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| 1 | Increased proliferation activity measured by immunoreactive Ki67 is associated with survival improvement in rectal/recto sigmoid cancer显示文摘AIM: To assess the expression of Ki67 as prognosticator in rectal/recto sigmoid cancer.METHODS: Samples from 146 patients with rectal and recto sigmoid cancer were studied for expression of Ki67 and its prognostic significance in comparison with clinicopathological predictors of survival. Formalin-fixed, paraffin-embedded tissues from 6 (4.1%) patients with T1, 26 (17.8%) with T2, 94 (64.4%) with T3, and 20 (13.7%) with T4 tumors were studied. Ki67 expression was determined immunohistochemically. Samples were divided according to mean value into high (>40%) and low (≤40%) expression. Areas of extensive proliferation (>50%) were defined as 'hot spot' areas. RESULTS: Hot spot areas were present in samples regardless of histopathological grade. Lower TNM and Dukes stage and higher expression of Ki67 and presence of Ki67 hot spot areas in histopathological samples were associated with better survival, whereas no association was observed with histopathological grade (P = 0.78). In Cox multivariate regression analysis, significant prognostic factors were Dukes stage (P<0.001), presence of lymph node metastases (P = 0.015), age (P = 0.035) andpresence of Ki67 hot spot areas (P = 0.044). CONCLUSION: Proliferative activity as measured by Ki67 in rectal cancer is associated with survival improvement compared with patients with low Ki67. Areas of prognostically significant increased proliferation were found independently of histopathological tumor grade. | Eeva Salminen Salla Palmu Tero Vahlberg Peter J.Roberts Karl-Owe S(o|¨)derstr(o|¨)m | 2005 | World Journal of Gastroenterology2005，11，21： | 15 |
| 2 | Effects of a health advoca cy,counselling,and activation programme on depressive symptoms in older coronary heart disease patients显示文摘 | Salrninen M Isoaho R Vahlberg T | 2005 | Int J Geriatr Psychia- try2005，20，6： | 1 |
| 3 | Local inflammatory re- sponse in choriodecidua induced by Ureaplasma urealyticum 显示文摘 | Aaltonen BI Heikkinen J Vahlberg T | 2007 | BJOG2007，114，11： | 1 |
| 4 | Withdrawal of psy- chotropic drugs decreases the risk of falls requiring treatment 显示文摘 | Salonoja M Salminen M Vahlberg T | 2012 | Arch Gerontol Geriatr2012，54，1： | 1 |
| 5 | Brain glucose metabolism and temperament in relation to severe somatization 显示文摘 | Hakala M Vahlberg T Niemi PM | 2006 | Psychiatry Clin Neurosci2006，60，： | 1 |
| 6 | Fear of falling,fall-related self-efficacy,anxiety and depression in individuals with chronic obstructive pulmonary disease显示文摘 | HELLSTR(O)M K VAHLBERG B URELL C | 2009 | Clin Rehabil2009，23，12： | 1 |
| 7 | Local inflammatory response in choriodecidua induced by Ureaplasma urealyticum显示文摘 | Aaltonen R Heikinen J Vahlberg T | 2007 | BJOG2007，114，11： | 1 |
| 8 | The effect of thyroid anti- body positivity on reference intervals for thyroid stimulating hor- mone and free thyroxine in an aged population 显示文摘 | Eskelinen S Suominen P Vahlberg T | 2005 | Clin Chem Lab Med2005，43，： | 1 |
| 9 | Comparison of metformin and insulin in the treatment of gestational diabetes,a retrospective,case-control study显示文摘 | Tertti K Ekblad U Vahlberg T | 2008 | Rev Diabet Stud2008，5，： | 1 |
| 10 | Effects of risk based multifactorial fall prevention on postural balance in the community- dwelling aged: A randomized controlled trial显示文摘 | Salminen M Vahlberg T Sihvonen S | 2009 | Arch Geront Geriatr2009，48，： | 1 |
| 11 | The effect of drug interactions on bleeding risk associated with warfarin therapy in hospitalized patients显示文摘 | Hauta-Aho M Tirkkonen T Vahlberg T | 2009 | Ann Med2009，41，8： | 1 |
| 12 | Effect of physician-staffed helicopter emergency medical service on blunt trauma patient survival and prehospital care显示文摘 | Iirola TT Laaksonen MI Vahlberg TJ | | 0，，06： | 1 |
| 13 | Effect of physicianstaffed helicopter emergency medical service on blunt trauma patient survival and prehospital care显示文摘 | Iirola T Laaksonen M Vahlberg T | 2006 | Eur J Emerg Med2006，13，6： | 1 |
| 14 | Associations of thyroid-stimulating hormone and free thyroxine concentrations with health and life satisfaction in elderly adults显示文摘 | Eskelinen S I Vahlberg T J Isoaho R E | 2007 | Rev Med Endocr Pract2007，13，5： | 1 |
| 15 | Fear of falling, fall-related self-efficacy, anxiety and depression in individu- als with chronic obstructive pulmonary disease显示文摘 | Hellstrm K Vahlberg B Urell C | 2009 | Clin Reha- bil2009，23，12： | 1 |
| 16 | Comparison ofmetformin and insulin in the treatment of gestational diaetes: a retrospective, case- control study显示文摘 | Tertti K Ekblad U Vahlberg T | 2008 | Rev Diabet Stud2008，5，2： | 1 |
| 17 | Associations of thyroid stimulating hormone and free thyroxine concentrations withhealth and life satisfaction in elderly adults显示文摘 | Eskelinen S I Vahlberg T J Isoaho R E | 2007 | Endocr Pract2007，13，： | 1 |
| 18 | MMP-1 expression has an independent prognostic value in breast cancer显示文摘 | Bostrom P Soderstrom M Vahlberg T | | 0，，： | 1 |
| 19 | Effect of femoral head size on risk of revision for dislocation after total hip arthroplasty显示文摘 | Inari Kostensalo Mika Junnila Petri Virolainen Ville Remes Markus Matilainen Tero Vahlberg Pekka Pulkkinen Antti Eskelinen Keijo T Mä kelä | 2013 | Acta Orthopaedica2013，，4： | 1 |
| 20 | Local inflammatory response in chorio-decidua induced by Ureaplasma urealyticam显示文摘 | Aaltonen R Heikkinen J Vahlberg T | 2007 | BJOG2007，，114： | 1 |
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