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| 1 | Comparison of inhaled milrinone, nitric oxide and prostacyclin in acute respiratory distress syndrome显示文摘AIM To evaluate the safety and efficacy of inhaled milrinone in acute respiratory distress syndrome(ARDS).METHODS Open-label prospective cross-over pilot study where fifteen adult patients with hypoxemic failure meeting standard ARDS criteria and monitored with a pulmonary artery catheter were recruited in an academic 24-bed medico-surgical intensive care unit. Random sequential administration of i NO(20 ppm) or nebulized epoprostenol(10 μg/mL) was done in all patients. Thereafter, inhaled milrinone(1 mg/mL) alone followed by inhaled milrinone in association with inhaled nitric oxide(iN O) was administered. A jet nebulization device synchronized with the mechanical ventilation was use to administrate the epoprostenol and the milrinone. Hemodynamic measurements and partial pressure of arterial oxygen(PaO_2) were recorded before and after each inhaled therapyadministration.RESULTS The majority of ARDS were of pulmonary cause(n = 13) and pneumonia(n = 7) was the leading underlying initial disease. Other pulmonary causes of ARDS were: Post cardiopulmonary bypass(n = 2), smoke inhalation injury(n = 1), thoracic trauma and pulmonary contusions(n = 2) and aspiration(n = 1). Two patients had an extra pulmonary cause of ARDS: A polytrauma patient and an intra-abdominal abscess Inhaled nitric oxide, epoprostenol, inhaled milrinone and the combination of inhaled milrinone and i NO had no impact on systemic hemodynamics. No significant adverse events related to study medications were observed. The median increase of PaO 2 from baseline was 8.8 mmH g [interquartile range(IQR) = 16.3], 6.0 mm Hg(IQR = 18.4), 6 mm Hg(IQR = 15.8) and 9.2 mm Hg(IQR = 20.2) respectively with i NO, epoprostenol, inhaled milrinone, and i NO added to milrinone. Only i NO and the combination of inhaled milrinone and i NO had a statistically significant effect on PaO 2. CONCLUSION When comparing the effects of inhaled NO, milrinone and epoprostenol, only NO significantly improved oxygenation. Inhaled milrinone appeared safe but failed to improve oxygenation in ARDS. | Martin Albert Daniel Corsilli David R Williamson Marc Brosseau Patrick Bellemare Stéphane Delisle Anne QN Nguyen France Varin | 2017 | World Journal of Critical Care Medicine2017，6，1： | 4 |
| 2 | Clot structure modification by fondaparinux and consequence on fibrinolysis:a new mechanism of antithrombotic activity显示文摘 | Varin R Mirshabi S Mirshabi P | | 0，，1： | 1 |
| 3 | Clot structure modification by fondaparinux and consequence on fibrinolysis:a new mechanism of antithrombotic activity显示文摘 | VARIN R MIRSHAHI S MIRSHAHI P | 2007 | Thromb Haemost2007，97，： | 1 |
| 4 | Oxidative stress and endothelial dysfunction in heart failure显示文摘 | Vaux C Varin R Mulder P | 2001 | Therapie2001，56，50： | 1 |
| 5 | The effect of sequential and continuous hight-energy on mechano-chemical synthesis of nanostructured ternary complex hydride Mg2FeH6显示文摘 | LI S VARIN R A WRONSKI Z | 2005 | Journal of Alloys and Compounds2005，396，12： | 1 |
| 6 | Characterization of nanocrystalline Fe-45%Al intermetallic powders obtained by controlled ball milling and the influence of annealing显示文摘 | Varin R A Bystrzycki J Calka A | 1999 | Intermetallics1999，7，： | 1 |
| 7 | Formation and environmental stability of nanocrystalline and amorphous hydrides in the 2Mg-Fe mixture processed by controlled reactive mechanical milling (CRMA)显示文摘 | VARIN R A LI S CALKA A | 2004 | Journal of Alloys and Compounds2004，373，12： | 1 |
| 8 | Structure and mechanical properties ofboron-doped cubic zirconium trialuminides 显示文摘 | VIRK I S VARIN R A | 1992 | MetallurgicalTransactions A1992，23，4： | 1 |
| 9 | Controlled mechano-chemical synthesis of nanostructured ternary complex hydride Mg2FeH6 under low-energy impact mode with andwithout premilling显示文摘 | LI S VARIN R A MOROZOVA O | 2004 | Journal of Alloys and Compounds2004，384，12： | 1 |
| 10 | Clot structure modification by fondaparinux and consequence on fibrinolysis:a new mechanism of antithrombotic activity显示文摘 | Varin R Mirshahi S Mirshahi P | | 0，，： | 1 |
| 11 | Improvement of endothelial function by chronic angiotensin-converting enzyme Inhibition In heart failure:role of nitric oxide,prostanoids,oxidant stress,and bradkinin显示文摘 | Varin R Mulder P Tamion F | 2000 | Circulation2000，102，3： | 1 |
| 12 | Mechanical alloying and electronic simulations of 2Mg-Fe mixture powders for hydrogen storage显示文摘 | ZHOU D W LI S L VARIN R A | 2006 | Materials Science and Engineering A2006，427，12： | 1 |
| 13 | Intermetallic-reinforced litht-metal matrix In-situ composites显示文摘 | VARIN R A | 2002 | Metallurgical and Materials Transactions2002，33，8： | 1 |
| 14 | Carbon fibers coated with chromium carbide using the liquid metal transfer agent technique 显示文摘 | Varin R A Piekarski K | 1989 | Metallurgical Transactions A1989，20，： | 1 |
| 15 | Feasibility study of the direct meehano-chemical synthesis of nanostructured magnesium tetrahydroaluminate (alanate) complex hydride显示文摘 | Varin R A Chiu C Czujko T | 2005 | Nanotechnology2005，16，： | 1 |
| 16 | Magnesium suicide intermetallic alloys 显示文摘 | Li G H Gill H S Varin R A | 1993 | Metallurgical and Materials Transactions A1993，24，11： | 1 |
| 17 | Clot structure modification by fondaparinux and consequence on fibrinolysis:a new mechanism of an- tithrombotic activity 显示文摘 | Varin R Mirshahi S Mirshahi P | 2007 | Thromb Haemost2007，97，1： | 1 |
| 18 | Fracture toughness of intermetallic compacts consolidated from nanocrystalline powders显示文摘 | Varin R A Zbroniec L Czujko T | 2001 | Materials Science and Engineering2001，300，： | 1 |
| 19 | Tensile Properties of Titanium Carbide Coated Carbon Fibre- Aluminum Alloy Composites显示文摘 | HIMBEAULT D D VARIN R A PIEKARSKI K | 1989 | Composites1989，20，5： | 1 |
| 20 | Fracture toughness and yield strength of boron-doped,high (Ti+Mn)L12 titanium trialuminides显示文摘 | Varin R A Zbroniec L Wang Z G | 2001 | Intermetallics2001，9，： | 1 |
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