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| 1 | 小青龙汤对油酸致豚鼠急性肺损伤低氧血症的预防作用显示文摘目的:探讨血栓素A2(TXA2)在油酸致豚鼠急性肺损伤中的作用,同时观察小青龙汤对急性肺损伤低氧血症的预防作用。方法:给豚鼠静脉注射油酸制造急性肺损伤动物模型。15只豚鼠随机分为油酸对照组(OA组)、生理盐水对照组(NS组)、小青龙汤治疗组(TR组),用于观察血浆和支气管肺泡灌洗液(BALF)中血栓素B2(TXB2,TXA2的稳定代谢产物)和6-酮-前列腺素F1a(6-ketoPGF1a,前列环素的稳定代谢产物)的变化。12只豚鼠随机分为血气-油酸对照组(BOA)和血气-小青龙汤治疗组(BTR),用于观察小青龙汤对油酸致豚鼠急性肺损伤低氧血症的影响。结果:BOA组与BTR组比较,血气指标中PaO2有明显下降(P<0.01)。OA组较NS组血浆中TXB2的含量有所升高,而TR组较OA组有所下降。OA组与NS组比较,BALF中TXB2含量明显升高(P<0.01),并且TXB2/6-ketoPGF1a比值明显升高(P<0.05)。TR组与OA组比较,BALF中TXB2含量及TXB2/6-ketoPGF1a比值均明显下降(P<0.01,P<0.05)。结论:在油酸致豚鼠急性肺损伤动物模型中TXA2是与低氧血症有密切关系的一种重要介质。小青龙汤对急性肺损伤具有一定的预防作用,其机制可能是通过抑制TXA2的生成改善低氧血症。建议小青龙汤能够成为预防急性呼吸窘迫症/急性肺损伤的候补药物。 | 杨长青 孙鹏远 李天洙 丁大植 Irie Tetsumi | 2008 | 中国医院药学杂志2008，28，3： | 3 |
| 2 | Factors affecting membrane-controlled drug release for an osmotic pump tablet (OPT) utilizing (SBE) 7 m -β-CD as both a solubilizer and osmotic agent显示文摘 | Kazuto Okimoto Atsuo Ohike Rinta Ibuki Osamu Aoki Norio Ohnishi Roger A. Rajewski Valentino J. Stella Tetsumi Irie Kaneto Uekama | 1999 | Journal of Controlled Release1999，，2： | 2 |
| 3 | Crystal and molecular structure of grayanotoxin VII显示文摘 | JUN' ICHI KATAKAWA TADAHIRO TETSUMI TAD- AMASA TERAI | 2000 | Journal of Chemical Crystallography2000，30，2： | 1 |
| 4 | Recent findings on safety profiles of cyclodextrins, cyclodextrin conjugates and polypseudorotaxanes显示文摘 | Hidetoshi A Keiichi M Tetsumi I | 2011 | Cyclodextrins in Pharmaceufics Cosmetics and Biomedicine2011，3，1： | 1 |
| 5 | A new triterpene from leaves and stems of Euonymus fortunei Handmazz显示文摘 | KATAKAWA J TETSUMI T HASEGAWA H | 2000 | Nature Medicine2000，54，1： | 1 |
| 6 | Cyclodextrin drug carder systems 显示文摘 | KANETO U FUMITOSHI H TETSUMI L | 1998 | Chem Rev1998，98，5： | 1 |
| 7 | Usefulness of Beta-Catenin Immunostaining for the Differential Diagnosis of Solid-Pseudopapillary Neoplasm of the Pancreas显示文摘 | Yukichi Tanaka Kenji Notohara Keisuke Kato Rieko Ijiri Shigeo Nishimata Tetsumi Miyake Masaharu Fukunaga Minoru Horisawa Yukio Nakatani | 2002 | The American Journal of Surgical Pathology2002，，： | 1 |
| 8 | Effect of welding structure and δ-ferrite on fatigue properties for TIG welded austenitic stainless steels at cryogenic temperatures显示文摘 | Tetsumi Y Toshio O Masahiro S Yoshiaki H | 2000 | Cryogenics2000，，40： | 1 |
| 9 | A new triterpene fromleaves and stems of Euonymus fortunei HAND-MAZZ 显示文摘 | Katakawa J Tetsumi T Hasegawa H | 2000 | NatlMed2000，54，1： | 1 |
| 10 | Effect of welding structure andδ-ferrite on fatigue properties for TIG welded austenitic stainless steels at cryogenic temperatures显示文摘 | Tetsumi Y Toshio O Masahiro S | 2000 | Crygenics2000，40，45： | 1 |
| 11 | The Relationship Between Salivary Biomarkers and State-Trait Anxiety Inventory Score Under Mental Arithmetic Stress: A Pilot Study.显示文摘 | Yuka Noto Tetsumi Sato Mihoko Kudo Kiyoshi Kurata Kazuyoshi Hirota | 2005 | Anesthesia & Analgesia2005，，6： | 1 |
| 12 | A new triterpene from leaves and stems of Euonymus fortunei HANDMAZZ显示文摘 | Katakawa J Tetsumi T Hasegawa H | 2000 | NetMed2000，54，1： | 1 |
| 13 | A new triterpene from leaves and stems of Euonymus fortunei HAND-MAZZ显示文摘 | Katakawa J Tetsumi T Hasegawa H | 2000 | Natural Medicines2000，54，1： | 1 |
| 14 | A new triperpene from leaves and stems of Eyonymus fortunei HAND-MAZZ显示文摘 | Tetsumi T Hasegawa H | 2000 | Nat Med(Tokyo)2000，54，1： | 1 |
| 15 | In vitro and in vivo antibacterial activity of T-3912,a novel non-fluorinated topical quinolone显示文摘 | Tetsumi Junichi M Kazuya H | 2002 | J Antimicrob Chemother2002，49，： | 1 |
| 16 | Fracture analysis of the volcanic reservoir in the Minami--Nagaoka gas field,Japan (prediction of effective fractures in highly stressed field) 显示文摘 | Imamura Tetsumi Annaka Hitoshi | 2002 | Petrophysics2002，43，2： | 1 |
| 17 | On the metabolism and mutagen- ic activity of nitrofuran derivatives as veterinary medicine 显示文摘 | Tetsumi K Kitamura S | 1992 | Eisei Kagahu1992，38，4： | 1 |
| 18 | Cyclodextrin Drug Carrier Systems 显示文摘 | Kaneto Uekama Fumitoshi Hirayama Tetsumi Irie | 1998 | Chem Rev1998，98，： | 1 |
| 19 | Possible correlation betweeen DNA damage indused by hydrogen proxide and translocation of heat shock protein 70 protein into the nucleus显示文摘 | Tetsuta ABE Tetsumi K Takeshi T | 1995 | Bioch Bioph Res Communi1995，206，： | 1 |
| 20 | HPGCD Outperforms HPBCD as a Potential Treatment for N iemann‐ P ick Disease Type C During Disease Modeling with i PS Cells显示文摘 | Minami Soga Yoichi Ishitsuka Makoto Hamasaki Kaori Yoneda Hirokazu Furuya Muneaki Matsuo Hironobu Ihn Noemi Fusaki Kimitoshi Nakamura Naomi Nakagata Fumio Endo Tetsumi Irie Takumi Era | 2015 | Stem Cells2015，，4： | 1 |
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