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| 1 | The IL-1R/TLR signaling pathway is essential for efficient CD8+ T-cell responses against hepatitis B virus in the hydrodynamic injection mouse model显示文摘The outcome of hepatitis B viral(HBV)infection is determined by the complex interactions between replicating HBV and the immune system.While the role of the adaptive immune system in the resolution of HBV infection has been studied extensively,the contribution of innate immune mechanisms remains to be defined.Here we examined the role of the interleukin-1 receptor/Toll-like receptor(IL-1R/TLR)signaling pathway in adaptive immune responses and viral clearance by exploring the HBV mouse model.Hydrodynamic injection with a replication-competent HBV genome was performed in wild-type mice(WT)and a panel of mouse strains lacking specific innate immunity component expression.We found higher levels of HBV protein production and replication in Tlr2^(−/−),Tlr23479^(−/−),3d/Tlr24^(−/−),Myd88/Trif^(−/−)and Irak4^(−/−)mice,which was associated with reduced HBV-specific CD8+T-cell responses in these mice.Importantly,HBV clearance was delayed for more than 2 weeks in 3d/Tlr24^(−/−),Myd88/Trif^(−/−)and Irak4^(−/−)mice compared to WT mice.HBV-specific CD8+T-cell responses were functionally impaired for producing the cytokines IFN-γ,TNF-αand IL-2 in TLR signaling-deficient mice compared to WT mice.In conclusion,the IL-1R/TLR signaling pathway might contribute to controlling HBV infection by augmenting HBV-specific CD8+T-cell responses. | Zhiyong Ma Jia Liu Weimin Wu Ejuan Zhang Xiaoyong Zhang Qian Li Gennadiy Zelinskyy Jan Buer Ulf Dittmer Carsten J Kirschning Mengji Lu | 2017 | Cellular & Molecular Immunology2017，14，12： | 6 |
| 2 | Distal Pancreatectomy: Risk Factors for Surgical Failure in 302 Consecutive Cases显示文摘 | J?rg Kleeff Markus K. Diener Kaspar Z?graggen Ulf Hinz Markus Wagner Jeannine Bachmann J?rg Zehetner Michael W. Müller Helmut Friess Markus W. Büchler | 2007 | Annals of Surgery2007，，4： | 3 |
| 3 | Pancreatic Resection for M1 Pancreatic Ductal Adenocarcinoma显示文摘 | Shailesh V. Shrikhande MD J?rg Kleeff MD Carolin Reiser MD Jürgen Weitz MD Ulf Hinz MSc Irene Esposito MD Jan Schmidt MD Helmut Friess MD Markus W. Büchler MD | 2007 | Annals of Surgical Oncology2007，，1： | 2 |
| 4 | Cloning,sequencing,and regulation of the glutathione reductase gene from the Cyanobacterium anabaena PCC 7120显示文摘 | Fanyi J Ulf H Grazyna E S | 1995 | J Biol Chem1995，270，22： | 1 |
| 5 | 难治性类风湿关节炎的临床特点:一项国际问卷调查研究显示文摘目的尽管按照目前欧洲抗风湿联盟(EULAR)的推荐对类风湿关节炎(rheumatoid arthritis,RA)患者进行治疗,难治性RA患者的临床症状却仍然没有得到完全控制,目前EULAR指南主要关注的是RA的早期治疗和药物治疗。本研究的目的在于分析难治性RA患者的临床特点,以及在患者管理中需要探索然而现有EULAR指南并未涉及的问题。方法对多个国家的风湿科医生进行问卷调查,分析难治性RA的临床特点。问卷包括多选题以及开放性问题,从开放性问题的回答中发现需要进一步阐明的问题以及现有EULAR指南需要增加的内容。结果410名受访者完成了调查问卷,关于难治性RA的特点:50%受访者认为基于28个关节评估的疾病活动评分(disease activity score assessing 28 joints,DAS28)>3.2或存在疾病活动的征象;42%受访者认为疲劳是其特点;48%认为至少两种传统合成改变病情抗风湿药(DMARDs)以及使用至少两种生物制剂或靶向合成DMARDs治疗失败;89%认为糖皮质激素不能减量到5 mg/天或泼尼松不能减量到10 mg/天或同等剂量的其他激素。另外,现有EULAR指南中应增加合并症和关节外表现的干预以及多种药物联合治疗等重要内容。结论目前风湿科医生对难治性RA的定义有很大争议。难治性RA患者的很多重要问题目前EULAR指南中均没有涉及。 | Nadia MT Roodenrijs Maria J H de Hair Marlies C van der Goes Johannes WG Jacobs Paco MJ Welsing Désirée van der Heijde Daniel Aletaha Maxime Dougados Kimme L Hyrich Iain B McInnes Ulf Mueller-Ladner Ladislav Senolt Zoltan Szekanecz Jacob Mvan Laar Nagy Gyorgy 黄艳荣(译) 张卓莉(审校) | 2019 | 英国医学杂志中文版2019，22，2： | 1 |
| 6 | Mesohepatectomy as an Option for the Treatment of Central Liver Tumors显示文摘 | Arianeb Mehrabi Zhoobin Mood Navid Roshanaei Hamidreza Fonouni Sascha A. Müller Bruno M. Schmied Ulf Hinz Jürgen Weitz Markus W. Büchler Jan Schmidt | 2008 | Journal of the American College of Surgeons2008，，4： | 1 |
| 7 | Corticosteroids and immunosuppressive therapy influence the result of QuantiFERON TB Gold testing in inflammatory bowel disease patients显示文摘 | Ulf Helwig Michael Müller Jürgen Hedderich Stefan Schreiber | 2011 | Journal of Crohn’s and Colitis2011，，4： | 1 |
| 8 | Pruri's circumscriptus sine materia:a sequel of postzosteric neuralgia显示文摘 | Darsow ULF Lorenz J Burkhart BR | 1996 | Acta DermVenereol1996，76，： | 1 |
| 9 | Enriched environment increases neurogenesis in the adult rat dentate gyrus and improves spatial memory显示文摘 | Michael N Ekaterina P Ulf J | 1999 | J Neurobiol1999，39，3： | 1 |
| 10 | HMGB1 as a mediator of necrosis-induced inflammation and a therapeutic target in arthritis显示文摘 | Ulf Andersson Kevin J Tracey | 2004 | Rheumatic Disease Clinics of North America2004，，3： | 1 |
| 11 | Using eye movement activity as a correlation of cognitive workload显示文摘 | Ulf Ahlstrom Feme J Friedman-Berg | 2006 | Internation-al Journal of Industrial Ergonomics2006，36，7： | 1 |
| 12 | A frame work for systems analysis of sustainable urban water management 显示文摘 | Daniel H Ulf J E K | 2000 | Environment Impact Assessment Review2000，20，： | 1 |
| 13 | Pruri's circum scrip tussine materia:a sequel of post zosteric neuralgia显示文摘 | Darsow ULF Lorenz J Burkhart Bromm Ring J | 1996 | Acta Derm Venereo 1 (stockh)1996，76，： | 1 |
| 14 | Exact CT-Based Liver Volume Calculation Including Nonmetabolic Liver Tissue in Three-Dimensional Liver Reconstruction显示文摘 | Sascha A. Müller Karin Bl?uer Michael Kremer Matthias Thorn Arianeb Mehrabi Hans-Peter Meinzer Ulf Hinz Jürg Metzger Markus W. Büchler Bruno M. Schmied | 2010 | Journal of Surgical Research2010，，2： | 1 |
| 15 | DDT化合物和PCB在富营养和贫营养湖中的季节性变化及其与藻类生物量之关系显示文摘1996~1997期间,在一个富营养湖(湖E)和一个贫营养湖(湖O)中进行了富营养化和有机污染物(PCB,DDTs及γ-HCH)的交互作用研究,两湖的地貌形态和水化学相似。集水区的土壤样品表明两湖暴露于相似的大气条件下。与湖O相比湖E没有观测到生物稀释。湖E的沉积物(1.5倍)、表面沉积物(1.4倍)和河鲈(Perca fluviatilis)(2.4倍)的有机碳和脂质物质中的PCB水平较高,并且微粒的沉降流较大,沉积物捕集器和沉淀物表面PCB的水平也较高。湖E中PCB的大部分转运主要是靠浮游植物。DDD/DDE比值较高似乎与p,p’-DDT的高负载相关而非厌氧的原因。所记录的湖O深层沉积岩心的高DDD/DDE比值和sDDT的高水平以及在此期间沉积最多,大概是由于从集水区流入的前体DDT最高的缘故。 | Maria Sderstrm Kerstin Nylund Ulf Jrnberg Gran Lithner Gran Rosén Henrik Kylin 邵平 樊恩源 | 2000 | AMBIO-人类环境杂志2000，29，4： | 1 |
| 16 | A model of settler coupled to the biological reactor显示文摘 | Diefel S Ulf J | 1998 | Water Research1998，32，2： | 1 |
| 17 | Determination ofdiethylstilbestrol residues in animal tissue with solid phase extraction by high-performance liquid chromatography and fluorescence detection显示文摘 | Rom SH Ulf B J Bergo VY | 2003 | Scand Clin Lab Invest2003，63，1： | 1 |
| 18 | A framework for systems analysis of sustainable urban water management显示文摘 | DANIEL H ULF J ERIK K | 2000 | Environmental Impact Assessment Review2000，20，3： | 1 |
| 19 | Alkali metal emission during pyrolysis of biomass显示文摘 | OLSSON JOHN G ULF Jglid | 1997 | Energy Fuel1997，11，4： | 1 |
| 20 | Resilient properties of unbound road materials during seasonal frost eonditions显示文摘 | Erik S Vincent C J Ulf I | 2002 | Journal of Cold Regions Engineering2002，16，1： | 1 |
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