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| 1 | 母牛安静发情鉴定技术概况及影响因素分析显示文摘安静发情母牛无明显发情行为,但具有正常卵泡发育、排卵过程,尚无理想的发情鉴定方法,常常错过人工输精最佳时机,导致产犊间隔延长,饲养成本增加。为此,本文综述了安静发情的鉴定方法概况及母牛安静发情的可能诱因。并指出,科学的管理及合理的营养可尽量减少母牛安静发情。此外,深入挖掘粪便、尿液、乳汁等发情标志物,研究其化合物在发情周期中的变化规律,并借助物联网、生物信息等技术,研发更精准、高效的发情鉴定技术,就有可能彻底突破安静发情鉴定技术瓶颈。 | 周正义 田莉 田宏志 李茹意 段晨莹 OBIANWUNA Uchechukwu Edna 吕丽华 王栋 | 2021 | 畜牧兽医学报2021，52，4： | 5 |
| 2 | Antidiabetic principles of Loranthus micranthus Linn.parasitic on Persea americana显示文摘Objective:To explore antidiabetic principles of the Eastern Nigeria mistletoe,Loranlhus micranthus Linn,parasitic on Persea Americana.Methods:The weakly acidic fraction of the aqueous methanol extract of the leaves of Loranlhus micranthus(Linn.) was isolated and tested for its antidiabetic activities.The isolation of the weakly acidic fraction was carried out following established physico-chemical based procedures.Furthermore,alloxan-induced diabetic rats were treated intraperitoneally(ip) with 250 mg/kg and 400 mg/kg of the weakly acidic fraction, glibenclamide 10 mg/kg(positive control) and 2 mg/kg of 3%v/v tween 20(negative control).The sugar levels of the treated and untreated animals were determined by withdrawing the blood at regular intervals and testing them with an automated glucometer.The phytochemical analysis of the acidic fraction was carried out using standard procedures.Chromatographic techniques were employed in the subsequent isolation and purification of the constituents of the weakly acidic fraction.Results:It was shown that the maximum effect of the weakly acidic fraction was obtained at 24 hours after administration and was found to be statistically comparable with that of the positive control.The phytochemical analysis revealed the presence of steroids,terpenoids, alkaloids,flavonoids,glycosides,carbohydrates,saponins,and acidic compounds in the crude extract and carbohydrates,flavonoids.terpenoids and oil in the weakly acidic fraction.Further purification of the weakly acidic fraction of the methanol extract using thin layer chromatography shows that toluene:methanol:diethyl amine(3:1:1) and chloroform:methanol:diethyl amine (9:1:1) are the best solvent system for the isolation of the various components of the weakly acidic fraction of the crude methanol extract of Loranlhus micranthus.Conclusions:The present study has led to the conclusion that the weakly acidic fraction of the plant under study has the potent antidiabetic activity and that the various components can be isolated using basic chromatographic techniques. | Patience Ogoamaka Osadebe Edwin Ogechukwu Omeje Sylvester Chukwuemeka Nworu Charles Okechukwu Esimone Philip Felix Uzor Ernest kenechukwu David John Uchechukwu Uzoma | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，8： | 4 |
| 3 | Friction anisotropy dependence on lattice orientation of graphene显示文摘The observation of friction anisotropy on graphene by friction measurement at atomic scale has been reported in this paper.Atomic-scale friction measurement revealed friction anisotropy with a periodicity of 60°,which is consistent with the hexagonal periodicity of the graphene.Both experiments and theory show that the value of the friction force is related to the graphene lattice orientation,and the friction force along armchair orientation is also larger than the one along zigzag orientation.These results will play a critical role in the use of graphene to manufacture nanoscale devices. | ZHANG Yu LIU LianQing XI Ning WANG YueChao DONG ZaiLi WEJINYA Uchechukwu C | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，4： | 4 |
| 4 | Eye rubbing-induced changes in intraocular pressure and corneal thickness measured at five locations, in subjects with ocular allergy显示文摘AIM: To assess the effects of eye rubbing on corneal thickness(CT) and intraocular pressure(IOP)measurements obtained 0-30 min after habitual eye rubbing in symptomatic patients.METHODS: Measurements of IOP and CT were obtained at five locations(central, temporal, superior,nasal and inferior) before, and every 5min for 30 min interval after 30 s of eye rubbing, for 25 randomly selected eyes of 14 subjects with ocular allergy and 11age-matched normals. Differences in measurements were calculated in each group [Baseline measurements minus measurements recorded at each time interval after eye rubbing(for IOP), and for each corneal location(for CT)]and comparison were then made between groups(allergic versus control) for differences in any observed effects.RESULTS: Within groups, baseline mean IOPs in the allergic patient-group(14.2 ±3.0 mm Hg) and in the control group(13.1±1.9 mm Hg) were similar at all times,after eye rubbing(P >0.05, for all). The maximum reduction in IOP was 0.8 mm Hg in the control subjects and the maximum increase was also 0.8 mm Hg in the allergic subjects. Between groups(allergic versus control), the changes in IOP remained under 1 mm Hg at all times(P =0.2) after 30 min of eye rubbing. Between 0and 30 min of CT measurements after eye rubbing, the mean central CT(CCT), inferior CT(ICT), superior CT(SCT), temporal CT(TCT) and nasal CT(NCT) did not vary significantly from baseline values in the control and allergic-subject groups(P >0.05, for both). Between both groups, changes in CT were similar at all locations(P >0.05)except for the TC which was minimally thinner by about4.4 μm(P =0.001) in the allergic subjects than in the control subjects, 30 min following 30 s of eye rubbing.CONCLUSION: IOP measured in allergic subjects after30 s of habitual eye rubbing was comparable with that obtained in normal subjects at all times between 0 and30 min. Although, CT in the allergic subjects were similar to those of the control subjects at all times, it varied between +10 and-7.5 μm following eye rubbing, with the temporal cornea showing consistent reductions in thickness in the subjects with allergy. However, this reduction was minimal and was considered to not be clinically relevant. | Uchechukwu L.Osuagwu Saud A.Alanazi | 2015 | International Journal of Ophthalmology(English edition)2015，8，1： | 2 |
| 5 | 随钻储层成像技术显示文摘水平井钻井技术的新突破为一些新远景区的成功钻探以及许多老油气田的挖潜铺平了道路。然而,水平井钻井和大位移井钻井的成功并非由所钻距离来衡量,而是由在多大程度上能够使井保持在储层中钻进来衡量。一种新型的深探测随钻电磁测井服务通过识别流体界面、断层以及井筒外地层的变化,正在帮助地质导向人员最大程度地扩大井筒与储层的接触范围。 | Oystein Bo Jean-Michel Denichou Uchechukwu Ezioba Ettore Mirto James Donley James Telford Christophe Dupuis Laura Pontarelli Grant Skinner Mauro Viandante Jean Seydoux Matthew Spotkaeff Petter Vikhamar | 2016 | 国外测井技术2016，0，1： | 2 |
| 6 | Assessing the role of optometrists in the control of systemic hypertension in Saudi Arabia显示文摘 | Uchechukwu L. Osuagwu Kelechi C. Ogbuehi Turki M. AlMubrad | 2013 | Journal of the American Society of Hypertension2013，，4： | 1 |
| 7 | Construction cost factors in Nigeria显示文摘 | A Uchechukwu Ellnwa Silas A Buba | 1993 | Journal of Construction Engineering and Management1993，119，4： | 1 |
| 8 | Biodegradation of phenanthrene by indigenous microorgan- isms in soils from Livingstone Island, Antarctica 显示文摘 | Uchechukwu V Okere Ana Cabrerizo Jordi Dachs | 2012 | FEMS Microbiology Letter2012，329，1： | 1 |
| 9 | Depression and race affect hospitalization costs of heart failure patients显示文摘Objective:Depression and anxiety are frequently observed in heart failure(HF)patients;however,the effect of such factors on hospitalization costs of HF patients,and whether such costs vary by race and gender remain poorly understood.This analysis delineated the preva-lence of depression/anxiety among HF patients and estimated the effect of race and gender on hospitalization costs.Methods:We examined the 2008 files of the Tennessee Hospital Discharge Data System(HDDS)on patients(≥20 years of age)with a primary diagnosis of HF(ICD-9 codes 402,404,and 428)along with demographic data,depression/anxiety diagnoses,hospital costs,and comorbidities.Among the HF sample(n=16,889)53%were female and 23%were black.Race and gender differences in hospital costs were evaluated for the following three groups:(1)HF patients with depression/anxiety(HF+D);(2)HF-only patients without depression/anxiety(HFO);and(3)HF patients with other mental diagnoses(HF+M).Results:HF was significantly(p<0.000)higher among blacks compared to whites,and higher among males than females.Nearly 25%of HF patients had depression/anxiety(more whites and females were depressed).HF patients averaged more than 3 comorbidities(blacks had a greater number of comorbidities and hospitalization cost for the year).Costs were higher among HF+D patients compared to HFO patients.Among HF+D patients,costs were higher for black males compared with white males.These cost patterns prevailed largely because of higher comorbidities that required more re-admissions and longer hospital stays.Conclusion:Race and depression/anxiety are associated with increased hospitalization costs of HF patients.The higher costs among blacks reflect the higher burden of comorbidities,such as hypertension and diabetes,which calls for widespread dissemination,adoption,and implementation of proven interventions for the control of these comorbidities. | Baqar A.Husaini Robert S.Levine Meggan L.Novotny Van A.Cain Uchechukwu K.A.Sampson Majaz Moonis | 2015 | Family Medicine and Community Health2015，3，2： | 1 |
| 10 | Augmented Cardiac Formation of Oxidatively-Induced Carbonylated Proteins Accompanies the Increased Functional Severity of Post-Myocardial Infarction Heart Failure in the Setting of Type 1 Diabetes Mellitus显示文摘 | Kathleen E. Dennis Salisha Hill Kristie L. Rose Uchechukwu K.A. Sampson Michael F. Hill | 2013 | Cardiovascular Pathology2013，，： | 1 |
| 11 | Manifestations of type 2 diabetes in corneal endothelial cell density,corneal thickness and intraocular pressure显示文摘We sought to evaluate central corneal thickness(CCT),corneal endothelial cell density(ECD)and intraocular pressure(IOP)in patients with type 2 diabetes mellitus(DM)and to associate potential differences with diabetes duration and treatment modality in a prospective,randomized study.We measured ECD,CCT and IOP of125 patients with type 2 DM(mean age 57.1±11.5 years)and compared them with 90 age-matched controls.Measured parameters were analyzed for association with diabetes duration and glucose control modalities(insulin injection or oral medication)while controlling for age.In the diabetic group,the mean ECD(2511±252 cells/mm^2),mean CCT(539.7±33.6μm)and mean IOP(18.3±2.5 mmHg)varied significantly from those the control group[ECD:2713±132 cells/mm^2(P<0.0001),CCT:525.0±45.3μm(P=0.003)and IOP:16.7±1.8 mmHg(P<0.0001)].ECD was significantly reduced by about 32 cell/mm^2 for diabetics with duration of>10 years when compared with those with duration of<10 years(P<0.05).CCT was thicker and IOP was higher for diabetics with duration of>10 years than those with duration of<10 years(P>0.05).None of the measured parameters was significantly associated with diabetes duration and treatment modality(P>0.05).In conclusion,subjects with type 2DM exhibit significant changes in ECD,IOP and CCT,which,however,are not correlated with disease duration or if the patients receive on insulin injection or oral medications. | Stella Briggs Uchechukwu L Osuagwu Essam M AlHarthi | 2016 | The Journal of Biomedical Research2016，30，1： | 1 |
| 12 | Asthma man- agement by medical practitioners :the situation in a devel- oping country 显示文摘 | Osaretin OW Uchechukwu ND Osawaru O | 2013 | World J Pediatr2013，9，1： | 1 |
| 13 | Picralima nitida seeds suppress PGE2 production by interfering with multiple signalling pathways in IL - 1βstimulated SK - N - SH neuronal cells 显示文摘 | Olumayokun A Olajide Ravikanth Velagapudi Uchechukwu P | 2014 | J Ethnopharmacol2014，152，2： | 1 |
| 14 | Up-regulation of oxidative stress and inflammation in the brain of albino wistar rats following sub-acute administration of Synclisia scabrida root extract显示文摘Objective: Synclisia scabrida is a medicinal plant used over the years for the treatment ofseveral medical conditions yet there is paucity of information on its systemic and organspecific toxicity. Consequently, sub-acute neurotoxicity of root extract of Synclisia scabridawas evaluated in albino Wistar rats. Methods: Thirty male albino rats with average weightof 140g were randomized into 5 groups consisting of 6 rats in each group. Group 1 was thecontrol while 50 mg/kg, 100 mg/kg, 200 mg/kg and 400 mg/kg of the root extract wereadministered to Groups 2, 3, 4 and 5 respectively for 28 days. Malondialdehyde,glutathione, nitric oxide, protein, tumour necrosis factor-α, acetylcholine, catalase andacetylcholinesterase levels were measured in brain homogenates. Body weight of theanimals and histology of the hippocampus and cerebral cortex were evaluated. Results:Root extract of Synclisia scabrida was observed to increase malondialdehyde concentrationand decrease antioxidants biomarkers when compared with the control. Significantly(p<0.05) increased TNF-α concentration and acetylcholinesterase activity caused by theextract when compared with the control was observed. The concentration of acetylcholinesignificantly decreased in Synclisia scabrida treated groups in comparison with the control.The histomorphology of the hippocampus and cerebral cortex revealed pyknotic pyramidalneurons in Synclisia scabrida treated rat relative to the control with normal pyramidalneurons. The body weight of the extract treated groups were significantly decreased whencompared to the control Group. Conclusion: The study has demonstrated that the rootextract of Synclisia scabrida induces and up-regulates oxidative stress and inflammation inthe brain of male albino Wistar rat coupled with reduced acetylcholine concentration hencethe extract possesses neurotoxic potentials. | Emmanuel Uchechukwu Modo Ijeoma Nina Eke Utibe Evans Bassey Anthony Chibuzor Nnamudi Ekam Ime Akpakpan Okon Effiom Etim Iheanyichukwu Wopara Prosper Great Legborsi | 2022 | TMR Integrative Medicine2022，6，30： | 0 |
| 15 | Effectiveness of in-office blood pressure measurement by eye care practitioners in early detection and management of hypertension显示文摘AIM: To investigate the number of hypertensive patients, the optometrist is able to identify by routinely taking blood pressure(BP) measurements for patients in 'at-risk' groups, and to sample patients' opinions regarding in-office BP measurement. Many of the optometrists in Saudi Arabia practice in optical stores.These stores are wide spread, easily accessible and seldom need appointments. The expanding role of the optometrist as a primary health care provider(PHCP) and the increasing global prevalence of hypertension,highlight the need for an integrated approach towards detecting and monitoring hypertension.METHODS: Automated BP measurements were made twice(during the same session) at five selected optometry practices using a validated BP monitor(Omron M6) to assess the number of patients with high BP(HBP)- in at-risk groups-visiting the eye clinic routinely. Prior to data collection, practitioners underwent a two-day training workshop by a cardiologist on hypertension and how to obtain accurate BP readings. A protocol for BP measurement was distributed and retained in all participating clinics. The general,,.,attitude towards cardiovascular health of 480 patients aged 37.2(±12.4)y and their opinion towards in-office BP measurement was assessed using a self-administered questionnaire.RESULTS: A response rate of 83.6% was obtained for the survey. Ninety-three of the 443 patients(21.0%)tested for BP in this study had HBP. Of these,(62subjects) 67.7% were unaware of their HBP status. Thirty of the 105 subjects(28.6%) who had previously been diagnosed with HBP, still had HBP at the time of this study, and only 22(73.3%) of these patients were on medication. Also, only 25% of the diagnosed hypertensive patients owned a BP monitor.CONCLUSION: Taking BP measurements in optometry practices, we were able to identify one previously undiagnosed patient with HBP for every 8 adults tested.We also identified 30 of 105 previously diagnosed patients whose BP was poorly controlled, twenty-two of whom were on medication. The patients who participated in this study were positively disposed toward the routine measurement of BP by optometrists. | Saud A.Al Anazi Uchechukwu L.Osuagwu Turki M.Al Mubrad Hany K.Ahmed Kelechi C.Ogbuehi | 2015 | International Journal of Ophthalmology(English edition)2015，8，3： | 0 |
| 16 | Heterosis and combining ability in cucumber(Cucumis sativus L.)显示文摘The objective of this work was to evaluate four parental lines of cucumber which included:‘Zeina’(Zna),‘Beit Alpha’(BA),‘Straight 8’(Strght 8)and‘Calypso’(Capso)and six F1s generated by diallel cross,using randomized complete block design with three replications to study heterosis and combining ability for yield and yield component traits.Estimated heterosis showed that cross‘ZnaCapso’had the highest Better Parent(BP)heterosis in total fruit yield/ha while‘BACapso’had the highest Mid Parent(MP)heterosis in the same trait.Significant general(GCA)and specific(SCA)combining ability variances were obtained in all the traits implying that both the additive and non-additive gene effects operated in the genetic expression of the traits.Relative magnitude of GCA and SCA variances indicated preponderance of additive gene action for all the traits.‘Beit Alpha’and‘Straight 8’are best general combiners while‘BACapso’and‘CapsoStrght 8’were the best specific combiners for total fruit yield. | Chikezie Onuora Ene Peter Ejimofor Ogbonna Christian Ugwu Agbo Uchechukwu Paschal Chukwudi | 2019 | Information Processing in Agriculture2019，6，1： | 0 |
| 17 | Quality of life and depression among patients with high myopia in Nigeria:a cross sectional study显示文摘AIM:To evaluate the quality of life(QOL)and level of depression among participants with high myopia in Nigeria and the demographic factors associated with these outcomes.METHODS:This cross-sectional study was conducted on 100 adult participants with high myopia(defined as refractive error≤-5.00 D or worse,and uncorrected visual acuity worse than 6/18 in the better seeing eye)attending ophthalmology centres in Nigeria from 2 October 2021 to 30 August 2022.The means and standard deviations were calculated for each of the four domains of World Health Organization Quality of life scale(WHOQOL-BREF)using the transformed scores.The Beck Depression Inventory(BDI)scale was used to assess the level of depression.RESULTS:The highest and the lowest mean scores of WHOQOL-BREF domains were found for the psychological and physical health domains(mean percentage scores were 67.0[95% confidence intervals(CI)64.1-68.9]and 55.3(95%CI 51.8-58.8,P<0.001),respectively.One-way analysis of variance(ANOVA)revealed significant differences in physical health with educational status(higher among those with tertiary education:mean difference 0.9,95%CI-0.2-2.1;P=0.049),differences in psychological health with working status(higher among those who were working 1.2,95%CI 0.3-2.1;P=0.012).Also,the result showed a statistically significant association between environmental health and marital status(higher among non-married:1.7,95%CI-0.9-2.3;P=0.012)while overall health was associated with place of residence(higher in urban areas:2.3,95%CI 1.2-3.5;P=0.024).For depression,one in every nine participants reported major depressive symptom,mostly younger people(aged 16-29 vs 30-49y:17.0%vs 0,P=0.019),and slightly more women than men(14.3%vs 0,P=0.064).There were significant negative correlations between the depression scores and psychological health(r=-0.48,P<0.001),physical health(r=-0.29,P=0.002),social and relationship(r=-0.49,P<0.001),environmental(r=-0.48,P<0.001)and overall health(r=-0.49,P<0.001)CONCLUSION:People with high myopia have a relatively moderate QOL,but poor physical health,particularly the younger age group,and women who are more likely to experience clinically relevant depression.Eye care professionals should consider possible referrals for counselling for people with high myopia. | Uchechukwu Levi Osuagwu Kelechukwu Enyinnaya Ahaiwe Nnaemeka Meribe ElizabethDennis Nkanga Bernadine Nsa Ekpenyong Affiong Andem Ibanga Piwuna ChristopherGoson Dennis George Nkanga | 2023 | International Journal of Ophthalmology(English edition)2023，16，12： | 0 |
| 18 | Paediatric Chronic Myeloid Leukaemia in a Tertiary Hospital in Nigeria: A Report of Two Cases显示文摘Background: Chronic myeloid leukaemia (CML) is a myeloproliferative disorder with BCR/ABL mutation characterized by proliferation of granulocytic cell lines at varying stages of development. It is predominantly a disease of the adult population, only accounting for 2-3% of all childhood leukaemia. In our tertiary hospital, we recorded two cases of paediatric CML within three years. Objective: To increase the awareness of physicians on this seemingly rare form of childhood leukaemia. Case reports: We report a 10 year-old boy and a 16 year-old girl who presented to our facility with features suggestive of CML. Both cases had splenomegaly and leucocytosis. Cytogenetic assessment was positive for BCR-ABL in both cases. The first case was in chronic phase (CP) and had an initial therapy of hydroxyurea (HU) before referral for imatinib therapy. The second case received imatinib therapy, however due to blastic transformation to acute myeloid leukaemia (AML), she received treatment comprising of intravenous anthracycline and cytarabine. Conclusion: CML, although one of the rare childhood leukaemia is becoming increasingly noticed, probably due to availability of diagnostic facilities. There is therefore need for increased awareness of the disease among physicians to minimize delays in the diagnosis for improved care and better outcome. | Udechukwu Ngozi Patricia Nwagha Theresa Ukamaka Okike Clifford Ukoh Uchechukwu Chukwuebuka Oyim-Elechi Oluchi Cecilia | 2019 | Journal of Pharmacy and Pharmacology2019，7，9： | 0 |
| 19 | Immune System and Body Defence Enhancement Effects of Oral Dihydroartemisinin in Wistar Albino Rats显示文摘 | A. Utoh-Nedosa Uchechukwu A. Akah Peter Nedosa S. Kenechi Anowi F. Chinedu Adeyanju N.Oluwafemi NedosaV. Ikenna Onyekwelu N.A. Ojemudia Thiophilus | 2014 | Journal of Pharmacy and Pharmacology2014，2，7： | 0 |
| 20 | Visual rehabilitation in low-moderate keratoconus:intracorneal ring segment implantation followed by same-day topography-guided photorefractive keratectomy and collagen cross linking显示文摘AIM:To present the results of same-day topographyguided photorefractive keratectomy(TG-PRK) and corneal collagen crosslinking(CXL) after previous intrastromal corneal ring segment(ISCR) implantation for keratoconus.METHODS:An experimental clinical study on twentyone eyes of 19 patients aged 27.1±6.6y(range 19-43y),with low to moderate keratoconus who were selected to undergo customized TG-PRK immediately followed by same-day CXL, 9mo after ISCR implantation in a university ophthalmology clinic. Refraction, uncorrected distance visual acuities(UDVA) and corrected distance visual acuities(CDVA), keratometry(K) values, central corneal thickness(CCT) and coma were assessed 3mo after TG-PRK and CXL.RESULTS:After TG-PRK/CXL: the mean UDVA(logMAR) improved significantly from 0.66 ±0.41 to 0.20 ±0.25(P <0.05); Kflatvalue decreased from: 48.44±3.66 D to43.71±1.95 D; Ksteepvalue decreased from 45.61±2.40 D to41.56±2.05 D; Kaveragealso decreased from 47.00±2.66 D to42.42 ±2.07 D(P <0.05 for all). The mean sphere andcylinder decreased significantly post- surgery from,- 3. 10 ± 2. 99 D to-0.11±0.93 D and from-3.68±1.53 to-1.11 ±0.75 D respectively, while the CDVA, CCT and coma showed no significant changes. Compared to postISCR, significant reductions(P <0.05 or all) in all K values,sphere and cylinder were observed after TG-PRK/CXL.CONCLUSION:Same-day combined topography-guided PRK and corneal crosslinking following placement of ISCR is a safe and potentially effective option in treating low-moderate keratoconus. It significantly improves all visual acuity, reduced keratometry, sphere and astigmatism, but causes no change in central corneal thickness and coma. | Ferial M.Zeraid Asma A Jawkhab Waleed S Al-Tuwairqi Uchechukwu L.Osuagwu | 2014 | International Journal of Ophthalmology(English edition)2014，7，5： | 0 |
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