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| 1 | Epigenetic profiles of pre-diabetes transitioning to type 2 diabetes and nephropathy显示文摘AIM: To examine DNA methylation profiles in a longitudinal comparison of pre-diabetes mellitus(Pre-DM) subjects who transitioned to type 2 diabetes mellitus(T2DM).METHODS: We performed DNA methylation study in bisulphite converted DNA from Pre-DM(n = 11) at baseline and at their transition to T2 DM using Illumina Infinium Human Methylation27 Bead Chip, that enables the query of 27578 individual cytosines at Cp G loci throughout the genome, which are focused on the promoter regions of 14495 genes.RESULTS: There were 694 Cp G sites hypomethylated and 174 Cp G sites hypermethylated in progression from Pre-DM to T2 DM, representing putative genes involved in glucose and fructose metabolism, inflammation, oxidative and mitochondrial stress, and fatty acid metabolism. These results suggest that this high throughput platform is able to identify hundreds of prospective Cp G sites associated with diverse genes that may reflect differences in Pre-DM compared with T2 DM. In addition, there were Cp G hypomethylation changes associated with a number of genes that may be associated with development of complications of diabetes, such as nephropathy. These hypomethylation changes were observed in all of the subjects.CONCLUSION: These data suggest that some epigenomic changes that may be involved in the progression of diabetes and/or the development of complications may be apparent at the Pre-DM state or during the transition to diabetes. Hypomethylation of a number of genes related to kidney function may be an early marker for developing diabetic nephropathy. | Thomas A Vander Jagt Monica H Neugebauer Marilee Morgan Donald W Bowden Vallabh O Shah | 2015 | World Journal of Diabetes2015，6，9： | 5 |
| 2 | 营养不良:实验室指标vs营养评估显示文摘营养不良是患者并发症发生率和病死率的一项独立危险因素,并造成医疗费用的增高。然而,由于对营养不良没有一个统一的定义,也没有一个标准的营养不良筛查/诊断方法,导致全世界各地的医生对营养不良在认识上十分混乱,各地的临床实践也有着各不相同的标准。作为营养不良的危险因素,炎症的作用近期已被证实。组织学上,一些血清蛋白如白蛋白和前白蛋白被广泛用于监测患者的营养状态。然而,目前的研究热点是采用恰当的营养状态体格检查(NFPE)来诊断营养不良。目前认为,实验室指标本身不太可靠,只能作为NFPE的一个补充。今后的研究中需要筛选出一些诊断营养不良的血清生物学标志物,这些标志物必须是不受炎症状态影响且具有无创及价格相对低廉的优势。然而,一个完全的NFPE在营养不良的诊断中具有无可替代的作用。 | Shishira Bharadwaj Shaiva Ginoya Parul Tandon Tushar D.Gohel John Guirguis Hiren Vallabh Andrea Jevenn Ibrahim Hanouneh | 2016 | Gastroenterology Report2016，4，4： | 5 |
| 3 | Fraud detection in online consumer reviews显示文摘 | Nan Hu Ling Liu Vallabh Sambamurthy | 2010 | Decision Support Systems2010，，： | 2 |
| 4 | Fraud detection in online consumer reviews显示文摘 | Nan Hu Ling Liu Vallabh Sambamurthy | 2010 | Decision Support Systems2010，，3： | 2 |
| 5 | Mechanisms of ischemic brain injury显示文摘 | Vallabh Janardhan Adnan I. Qureshi | 2004 | Current Cardiology Reports2004，，2： | 1 |
| 6 | Anticardiolipin antibodies and risk of ischemic stroke and transient ischemic attack:the framingham cohort and offspring study显示文摘 | Vallabh Janardhan Philip AW Carlos SK | 2004 | Stroke2004，35，3： | 1 |
| 7 | Identification of Patients at Risk for Periprocedural Neurological Deficits Associated With Carotid Angioplasty and Stenting显示文摘 | Adnan I. Qureshi Andreas R. Luft Vallabh Janardhan M. Fareed K. Suri Mudit Sharma Giuseppe Lanzino Ajay K. Wakhloo Lee R. Guterman L. Nelson Hopkins | 2000 | Stroke: Journal of the American Heart Association2000，，2： | 1 |
| 8 | Fraud detection in online consumer reviews显示文摘 | Nan Hu Ling Liu Vallabh Sambamurthy | 2011 | Decision Support Systems2011，50，3： | 1 |
| 9 | Stem cell therapy in ischemic stroke: Role of IV and intra-arterial therapy显示文摘 | Vivek Misra Michael M. Ritchie Laura L. Stone Walter C. Low Vallabh Janardhan | 2012 | Neurology . 2012 (13_S)2012，，13： | 1 |
| 10 | Fraud detec- tion in online consumer reviews显示文摘 | Hu Nan Liu Ling Sambamurthy Vallabh | 2011 | Decision Support Systems2011，50，3： | 1 |
| 11 | Anti-Arthritic Activity of Bartogenic Acid Isolated from Fruits of Barringtonia racemosa Roxb. (Lecythidaceae)显示文摘 | Kalpesh Ramdas Patil Chandragouda Raosaheb Patil Ramchandra Baburao Jadhav Vallabh Krishnalal Mahajan Prabhakar Raosaheb Patil Pradeep Sampatrao Gaikwad | 2011 | Evidence-Based Complementary and Alternative Medicine2011，，： | 1 |
| 12 | Mechanisms of ishcemic brain injury 显示文摘 | Vallabh Janardhan Adnan I Qureshi | 2004 | Current Cardiology Reports2004，6，2： | 1 |
| 13 | Anticardiolipin antibodies and risk of isehemie stroke and transient isehemie attack:the framingham cohort and offspring study显示文摘 | Vallabh Janardhan Philip AW Carlos SK | 2004 | Stroke2004，35，3： | 1 |
| 14 | Blood–brain barrier, reperfusion injury, and hemorrhagic transformation in acute ischemic stroke显示文摘 | Rakesh Khatri Alexander M. McKinney Barbara Swenson Vallabh Janardhan | 2012 | 2012 (13_S)2012，，13： | 1 |
| 15 | 机械血栓切除术综合性卒中中心的要求和卒中血管内治疗医疗体系:血管和介入神经病学学会(SVIN)卒中血管内治疗标准委员会的推荐意见显示文摘最近,5项具有里程碑意义的多中心、前瞻性、随机、开放标签、盲法终点的临床试验证实,在伴有颅内大血管闭塞的急性缺血性卒中(acute ischemic stroke,AIS)患者中,应用机械血栓切除术进行血管内治疗具有显著的临床获益。血管和介入神经病学学会(Society of Vascular and Interventional,SVIN)任命了一个专业写作委员会来总结这些新证据,并就如何应用这些数据指导AIS患者的急诊血管内治疗提出了推荐意见。 | Joey D. English Dileep R. Yavagal Rishi Gupta Vallabh Janardhan Osama O. Zaidat Andrew R. Xavier Raul G. Nogueira Jawad F. Kirmani Tudor G. Jovin 刘晓昀 许岩 孙文 | 2017 | 国际脑血管病杂志2017，25，6： | 1 |
| 16 | Endovascular Procedures for Treating Wide-Necked Aneurysms显示文摘 | Alessandra Biondi Vallabh Janardhan | 2005 | Neurosurg Focus2005，18，2： | 1 |
| 17 | The Effects of Social Network Structure on Enterprise Systems Success: A Longitudinal Multilevel Analysis显示文摘 | Sharath Sasidharan Radhika Santhanam Daniel J. Brass Vallabh Sambamurthy | 2012 | Information Systems Research (-Part-)2012，，3： | 1 |
| 18 | Shaking limb transient ischemic attacks unusual presentation of carotid artery occlusive disease : report of two cases 显示文摘 | Nicole L Klempen BS Vallabh Janardhan MD | 2002 | Neurosurgery2002，51，2： | 1 |
| 19 | Quantifying Priondisease Penetrance Using Large Population Control Cohorts显示文摘 | Minikel EV Vallabh SM Lek M | 2016 | Science Translational Medicine2016，，8： | 1 |
| 20 | The Effects of Retail Channel Integration through the Use of In- formation Technologies on Firm Perfor- 显示文摘 | Oh Lih-Bin Hock-Hai Teo and Vallabh Sambamurthy | 2012 | Journal of Operations Management2012，30，5： | 1 |
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