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| 1 | 术中应用荧光素钠有利于胶质母细胞瘤浸润边缘的手术切除(英文)显示文摘Objective Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma( GBM).Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue,facilitating safe maximal resection of GBM. In this study,the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing( CE) regions,where this relationship has been established,and into the nonCE( NCE),diffusely infiltrated margins. Methods Thirty-two patients received fluorescein sodium( 3 mg/kg) intravenously prior to resection. Fluorescence was intraoperatively visualized using a Zeiss Pentero surgical microscope equipped with a YELLOW 560 filter.Stereotactically localized biopsy specimens were acquired from CE and NCE regions based on preoperative MRI in conjunction with neuronavigation. The fluorescence intensity of these specimens was subjectively classified in real time with subsequent quantitative image analysis,histopathological evaluation of localized biopsy specimens,and radiological volumetric assessment of the extent of resection.Results Bright fluorescence was observed in all GBMs and localized to the CE regions and portions of the NCE margins of the tumors,thus serving as a visual guide during resection. Gross-total resection( GTR) was achieved in 84% of the patients with an average resected volume of 95%,and this rate was higher among patients for whom GTR was the surgical goal( GTR achieved in 93. 1% of patients,average resected volume of 99. 7%). Intraoperative fluorescein staining correlated with histopathological alteration in both CE and NCE regions,with positive predictive values by subjective fluorescence evaluation greater than 96% in NCE regions. Conclusions Intraoperative administration of fluorescein provides an easily visualized marker for glioma pathology in both CE and NCE regions of GBM. These findingssupport the use of fluorescein as a microsurgical adjunct for guiding GBM resection to facilitate safe maximal removal. | Neira JA Ung TH Sims J Malone HR Chow DS Samanamud JL Zanazzi GJ Guo X Bowden SG Zhao B Sheth SA McKhann GM 2nd Sisti MB Canoll P D'Amico RS Bruce JN | 2016 | 中华神经外科疾病研究杂志2016，15，5： | 2 |
| 2 | Clinical study of the color stability of veneering ceramics for zirconia frameworks显示文摘 | Sailer I H olderegger C J ung R E Suter A Thievent B Pietrobon N | 2007 | Int J Prosthodont2007，20，： | 1 |
| 3 | Synthesis and dentifieation of 4-Methyl-N-(4H-1,2,4-triazol-4-yl)- 2-Benzo- thiazo-laminc, an Impurity in the Synthesis of Tricyclazole显示文摘 | Drcikorn B A Unge r P J | 1989 | Helerocyehe Chem1989，26，6： | 1 |
| 4 | In vitro bacterial penetration of coronally unsealed endodontically treated teeth 显示文摘 | Torabinejad M Ung B Kettering JD | 1990 | J Endod1990，16，12： | 1 |
| 5 | Omeprazole or ranitidine in long-termt reatment of reflux esophagitis显示文摘 | Unge P Carling L | 1994 | Gastroenterology1994，107，： | 1 |
| 6 | Mierobiogical data, hut not procalcitonin improve the accuracy of the clinical pulmonary infection score显示文摘 | J ung B Embriaco N Roux F eta | 2010 | Intensive Care Med2010，36，5： | 1 |
| 7 | Effects of Cr3C2 on the microstruc- ture and mechanical properties of the brazed joints between WC-Co and carbon steel 显示文摘 | Lee W B Kwon B D ]ung S B | 2006 | Int J Refract Met Hard Mater2006，24，3： | 1 |
| 8 | AtPIN4 mediates sink driven auxin gradients and root patterning in Arabidopsis显示文摘 | FRIML J BENKOVA E BLILOU I WISNIEWSKA J HAMANN T LJ UNG K WOODY S SANDBERG G SCH ERES B JURGENS G PALME K | 2002 | Cell2002，108，5： | 1 |
| 9 | Purification of collagen-binding proteins of Lactobacillus reuteri NCIB 11951 显示文摘 | Alelj ung P Shen W Rozalska B | 1994 | Curr Microbiol1994，28，： | 1 |
| 10 | Few-mode fiber with inverse-parabolic graded-index profile for transmission of OAM-carrying modes显示文摘 | Ung B Vaity P Wang L | 2014 | Optics Express2014，22，18： | 1 |
| 11 | Transplantation strategies to promote repair of the injured spinal cord显示文摘 | B unge MB Pearse DD | 2003 | J Rehabil Res Dev2003，40，41： | 1 |
| 12 | Omeprazole or ranitidine in long term treatment of reflux esophagitis显示文摘 | Hallerback B Unge P Carling L | 1994 | Gastroenterology1994，107，5： | 1 |
| 13 | Enhanced interconnection of Ti02 nanoparticles using atomic layer deposition for Flexible dye-sensitized solar cells with plastic substrates显示文摘 | Kim B Li Y J ung H | 2014 | Nano2014，9，14： | 1 |
| 14 | Fiber Bragg grating temperature sensor with controllable sensitivity 显示文摘 | J ung J Nam H Lee B | 1999 | Applied optics1999，38，： | 1 |
| 15 | Fairness-aware adaptive resource allocation scheme in multihop OFDMA systems显示文摘 | ChiS ung B Dong-Ho C | 2007 | IEEE Communications Letters2007，11，： | 1 |
| 16 | In vitro bacterial penetration of coronal unsealed endodonfically treated teeth显示文摘 | Ung B Kettering JD | 1990 | J Endod1990，16，12： | 1 |
| 17 | In vitro bacterial penetration of coronally unsealed endodontically treated teeth 显示文摘 | Torabinejad M Ung B Kettering JD | 1990 | J Endodon1990，16，： | 1 |
| 18 | Frequency andpredictors of axillary lymph node metastases in invasivebreast cancer显示文摘 | Chua B Ung 0 Taylor R | 2001 | ANZ J Surg2001，71，12： | 1 |
| 19 | Frequency and predictors of axillary lymph node metastases in invasive breast cancer显示文摘 | Chua B Ung O Taylor R | 2001 | ANZJS2001，71，12： | 1 |
| 20 | Differential regulation of microRNAs by p53 revealed by massively parallel sequencing:miR-34a is a p53 target that induces apoptosis and Gl-arrest显示文摘 | Tarasov V J ung P Verdoodt B | 2007 | Cell Cycle2007，6，13： | 1 |
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