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| 1 | Multi-platform omics analysis reveals molecular signature for COVID-19 pathogenesis,prognosis and drug target discovery显示文摘Disease progression prediction and therapeutic drug target discovery for Coronavirus disease 2019(COVID-19)are particularly important,as there is still no effective strategy for severe COVID-19 patient treatment.Herein,we performed multi-platform omics analysis of serial plasma and urine samples collected from patients during the course of COVID-19.Integrative analyses of these omics data revealed several potential therapeutic targets,such as ANXA1 and CLEC3B.Molecular changes in plasma indicated dysregulation of macrophage and suppression of T cell functions in severe patients compared to those in non-severe patients.Further,we chose 25 important molecular signatures as potential biomarkers for the prediction of disease severity.The prediction power was validated using corresponding urine samples and plasma samples from new COVID-19 patient cohort,with AUC reached to 0.904 and 0.988,respectively.In conclusion,our omics data proposed not only potential therapeutic targets,but also biomarkers for understanding the pathogenesis of severe COVID-19. | Yuming Li Guixue Hou Haibo Zhou Yanqun Wang Hein Min Tun Airu Zhu Jingxian Zhao Fei Xiao Shanwen Lin Dongdong Liu Dunrong Zhou Lang Mai Lu Zhang Zhaoyong Zhang Lijun Kuang Jiao Guan Qiushi Chen Liyan Wen Yanjun Zhang Jianfen Zhuo Fang Li Zhen Zhuang Zhao Chen Ling Luo Donglan Liu Chunke Chen Mian Gan Nanshan Zhong Jincun Zhao Yan Ren Yonghao Xu | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 1 |
| 2 | Thoracic interstitial injection of drug-liposomes in mice for treating atherosclerosis显示文摘Intervaginal space injection(ISI)is a novel mode of administration investigated over the last decade.After injecting nanoparticles into the intervaginal space,they can be transported along low flow resistance channels into the interstitial space.This transport has a certain delivery direction,and site-specific injection can work on specific organs or tissues.In this study,the thorax,a new ISI site in the interstitial surrounding the internal thoracic artery named the thoracic interstitial injection(tISI)was investigated.To prove the targeting ability of the tISI,two sizes of gold nanoparticles(AuNPs)(47 and 87 nm)were administered to mice.After 1 h,the biodistribution of AuNPs in the tissues was measured via single particle inductively coupled plasma mass spectrometry(spICP-MS).The results showed that the concentration of AuNPs in the aorta after tISI injection was significantly higher than that after intravenous injection.Moreover,fewer nanoparticles with larger particle sizes were observed to have entered the blood and were better targeted to the aorta.Thereafter,tanshinone IIa sodium sulfonate liposomes were administered for the treatment of aortic atherosclerosis.The proportion of aortic plaques in atherosclerotic Apoe-/-mice administered via tISI was significantly lower than that in other model animals(P<0.001).Furthermore,the proteoglycan content and CD68-positive cell count in the plaques were significantly reduced.The vascular elastic fibers at the plaque site were thickened,and fractures were reduced.tISI was,therefore,determined to be an effective strategy for the treatment of atherosclerotic aortic plaques. | Tun Yan Huizhen Sun Yahong Shi Ya Gao Xi Lu Kai Li Yuting Zhu Qiang Zhang Tingting Li Zhongxian Li Xiaohan Zhou Yuting Guo Yinglu Ji Xiaoli Shi Dong Han | 2023 | Nano Research2023，16，4： | 0 |
| 3 | Three-dimensional flow field simulation of steady flow in the serrated diffusers and nozzles of valveless micro-pumps显示文摘This paper presents a three-dimensional flow field simulation of the steady flows through diffusers and nozzles with straight or serrated-sided walls to analyze the effect of the channel structure on the flow characteristics.The pressure and velocity profiles in the diffusers and the nozzles as well as the net volumetric flow rate are determined.Our simulation demonstrates that the pressure and velocity profiles in the serrated diffuser/nozzles are more complicated than those with the straight-sided wall,while the net steady flow rate with the straight-sided wall increases monotonically with the increase of the pressure difference,the steady flow rate with serrated sided walls increases gradually to reach a maximum and then decreases with the increase of the pressure difference.The results suggest that the number of the sawteeth plays a significant role in optimizing the design of serrated diffusers and nozzles for improving the transport efficiency of valveless micro-pumps. | Ying-hua Xu Wei-ping Yan Kai-rong Qin Tun Cao | 2019 | Journal of Hydrodynamics2019，31，2： | 0 |
| 4 | Molecular hexagram and octagram:Position determined 3D metallo-supermolecules and concentration-induced transformation显示文摘The reaction of a metallo-organic ligand(LA)in which two'V'-shaped bisterpyridines attaching to metaposition of'X'-shaped tetraterpyridine via connectivity and Zn^(2+)ions gave rise to 3D supramolecular architectures:octagram(Zn_(8)LA_(4)).However,a position varied ligand(LB)in which two'V'-shaped bisterpyridines locating at the ortho-position of'X'-shaped tetraterpyridine afforded a different 3D hexagram(Zn_(6)LB_(3)).Full characterizations included NMR(^(1)H,^(13)C,^(2)D COSY,NOESY and DOSY),ESI-MS,TWIM-MS,TEM and AFM.The resulted structures were directly determined by the position of two'V'-shaped bisterpyridines attaching to'X'-shaped tetraterpyridine. | Tun Wu Zhiyuan Jiang Xiaobo Xue Shi-Cheng Wang Mingzhao Chen Jun Wang Haisheng Liu Jun Yan Yi-Tsu Chan Pingshan Wang | 2021 | Chinese Chemical Letters2021，32，6： | 0 |
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