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| 1 | Microbial markers in colorectal cancer detection and/or prognosis显示文摘Colorectal cancer(CRC) is the second leading cause of cancer worldwide. CRC is still associated with a poor prognosis among patients with advanced disease. On the contrary, due to its slow progression from detectable precancerous lesions, the prognosis for patients with early stages of CRC is encouraging. While most robust methods are invasive and costly, actual patient-friendly screening methods for CRC suffer of lack of sensitivity and specificity. Therefore, the development of sensitive, non-invasive and cost-effective methods for CRC detection and prognosis are necessary for increasing the chances of a cure. Beyond its beneficial functions for the host, increasing evidence suggests that the intestinal microbiota is a key factor associated with carcinogenesis. Many clinical studies have reported a disruption in the gut microbiota balance and an alteration in the faecal metabolome of CRC patients, suggesting the potential use of a microbialbased test as a non-invasive diagnostic and/or prognostic tool for CRC screening. This review aims to discuss the microbial signatures associated with CRC known to date, including dysbiosis and faecal metabolome alterations, andthe potential use of microbial variation markers for noninvasive early diagnosis and/or prognostic assessment of CRC and advanced adenomas. We will finally discuss the possible use of these markers as predicators for treatment response and their limitations. | Romain Villéger Amélie Lopès Julie Veziant Johan Gagnière Nicolas Barnich Elisabeth Billard Delphine Boucher Mathilde Bonnet | 2018 | World Journal of Gastroenterology2018，24，22： | 10 |
| 2 | Radiation and concomitant chemotherapy for patients with glioblastoma multiforme显示文摘Postoperative external beam radiotherapy was considered the standard adjuvant treatment for patients with glioblastoma multiforme until the advent of using the drug temozolomide(TMZ) in addition to radiotherapy. High-dose volume should be focal, minimizing whole brain irradiation. Modern imaging, using several magnetic resonance sequences, has improved the planning target volume definition. The total dose delivered should be in the range of 60 Gy in fraction sizes of 1.8-2.0 Gy. Currently, TMZ concomitant and adjuvant to radiotherapy has become the standard of care for glioblastoma multiforme patients. Radiotherapy dose-intensification and radiosensitizer approaches have not improved the outcome. In spite of the lack of high quality evidence, stereotactic radiotherapy can be considered for a selected group of patients. For elderly patients, data suggest that the same survival benefit can be achieved with similar morbidity using a shorter course of radiotherapy(hypofractionation). Elderly patients with tumors that exhibit methylation of the O-6-methylguanine-DNA methyltransferase promoter can benefit from TMZ alone. | Salvador Villà Carme Balaà Sílvia Comas | 2014 | Chinese Journal of Cancer2014，33，1： | 6 |
| 3 | Ultrasound evaluation of the length of fetal nasal bones throughout gestation 显示文摘 | Guis F Ville Y Vincent S | 1995 | Ultrasound Obstet Gynecol1995，5，： | 1 |
| 4 | Pancreatitis associated with naproxen显示文摘 | Du Ville L Debeuckelaere S Reynaert H | 1993 | Am J Gastroenterol1993，88，： | 1 |
| 5 | A randomized outcome study of enteral versus intravenous nimodipine in 171 patients after acute aneurysmal subarachnoid hemorrhage显示文摘 | VILLE S PETROS N K TIMO K | 2012 | World Neurosurg2012，78，12： | 1 |
| 6 | Hirschs- prung's disease: a 20-year experience显示文摘 | Reding R de Ville de Goyet J Gosseye S | 1997 | J Pediatr Surg1997，32，8： | 1 |
| 7 | Analysis of free and esterified sterols in edible oils by online reversed phase liquid chromatography–gas chromatography (RPLC–GC) using the through oven transfer adsorption desorption (TOTAD) interface显示文摘 | Rosa M. Toledano Jose M. Cortés ángela Rubio-Moraga Jesús Villén Ana Vázquez | 2012 | Food Chemistry2012，，2： | 1 |
| 8 | Long-term molecular and cellular stability of human neural stem cell lines显示文摘 | Vill A Bueno C Frcuso S | 2004 | Ex- peri-mental Cell Research2004，294，： | 1 |
| 9 | Hirschsprung's Disease: A 20-year experience显示文摘 | Reding R de Ville de Goyet J Gosseye S | 1997 | J Pediatr Surg1997，32，： | 1 |
| 10 | Mammalian small stress proteins protect against oxidative stress through their ability toincrease glucose-6-phosphate dehydrogenase activity and by maintaining optimal cellular detoxifying machinery显示文摘 | Préville X Salvemini F Giraud S | 1999 | Exp Cell Res1999，247，1： | 1 |
| 11 | A probability-based approach for high-throughput protein phosphorylation analysis and site localization显示文摘 | Beausoleil S A Villén J Gerber S A Rush J Gygi S P | | 0，，10： | 1 |
| 12 | Social innovation: Buzz word or enduring term? 显示文摘 | Pol E and Ville S | 2009 | Journal of Socio- Economics2009，38，4： | 1 |
| 13 | Expression of caspase-3 and structural changes associated with apoptotic cell death of keratinocytes in oral lichen planus显示文摘 | TOBON-ARROYAVE S I VILLE GAS-ACOSTA F A RUIZ-RESTREPO S M | 2004 | Oral Diseases2004，10，3： | 1 |
| 14 | Cardiomyocyte apoptosis after antegrade and retrograde cardioplegia显示文摘 | Tommi V Antti S Ville K | 2005 | Ann Thorac Surg2005，80，： | 1 |
| 15 | Improved nonlinear finite elements for oriented bodies using an extension of Marguerre' s theory显示文摘 | Jetteur P Cescotto S Vill De G | | 0，，01： | 1 |
| 16 | Concise review: anemia caused by viruses显示文摘 | MORINET F LERUEZ -VILLE M PILLET S | 2011 | Stem Cells2011，29，11： | 1 |
| 17 | Dopaminergic cell d^iageand vulnerability to MPTP in Pinkl knockdown zebrafish 显示文摘 | Ville S Juha K Priyadarshini M | 2010 | Neurobiol Dis2010，40，1： | 1 |
| 18 | A probability-based approach for high-throghput protein phosphorylation analysis and site localization显示文摘 | BEAUSOLEI S A VILL(E)N J GERBERS | | 0，，： | 1 |
| 19 | Impact of transient emotions on functional connectivity during subsequent resting state:a wavelet correlation approach显示文摘 | Eryilmaz H Van De Ville D Schwartz S | 2011 | Neuroimage2011，54，3： | 1 |
| 20 | First-trimester diagnosis of nuchal anomalies:significance and fetal outcome显示文摘 | Ville Y Lalondrelle C Doumerc S | | 0，，05： | 1 |
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