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| 1 | Impact of an acute hemodynamic response-guided protocol for primary prophylaxis of variceal bleeding显示文摘AIM To evaluate the long-term outcome of an acute hemodynamic response-guided protocol in which acute responders to intravenous propranolol received traditional nonselective beta-blockers(NSBBs) and acute nonresponders received carvedilol.METHODS Retrospective review of a protocol for primary prophylaxis of variceal bleeding guided by the acute hemodynamic response to intravenous propranolol. Fifty-two acute responders treated with traditional NSBB(i.e. propranolol or nadolol) were compared with 24 acute nonresponders receiving carvedilol. A second hemodynamic study was performed in 27 and 13 patients, respectively. The primary endpoint was development of first or further decompensation. Secondary endpoints included death from any cause, association between acute and chronic hemodynamic response, and baseline clinical and laboratory variables related to the acute hemodynamic response.RESULTS Acute responders and acute nonresponders presented similar 1, 2, and 3-year probabilities of first decompensation(NSBB: 0%, 13.7%, 26.1% vs carvedilol: 0%, 20%, 20%, P = 0.968) or further decompensation(21.2%, 26.1%, 40.9% vs 21.2%, 50.0%, 50.0%, P = 0.525). A previous episode of hepatic encephalopathy was the only independent predictor of decompensation [hazard ratio(95% confidence interval): 8.03(2.76-23.37)]. Mortality rates were similar in acute responders and acute nonresponders with compensated(P = 0.428) or decompensated cirrhosis(P = 0.429). No clinical, laboratory, endoscopic or hemodynamic parameter predicted the acute hemodynamic response. In patients receiving traditional NSBB, the acute and chronic changes of hepatic venous pressure gradient were correlated(r = 0.59, P = 0.001). Up to 69.2% of acute nonresponders gained chronic response with carvedilol.CONCLUSION Early identification and treatment with carvedilol of acute nonresponders to intravenous propranolol improves the clinical outcome of this high-risk group of patients, probably due to its greater effects for reducing portal pressure. | José Ignacio Fortea ángela Puente Patricia Ruiz Iranzu Ezcurra Javier Vaquero Antonio Cuadrado María Teresa Arias-Loste Joaquín Cabezas Susana Llerena Paula Iruzubieta Carlos Rodríguez-Lope Patricia Huelin Fernando Casafont Emilio Fábrega Javier Crespo | 2018 | World Journal of Clinical Cases2018，6，13： | 6 |
| 2 | A break in the clouds显示文摘 | Luis M. Vaquero Luis Rodero-Merino Juan Caceres Maik Lindner | 2008 | ACM SIGCOMM Computer Communication Review2008，，1： | 5 |
| 3 | Management of oligometastatic non-small cell lung cancer patients:Current controversies and future directions显示文摘Oligometastatic non-small cell lung cancer(NSCLC)describes an intermediate stage of NSCLC between localized and widely-disseminated disease.This stage of NSCLC is characterized by a limited number of metastases and a more indolent tumor biology.Currently,the management of oligometastatic NSCLC involves radical treatment(radiotherapy or surgery)that targets the metastatic lesions and the primary tumor to achieve disease control.This approach offers the potential to achieve prolonged survival in patients who,in the past,would have only received palliative measures.The optimal therapeutic strategies for the different scenarios of oligometastatic disease(intracranial vs extracranial disease,synchronous vs metachronous)remain undefined.Given the lack of head-to-head studies comparing radiotherapy to surgery in these patients,the decision to apply surgery or radiotherapy(with or without systemic treatment)must be based on prognostic factors that allow us to classify patients.This classification will allow us to select the most appropriate therapeutic strategy on an individualized basis.In the future,the molecular or microRNA profiles will likely improve the treatment selection process.The objective of the present article is to review the most relevant scientific evidence on the management of patients with oligometastatic NSCLC,focusing on the role of radiotherapy and surgery.We also discuss areas of controversy and future directions. | Felipe Counago Javier Luna Luis Leonardo Guerrero Blanca Vaquero María Cecilia Guillén-Sacoto Teresa González-Merino Begona Taboada Verónica Díaz Belén Rubio-Viqueira Ana Aurora Díaz-Gavela Francisco JoséMarcos Elia del Cerro | 2019 | World Journal of Clinical Oncology2019，10，10： | 5 |
| 4 | Functional Recovery of Chronic Paraplegic Pigs After Autologous Transplantation of Bone Marrow Stromal Cells显示文摘 | Mercedes Zurita Jesús Vaquero Celia Bonilla Martín Santos Javier De Haro Santiago Oya Concepción Aguayo | 2008 | Transplantation2008，，6： | 3 |
| 5 | Oral probiotic VSL #3 attenuates the circulatory disturbances of patients with cirrhosis and ascites显示文摘 | Diego Rincón Javier Vaquero Ana Hernando Evelyn Galindo Cristina Ripoll Marta Puerto Magdalena Salcedo Rubén Francés Ana Matilla María V. Catalina Gerardo Clemente José Such Rafael Ba?ares | 2014 | Liver Int2014，，10： | 2 |
| 6 | “Small-for-flow” syndrome: Shifting the “size” paradigm显示文摘 | J.M. Asencio J. Vaquero L. Olmedilla J.L. García Sabrido | 2013 | Medical Hypotheses2013，，5： | 2 |
| 7 | A break in the clouds显示文摘 | Luis M. Vaquero Luis Rodero-Merino Juan Caceres Maik Lindner | 2008 | ACM SIGCOMM Computer Communication Review2008，，1： | 2 |
| 8 | Transabdominal Surgical Approach in the Management of Renal Tumors Involving the Retrohepatic Inferior Vena Cava显示文摘 | Jose A. Gonzalez-Fajardo Ernesto Fernandez Jesús Rivera Alejandro Pelaz Javier Gonzalez-Zarate Juan C. Alvarez E. González C. Vaquero | 2000 | Annals of Vascular Surgery2000，，5： | 2 |
| 9 | Littoral-cell angioma of the spleen:A case report显示文摘Littoral-cell angioma (LCA) is a primary splenic vascular tumor that arises from the normal littoral cells lining the sinus channels of the splenic red pulp. We report a case of LCA of the spleen, which has been infrequently communicated in the literature. A 76-year-old man with a 2-wk history of weight loss, abdominal pain and changes in bowel habits was admitted to our hospital. Imaging studies (CT and MRI) showed multiple lesions in the spleen. Splenectomy was performed. Lining cells were positive for CD31/CD68 markers. Our case was associated with a serrated colonic adenoma. LCA is a benign vascular tumor of the spleen that needs to be included in the differential diagnosis of multiple splenic nodules. | ngel Cosme ngel Tejada Luis Bujanda Manuel Vaquero José Luis Elorza Evelia Ojeda Unai Goikoetxea | 2007 | World Journal of Gastroenterology2007，13，48： | 2 |
| 10 | Cogan's syndrome: an oculoaudiovestibular Disease 显示文摘 | Garcia Berrocal JR Vargas JA Vaquero M | 1999 | Postgrad Med J1999，75，883： | 1 |
| 11 | Visual function with monofocal versus multifocal IOLs显示文摘 | Encinas JL Jimenez F | 1996 | J Cataract Refract Surg1996，22，9： | 1 |
| 12 | Vascular endothelial growth-permeability factor in granulation tissue of chronic subdural haematomas 显示文摘 | Vaquero J Zufita M Cincu R | 2002 | Acta Neurochir2002，144，4： | 1 |
| 13 | A breakin the clouds: Towards a cloud definition 显示文摘 | Vaquero L M Rodero-Merino L Caceres J | 2008 | ACMSIGCOMM Computer Communication Review2008，39，1： | 1 |
| 14 | Effects of atorvastatin and simvastatin on atrial plateau currents显示文摘 | Vaquero M Caballero R Gomez R | 2007 | J Mol Cell Cardiol2007，42，5： | 1 |
| 15 | Localized pancreatic NF- kappaB activation and inflammatory response in taurocholate - induced pancreatitis 显示文摘 | Vaquero E Gukovsky I Zaninovic V | 2001 | Am J Physiol Gastrointest Liver Physiol2001，280，6： | 1 |
| 16 | Effccts of atorvastatin andsimvastatin on atrial plateau currents 显示文摘 | Vaquero M Caballero R Gomez R | 2007 | J Mol Cell Cardiol2007，42，5： | 1 |
| 17 | Functional recovery after severe CNS trauma: Current perspectives for cell therapy with bone marrow stromal cells 显示文摘 | Vaquero J Zurita M | 2011 | Progress in Neurobiology2011，93，5： | 1 |
| 18 | Atypical papillary glioneuronal tumor 显示文摘 | Vaquero J Coca S | 2007 | Cancer2007，83，： | 1 |
| 19 | Infection and the progression of encephlopathy in acute liver failure显示文摘 | Vaquero J Polson J Chung C | 2003 | Gastroenterlogy2003，125，： | 1 |
| 20 | Termination of disease modifying drugs in psoriatic arthritis:study of 109 courses of treatment显示文摘 | Vaquero CG Moreno JR Ros S | 1996 | Br J Rheumatol1996，35，： | 1 |
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