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| 1 | Differing profiles of people diagnosed with acute and chronic hepatitis B virus infection in British Columbia,Canada显示文摘AIM To describe the characteristics of people diagnosed with acute and chronic hepatitis B virus(HBV) infection in British Columbia(BC).METHODS We used data from the BC Hepatitis Testers Cohort(BCHTC),which includes all individuals tested for hepatitis C virus(HCV) or human immunodeficiency virus(HIV) or those diagnosed with HBV or active tuberculosis in BC since 1990.These data were integrated with prescription drug,medical visit,hospitalization and mortality data.HBV cases were classified as acute or chronic according to provincial guidelines.We compared characteristics of individuals by HBV infection group(acute,chronic and negative).Factors associated with acute or chronic HBV infection were assessed with multinomial logistic regression models in comparison to the HBV negative group.RESULTS46498 of the 1058056 eligible BC-HTC participants were diagnosed with HBV infection.4.3% of HBV positive individuals were diagnosed with acute HBV infections while 95.7% had chronic infections.Problematic alcohol use,injection drug use,and HIV or HCV co-infection were more common among individuals diagnosed with acute HBV compared to those with chronic infections and HBV negative individuals.In multivariable multinomial logistic regression models,we observed significant associations between acute or chronic HBV diagnosis and being male,age at HBV diagnosis or birth cohort,South and East Asian ethnicity,HCV or HIV infection,and injection drug use.The odds of acute HBV decreased with increasing age among people who inject drugs,while the opposite was true for chronic HBV.Persons with acute HBV were predominantly White(78%) while those with chronic HBV were mostly East Asian(60%).Relative to Whites,East Asians had 12 times greater odds of being diagnosed with chronic HBV infection.These odds increased with increasing socioeconomic deprivation.CONCLUSION Differences in the profiles of people diagnosed with acute and chronic HBV infection necessitate differentiated screening,prevention,care and treatment programs. | Mawuena Binka Zahid A Butt Stanley Wong Mei Chong Jane A Buxton Nuria Chapinal Amanda Yu Maria Alvarez Maryam Darvishian Jason Wong Gina McGowan Mikhail Torban Mark Gilbert Mark Tyndall Mel Krajden Naveed Z Janjua | 2018 | World Journal of Gastroenterology2018，24，11： | 3 |
| 2 | Mutations in VANGL1 as-sociated withneural-tube defects显示文摘 | Kibar Z Torban E McDearmid JR | 2007 | N Engl J Med2007，356，： | 1 |
| 3 | Hes6 promotes cortical neurogenesis and inhibits Hesl transcription repression activity by multiple mechanisms 显示文摘 | Gratton MO Torban E Jasmin SB | 2003 | Mol Cell Biol2003，23，19： | 1 |
| 4 | PAX2 activates WNT4 expression during mammalian kidney developmen 显示文摘 | Torban E Dziarmaga A Iglesias D | 2006 | J Biol Chem2006，281，12： | 1 |
| 5 | Independent mutations in mouse Vangl2 that cause neural tube defects in loop-tail mine impair interaction with members of the Dishevelled family 显示文摘 | Torban E Wang HJ Groulx N Gins P | 2004 | J Biol Chem2004，279，52： | 1 |
| 6 | Mutations in VANGL1 associated with neural -tube defects 显示文摘 | Kibar Z Torban E McDearmid JR Reynolds A Berghout J Mathieu M Kirillova I De Marco P Merello E Hayes JM Wall- ingford JB Drapeau P Capra V Gros P | 2007 | N Engl J Med2007，356，14： | 1 |
| 7 | Mutations in VANGL1 associated with neural-tube defects显示文摘 | Kibar Z Torban E McDearmid JR | | 0，，： | 1 |
| 8 | Mutations in VANGL1 associated with neural tube defects显示文摘 | Kibar Z Torban E McDearmid JR | 2007 | N Engl J Med2007，356，14： | 1 |
| 9 | Genetic interaction between members of the Vangl family causes neural tube defects in mice 显示文摘 | Torban E Patenaude AM Leclerc S | 2008 | Proc Natl Acad Sci U S A2008，105，9： | 1 |
| 10 | Mutations in VANGL1 Associat- ed with Neural-Tube Defects显示文摘 | Zoha Kibar Elena Torban | 2007 | N Engl J Med2007，356，： | 1 |
| 11 | Tissue,cellular and sub-cellular localization of the Vang12 protein during embryonic development:effect of the Lp mutation显示文摘 | Torban E Wang HJ Patenaude AM | 2007 | Gene Expr Patterns2007，7，3： | 1 |
| 12 | Van Gogh - like2 (Strabismus) and its role in planar cell polarity and convergent extension in vertebrates 显示文摘 | Torban E Kor C Gros P | 2004 | Trends Genet2004，20，11： | 1 |
| 13 | Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family显示文摘 | Torban E Wang HJ Groulx N | 2004 | J Biol Chem2004，279，52： | 1 |
| 14 | Repression of the Retinoic Acid Receptor-alpha Gene by the Wilms'tumor Suppressor Gene Product显示文摘 | Goodyer P Dehbi M Torban E | 1995 | Oncogene1995，10，： | 1 |
| 15 | Mutations in VANGL1 associated with neural -tube defects显示文摘 | Kibar Z Torban E Mcdearmid JR | 2007 | N Engl J Med2007，356，14： | 1 |
| 16 | Mutations in Vangl1 associated with neural-tube defects显示文摘 | Kibar Z Torban E McDearmid JR | 2007 | N Engl J Med2007，356，14： | 1 |
| 17 | Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family显示文摘 | Torban E Wang HJ Groulx N | 2004 | J Biol Chem2004，279，52： | 1 |
| 18 | PAX2 activates WNT4 expression during mammalian kidney development显示文摘 | Torban E Dziarmaga A Iglesias D | 2006 | J Bioi Chern2006，281，12： | 1 |
| 19 | Genetic interaction between members of the Vangl family causes neural tube defects in mice显示文摘 | Torban E Patenaude AM Leclerc S | 2008 | Proc Natl Acad Sci S A2008，105，9： | 1 |
| 20 | Primary renal hypoplasia in humans and mice with PAX2 mutations:evidence of increased apoptosis in fetal kidneys of Pax2(1Neu)+/-mutant mice显示文摘 | Porteous S Torban E Cho NP | 2000 | Hum Mol Genet2000，9，1： | 1 |
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