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| 1 | Increased proliferation activity measured by immunoreactive Ki67 is associated with survival improvement in rectal/recto sigmoid cancer显示文摘AIM: To assess the expression of Ki67 as prognosticator in rectal/recto sigmoid cancer.METHODS: Samples from 146 patients with rectal and recto sigmoid cancer were studied for expression of Ki67 and its prognostic significance in comparison with clinicopathological predictors of survival. Formalin-fixed, paraffin-embedded tissues from 6 (4.1%) patients with T1, 26 (17.8%) with T2, 94 (64.4%) with T3, and 20 (13.7%) with T4 tumors were studied. Ki67 expression was determined immunohistochemically. Samples were divided according to mean value into high (>40%) and low (≤40%) expression. Areas of extensive proliferation (>50%) were defined as 'hot spot' areas. RESULTS: Hot spot areas were present in samples regardless of histopathological grade. Lower TNM and Dukes stage and higher expression of Ki67 and presence of Ki67 hot spot areas in histopathological samples were associated with better survival, whereas no association was observed with histopathological grade (P = 0.78). In Cox multivariate regression analysis, significant prognostic factors were Dukes stage (P<0.001), presence of lymph node metastases (P = 0.015), age (P = 0.035) andpresence of Ki67 hot spot areas (P = 0.044). CONCLUSION: Proliferative activity as measured by Ki67 in rectal cancer is associated with survival improvement compared with patients with low Ki67. Areas of prognostically significant increased proliferation were found independently of histopathological tumor grade. | Eeva Salminen Salla Palmu Tero Vahlberg Peter J.Roberts Karl-Owe S(o|¨)derstr(o|¨)m | 2005 | World Journal of Gastroenterology2005，11，21： | 15 |
| 2 | Compression-related EMIC waves drive relativistic electron precipitation显示文摘With coordinated observations of the NOAA 15 satellite and OUL magnetometer station in Finland, we report that the electromagnetic ion cyclotron(EMIC) waves which were stimulated by the compression of the magnetosphere drive relativistic electron precipitation in geoquiescence on 1 Jan 2007. After an enhancement of solar wind dynamic pressure(SWDP), a dayside Pc1 pulsation was observed by the OUL station. Such a Pc1 pulsation is caused by an EMIC wave which propagates from the generation source to lower altitudes. Simultaneously, the NOAA 15 satellite registered an enhancement of precipitating electron count rates with energies >3 Me V within the anisotropic zone of protons. This phenomenon is coincident with the quasi-linear theoretical calculation presented in this paper. Our observations suggest that after a positive impulse of solar wind, the compression-related EMIC waves can drive relativistic electrons precipitation and play a pivotal role in the dynamic of radiation belts. | WANG De Dong YUAN Zhi Gang DENG Xiao Hua ZHOU Meng HUANG Shi Yong LI Ming LI Hui Min LI Hai Meng RAITA Tero PANG Ye | 2014 | Science China(Technological Sciences)2014，57，12： | 6 |
| 3 | Explaining the influence of dopant concentration and excitation power density on the luminescence and brightness of β-NaYF4:Yb^3+,Er^3+ nanoparticles:Measurements and simulations显示文摘We assessed the influence of Yb^3+ and Er34 dopant concentration on the relative spectral distribution, quantum yield (Фuc), and decay kinetics of the upconversion luminescence (UCL) and particle brightness (BUC) for similarly sized (33 nm) oleate-capped p-NaYF4:Yb3t,Er^3+ upconversion (UC) nanoparticles (UCNPs) in toluene at broadly varied excitation power densities (F). This included an Yb^3+ series where the Yb^3+ concentration was varied between 11%—21% for a constant Er^3+ concentration of 3%, and an Er^3+ series, where the Er^3+ concentration was varied between 1%-4% for a constant Yb^3+ concentration of 14%. The results were fitted with a coupled rate equation model utilizing the UCL data and decay kinetics of the green and red Er34 emission and the Yb34 luminescence at 980 nm. An increasing Yb34 concentration favors a pronounced triphotonic population of 4F9/2 at high P by an enhanced back energy transfer (BET) from the 4G11/2 level. Simultaneously, the Yb^3+-controlled UCNPs absorption cross section overcompensates for the reduction in Фuc with increasing Yb^3+ concentration at high P, resulting in an increase in Sue. Additionally, our results show that an increase in Yb34 and a decrease in Er^3+ concentration enhance the color tuning range by P. These findings will pave the road to a deeper understanding of the energy transfer processes and their contribution to efficient UCL, as well as still debated trends in green-to-red intensity ratios of UCNPs at different P. | Martin Kaiser Christian Wurth Marco Kraft Tero Soukka Ute Resch-Genger | 2019 | Nano Research2019，12，8： | 3 |
| 4 | Incidence and risk faction of benigy creatine phosphokinase elevation in chronic psychiatric patients显示文摘 | Tero T Matsuda S Kojima H | 1999 | Neuropsychobiology1999，39，： | 1 |
| 5 | A Mathematical Model for Adaptive Transport Network in Path Finding by True slime Mold 显示文摘 | TERO A RYO K NAKAGAKI T | 2007 | Journal of Theoretical Biology2007，244，： | 1 |
| 6 | Rules for Biologically Inspired Adaptive Network Design 显示文摘 | TERO A | 2010 | Science2010，327，： | 1 |
| 7 | Two methods for fast ray- cast ambient occlusion显示文摘 | Laine S Karras Tero | 2010 | Computer Graphics Fo- rum2010，29，4： | 1 |
| 8 | Macrophage inflammatory pro- tein 3 alpha plays a key role in the inflammatory cascade in rat focal cerebral is chemia显示文摘 | Tero Y Ohta H Oda A | 2009 | Neurosci Res2009，64，1： | 1 |
| 9 | A compact power-efficient 3V CMOS Rail-to-Rail input/output operational amplifier for VLSI cell libraries 显示文摘 | Tero J P Ruud G H | 1994 | IEEE J Sol Sta Circ1994，29，12： | 1 |
| 10 | Pushing Technology to Where the Market will be:the Case of Nolda显示文摘 | Karkkalnen Pertti Ojanpera Tero | 2006 | International Journal of Technology Management2006，34，12： | 1 |
| 11 | A compact power-ecient 3 V CMOS rail-to-rail input/ output operational amplifier for VLSI cell libraries 显示文摘 | HOGERVORSTR TERO J P ESCHAUZIER R G H | 1994 | JSSC1994，12，： | 1 |
| 12 | Neurogenic Pulmonary Edema in Patients with Nontraumatic Intracerebral Hemorrhage: Predictors and Association with Outcome显示文摘 | Eija Junttila Tero Ala-Kokko Pasi Ohtonen Anne Vaarala Ari Karttunen Olli Vuolteenaho Tuula Salo Meeri Sutinen Toni Karhu Karl-Heinz Herzig Juha Koskenkari | 2013 | Anesthesia & Analgesia2013，，4： | 1 |
| 13 | Risk factors for Acinetobacter baumannil nosecomial bac- teremia in critical ill patients: a cohort study 显示文摘 | GARCIA-GARMENDIA J L ORTIZ-LEYHA C GARNACHO-MON- TERO J | 2001 | Clin Infect Dis2001，33，7： | 1 |
| 14 | A review in design and manufacturing of stainless steel sand- wieh panels显示文摘 | Jukka Saynaja kangas Tero Taulavuori Outokumpu Stainless | 2004 | Stainless steel world oktober2004，，： | 1 |
| 15 | A compact power-efficient 3 V CMOS rail-to-rail input/output operational amplifier for VLSI cell libraries 显示文摘 | HOGERVORST R TERO J P ESCHAUZIER R G H | 1994 | IEEE J Sol Sta Circ1994，29，12： | 1 |
| 16 | Comparison of model - based flow rate estimation methods in frequency converter driven pumps and fans显示文摘 | Jussi Tamminen Tero Ahonen | 2014 | Energy Efficiency2014，，7： | 1 |
| 17 | Effects of temperature and oxygenavailability on greenhouse gas and nutrient dynamics in sediment of a eutrophic mid-boreal lake显示文摘 | Anu Liikanen Timo Murtoniemi Heikki Tanskanen Tero V?is?nen Pertti J. Martikainen | 2002 | Biogeochemistry2002，，3： | 1 |
| 18 | A Compact 3-V CMOS Rail-to-Rail Input/Output Operational Amplifier for VLSI Cell Library显示文摘 | Hogervorst R Tero J P Eschauzier R G H | 1994 | IEEE J of Solid-State Circuits1994，29，： | 1 |
| 19 | Effect of microfibrillated cellulose and fines on the drainage of kraft pulp suspension and paper strength显示文摘 | Tero T Monika O Antti N | 2010 | Cellulose2010，，17： | 1 |
| 20 | Axis Ⅰ and Ⅱ psychiatric disorders after traumatic brain injury:a 30-years follow-up study显示文摘 | Salla K Tero T Raija P | 2002 | Am J Psychiatry2002，159，： | 1 |
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