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| 1 | Differing profiles of people diagnosed with acute and chronic hepatitis B virus infection in British Columbia,Canada显示文摘AIM To describe the characteristics of people diagnosed with acute and chronic hepatitis B virus(HBV) infection in British Columbia(BC).METHODS We used data from the BC Hepatitis Testers Cohort(BCHTC),which includes all individuals tested for hepatitis C virus(HCV) or human immunodeficiency virus(HIV) or those diagnosed with HBV or active tuberculosis in BC since 1990.These data were integrated with prescription drug,medical visit,hospitalization and mortality data.HBV cases were classified as acute or chronic according to provincial guidelines.We compared characteristics of individuals by HBV infection group(acute,chronic and negative).Factors associated with acute or chronic HBV infection were assessed with multinomial logistic regression models in comparison to the HBV negative group.RESULTS46498 of the 1058056 eligible BC-HTC participants were diagnosed with HBV infection.4.3% of HBV positive individuals were diagnosed with acute HBV infections while 95.7% had chronic infections.Problematic alcohol use,injection drug use,and HIV or HCV co-infection were more common among individuals diagnosed with acute HBV compared to those with chronic infections and HBV negative individuals.In multivariable multinomial logistic regression models,we observed significant associations between acute or chronic HBV diagnosis and being male,age at HBV diagnosis or birth cohort,South and East Asian ethnicity,HCV or HIV infection,and injection drug use.The odds of acute HBV decreased with increasing age among people who inject drugs,while the opposite was true for chronic HBV.Persons with acute HBV were predominantly White(78%) while those with chronic HBV were mostly East Asian(60%).Relative to Whites,East Asians had 12 times greater odds of being diagnosed with chronic HBV infection.These odds increased with increasing socioeconomic deprivation.CONCLUSION Differences in the profiles of people diagnosed with acute and chronic HBV infection necessitate differentiated screening,prevention,care and treatment programs. | Mawuena Binka Zahid A Butt Stanley Wong Mei Chong Jane A Buxton Nuria Chapinal Amanda Yu Maria Alvarez Maryam Darvishian Jason Wong Gina McGowan Mikhail Torban Mark Gilbert Mark Tyndall Mel Krajden Naveed Z Janjua | 2018 | World Journal of Gastroenterology2018，24，11： | 3 |
| 2 | Autologous hematopoietic stem cell transplantation for autoimmune diseases 显示文摘 | Tyndall A Daikeler T | 2005 | Acta Haematol2005，114，4： | 1 |
| 3 | Autologous haemopoietic stem cell transplants for autoimmune diseases-feasibility and transplant-related mortality显示文摘 | Tyndall A Fassas Passweg J | 1999 | Bone Marrow transplantion1999，24，7： | 1 |
| 4 | Intense immunosuppression and stem- cell transplantation for patients with severe rheumatic autoimmune disease a review 显示文摘 | Van Laar JM Tyndall A | 2003 | Cancer Control2003，10，： | 1 |
| 5 | In vitro assessment of local computed tomography for the detection of longitudinal tooth fractures显示文摘 | Mora MA Mol A Tyndall DA | | 0，，06： | 1 |
| 6 | Position statement of the American Academy of Oral and Maxillofacial Radiology on selection criteria for the use of radiology in dental implantology with emphasis on cone beam computed tomography显示文摘 | Donald A Tyndall Jeffery B Price Sotirios Tetradis | 2012 | Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontics2012，113，6： | 1 |
| 7 | Haemopoietic stem cell transplantation in the treatment of severe autoimmune diseases 2000显示文摘 | Tyndall A Passweg J Gratwohl A | 2001 | Ann Rheum Dis2001，60，7： | 1 |
| 8 | Clinical risk assessment of organ manifestations in systemic sclerosis:a report from the EULAR Scleroderma Trials And Research group database显示文摘 | Walker UA Tyndall A Czirjdk L | 2007 | Ann Rheum Dis2007，66，6： | 1 |
| 9 | Cytochrome Pd502C9 (CYP2C9) allele frequencies in Canadian Native Indian and Inuit populations 显示文摘 | Gaedigk A Casley WL Tyndale RF | 2001 | Can J Physiol Pharmacol2001，79，10： | 1 |
| 10 | Autologous hematopoietic stem cell transplantation for autoimmune diseases 显示文摘 | Tyndall A Daikeler T | 2005 | Acta Haematol2005，114，： | 1 |
| 11 | Stem cell treatment of autoim- mune disease 显示文摘 | Daikeler T Tyndall A | 2011 | Dtsch Med Wochenschr2011，136，33： | 1 |
| 12 | Stem cells in the aetiopathogenesis and therapy of rheumatic disease 显示文摘 | Moore J Tyndall A Brooks P | 2001 | Best Pract Res Clin Rheumatol2001，15，5： | 1 |
| 13 | Treatment of upper gastroiontestinal leaks with a removable, covered, self-expanding metallic stent 显示文摘 | Babor R Talbot M Tyndal A | 2009 | Surg Laparosc Endosc Pereutan Tech2009，19，1： | 1 |
| 14 | Hemotopietic blood and marrow transplants in the treatment of severe autoimmune disease显示文摘 | Tyndall A | 1997 | Current Opin Hematol1997，4，： | 1 |
| 15 | Blood and marrow stem cell transplants in auto-immune disease: a consensus report written on behalf of the European League against Rheumatism (EULAR) and the European Group for Blood and Marrow Transplantation(EBMT) 显示文摘 | Tyndall A Gratwohl A | 1997 | Bone Marrow Transplant1997，19，： | 1 |
| 16 | Autoimmunity following haematopoietic stem-cell transplantation显示文摘 | Daikeler T Tyndall A | | 0，，： | 1 |
| 17 | High-dose immunoablative therapy with hematopoietic stem cell support in the treatment of severe autoimmune disease: current status and future direction 显示文摘 | Tyndall A Koike T | 2002 | Intern Med2002，41，8： | 1 |
| 18 | Update 1 of: Proteases universally recognize beta strands in their active sites显示文摘 | Praveen K Madala Joel D A Tyndall Tessa Nall | 2011 | Chemical Reviews2011，110，6： | 1 |
| 19 | Kinetics and mechanism of the reactions of CH3S with O2,and NO2 at 298 K显示文摘 | Tyndall G S Ravishnanhara A R | | 0，，： | 1 |
| 20 | Haemopoietic stem cell trans- plantation in the trealmen! of se;rere auloimmune diseases 2000 显示文摘 | Tyndall A Passweg J Gratwohl A | 2001 | Ann Rheum Dis2001，60，： | 1 |
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