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| 1 | Narrow line between benefit and harm: Additivity of hyperthermia to cisplatin cytotoxicity in different gastrointestinal cancer cells显示文摘AIM To investigate the response to hyperthermia and chemotherapy, analyzing apoptosis, cytotoxicity, and cisplatin concentration in different digestive system cancer cells.METHODS AGS(gastric cancer cell line), Caco-2(colon cancer cell line) and T3M4(pancreatic cancer cell line) were treated by cisplatin and different temperature setting(37 ℃ to 45 ℃) either in isolation, or in combination. Treatment lasted for one hour. 48 h after the treatment viability was evaluated by MTT, cell apoptosis by Annexin V-PE and 7 ADD flow cytometry. Intracellular cisplatin concentration was measured immediately after the treatment, using mass spectrometry. Isobologram analysis was performed to evaluate the mathematical combined effect of temperature and cisplatin.RESULTS AGS cells were the most sensitive to isolated application of hyperthermia. Hyperthermia, in addition to cisplatin treatment, did not provoke a synergistic effect at intervals from 37 ℃ to 41 ℃ in neither cancer cell line. However, a temperature of 43 ℃ enhanced cisplatin cytotoxicity for Caco-2 cells. Moreover, isobologram analysis revealed mathematical antagonistic effects of cisplatin and temperature combined treatment in AGS cells; variations between synergistic, additive, and antagonistic effects in Caco-2 cells; and additive and antagonistic effects in T3 M4 cells. Combined treatment enhanced initiation of cell apoptosis in AGS, Caco-2, and T3 M4 cells by 61%, 20%, and 19% respectively. The increase of intracellular cisplatin concentration was observed at 43 ℃ by 30%, 20%, and 18% in AGS, Caco-2, and T3 M4 cells, respectively.CONCLUSION In addition to cisplatin, hyperthermia up to 43 ℃ does not affect the viability of cancer cells in a synergistic manner. | Vaidotas Cesna Arturas Sukovas Aldona Jasukaitiene Rima Naginiene Giedrius Barauskas Zilvinas Dambrauskas Saulius Paskauskas Antanas Gulbinas | 2018 | World Journal of Gastroenterology2018，24，10： | 6 |
| 2 | Gut microbiota contribution to hepatocellular carcinoma manifestation in non-alcoholic steatohepatitis显示文摘Recently,the gut microbiota has been recognized as an obvious active player in addition to liver steatosis/steatohepatitis in the pathophysiological mechanisms of the development of hepatocellular carcinoma(HCC),even in the absence of cirrhosis.Evidence from clinical and experimental studies shows the association of specific changes in the gut microbiome and the direct contribution to maintaining liver inflammation and/or cancerogenesis in nonalcoholic fatty liver disease-induced HCC.The composition of the gut microbiota differs significantly in obese and lean individuals,especially in the abundance of pro-inflammatory lipopolysaccharide-producing phyla,and,after establishing steatohepatitis,it undergoes minor changes during the progression of the disease toward advanced fibrosis.Experimental studies proved that the microbiota of obese subjects can induce steatohepatitis in normally fed mice.On the contrary,the transplantation of healthy microbiota to obese mice relieves steatosis.However,further studies are needed to confirm these findings and the mechanisms involved.In this review,we have evaluated well-documented clinical and experimental research on the role of the gut microbiota in the manifestation and promotion of HCC in nonalcoholic steatohepatitis(NASH).Furthermore,a literature review of microbiota alterations and consequences of dysbiosis for the promotion of NASH-induced HCC was performed,and the advantages and limitations of the microbiota as an early marker of the diagnosis of HCC were discussed. | Valentina Liakina Sandra Strainiene Ieva Stundiene Vaidota Maksimaityte Edita Kazenaite | 2022 | World Journal of Hepatology2022，14，7： | 2 |
| 3 | Nurses' per-ception on the results of quality indicators for the im-provement of professional practice显示文摘 | Franco J N Barros B P Vaidotas M | 2010 | Rev Bras Enferm2010，63，5： | 1 |
| 4 | 显示文摘 | Dovile Grinkevicit~te Rimantas Kevalas Arimantas Tamasauskas Algimantas Matukevicius Vaidotas Gurskis Rota Liesiene | 2006 | Medicina (Kaunas Lithuania)2006，，4： | 1 |
| 5 | Low-temperature quantum transport in CVD-grown single crystal graphene显示文摘化学蒸汽免职(CVD ) 典型地为实际应用为大规模 graphene 合成被使用。然而, CVD graphene 的劣等的电子性质是要解决的关键问题之一。因此,我们在场高质量的单个水晶的单层 graphene 的电子性质上的详细研究。graphene 经由铜上的 CVD 是成年的,由使用一个冷墙的反应堆,然后转到 Si/SiO 2 。我们的低温度的磁电机运输数据证明单个水晶的 CVD graphene 样品的特征比多晶的 graphene 的那些优异并且有比得上 Si/SiO 2 上的 exfoliated graphene 的质量。在我们的最好的样品的迪拉克点发生在比 10 V,和 11,000 厘米 2/(V 功能 of-5.4 eV 的最大的活动性低的背门电压,作为搬运洞的层。它的力量变换效率达到了螼?螼 的价值吗?? | Shaohua Xiang Vaidotas Miseikis Luca Planat Stefano Guiducci Stefano Roddaro Camilla Coletti Fabio Beltram Stefan Heun | 2016 | Nano Research2016，9，6： | 0 |
| 6 | Gastrectomy impact on the gut microbiome in patients with gastric cancer:A comprehensive review显示文摘Gastric cancer is one of the most common malignancies worldwide and gastrectomy remains the only potentially curative treatment option for this disease.However,the surgery leads to significant physiological and anatomical changes in the gastrointestinal(GI)tract including loss of the gastric barrier,an increase in oxygenation levels in the distal gut,and biliary diversion after gastrectomy.These changes in the GI tract influence the composition of the gut microbiome and thus,host health.Gastrectomy-induced dysbiosis is characterized by increased abundance of typical oral cavity bacteria,an increase in aero-tolerant bacteria(aerobes/facultative anaerobes),and increased abundance of bile acidtransforming bacteria.Furthermore,this dysbiosis is linked to intestinal inflammation,small intestinal bacterial overgrowth,various GI symptoms,and an increased risk of colorectal cancer. | Vaidota Maksimaityte Augustinas Bausys Marius Kryzauskas Martynas Luksta Ieva Stundiene Klaudija Bickaite Bernardas Bausys Tomas Poskus Rimantas Bausys Kestutis Strupas | 2021 | World Journal of Gastrointestinal Surgery2021，13，7： | 0 |
| 7 | Mucosa-associated lymphoid tissue lymphoma simulating Crohn’s disease:A case report显示文摘BACKGROUND Differential diagnosis between extranodal marginal zone lymphoma of mucosaassociated lymphoid tissue and inflammatory bowel disease is mainly based on histopathologic evaluation of intestinal biopsies,although there is no single definitive diagnostic investigation and that circumstance can lead to misdiagnosis in particular cases.Herein we present a rare,ulcerative form of marginal zone lymphoma which mimics the Crohn’s disease(CD)of upper digestive tract.CASE SUMMARY A 50-year-old man was presented with recurrent episodes of malaise and melena also weight loss.Enteroscopy of the small bowel demonstrated an ulcer in the jejunum.Microscopically,biopsies showed lymphoplasmacytic infiltrate.Diagnosis of CD was made.Primary treatment consisted of prednisone and azathioprine and was followed by azathioprine 100 mg per day with good clinical response in the following 2 years until relapse.At this time the results of endoscopic biopsies derived from proximal wall of stomach revealed Helicobacter pylori-negative marginal zone lymphoma of the gastric fundus.Immunophenotyping confirmed atypical CD20-positive cell population.Based on these biopsies,marginal zone lymphoma of mucosa-associated lymphoid tissue was diagnosed.Unfortunately,the contact with the patient was lost until one year later he was hospitalized with nausea,vomiting and severe pain because of gastrointestinal perforation.Four months later after laparotomy,the patient was treated with a course of chemotherapy.Complete remission was observed following 6 cycles of treatment.CONCLUSION This case report highlights the clinical relevance of knowledge and awareness of marginal zone lymphoma simulating CD. | Ieva Stundiene Vaidota Maksimaityte Valentina Liakina Jonas Valantinas | 2020 | World Journal of Clinical Cases2020，8，8： | 0 |
| 8 | Metastatic multifocal melanoma of multiple organ systems:A case report显示文摘BACKGROUND Malignant melanoma is becoming more common among middle-aged individuals all over the world.Melanoma metastasis can be found in various organs,although metastases to the spleen and stomach are rare.Herein we present a rare metastatic multifocal melanoma,clinically and histologically mimicking lymphoma,with metastases of multiple organs.CASE SUMMARY A 46-year-old Caucasian male with a history of nodular cutaneous malignant melanoma was presented with nausea,general weakness,shortness of breath,abdominal enlargement,and night sweating.The abdominal ultrasound revealed enlarged liver and spleen with multiple lesions.Computed tomography demonstrated multiple lesions in the lungs,liver,spleen,subcutaneous tissue,bones and a pathological lymphadenopathy of the neck.Trephine biopsy and the biopsy from the enlarged lymph node were taken.Tumor cells showed diffuse or partial positivity for melanocytic markers,such as microphthalmia-associated transcription factor,S100,HMB45 and Melan-A.The tumor harbored BRAF V600E mutation,demonstrated by immunohistochemical labelling for BRAF V600E and detected by real-time polymerase chain reaction test.Having combined all the findings,a diagnosis was made of a metastatic multifocal melanoma of the stomach,duodenum,liver,spleen,lungs,lymph nodes and bones.The patient refused treatment and died a week later.CONCLUSION This case report highlights the clinical relevance of rare metastatic multifocal melanoma of multiple organ systems. | Vaidota Maksimaityte Rosita Reivytyte Gabriele Milaknyte Ugnius Mickys Gintare Razanskiene Domantas Stundys Edita Kazenaite Jonas Valantinas Ieva Stundiene | 2022 | World Journal of Clinical Cases2022，10，28： | 0 |
| 9 | Menstrual cycle abnormalities in women with inflammatory bowel disease and effects of biological therapy on gynecological pathology显示文摘Inflammatory bowel disease(IBD)is a chronic condition that affects young individuals in their reproductive years.It may have long-term implications on their reproductive,sexual,and mental health.IBD has been related to menstrual abnormalities.Furthermore,the administration of biological therapy can also result in gynecological issues in addition to the disease itself.The purpose of this review was to present potential menstrual cycle problems in patients with IBD,as well as the impact of adalimumab and other anti-tumor necrosis factor medications on gynecological pathology. | Vaidota Malinauskiene Anastasija Zuzo Valentina Liakina Edita Kazenaite Ieva Stundiene | 2023 | World Journal of Clinical Cases2023，11，21： | 0 |
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