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| 1 | Criteria for the diagnosis and severity stratification of acute pancreatitis显示文摘Recent diagnostic and therapeutic progress for severe acute pancreatitis(SAP)remarkably decreased the casemortality rate.To further decrease the mortality rate of SAP,it is important to precisely evaluate the severity at an early stage,and initiate appropriate treatment as early as possible.Research Committee of Intractable Diseases of the Pancreas in Japan developed simpler criteria combining routinely available data with clinical signs.Severity can be evaluated by laboratory examinations or by clinical signs,reducing the defect values of the severity factors.Moreover,the severity criteria considered laboratory/clinical severity scores and contrastenhanced computed tomography(CE-CT)findings as independent risk factors.Thus,CE-CT scans are not necessarily required to evaluate the severity of acute pancreatitis.There was no fatal case in mild AP diagnosed by the CE-CT severity score,whereas case-mortality rate in those with SAP was 14.8%.Case-mortality of SAP that fulfilled both the laboratory/clinical and the CE-CT severity criteria was 30.8%.It is recommended,therefore,to perform CE-CT examination to clarify the prognosis in those patients who were diagnosed as SAP by laboratory/clinical severity criteria.Because the mortality rate of these patients with SAP is high,such patients should be transferred to advanced medical units. | Makoto Otsuki Kazunori Takeda Seiki Matsuno Yasuyuki Kihara Masaru Koizumi Masahiko Hirota Tetsuhide Ito Keisho Kataoka Motoji Kitagawa Kazuo Inui Yoshifumi Takeyama | 2013 | World Journal of Gastroenterology2013，19，35： | 24 |
| 2 | Eight-year survival after advanced gastric cancer treated with S-1 followed by surgery显示文摘We report a case of advanced gastric cancer, with cervical, axillary, and abdominal paraaortic lymph node metastases, that was successfully treated with chemotherapy and surgery. The disease was initially considered unresectable, and the patient was treated with orally administered S-1. Chemotherapy was effective, and all lymph node metastases disappeared after 6 courses. After 27 mo of chemotherapy, the patient underwent curative surgery, with subtotal gastrectomy and lymph node dissection. Histopathological examination revealed many viable poorly differentiated adenocarcinoma cells in the stomach, but no cancer cells in the lymph nodes. The patient is alive, without recurrence, 8 years later. This, therefore, is a case report of an 8-year survivor of advanced gastric cancer with distant lymph node metastasis. | Susumu Hijioka Keisho Chin Yasuyuki Seto Noriko Yamamoto Kiyohiko Hatake | 2010 | World Journal of Gastroenterology2010，16，22： | 10 |
| 3 | Consensus of primary care in acute pancreatitis in Japan显示文摘在日本的尖锐胰腺炎的发生正在增加并且每百万张人口从 187 ~ 347 个盒子。盒子命运是 0.2% 为对温和中等,并且 9.0% 为在在 2003 的日本的严重尖锐胰腺炎。在日本的胰腺炎的专家做了与尖锐胰腺炎在病人的早管理集中于实际方面的这个文件。尖锐胰腺炎和严厉层化的正确诊断应该为尖锐胰腺炎的诊断用标准在所有病人被做并且多,因素得分系统尽早由胰的难处理的疾病的研究委员会求婚了。与尖锐胰腺炎诊断的所有病人应该在医院里被管理。血压监视,脉搏和呼吸率,体温,时时尿的体积,和血氧饱和水平在如此的病人的管理是必要的。早精力旺盛的静脉内的水和具有最前的重要性稳定循环动力学。有鸦片剂的足够的疼痛地势也是重要的。在严重尖锐胰腺炎,在一个早阶段的抗菌素的预防静脉内的管理被推荐。一旦尖锐胰腺炎的诊断被证实,朊酶禁止者的管理应该被开始。如果没有肠塞痛并且胃肠的流血的清楚的症状,从早舞台用非肠道的营养喂的肠内的联合被推荐。有严重尖锐胰腺炎的病人应该尽早被转移到 ICU 执行象朊酶的连续地区性的动脉的注入那样的特殊措施禁止者和抗菌素,和连续牙齿过敏过滤。日本政府为难处理的疾病作为关于措施的研究的工程之一为严重尖锐胰腺炎盖住医疗保健开销。 | Makoto Otsuki Masahiko Hirota Shinju Arata Masaru Koizumi Shigeyuki Kawa Terumi Kamisawa Kazunori Takeda Toshihiko Mayumi Motoji Kitagawa Tetsuhide Ito Kazuo Inui Tooru Shimosegawa Shigeki Tanaka Keisho Kataoka Hiromitsu Saisho Kazuichi Okazaki Yosikazu Kuroda Norio Sawabu Yoshifumi Takeyama | 2006 | World Journal of Gastroenterology2006，12，21： | 9 |
| 4 | Usefulness of urinary trypsinogen-2 and trypsinogen activation peptide in acute pancreatitis:A multicenter study in Japan显示文摘BACKGROUND Rapid urinary trypsinogen-2 dipstick test and levels of urinary trypsinogen-2 and trypsinogen activation peptide(TAP) concentration have been reported as prognostic markers for the diagnosis of acute pancreatitis.AIM To reconfirm the validity of all these markers in the diagnosis of acute pancreatitis by undertaking a multi-center study in Japan.METHODS Patients with acute abdominal pain were recruited from 17 medical institutions in Japan from April 2009 to December 2012. Urinary and serum samples were collected twice, at enrollment and on the following day for measuring target markers. The diagnosis and severity assessment of acute pancreatitis were assessed based on prognostic factors and computed tomography(CT) Grade of the Japanese Ministry of Health, Labour, and Welfare criteria.RESULTS A total of 94 patients were enrolled during the study period. The trypsinogen-2 dipstick test was positive in 57 of 78 patients with acute pancreatitis(sensitivity,73.1%) and in 6 of 16 patients with abdominal pain but without any evidence of acute pancreatitis(specificity, 62.5%). The area under the curve(AUC) score of urinary trypsinogen-2 according to prognostic factors was 0.704, which was highest in all parameter. The AUC scores of urinary trypsinogen-2 and TAP according to CT Grade were 0.701 and 0.692, respectively, which shows higher than other pancreatic enzymes. The levels of urinary trypsinogen-2 and TAP were significantly higher in patients with extended extra-pancreatic inflammation as evaluated by CT Grade.CONCLUSION We reconfirmed urinary trypsinogen-2 dipstick test is useful as a marker for the diagnosis of acute pancreatitis. Urinary trypsinogen-2 and TAP may be considered as useful markers to determine extra-pancreatic inflammation in acute pancreatitis. | Hiroaki Yasuda Keisho Kataoka Yoshifumi Takeyama Kazunori Takeda Tetsuhide Ito Toshihiko Mayumi Shuji Isaji Tetsuya Mine Motoji Kitagawa Seiki Kiriyama Junichi Sakagami Atsushi Masamune Kazuo Inui Kenji Hirano Ryukichi Akashi Masamichi Yokoe Yoshio Sogame Kazuichi Okazaki Chie Morioka Yasuyuki Kihara Shigeyuki Kawa Masao Tanaka Akira Andoh Wataru Kimura Isao Nishimori Junji Furuse Isao Yokota Tooru Shimosegawa | 2019 | World Journal of Gastroenterology2019，25，1： | 7 |
| 5 | Clear cell adenocarcinoma of the colon:A case report and review of literature显示文摘A primary clear cell adenocarcinoma of the colon is a rare oncologic entity. We herein report a case of such a tumor of the sigmoid colon in a 71-year-old woman who was successfully treated by an endoscopic polypectomy in our hospital. We also reviewed the published reports regarding cases of primary clear cell tumors in the colon. | Koichi Soga Hideyuki Konishi Natsuko Tatsumi Chika Konishi Keimei Nakano Naoki Wakabayashi Shoji Mitsufuji Keisho Kataoka Takeshi Okanoue Ken-Ichi Mukaisho Takanori Hattori | 2008 | World Journal of Gastroenterology2008，14，7： | 4 |
| 6 | Detection of BCL2-IGHrearrangement on paraffin-embedded tissue sections obtained from a small submucosal tumor of the rectum in a patient with recurrent follicular lymphoma显示文摘A 59-year-old woman was admitted to our hospital because of recurrent follicular lymphorna (FL). Colonoscopic examination revealed a rectal submucosal tumor (SMT) without any erosions and ulcers. In this patient, it was difficult to distinguish non-Hodgkin's lymphoma (NHL) invasion from other disorders of the colon including carcinoid tumor merely based on endoscopic findings. Histopathologic and immunohistochemical studies on biopsy specimens showed an infiltration of atypical lymphocytes that were positive for CD20 and BCL2 but negative for UCHL-1. Fluorescence in situ hybridization on paraffin-embedded tissue sections (T-FISH) identified a translocation of BCL2 with IGHgene.Based on these findings, the tumor was defined as an invasion of FL. T-FISH method is useful for the detection of a monoclonality of atypical lymphocytes in an SMT of the gastrointestinal tract, and particularly for the detection of chromosomal translocations specific to lymphoma subtypes. | Naohisa Yoshida Kenichi Nomura Yosuke Matsumoto Kazuhiro Nishida Naoki Wakabayashi Hideyuki Konishi Shoji Mitsufuji Keisho Kataoka Takeshi Okanoue Masafumi Taniwaki | 2004 | World Journal of Gastroenterology2004，10，17： | 3 |
| 7 | Lack of evidence for leukocyte maternal microchimerism in primary biliary cirrhosis显示文摘It is reasonable to assume that microchimerism could also be involved in the induction of primary biliary cirrhosis (PBC). However, previous reports investigated only fetus-microchimerism in women patients. Maternal microchimerism has not been investigated until now.The current study aimed to clear either maternal microchimerism was involved in the pathogenesis of PBC or not.METHODS: We used fluorescence in situ hybridization on paraffin-embedded tissue (We called 'Tissue-FiSH'.) to determine whether maternal cells infiltrated in male patients who were diagnosed as having PBC. Tissue-FiSH was performed by using both X and Y specific probes on the biopsy liver sample of 3 male PBC patients.RESULTS: Infiltrating lymphocytes demonstrated both X and Y signals in all 3 male patients.CONCLUSION: Maternal microchimerism dose not play asignificant role in PBC. PBC may not relate to fetus and maternal microchimerism. | Kenichi Nomura Yoshio Sumida Takaharu Yoh Atsuhiro Morita Yosuke Matsumoto SawakoTaji NaohisaYoshida MasahitoMinami YoshitoItoh ShigeoHoriike Keisho Kataoka Masafumi Taniwaki Takeshi Okanoue | 2004 | World Journal of Gastroenterology2004，10，16： | 2 |
| 8 | The revised Japanese clinical diagnostic criteria for chronic pancreatitis显示文摘 | Tooru Shimosegawa Keisho Kataoka Terumi Kamisawa Hiroyuki Miyakawa Hirotaka Ohara Tetsuhide Ito Satoru Naruse Naohiro Sata Koichi Suda Morihisa Hirota Yoshifumi Takeyama Keiko Shiratori Takashi Hatori Makoto Otsuki Yutaka Atomi Kentaro Sugano Masao Tanaka | 2010 | Journal of Gastroenterology2010，，6： | 2 |
| 9 | Involvement of IL-17A in the pathogenesis of DSS-induced colitis in mice显示文摘 | Reiko Ito Masakazu Kita Masaharu Shin-Ya Tsunao Kishida Atsuyo Urano Ryusuke Takada Junichi Sakagami Jiro Imanishi Yoichiro Iwakura Takeshi Okanoue Toshikazu Yoshikawa Keisho Kataoka Osam Mazda | 2008 | Biochemical and Biophysical Research Communications2008，，1： | 1 |
| 10 | Post-ERCP pancreatitis显示文摘 | Shinju Arata Tadahiro Takada Koichi Hirata Masahiro Yoshida Toshihiko Mayumi Morihisa Hirota Masamichi Yokoe Masahiko Hirota Seiki Kiriyama Miho Sekimoto Hodaka Amano Keita Wada Yasutoshi Kimura Toshifumi Gabata Kazunori Takeda Keisho Kataoka Tetsuhide It | 2010 | Journal of Hepato-Biliary-Pancreatic Sciences2010，，1： | 1 |
| 11 | Endoscopic Injection Sclerotherapy with Ethanolamine Oleate with Iopamidol for Esophagojejunal Varices in Idiopathic Portal Hypertension显示文摘 | Koichi Soga Koichi Tomikashi Ki-ichiro Miyawaki Kotaro Okuda Yusuke Sugiyama Shuji Sekikawa Naoki Wakabayashi Hideyuki Konishi Shoji Mitsufuji Keisho Kataoka Toshikazu Yoshikawa | 2009 | Digestive Diseases and Sciences2009，，7： | 1 |
| 12 | Adenoendocrine cell carcinoma of the gallbladder clinically mimicking squamous cell carcinoma显示文摘 | Hiroya Taniguchi Junichi Sakagami Norihisa Suzuki Hirohito Hasegawa Misumi Shinoda Masatoshi Tosa Takehiko Baba Hiroaki Yasuda Keisho Kataoka Toshikazu Yoshikawa | 2009 | International Journal of Clinical Oncology2009，，2： | 1 |
| 13 | Assessment of severity of acute pancreatitis according to new prognostic factors and CT grading显示文摘 | Kazunori Takeda Masamichi Yokoe Tadahiro Takada Keisho Kataoka Masahiro Yoshida Toshifumi Gabata Masahiko Hirota Toshihiko Mayumi Masumi Kadoya Eigoro Yamanouchi Takayuki Hattori Miho Sekimoto Hodaka Amano Keita Wada Yasutoshi Kimura Seiki Kiriyama Shinju | 2010 | Journal of Hepato - Biliary - Pancreatic Sciences2010，，1： | 1 |
| 14 | Effect of prolonged intraluminal α-amylase inhibition on eating, weight, and the small intestine of rats显示文摘 | Keisho Kataoka Eugene P DiMagno | 1999 | Nutrition1999，，2： | 1 |
| 15 | Post-ERCP pancreatitis显示文摘 | Shinju Arata Tadahiro Takada Koichi Hirata Masahiro Yoshida Toshihiko Mayumi Morihisa Hirota Masamichi Yokoe Masahiko Hirota Seiki Kiriyama Miho Sekimoto Hodaka Amano Keita Wada Yasutoshi Kimura Toshifumi Gabata Kazunori Takeda Keisho Kataoka Tetsuhide It | 2010 | Journal of Hepato - Biliary - Pancreatic Sciences2010，，1： | 1 |
| 16 | Serum squamous cell carcinoma antigen is a predictive factor of outcomes in patients with locally advanced unresectable esophageal squamous cell carcinoma treated by definitive chemoradiotherapy显示文摘Aim:Definitive chemoradiotherapy(dCRT)is the standard treatment for locally advanced unresectable esophageal squamous cell carcinoma(LU-ESCC).This study aimed to describe the results of dCRT for T4 ESCC and evaluate the pretherapeutic predictive factors of the outcomes.Methods:A total of 133 patients with T4 ESCC who received dCRT were grouped into those who achieved a complete response(CR)or those who had residual disease(RD).The clinicopathologic variables were compared between the groups and the overall survival(OS)was evaluated.The predictive factor of RD was assessed and the prognostic factor for OS was identified.Results:Among the 133 patients,31(23%)achieved CR.The CR group had a significantly better OS than the RD group(89.9 months vs.10.7 months;hazard ratio=0.096;95%confidence interval:0.05-0.19;P<0.001).Multivariate analysis showed that a supracarinal tumor(OR=3.21;P=0.016),higher pretherapeutic serum SCC-Ag level(>1.6 ng/mL)(OR=2.86;P=0.018),and metastatic node invasion(OR=3.19;P=0.048)were independent predictors of RD.The increased level of pretherapeutic serum squamous cell carcinoma antigen(>1.6 ng/mL)(OR=1.61;P=0.022)was an independent predictor of poor survival.Conclusions:Among the patients who underwent dCRT for LU-ESCC,23%achieved CR,and the long-term outcome of these patients was favorable.Increased levels of pretherapeutic serum squamous cell carcinoma antigen were also found to be predictive of treatment failure. | Takeshi Suzuki Akihiko Okamura Masayuki Watanabe Takao Asari Izuma Nakayama Mariko Ogura Akira Ooki Daisuke Takahari Kensei Yamaguchi Keisho Chin | 2022 | Journal of Cancer Metastasis and Treatment2022，8，1： | 0 |
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