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| 1 | Multicenter study of endoscopic preoperative biliary drainage for malignant distal biliary obstruction显示文摘AIM: To determine the optimal method of endoscopic preoperative biliary drainage for malignant distal biliary obstruction.METHODS: Multicenter retrospective study was conducted in patients who underwent plastic stent(PS) or nasobiliary catheter(NBC) placement for resectable malignant distal biliary obstruction followed by surgery between January 2010 and March 2012. Procedurerelated adverse events, stent/catheter dysfunction(occlusion or migration of PS/NBC, developmentof cholangitis, or other conditions that required repeat endoscopic biliary intervention), and jaundice resolution(bilirubin level < 3.0 mg/d L) were evaluated. Cumulative incidence of jaundice resolution and dysfunction of PS/NBC were estimated using competing risk analysis. Patient characteristics and preoperative biliary drainage were also evaluated for association with the time to jaundice resolution and PS/NBC dysfunction using competing risk regression analysis.RESULTS: In total, 419 patients were included in the study(PS, 253 and NBC, 166). Primary cancers included pancreatic cancer in 194 patients(46%), bile duct cancer in 172(41%), gallbladder cancer in three(1%), and ampullary cancer in 50(12%). The median serum total bilirubin was 7.8 mg/d L and 324 patients(77%) had ≥ 3.0 mg/d L. During the median time to surgery of 29 d [interquartile range(IQR), 30-39 d]. PS/NBC dysfunction rate was 35% for PS and 18% for NBC [Subdistribution hazard ratio(SHR) = 4.76; 95%CI: 2.44-10.0, P < 0.001]; the pig-tailed tip was a risk factor for PS dysfunction. Jaundice resolution was achieved in 85% of patients and did not depend on the drainage method(PS or NBC).CONCLUSION: PS has insufficient patency for preoperative biliary drainage. Given the drawbacks of external drainage via NBC, an alternative method of internal drainage should be explored. | Naoki Sasahira Tsuyoshi Hamada Osamu Togawa Ryuichi Yamamoto Tomohisa Iwai Kiichi Tamada Yoshiaki Kawaguchi Kenji Shimura Takero Koike Yu Yoshida Kazuya Sugimori Shomei Ryozawa Toshiharu Kakimoto Ko Nishikawa Katsuya Kitamura Tsunao Imamura Masafumi Mizuide Nobuo Toda Iruru Maetani Yuji Sakai Takao Itoi Masatsugu Nagahama Yousuke Nakai Hiroyuki Isayama | 2016 | World Journal of Gastroenterology2016，22，14： | 18 |
| 2 | 上海市社区人群阿尔茨海默病与载脂蛋白E基因的关联分析显示文摘目的 探讨上海地区社区老年人群中阿尔茨海默病 (AD)与载脂蛋白E(ApoE)ε4 等位基因之间的关联性。方法 应用聚合酶链反应扩增技术及限制性片断长度多态性技术对上海某一社区的 6 3例AD患者、35例血管性痴呆 (VD)患者、71例可疑痴呆 (QD)患者及 36 9名非痴呆者 (不符合痴呆诊断、认知功能无缺陷者 ,对照组 )的ApoE基因进行分型 ,计算各组基因型频数的分布、基因频率及ApoEε4 基因的剂量 ,对AD与ApoE基因多态性进行了关联分析。结果 (1)AD组中含ApoEε4 基因者比例 (47 6 % )明显高于对照组 (2 0 9% ) ,AD组ApoEε4 基因频率 (2 6 2± 3 9) %明显高于对照组(10 5± 1 1) % ,P均 <0 0 1;(2 )从AD与ApoEε4 基因剂量效应来看 ,随着ApoEε4 基因剂量增加 ,不含ApoEε4 、含 1个和含 2个ApoEε4 的AD患病比率 (分别为 9 3%、2 5 %和 5 0 % )明显上升 ;(3)AD组与对照组比较 ,ApoEε4 基因型的比数比为 2 2 8倍 (P <0 0 5 ) ,其 95 %的可信区间为 1 32~ 3 97,归因危险度为 5 6 %。结论 中国上海社区人群AD的发病与ApoEε4 | 陆峥 江三多 张明园 冯国鄞 Robert Katzman Tsunao Saitok | 2001 | 中华精神科杂志2001，34，1： | 10 |
| 3 | Involvement of IL-17A in the pathogenesis of DSS-induced colitis in mice显示文摘 | Reiko Ito Masakazu Kita Masaharu Shin-Ya Tsunao Kishida Atsuyo Urano Ryusuke Takada Junichi Sakagami Jiro Imanishi Yoichiro Iwakura Takeshi Okanoue Toshikazu Yoshikawa Keisho Kataoka Osam Mazda | 2008 | Biochemical and Biophysical Research Communications2008，，1： | 1 |
| 4 | Hydrodynamic characterization and performance evaluation of an aerobic three phase airlift fluidized bed reactor in a recirculation aquaculture system for Nile Tilapia production显示文摘 | Iván Andrés Sánchez O. Tsunao Matsumoto | 2011 | Aquacultural Engineering2011，，： | 1 |
| 5 | Hydrodynamic characterization and performance evaluation of an aerobic three phase airlift fluidized bed reactor in a recirculation aquaculture system for nile tilapia production 显示文摘 | IVANANDRES SANCHEZ O TSUNAO MATSUMOTO | 2012 | Aquaculture Engineering2012，47，： | 1 |
| 6 | Efffect of IS-741 on ethionine-induced acute pancreatitis in rats:ralation to pancreatic acinar cell regeneration 显示文摘 | Tsunao Imamura Junichi Niikawa Katsuya Kitamura | 2003 | Journal of Gastroenterology2003，28，： | 1 |
| 7 | Significant antitumor effects obtained by autologous tumor cell vaccine engineered to secrete Interleukin(IL)-12 and IL-8 by means of the EBW lipoplex显示文摘 | Asada H Kishida Tsunao | 2002 | Mol Ther2002，5，51： | 1 |
| 8 | Hydrodynamic characterization and performance evaluation of an aerobic three phase airlift fluidized bed reactor in a recirculation aquaculture system for Nile Tilapia production显示文摘 | Iván Andrés Sánchez O Tsunao Matsumoto | 2012 | Aquacultural Engineering2012，47，： | 1 |
| 9 | Iridoid glu- eosides from Vibumttm suspensum 显示文摘 | Tetsuo Iwagawa Shigetoshi Yaguchi Tsunao Hase | 1990 | Phytochemistry1990，29，： | 1 |
| 10 | 查看详情显示文摘 | Miwa K Yasuo W Yusuke H Tsunao O Ryoji T | | 0，，： | 1 |
| 11 | Significance of measurement of high-sensitivity C-reactive protein in acute pancreatitis 显示文摘 | Tsunao Imamura Shigeki Tanaka Hitoshi Yoshida | 2002 | Journal of Gastroenterology2002，37，11： | 1 |
| 12 | 胰岛素球显示文摘2005年8月,一62岁患1型糖尿病20年的日本男性,为了对明显的胰岛素抵抗进行检查而人住我院。其从2004年1月开始应用胰岛素,包括长效型(甘精胰岛素)和短效型(赖脯胰岛素),每天共66u。尽管剂量逐渐增加到每天94u,其血糖浓度仍很高,血糖控制不佳。 | Terumasa Nagase Yoshiyo Katsura Yoshiki Iwaki Kenji Nemoto Hidenori Sekine Kazuhiro Miwa Tsunao Oh-i Keni Kou Keiichi lwaya Masayuki Noritake Takeshi Matsuoka 郭占宏(译) | 2009 | 世界临床医学2009，，10： | 0 |
| 13 | Solid pseudopapillary neoplasm of the pancreas in a young male with main pancreatic duct dilatation: A case report显示文摘BACKGROUND Solid pseudopapillary neoplasms(SPNs)are rare tumors of the pancreas.Typically,they occur in young females,often have characteristic imaging features,such as cystic components and calcification,and have few effects on the pancreatic duct.CASE SUMMARY A 31-year-old man was admitted to our hospital with the chief complaint of epigastric pain.There was only mild tenderness in his upper abdomen,and blood tests showed only a slight increase in alkaline phosphatase.Contrast-enhanced computed tomography showed a 40-mm-diameter,hypovascular mass in the head of the pancreas,and the main pancreatic duct upstream of the mass was severely dilated.Magnetic resonance imaging showed low intensity on T1-weighted images,with high intensity on T2-weighted image in some parts.Pancreatic ductal adenocarcinoma was the primary differential diagnosis.Portal vein infiltration could not be ruled out,so this case was a candidate for neoadjuvant chemotherapy.Subsequently,endoscopic ultrasound-guided fine needle aspiration was performed,and pathological evaluation and immunostaining suggested a diagnosis of SPN.Thus,pancreatoduodenectomy was performed.One year after the operation,the patient is alive with no recurrence.CONCLUSION Main pancreatic duct dilatation is usually a finding of suspected pancreatic cancer.However,pancreatic duct dilatation can occur in SPN depending on the location and growth speed.Therefore,SPN should be considered in the differential diagnosis of tumors with pancreatic duct dilatation,and pathological evaluation by endoscopic ultrasound-guided fine needle aspiration should be actively performed. | Saki Nakashima Yoshiki Sato Tsunao Imamura Daisuke Hattori Tetsuo Tamura Rikako Koyama Junichiro Sato Yuta Kobayashi Masaji Hashimoto | 2021 | World Journal of Clinical Cases2021，9，36： | 0 |
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