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| 1 | 西地那非能改善慢性肾功能衰竭大鼠的勃起功能显示文摘勃起功能障碍(ED)和慢性肾衰竭(CRF)之间的关系已在几个研究中被报道。本研究旨在探讨长期使用西地那非是否能增强CRF诱导大鼠的勃起能力。此外,我们评估了该治疗对某些分子的影响,这些分子被认为在勃起生理学及CRF相关的ED中起关键作用。研究分三组:(1)年龄配对的对照组,(2)CRF诱导的大鼠模型组,(3)CRF诱导大鼠给予西地那非慢性给药组((5 mg /kg口服6周[CRF诱导后6周开始治疗])。 3个月时,所有的动物进行海绵体神经刺激(CNS)来评估勃起功能。在所有大鼠组进行,阴茎组织晚期糖化终产物(AGE的) / 5-羟甲基-2-糠醛,丙二醛(MDA),cGMP(ELISA),诱导型一氧化氮合酶(iNOS)和神经元型NOS(nNOS的)(Western印迹)分析。CRF诱导大鼠与对照组相比,勃起功能有显著降低(P 〈0.05)。CRF诱导大鼠西地那非治疗组(第3组),海绵体内压(ICP)和曲线下面积的
增加量,大于CRF诱导大鼠组(第2组)。此外,西地那非治疗下调了AGE,MDA和iNOS的水平,同时保持了CRF诱导阴茎组织的nNOS和cGMP含量。西地那非治疗组AGE,MDA,iNOS的下降和nNOS,cGMP水平的增加,增加了ICP和海绵体神经刺激(CNS)的总ICP,使得CRF诱导大鼠阴茎勃起功能得到改善。本研究的结果表明慢性西地那非给药对CRF诱导大鼠的勃起功能有治疗效果。 | Nilgun Gurbuz Arif Kol Tumay Ipekci Erhan Ates Asli Baykal Mustafa F Usta | 2015 | Asian Journal of Andrology2015，17，5： | 3 |
| 2 | Horizontal transmission of hepatitis B virus in children with chronic hepatitis B显示文摘AIM: To determine the possible routes of intrafamilial transmission pattern in pediatric cases of chronic hepatitis B virus (HBV) infection.METHODS: In this descriptive retrospective study, 302 children with chronic HBV infection from 251 families and their parents attending the Social Security Children's Hospital and Doctor Sami Ulus Children's Hopsital in Ankara between December 1998 and May 2000, were enrolled in. Screenings and diagnosis of chronic HBV infections were established according to the Consensus 2000.RESULTS: In the studied 302 children with chronic HBV infection, mothers of 38% and fathers of 23% were HBsAg positive. The HBsAg positivity in at least two siblings of the same family was 61% when both parents were HBsAg positive.CONCLUSION: It is well known that horizontal transmission is quite common in countries where Hepatitis B Virus is moderately endemic. To our best knowledge, this is the largest series observed regarding the horizontal transmission in pediatric chronic HBV infection in Turkey. It is necessary to expand the preventive programs to target not only the newborn period but also all stages of childhood. | Tumay Doganci Gulnar Uysal Tayfun Kir Arzu Bakirtas Necdet Kuyucu Levent Doganci | 2005 | World Journal of Gastroenterology2005，11，3： | 2 |
| 3 | Interfaceproperties of sands显示文摘 | Acer Y B Durgunoglu H T Tumay M T | 1982 | Journal of Geotechnical Engineering1982，108，4： | 2 |
| 4 | Quantificationand simulation of particle kinematics and local strainin granular materials using X-ray tomography ima-ging and discrete- element method显示文摘 | YR Fu LB Wang MT Tumay | 2008 | Journal of En-gineering Mechanics2008，134，2： | 1 |
| 5 | Finite- element analysis of inclined piezocone penetration test in clays显示文摘 | WEI L ABU-FARSAKH M Y TUMAY M T | 2004 | International Journal of Geomechanics American Society of Civil Engineers2004，5，3： | 1 |
| 6 | Statistical to fuzzy approach toward CtrF soil classification 显示文摘 | Zhang Z Tumay M T | 1999 | Journal of Geoteehnieal and Geoenvironmental Engineering: ASCE1999，125，3： | 1 |
| 7 | Histopathologic evalua- tion of neurovascular bundles and periprostatic tissue in interfas-cial and intrafascial nerve-sparing radical prostatectomy tech- nique: A cadaveric anatomic study 显示文摘 | Murat MR Mursel D Tumay O | 2013 | Urology2013，82，： | 1 |
| 8 | Quantification and simulation of particle kinematics and local strains in granular materials using X-ray tomography imaging and discrete-element method 显示文摘 | Fu Yanrong Wang Linbing Tumay Mehmet T | 2008 | Journal of Engineering Mechanics2008，134，2： | 1 |
| 9 | Interaction of fibroneetin with human colon adenocareinoma cells: effect on the in viva tumorigenic capacity显示文摘 | Lopez-Conejo MT Olmo N Tumay J | 2002 | Oncology2002，62，4： | 1 |
| 10 | Structural and physical properties of gelatin extracted from different marine species: a comparative study显示文摘 | GOMEZ-GUILLEN M C TUMAY J FEMANDEZ-DIAZ M D | 2002 | Food Hydrocolloids2002，16，1： | 1 |
| 11 | Fast sag/swell detection method for fuzzy logic controlled dynamic voltage restorer显示文摘 | Take A Bayindir K Tumay M | 2009 | The Institution of Engineering and Technology2009，4，1： | 1 |
| 12 | Serum annexin A2 levels in patients with colon cancer in comparison to healthy controls and in relation to tumor pathology显示文摘 | Guduler E Guner OS Tumay LV | 2014 | Med Sci Monit2014，20，： | 1 |
| 13 | Differentiation of hu-man colon adenocarcinoma cells alters the expression and intracellularlocalization of annexins Al,A2,and A5 显示文摘 | Guzmdn-Ar6nguez A Olmo N Tumay J | 2005 | J Cell Biochem2005，94，1： | 1 |
| 14 | Interface properties of sands显示文摘 | Acer Y B Durgunoglu H T Tumay M T | 1982 | Journal of the Geotechnieal Engineering Division1982，108，4： | 1 |
| 15 | Modeling business processes with simulation tools显示文摘 | TUMAY K | 1994 | Proceeding of the1994，，： | 1 |
| 16 | Sequence reference frame-based new sag/swell detection method for static transfer switches显示文摘 | TUMAY M MERAL M E BAYINDIR K C | 2009 | IET Power Electronics2009，2，4： | 1 |
| 17 | Quantification and simulation of particle kinematics and local strain in granular materials using X-ray tomography imaging and discrete-element method显示文摘 | Fu Y R Wang L B Tumay M T | 2008 | Journal of Engineering Mechanics2008，134，2： | 1 |
| 18 | The effects of levetiracetam, carbamazepine, and sodium valproate on P100 and P300 in epileptic patients 显示文摘 | Tumay Y Mtun Y Ekmekci K | 2013 | Clin Neuropharmacol2013，6，2： | 1 |
| 19 | Sonographic diagnosis of ascariasis causing small bowel obstruction显示文摘 | Ramazan Aydin Tumay Bekci Meltem Ceyhan Bilgici Ahmet Veysel Polat | 2014 | J Clin Ultrasound2014，，4： | 1 |
| 20 | The Protective Effect of Ebselen on Radiocontrast-Induced Nephrotoxicity显示文摘 | Tumay Ozgur Murat Tutanc Ismail Zararsiz Sedat Motor Oktay Hasan Ozturk Mehmet Yaldiz Ozgur Yildirim Kurtgoz | 2012 | Renal Failure2012，，8： | 1 |
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