letters1996，7，11： | 2 |
| 4 | A study of lubricants on silver flakes for microelectronicsconductive adhesive 显示文摘 | Lu D Tong Q K Wong C P | 1999 | IEEE Trans Compon Packg Manuf Tech Part A1999，22，3： | 2 |
| 5 | Hepatocellular carcinoma xenograft supports HCV replication:A mouse model for evaluating antivirals显示文摘AIM: To develop a hepatocellular carcinoma (HCC) xenograft model for studying hepatitis C virus (HCV) replication in a mice, and antiviral treatment.METHODS: We developed a stable S3-green fluorescence protein (GFP) cell line that replicated the GFP-tagged HCV sub-genomic RNA derived from a highly efficient JFH1 virus. S3-GFP replicon cell line was injected subcutaneously into γ-irradiated SCID mice. We showed that the S3-GFP replicon cell line formed human HCC xenografts in SCID mice. Cells were isolated from subcutaneous tumors and then serially passaged multiple times in SCID mice by culturing in growth medium supplemented with G-418. The mouse-adapted S3-GFP replicon cells were implanted subcutaneously and also into the liver of SCID mice via intrasplenic infusion to study the replication of HCV in the HCC xenografts. The tumor model was validated for antiviral testing after intraperitoneal injection of interferon-α (IFN-α). RESULTS: A highly tumorigenic S3-GFP replicon cell line was developed that formed subcutaneous tumors within 2 wk and diffuse liver metastasis within 4 wk in SCID mice. Replication of HCV in the subcutaneous and liver tumors was confirmed by cell colony assay, detection of the viral RNA by ribonuclease protection assay and real-time quantitative reverse transcription polymerase chain reaction. High-level replication of HCV sub-genomic RNA in the tumor could be visualized by GFP expression using fluorescence microscopy. IFN-α cleared HCV RNA replication in the subcutaneous tumors within 2 wk and 4 wk in the liver tumor model. CONCLUSION: A non-infectious mouse model allows us to study replication of HCV in subcutaneous and metastatic liver tumors. Clearance of HCV by IFN-α supports use of this model to test other anti-HCV drugs. | Sidhartha Hazari Henry J Hefler Partha K Chandra Bret Poat Feyza Gunduz Tara Ooms Tong Wu Luis A Balart Srikanta Dash | 2011 | World Journal of Gastroenterology2011，17，3： | 2 |
| 6 | Thermophilic Aerobic Digestion - a Reliable and Effective Process for Sludge Treatment at Small Works 显示文摘 | Murray K C Tong A | 1990 | Wat Sci Tech1990，22，34： | 1 |
| 7 | Threshold autoregressJve limit cycles and cyclical data 显示文摘 | H Tong K S Lira | | Journal of the Royal Statistical Society0，980，3： | 1 |
| 8 | Diffuse axonal injury in children:clinical correlation with hemorrhagic lesions显示文摘 | Tong K A Ashwal S Holshpuser B A | 2004 | Ann Neurol2004，56，1： | 1 |
| 9 | Use of advanced neuroimaging techniques in the evaluation of pediatric traumatic brain injury (Review)显示文摘 | Ashwal S Holshouser B A Tong K A | 2006 | Dev Neurosci2006，28，45： | 1 |
| 10 | Age-invariant face recognition 显示文摘 | Unsang P Tong Yi-ying Jain A K | 2010 | IEEE Trans Pattern Anal Math Intell2010，32，5： | 1 |
| 11 | Single-index volatility models and estimation显示文摘 | Xia Y C Tong H Li W K | 2002 | Statistica Sinica2002，12，3： | 1 |
| 12 | Use of allopurinol in showing the propression of renal diseased through its ability to lower serum uric acid level显示文摘 | Sin Y Leung K Tong M | 2006 | Am J Kinduey Dis2006，47，1： | 1 |
| 13 | Non-structural Fuzzy Decision Support System for Evaluation of Construction Safety Management System显示文摘 | Tam C M Tong Thomas K L Chiu Gerald C W Fung Ivan W H | 2002 | International Journal of Project Management2002，，20： | 1 |
| 14 | Tacrolimus for induction therapy of diffuse proliferative lupus nephritis:an open-labeled pilot study显示文摘 | MOK C C TONG K H TOC H | 2005 | Kidney Int2005，68，2： | 1 |
| 15 | Correlation between FDG uptake by PET/CT and the expressions of glucose transport- er type I and hexokinase II in cervical cancer显示文摘 | Tong S Y Lee J M Ki K D | 2012 | Internation- al Journal of Gynecological Cancer2012，22，4： | 1 |
| 16 | Closed-loop pulsating heat pipe显示文摘 | Tong B Y Wong T N Ooi K T | 2001 | Applied Thermal Engineering2001，21，18： | 1 |
| 17 | FNS therapy for the functional restoration of the paralysed eyelid显示文摘 | Cao J Li L Tong K | 2009 | J Plast Reconstr Aesthet Surg2009，62，12： | 1 |
| 18 | Fluorescent liquid- crystal gels with electrically switchable photolumines- cence显示文摘 | TONG X ZHAO Y AN B K | 2006 | Advanced Functional Materials2006，16，： | 1 |
| 19 | Purification and characterization of antioxidative peptides from round scad ( Decapterus maruadsi) muscle protein hydrolysate 显示文摘 | Jiang H P Tong T Z Sun J H Xu Y J Zhao Z X Liao D K | 2014 | Food Chemistry2014，154，： | 1 |
| 20 | Spatiotemporal relationship between particle air pollution and respiratory emergency hospital admissions in Brisbane, Australia显示文摘 | Chen L Mengersen K Tong S | 2007 | Sci Total Environ2007，373，： | 1 |
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