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| 1 | Subdominant CD8+ T-cell responses are involved in durable control of AIDS virus replication显示文摘 | Friedrich TC Valentine LE Yant LJ | 2007 | J Virol2007，81，7： | 1 |
| 2 | Organic acid accumulationmay inhibit N2 fixation in phosphorus-stressed lupin nodules显示文摘 | Le Roux M R Khan S Valentine A J | 2008 | New Phytologist2008，177，4： | 1 |
| 3 | ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation显示文摘 | Valentin Fuster Lars E. Rydén David S. Cannom Harry J. Crijns Anne B. Curtis Kenneth A. Ellenbogen Jonathan L. Halperin Jean-Yves Le Heuzey G. Neal Kay James E. Lowe S. Bertil Olsson Eric N. Prystowsky Juan Luis Tamargo Samuel Wann | 2006 | Journal of the American College of Cardiology2006，，4： | 1 |
| 4 | A novel inverse relationship between mefformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells显示文摘 | Nelson LE Valentine ILl Cacicedo JM | 2012 | Am J Physiol Cell Physiol2012，303，1： | 1 |
| 5 | Identification of the antibodies involved in B-cell erossmateh positivity in renal transplantation 显示文摘 | Le Bas-Bernardet S Hourmant M Valentin N | 2003 | Transplantation2003，75，4： | 1 |
| 6 | Comparative resistance of candida albicans clinical isolates to fluconazole and itraconazole in vitro and in vivo in a murine model显示文摘 | Valentin A Le Guennec R Rodriguez E | 1996 | Antimicrob Agents Chemother1996，40，6： | 1 |
| 7 | Impact of Phytophthora dieback on birds in Banksia woodlands in south west Western Australia显示文摘 | Davis RA Valentine LE Craig MD | 2014 | Biological Conservation2014，171，： | 1 |
| 8 | 2011 ACCF/AHA/HRS Focused Updates Incorporated Into the ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation显示文摘 | Valentin Fuster Lars E. Rydén Davis S. Cannom Harry J. Crijns Anne B. Curtis Kenneth A. Ellenbogen Jonathan L. Halperin G. Neal Kay Jean-Yves Le Huezey James E. Lowe S. Bertil Olsson Eric N. Prystowsky Juan Luis Tamargo L. Samuel Wann | 2011 | Journal of the American College of Cardiology2011，，11： | 1 |
| 9 | Genome expression control during the photoperiodic response of aphids显示文摘 | GAEL LE TRIONNAIRE VALENTIN WUCHER DENIS TAGU | 2013 | Physiol. Entomol2013，，2： | 1 |
| 10 | The Giant Radio Array for Neutrino Detection(GRAND):Science and design显示文摘The Giant Radio Array for Neutrino Detection(GRAND)is a planned large-scale observatory of ultra-high-energy(UHE)cosmic particles,with energies exceeding 10~8 Ge V.Its goal is to solve the long-standing mystery of the origin of UHE cosmic rays.To do this,GRAND will detect an unprecedented number of UHE cosmic rays and search for the undiscovered UHE neutrinos and gamma rays associated to them with unmatched sensitivity.GRAND will use large arrays of antennas to detect the radio emission coming from extensive air showers initiated by UHE particles in the atmosphere.Its design is modular:20 separate,independent sub-arrays,each of 10000 radio antennas deployed over 10000 km^2.A staged construction plan will validate key detection techniques while achieving important science goals early.Here we present the science goals,detection strategy,preliminary design,performance goals,and construction plans for GRAND. | Jaime Alvarez-Muniz Rafael Alves Batista Aswathi Balagopal V. Julien Bolmont Mauricio Bustamante Washington Carvalho Jr. Didier Charrier Ismael Cognard Valentin Decoene Peter B.Denton Sijbrand De Jong Krijn D.De Vries Ralph Engel Ke Fang Chad Finley Stefano Gabici Quan Bu Gou Jun Hua Gu Claire Guépin Hong Bo Hu Yan Huang Kumiko Kotera Sandra Le Coz Jean-Philippe Lenain Guo Liang Léü Olivier Martineau-Huynh Miguel Mostafá Fabrice Mottez Kohta Murase Valentin Niess Foteini Oikonomou Tanguy Pierog Xiang Li Qian Bo Qin Duan Ran Nicolas Renault-Tinacci Markus Roth Frank G.Schroder Fabian Schüssler Cyril Tasse Charles Timmerman Matías Tueros Xiang Ping Wu Philippe Zarka Andreas Zech B.Theodore Zhang Jian Li Zhang Yi Zhang Qian Zheng Anne Zilles | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，1： | 1 |
| 11 | C'urcumin modulates drug metabolizing enzymes in the female SwissWebster mouse显示文摘 | VALENTINE S P Le NEDELEC M J MILNZIES A R el al | 2006 | Life Sciences2006，78，20： | 1 |
| 12 | Identification of the antibodies involved in B-cell crossmatch positivity in renal transplantation显示文摘 | Le Bas-Bernardet S Hourmant M Valentin N | | 0，，04： | 1 |
| 13 | Effects of N, P, and K on formation of vesicular-arbuscular mycorrhizae, growth and mineral content of onion显示文摘 | Valentin Furlan Michèle Bernier-Cardou | 1989 | Plant and Soil1989，，2： | 1 |
| 14 | Biomarkers of cetuximab resistance in patients with head and neck squamous cell carcinoma显示文摘Objective:In patients with head and neck squamous cell carcinoma(HNSCC),cetuximab[a monoclonal antibody targeting epidermal growth factor receptor(EGFR)]has been shown to improve overall survival when combined with radiotherapy in the locally advanced setting or with chemotherapy in first-line recurrent and/or metastatic(R/M)setting,respectively.While biomarkers of resistance to cetuximab have been identified in metastatic colorectal cancer,no biomarkers of efficacy have been identified in HNSCC.Here,we aimed to identify biomarkers of cetuximab sensitivity/resistance in HNSCC.Methods:HNSCC patients treated with cetuximab at the Curie Institute,for whom complete clinicopathological data and formalin-fixed paraffin-embedded(FFPE)tumor tissue collected before cetuximab treatment were available,were included.Immunohistochemistry analyses of PTEN and EGFR were performed to assess protein expression levels.PIK3 CA and H/N/KRAS mutations were analyzed using high-resolution melting(HRM)and Sanger sequencing.We evaluated the predictive value of these alterations in terms of progression-free survival(PFS).Results:Hot spot activating PIK3 CA and KRAS/HRAS mutations were associated with poor PFS among HNSCC patients treated with cetuximab in the first-line R/M setting,but not among HNSCC patients treated with cetuximab in combination with radiotherapy.Loss of PTEN protein expression had a negative predictive value among HNSCC patients treated with cetuximab and radiotherapy.High EGFR expression did not predict cetuximab sensitivity in our patient population.Conclusions:Hot spot activating PIK3 CA and RAS mutations predicted cetuximab resistance among HNSCC patients in the firstline R/M setting,whereas loss of PTEN protein expression predicted resistance to cetuximab when combined to radiotherapy. | Olivia Leblanc Sophie Vacher Charlotte Lecerf Emmanuelle Jeannot Jerzy Klijanienko Frederique Berger Caroline Hoffmann Valentin Calugaru Nathalie Badois Anne Chilles Maria Lesnik Samar Krhili IvanBieche Christophe Le Tourneau Maud Kamal | 2020 | Cancer Biology & Medicine2020，17，1： | 0 |
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