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| 1 | What are the latest developments in colorectal endoscopic submucosal dissection?显示文摘Endoscopic submucosal dissection (ESD) enables direct submucosal dissection so that even large early-stage gastrointestinal tumors can be resected en bloc . ESD has recently been applied to the colorectum since it was originally developed for use in the stomach. However, colorectal ESD is technically more difficult with an increased risk of perforation compared with gastric ESD. In addition, this procedure is seldom performed in Western countries. Consequently, further technical advances and the availability of a suitable clinical training system are required for the extensive use of colorectal ESD. In this topic highlight, we review the most recent developments in colorectal ESD. | Toshio Uraoka Yutaka Saito Naohisa Yahagi | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，7： | 8 |
| 2 | Effectiveness of narrow-band imaging magnification for invasion depth in early colorectal cancer显示文摘AIM: To evaluate the surface microvascular patterns of early colorectal cancer (ECC) using narrow-band imaging (NBI) with magnification and its effectiveness for invasion depth diagnosis. METHODS: We studied 112 ECC lesions [mucosal/ submucosal superficial (m/sm-s), 69; sm-deep (sm-d), 43] ≥ 10 mm that subsequently underwent endoscopic or surgical treatment at our hospital. We compared microvascular architecture revealed by NBI with magnification to histological findings and then to magnifi- cation colonoscopy pit pattern diagnosis. RESULTS: Univariate analysis indicated vessel density: non-dense (P < 0.0001); vessel regularity: negative (P < 0.0001); caliber regularity: negative (P < 0.0001); vessel length: short (P < 0.0001); and vessel meandering: positive (P = 0.002) occurred significantly more often with sm-d invasion than m/sm-s invasion. Multivariate analysis showed sm-d invasion was independently associated with vessel density: non-dense[odds ratio (OR) = 402.5, 95% confidence interval (CI): 12.4-13 133.1] and vessel regularity: negative (OR = 15.9, 95% CI: 1.2-219.1). Both of these findings when combined were an indicator of sm-d invasion with sensitivity, specificity and accuracy of 81.4%, 100% and 92.9%, respectively. Pit pattern diagnosis sensitivity, specificity and accuracy, meanwhile, were 86.0%, 98.6% and 93.8%, respectively, thus, the NBI with magnification findings of non-dense vessel density and negative vessel regularity when combined together were comparable to pit pattern diagnosis. CONCLUSION: Non-dense vessel density and/or negative vessel regularity observed by NBI with magnification could be indicators of ECC sm-d invasion. | Masakatsu Fukuzawa Yutaka Saito Takahisa Matsuda Toshio Uraoka Takao Itoi Fuminori Moriyasu | 2010 | World Journal of Gastroenterology2010，16，14： | 8 |
| 3 | A prospective, multicenter study of 1111 colorectal endoscopic submucosal dissections (with video)显示文摘 | Yutaka Saito Toshio Uraoka Yuichiro Yamaguchi Kinichi Hotta Naoto Sakamoto Hiroaki Ikematsu Masakatsu Fukuzawa Nozomu Kobayashi Junichirou Nasu Tomoki Michida Shigeaki Yoshida Hisatomo Ikehara Yosuke Otake Takeshi Nakajima Takahisa Matsuda Daizo Saito | 2010 | Gastrointestinal Endoscopy2010，，6： | 6 |
| 4 | Clinical outcome of endoscopic submucosal dissection versus endoscopic mucosal resection of large colorectal tumors as determined by curative resection显示文摘 | Yutaka Saito Masakatsu Fukuzawa Takahisa Matsuda Shusei Fukunaga Taku Sakamoto Toshio Uraoka Takeshi Nakajima Hisatomo Ikehara Kuang-I Fu Takao Itoi Takahiro Fujii | 2010 | Surgical Endoscopy2010，，2： | 5 |
| 5 | Clinical outcome of endoscopic submucosal dissection versus endoscopic mucosal resection of large colorectal tumors as determined by curative resection显示文摘 | Yutaka Saito Masakatsu Fukuzawa Takahisa Matsuda Shusei Fukunaga Taku Sakamoto Toshio Uraoka Takeshi Nakajima Hisatomo Ikehara Kuang-I Fu Takao Itoi Takahiro Fujii | 2010 | Surgical Endoscopy2010，，2： | 5 |
| 6 | CO_2 insufflation for potentially diffi cult colonoscopies: Effi cacy when used by less experienced colonoscopists显示文摘AIM: To clarify the effectiveness of CO2 insufflation in potentially difficult colonoscopy cases, particularly in relation to the experience level of colonoscopists.METHODS: One hundred twenty potentially difficult cases were included in this study, which involved females with a low body mass index and patients with earlier abdominal and/or pelvic open surgery or previously diagnosed left-side colon diverticulosis. Patients receiving colonoscopy examinations without sedation using a pediatric variable-stiffness colonoscope were divided into two groups based on either CO2 or standard air insufflation. Both insufflation procedures were also evaluated according to the experience level of the respective colonoscopists who were divided into an experienced colonoscopist (EC) group and a less experienced colonoscopist (LEC) group. Study measurements included a 100-mm visual analogue scale (VAS) for patient pain during and after colonoscopyexaminations, in addition to insertion to the cecum and withdrawal times.RESULTS: Examination times did not differ, however, VAS scores in the CO2 group were signifi cantly better than in the air group (P < 0.001, two-way ANOVA) from immediately after the procedure and up to 2 h later. There were no significant differences between either insufflation method in the EC group (P = 0.29), however, VAS scores for CO2 insufflation were significantly better than air insufflation in the LEC group (P = 0.023) immediately after colonoscopies and up to 4 h afterwards.CONCLUSION: CO2 insufflation reduced patient pain after colonoscopy in potentially difficult cases when performed by LECs. | Toshio Uraoka Jun Kato Motoaki Kuriyama Keisuke Hori Shin Ishikawa Keita Harada Koji Takemoto Sakiko Hiraoka Hideyuki Fujita Joichiro Horii Yutaka Saito Kazuhide Yamamoto | 2009 | World Journal of Gastroenterology2009，15，41： | 5 |
| 7 | Size does not determine the grade of malignancy of early invasive colorectal cancer显示文摘AIM:To clarify the clinicopathological characteristics of small and large early invasive colorectal cancers(EI-CRCs),and to determine whether malignancy grade depends on size.METHODS:A total of 583 consecutive EI-CRCs treated by endoscopic mucosal resection or surgery at the National Cancer Center Hospital between 1980 and 2004 were enrolled in this study.Lesions were classified into two groups based on size:small(≤10mm) and large(>10mm).Clinicopathological features,incidence of lymph node metastasis(LNM) and risk factors for LNM,such as depth of invasion,lymphovascular invasion(LVI) and poorly differentiated adenocarcinoma(PDA) were analyzed in all resected specimens.RESULTS:There were 120(21%) small and 463(79%) large lesions.Histopathological analysis of the small lesion group revealed submucosal deep cancer(sm:≥1000 μm) in 90(75%) cases,LVI in 26(22%) cases,and PDA in 12(10%) cases.Similarly,the large lesion group exhibited submucosal deep cancer in 380(82%) cases,LVI in 125(27%) cases,and PDA in 79(17%) cases.The rate of LNM was 11.2% and 12.1% in the small and large lesion groups,respectively.CONCLUSION:Small EI-CRC demonstrated the same aggressiveness and malignant potential as large cancer. | Takahisa Matsuda Yutaka Saito Takahiro Fujii Toshio Uraoka Takeshi Nakajima Nozomu Kobayashi Fabian Emura Akiko Ono Tadakazu Shimoda Hiroaki Ikematsu Kuang-I Fu Yasushi Sano Takahiro Fujimori | 2009 | World Journal of Gastroenterology2009，15，22： | 4 |
| 8 | A pilot study to assess the safety and efficacy of carbon dioxide insufflation during colorectal endoscopic submucosal dissection with the patient under conscious sedation显示文摘 | Yutaka Saito Toshio Uraoka Takahisa Matsuda Fabian Emura Hisatomo Ikehara Yumi Mashimo Tsuyoshi Kikuchi Takahiro Kozu Daizo Saito | 2007 | Gastrointestinal Endoscopy2007，，3： | 3 |
| 9 | Advanced technology for the improvement of adenoma and polyp detection during colonoscopy显示文摘 | Tomohiko Moriyama Toshio Uraoka Motohiro Esaki Takayuki Matsumoto | 2015 | Digestive Endoscopy2015，，： | 2 |
| 10 | Cold polypectomy techniques for diminutive polyps in the colorectum显示文摘 | Toshio Uraoka Hemchand Ramberan Takahisa Matsuda Takahiro Fujii Naohisa Yahagi | 2014 | Digestive Endoscopy2014，，： | 2 |
| 11 | A novel extra-wide-angle–view colonoscope: a simulated pilot study using anatomic colorectal models显示文摘 | Toshio Uraoka Shinji Tanaka Takayuki Matsumoto Takahisa Matsuda Shiro Oka Tomohiko Moriyama Reiji Higashi Yutaka Saito | 2012 | Gastrointestinal Endoscopy2012，，： | 2 |
| 12 | Micro RNA ‐148a is downregulated in gastric cancer, targets MMP 7, and indicates tumor invasiveness and poor prognosis显示文摘 | Naoya Sakamoto Yutaka Naito Naohide Oue Kazuhiro Sentani Naohiro Uraoka Htoo Zarni Oo Kazuyoshi Yanagihara Kazuhiko Aoyagi Hiroki Sasaki Wataru Yasui | 2014 | Cancer Sci2014，，2： | 2 |
| 13 | Non-invasive prediction of non-alcoholic steatohepatitis in Japanese patients with morbid obesity by artificial intelligence using rule extraction technology显示文摘AIM To construct a non-invasive prediction algorithm for predicting non-alcoholic steatohepatitis(NASH), we investigated Japanese morbidly obese patients using artificial intelligence with rule extraction technology.METHODS Consecutive patients who required bariatric surgery underwent a liver biopsy during the operation. Standard clinical, anthropometric, biochemical measurements were used as parameters to predict NASH and were analyzed using rule extraction technology. One hundred and two patients, including 79 NASH and 23 non-NASH patients were analyzed in order to create the predictionmodel, another cohort with 77 patients including 65 NASH and 12 non-NASH patients were analyzed to validate the algorithm.RESULTS Alanine aminotransferase, C-reactive protein, homeostasis model assessment insulin resistance, albumin were extracted as predictors of NASH using a recursive-rule extraction algorithm. When we adopted the extracted rules for the validation cohort using a highly accurate rule extraction algorithm, the predictive accuracy was 79.2%. The positive predictive value, negative predictive value,sensitivity and specificity were 88.9%, 35.7%, 86.2% and 41.7%, respectively.CONCLUSION We successfully generated a useful model for predicting NASH in Japanese morbidly obese patients based on their biochemical profile using a rule extraction algorithm. | Daisuke Uehara Yoichi Hayashi Yosuke Seki Satoru Kakizaki Norio Horiguchi Hiroki Tojima Yuichi Yamazaki Ken Sato Kazuki Yasuda Masanobu Yamada Toshio Uraoka Kazunori Kasama | 2018 | World Journal of Hepatology2018，10，12： | 2 |
| 14 | Challenge to overcome: Nonstructural protein 5A-P32 deletion in direct-acting antiviral-based therapy for hepatitis C virus显示文摘Interferon(IFN)-based therapy for hepatitis C virus(HCV) infection has recently been replaced by IFNfree direct-acting antiviral(DAA)-based therapy, which has been established as a 1^(st) line therapy with high efficacy and tolerability due to its reasonable safety profile. Resistance-associated substitutions(RASs) have been a weakness of DAA-based therapy. For example, combination therapy with daclatasvir and asunaprevir(DCV/ASV) is less effective for HCV genotype 1-infected patients with Y93H as a nonstructural protein 5A RAS. However, the problem regarding RASs has been gradually overcome with the advent of recently developed DAAs, such as sofosbuvir-based regimens or combination therapy with glecaprevir and pibrentasvir. Despite the high efficiency of DAA-based therapy, some cases fail to achieve viral eradication. P32 deletion, an NS5A RAS, has been gradually noticed in patients with DCV/ASV failure. P32 deletion has been sporadically reported and the prevalence of this RAS has been considered to be low in patients with DCV/ASV failure. Thus, the picture of P32 deletion has not been fully evaluated. Importantly, currently-commercialized DAA-based combination therapy was not likely to be effective for patients with P32 deletion. Exploring and overcoming this RAS is essential for antiviral therapy for chronic hepatitis C. | Ken Sato Toshio Uraoka | 2018 | World Journal of Gastroenterology2018，24，38： | 2 |
| 15 | Identification of ARIA regulating endothelial apoptosis and angiogenesis by modulating proteasomal degradation of cIAP-1 and cIAP-2显示文摘 | Ikeda K Nakano R Uraoka M | | 0，，： | 1 |
| 16 | Endoscopic treatment of large superficial colorectal tumors: a case series of 200 endo- scopic submucosal dissections (with video ) 显示文摘 | Saito Y Uraoka T Matsuda T | 2007 | Gastrointest En- dosc2007，66，5： | 1 |
| 17 | A pilot study to assess the safety and eficacy of carbon dioxide insufiation during colorectal endoscopic submucosal dissection with the patient under con- scious sedation 显示文摘 | SAITO Y URAOKA T MATSUDA T | 2007 | Gastrointest En- dosc2007，65，3： | 1 |
| 18 | Effectiveness of glyc- erol as a submucosal injection for EMR 显示文摘 | Uraoka T Fujii T Saito Y | 2005 | Gastrointest Endosc2005，61，6： | 1 |
| 19 | Prorenin induces ERK activation in endothelial cells to enhance neovascularization independently of the renin-angiotensin system显示文摘 | Uraoka M Ikeda K Nakagawa Y | | 0，，： | 1 |
| 20 | Effect of post-thermal annealing of thin-film transistors with ZnO channel layer fabricated by atomic layer deposition显示文摘 | KAWAMURA Y HORITA M URAOKA Y | 2010 | Japanese Journal of Applied Physics2010，49，4： | 1 |
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