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| 1 | Pancreatic stellate cell: Pandora's box for pancreatic disease biology显示文摘Pancreatic stellate cells(PSCs) were identified in the early 1980 s, but received much attention after 1998 when the methods to isolate and culture them from murine and human sources were developed. PSCs contribute to a small proportion of all pancreatic cells under physiological condition, but are essential for maintaining the normal pancreatic architecture. Quiescent PSCs are characterized by the presence of vitamin A laden lipid droplets. Upon PSC activation, these perinuclear lipid droplets disappear from the cytosol, attain a myofibroblast like phenotype and expresses the activation marker, alpha smooth muscle actin. PSCs maintain their activated phenotype via an autocrine loop involving different cytokines and contribute to progressive fibrosis in chronic pancreatitis(CP) and pancreatic ductal adenocarcinoma(PDAC). Several pathways(e.g., JAK-STAT, Smad, Wnt signaling, Hedgehog etc.), transcription factors and mi RNAs have been implicated in the inflammatory and profibrogenic function of PSCs. The role of PSCs goes much beyond fibrosis/desmoplasia in PDAC. It is now shown that PSCs are involved in significant crosstalk between the pancreatic cancer cells and the cancer stroma. These interactions result in tumour progression, metastasis, tumour hypoxia, immune evasion and drug resistance. This is the rationale for therapeutic preclinical and clinical trials that have targeted PSCs and the cancer stroma. | Ratnakar R Bynigeri Aparna Jakkampudi Ramaiah Jangala Chivukula Subramanyam Mitnala Sasikala G Venkat Rao D Nageshwar Reddy Rupjyoti Talukdar | 2017 | World Journal of Gastroenterology2017，23，3： | 25 |
| 2 | Genetic mechanisms underlying the pathogenesis of tropical calcific pancreatitis显示文摘Chronic pancreatitis is known to be a heterogeneous disease with varied etiologies.Tropical calcific pancreatitis(TCP) is a severe form of chronic pancreatitis unique to developing countries.With growing evidence of genetic factors contributing to the pathogenesis of TCP,this review is aimed at compiling the available information in this field.We also propose a two hit model to explain the sequence of events in the pathogenesis of TCP. | Swapna Mahurkar D Nageshwar Reddy G Venkat Rao Giriraj Ratan Chandak | 2009 | World Journal of Gastroenterology2009，15，3： | 4 |
| 3 | Comprehensive screening for reg1α gene rules out association with tropical calcific pancreatitis显示文摘AIM: To investigate the allelic and haplotypic association of reg1α gene with tropical calcific pancreatitis (TCP). Since TCP is known to have a variable genetic basis, we investigated the interaction between mutations in the susceptibility genes, SPINK1 and CTSB with reg1α polymorphisms. METHODS: We analyzed the polymorphisms in the reg1α gene by sequencing the gene including its promoter region in 195 TCP patients and 150 ethnically matched controls, compared their allele and haplotype frequencies, and their association with the pathogenesis and pancreaticolithiasis in TCP and fibro-calculous pancreatic diabetes. RESULTS: We found 8 reported and 2 novel polymo-rphisms including an insertion-deletion polymorphism in the promoter region of reg1α. None of the 5' UTR variants altered any known transcription factor binding sites, neither did any show a statistically significant association with TCP. No association with any reg1α variants was observed on dichotomization of patients based on their N34S SPINK1 or L26V CTSB status. CONCLUSION: Polymorphisms in reg1α gene, including the regulatory variants singly or in combination with the known mutations in SPINK1 and/or CTSB genes, are not associated with tropical calcific pancreatitis. | Swapna Mahurkar Seema Bhaskar D Nageshwar Reddy G Venkat Rao Giriraj Ratan Chandak | 2007 | World Journal of Gastroenterology2007，13，44： | 3 |
| 4 | One-pot synthesis of fluorine containing 3-cyano/ethoxycarbony1-2- methyl-benzofurans显示文摘 | RamaRao G Venkat Reddy Maitraie D | 2004 | Tetrahedron2004，60，12： | 1 |
| 5 | A simple and convenient method for the reduction of nitroacenes显示文摘 | Venkat R G Rama Rao V V V N S | 2002 | Synth Commun2002，32，18： | 1 |
| 6 | Effect of coal particle size distribution on agglomerate formation in a fluidized bed combustor显示文摘 | Venkat Reddy G Mahapatra S K | 1999 | Energy Conversion & Management1999，40，4： | 1 |
| 7 | Efect of coal particle size distribution on agglomerate formation in a fluidized bed combustor (FBC) 显示文摘 | Venkat Reddy G Mahapatra S K | 1999 | Energy Conversion & Management1999，40，： | 1 |
| 8 | Growth dynamics of InGaAs by MBE:process simulation and theoretical analysis显示文摘 | COLAYNI G VENKAT R | 2000 | Journal of Crystal Growth2000，211，1234： | 1 |
| 9 | Effect of coal particle size distribution on agglomerate formation in a fluidized bed combustor显示文摘 | VENKAT REDDY G MAHAPATRA S K | 1999 | Energy Convers Manage1999，40，4： | 1 |
| 10 | High Resolution Narrow Band Imaging (NBI) Can Identify Normal Gastric Mucosa and H. Pylori (HP) Associated Gastritis显示文摘 | Rupa Banerjee C. Ramji M.J. Mansard Anuradha Shekharan Santosh Darisetty Manu Tandan G Venkat Rao D.N. Reddy | 2007 | Gastrointestinal Endoscopy2007，，5： | 1 |
| 11 | Upper a i rwaycompromise by extravasated fluid:a rare complication afterarthroscopic repair of atrophic cuff tear显示文摘 | VENKAT G MOON YL NA WC et a l | 2009 | Orthopedics2009，32，10： | 1 |
| 12 | Superacid- promoted dual C - C bond formation by Friedel-Crafts alkylation and acylation of ethyl cinnamates:Synthesis of Indanones 显示文摘 | Venkat R B Gopi K R A Satyanar A G | 2013 | Synlett2013，24，07： | 1 |
| 13 | Upper airway com- promise by extravasated fluid: a rare complication after ar- throscopic repair of atrophic cuff tear 显示文摘 | Venkat G Moon Y L Na W C | 2009 | Orthopedics2009，32，77： | 1 |
| 14 | Comprehensive screening of chymotrypsin C (CTRC) gene in tropical calcific pancreatitis identifies novel variants显示文摘 | Sumit Paliwal Seema Bhaskar K Radha Mani D Nageshwar Reddy G Venkat Rao Shivaram Prasad Singh Varghese Thomas Giriraj Ratan Chandak | 2013 | Gut2013，，11： | 1 |
| 15 | Equitable allocation of congestion relief cost to transaction显示文摘 | Mesut E B Venkat B Kenneth E G | 2000 | IEEE Trans on PWRS2000，15，2： | 1 |
| 16 | Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes 显示文摘 | Lu A Magnpalli Venkat G Ruan J | 2014 | Ce112014，156，6： | 1 |
| 17 | A blind controlled trial of phase -contrast microscope by two observers for evaluating the source of haematuria 显示文摘 | Venkat Raman G Pead L Lee HA | 1986 | Nephron1986，44，4： | 1 |
| 18 | Simulation of biodegradation process of phenolic wastewater at higher concentrations in a fluidized-bed bioreactor显示文摘 | A Venu Vino G Venkat Reddy | 2005 | Biochemical Engineering Journal2005，24，： | 1 |
| 19 | Structural basis for the slow digestion property of native cereal starches 显示文摘 | Zhang G Y Venkat achalam M Hamaker B R | 2006 | Biomacromolecules2006，7，11： | 1 |
| 20 | Chemical and olfactometric characterization of volatile flavor compounds in a fish oil enriched milk显示文摘 | Venkate G S Let M B Meyer A S | 2004 | Agricultural and Food Chemistry2004，52，2： | 1 |
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